Doc 0000151516

·- ·-:., ~ t ;.. -; ~ TV,A CODE NO DEPARTMENT OF.-" LEX KY 477 ~-·· HEALTH. EDL!CATi~-')t'!. A. . r~D \tvELf--h.RS. ~~-=-?-~~l;tfftt:-Y=A.GE.Et{'~ PUBLIC HEALTH SERVICE LEXINGTON. KENTUCI<Y ·a March 1954 IN ltll!f01."1'1NC, Arl~"ESS T"! ~tt!X:X~<tt.t:.O:·~IIC lC!C~·~ PUBLIC HE.~LTH SEri'.'IC!:: HOSPITAl. NIWH Addtct!on Research Cent~r (b) (3) I am enclosing a table which gives data obtained tn experf ··ments concerned.·-wtth the development of tolerance to LSD-25. Eleven subjects completed the=e The first exp~riments. 5 s u b j e c t s we r ~{ n e g r o ~ s ; t h e I a s t 6 we r e tl h i t e • T 'tfO n e g r o s v b jects, RE and GO, did not ccm~'lete the experiment because they ., got into trouble with the authorJties. (not coAnected with the s r" e L D e X p ·! r i.n e n t s ) • e r e : u ( t $ .0 b t a l n d w i t h t he $ e 2 s u b j e c h~ ' for complete~ss sa~e, are shown below the totals and the av~rage$. In the .control all the subjects were water at cxperi~ent, gtv~n ·9 a.~. and at 9 p.m. On the fourth day, they were given 75 meg. of LSD-25 at 9 a.m.,' and w-ere filled out houriy questl·::>nnatrc~ fvr ~;fl;li hvt_jf~. c;inir-.;oi notes,on benavior were kept. In the other experiment, patients rec-eived increasing doses of LSD-25· . ~· •. CIO, 20 a~d 30 meg.) at 9 a.m. ~id 9 p.m.· for three days, On the fourth day, they were aga.Jn tested with 75 meg. of.LSD-25. Half of the patients went thiough the water routine ftrst; hdlf through the LSD first. we~t Dec!assifieu by --·~ S7475--__ ..:.._~V' da~o ---~.4. ,F.E,B. .19.7.7. .,~---- ... ""' ..... ~, ............ ,~ ~-. .. * . . ·- \ Results on t~~ qu~~ttonn~tres"were estimated $Imply by counting the number of positive a~swers (those scored postttvz, after being scored negative prtor to tngesttng the drug). The d~gree of the symptom so recorded was ignored. "CI tntcal grades" were assigned by myself on the basis of Interviews during the test day and the. day followl~g. Criteria for the grades •ere as follo'"s: 0- Abs~nce of nervousness and ~p~rehenst~~, ,.. .. - Nervt..,usness and appreliens ton without The image displays the title "THE BLACK VAULT" in large, stylized white font with a blue glow. Below this, in white text, is a description stating that the document was obtained from The Black Vault, an online database of declassified government documents, specifically the MKULTRA/Mind Control Collection, which contains over 20,000 pages declassified by the CIA. The text also provides a URL for the collection: http://mkultra.theblackvault.com, highlighted in yellow. To the left of the text, a graphic depicts the front of a large, metallic vault door with various gears, levers, and a circular dial, rendered in shades of gray and blue, suggesting security and stored information. There are no photographs of people, locations, equipment, or subjects, nor any handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures visible on this page. The d~gree of the symptom so recorded was ignored. "CI tntcal grades" were assigned by myself on the basis of Interviews during the test day and the. day followl~g. Criteria for the grades •ere as follo'"s: 0- Abs~nce of nervousness and ~p~rehenst~~, ,.. .. - Nervt..,usness and appreliens ton without distort ion tn shape or slze of ~elf, other persons, or t~ani~ate objects, ~{ 2- Nervousness a.nd appr-.e-henston, plus disfortTons in own body im.age, o,.ther persons, or inanimate objects, but without halluc.inat ions .and with retention of ins lght, / ." . :. I' '' 3 - N' r \'O us ness , · a p pre hens ton , d 1 s t or t ions and e I c: men t a r y · h a t l u c i n a I' tons • T rue ·n J I I u c i n a t ions may be p r c sen t, but/insight apparently retained, 4- Same as· Grade 3, but true hallucinations present and insight lost. Grade 4 is apparently quite rare tn my experience. Tabulated data .:how that these pattznts gdve an average of 98 positive responses after three days on water and only 22 after three days on LSD-25~ In terms of cltn1cal grade, the averages . '· were J .95 after three days of wat·c:r, and 0.6 after rhr'e ddys ,-, . ,. of LSD-25. \;..;:.