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DEP.\PTMENT OF LEX KY ... ·'· ! - ~ ~71 . O::ALTH. EDUCATION. AND . ·· ;_ _ ;-·,t....r,~ Ft:.OE;-{, ;;[:-~~i-B~tii~i!. ;~~=?iic'fi--~- PUBLIC HEALTH SERVfCE LEXINGTON. KENTUCKY 5 January 1954 IN ~f:PI.Y!NC.. AOeiiESS T~£ ~::2tl'i:~2' ~~Ft~i<!~ :tl'l A'R~ ~ PUSI..tC HEAL!H S:<:RVICE HOSPI!AL N I ~';H Ad d i c t i o n Re s e a r c h •• . 'i 1 am enclos tng copy of the Annual Progress Report to the ·-.9 f f 1 c: e o f Na v a l R e s ~ (; r c h • T h It! r e t s n o ma t e r t a t i n t h i s r ~ p o r t which was not covered in the Annual Report to the PublicHealth Service, c:o~v of which you already hav~ received. Since I have ~ast written you we have completed a large nomber n o f e x p e r i m~ n t {~ w i t h L AE - 3 2 , w. h v e-. r y d i..s a p p o i n t i n g r e s u I t s • We have se~n no evidence of ~ffects of any kind with doses as hioh as 1250 micrograms. Th"is compound seems so far infzrtor t o L SD -2 5 t h a t ·w o r k. w. i t h t t h a s b z e n d 1s co n r i n u e d • / We hav·z been busy gbfc::inlng control determinations (fasting) o n t "l e r a t e o f d i s a p p e cl r a n c e · o·f b t o o d a 1c o h o t , us i n g b o t h t h e breathmeter and direct blood determinations. The effect$ of three typcs'of food-- steak, bread and cream-- will be begun tater this month. Th~ necessary ~retlmtnary human ~harmacoloG­ ic:al·lnvestlgations are underway with the metabolic bloc\:.er, beta-dtethylaminoethy[pro~vlacetate, and wtrh chlorpromozinz. A variety of experi~ents are being planned with both agents, .. once the necessary backcrovnd information has been obtaln~d. . 1 will be in Washinqton on Wedne:dav. janu!!rY 2ist en route to the meeting of the Drug Addtction Committee The image displays a stylized graphic with text overlay. On the left, a silver vault door with intricate mechanisms, including gears and a central dial, is depicted against a dark background with blue lighting effects. The title "THE BLACK VAULT" is prominently displayed in white, distressed lettering at the top center of the image, accented by a blue glow. Below the title, white text provides information about the document's origin from "The Black Vault, an online database of declassified government documents," specifically mentioning the "MKULTRA/Mind Control Collection" and its availability for download. A yellow URL, "http://mkultra.theblackvault.com," is presented at the bottom as the online resource. There are no photographs, handwritten annotations, signatures, official stamps, forms, diagrams, or tables visible in this image. The content is purely illustrative and textual. ic:al·lnvestlgations are underway with the metabolic bloc\:.er, beta-dtethylaminoethy[pro~vlacetate, and wtrh chlorpromozinz. A variety of experi~ents are being planned with both agents, .. once the necessary backcrovnd information has been obtaln~d. . 1 will be in Washinqton on Wedne:dav. janu!!rY 2ist en route to the meeting of the Drug Addtction Committee in Rahway, N.j. t wo u t d t i k e to s p <l n d t he mo r n i n g w i t h you a n d ;..,rr • Bo rt r. e r , · i f t h d. t i s co n v en .i en t. P i e a s c I e t me k now • Very sincerely yours, HI: rn Enclosure The document is a typed letter dated January 5, 1954, from the Public Health Service Hospital in Lexington, Kentucky, to the NIMH Addiction Research Center. It features handwritten annotations including a circle containing "24" and a notation "(b)(3)" in the upper right and upper left quadrants of the page respectively, and an insignia of what appears to be a seal or crest in the upper left. There are also handwritten signatures and notes at the bottom of the page, including "Harris Isbell, M.D. Director of Research." Another annotation at the bottom right appears to be a coded symbol or reference, possibly "A-81". No photographs, diagrams, forms, tables, or visual evidence of experimental procedures are present.