~.r-i :·~·~...__:..-::' .,~--: :._~~::;_.:_ .. :::_ ... :r./' • o•'-" r -··., ,.. --:;.··< i : ··:..-._ . ·: Declassified b ~ ... date Y -1~t47r;; -:tr.F ::s ...._ ~77 108<;:; --- ........ -..~ ~ - ' I I Interpret indicating a very si.gntficant oeg(ee of tolerance after three days en these smal I amounts of lSD-25. Tolerance, however, was not complete tn 5 of the patients. Two of the patients, FO and GR, had v~ry little response to the 75-mcg. do s e , _ e v e n a f t e r t h r e e d •J y s o f wa t e r , s o t b e p r e s e n c e o r a b s e n c c -· _'( ;·"·>:..:..,. :,..:-:..~ '/';:..L.---- 1 ·db ~ I d no t b e de t e r m i n e d • .:;..:- ... :~ I hope to confirm The document is a declassified report page with official letterhead from the U.S. Department of Health, Education, and Welfare, Federal Security Agency, Public Health Service, in Lexington, Kentucky. There are handwritten annotations in the top right corner, a large circular marking with a number inside, and a boxed notation "(b)(3)" on the left side of the page. A rubber stamp at the bottom right indicates the document was "Declassified by 107475" on "4 FEB 1977" and features a handwritten signature. There are also dark, scribbled redactions towards the bottom center and on the right side of the page. The main body of the document contains typed text describing an experiment involving LSD-25. b e p r e s e n c e o r a b s e n c c -· _'( ;·"·>:..:..,. :,..:-:..~ '/';:..L.---- 1 ·db ~ I d no t b e de t e r m i n e d • .:;..:- ... :~ I hope to confirm these results, using pupillary, blood pressures and reflex responses, In another expertment which will begin as soon as f.he dose-effect .experiment which ts currently underway ts completed. I am curren~ly carry.tng out another tolerance expert~ent ',--- in rtl'd.ch patients ~ill r,ecetve one dose of lSD-2·5 daily during an 8-day period In amounts increas:tng from 20 to 75 meg. / wi believe tid$ particuiar schedule· II result tn complete, rather t h a n p a. r t i a I J 0'1 e r a n c e • I f . t h t s- i s t ru-e , we w t I I t h en · be i n position to attempt to determine how much the dose must be elevated to break through this degree of tolerance. - am sending .=t cop';" of th: t.-.t.:~ <Hld letter to Mr. Kornets~y, whom am expect in g to a r r tv e in lex i ng ton about Md r ch IS t h , have just rec~tved your letter of March 5th concerning OOL-148;- and three vla'ls have arrived in t·ne mail. This wil.l not permit more thdn a very preliminary evaluation, but wi! I give you the results as soon as possible. Yours very s lr.c.zre ly, Harris Isbell, •'"'.D. Director of Research HI: rn Enclosure Declassified b ·Y ~ 10'7~"""" A f t c r· 3 d a y s After 3-days LSD-25 (10 ~0 1 I H2_~ at 0900 a-nd - 2100 II 30 meg. at 0900 and 2100) I PAT lENT I No. Pos1tive C I i o i c~ I .I j No • Positive I Clt:dcal Answers Grade Ans v1e rs Grade I Jl FO .. 18 1/2 "' 7 1/2 - I . I! .--· SSM I I 251 3 I! 89 I I I GR 5 0 I 0 I. t DO 32 . IS I 0 l AU I 0 I 2 ro 0 ·-- 11 '·:, '~ FR 120 54 2 .. WA.. 41 II 30 WP.R 215 I t L. li ~~ I \Y/1 This page contains typed text detailing a methodology for scoring patients' responses to questionnaires, likely related to drug experimentation. There are no photographs, diagrams, or official stamps visible, but there are handwritten annotations, including a signature at the bottom right and some scribbled lines that indicate deletions or edits in the middle of the page, obscuring some content. Additionally, a "Declassified by" form is present with a date stamp. The overall image quality is poor, with faded ink and marks on the paper. 251 3 I! 89 I I I GR 5 0 I 0 I. t DO 32 . IS I 0 l AU I 0 I 2 ro 0 ·-- 11 '·:, '~ FR 120 54 2 .. WA.. 41 II 30 WP.R 215 I t L. li ~~ I \Y/1 167 IS DE 97 l i '} 3 ! ' I ' . ~ 8 0 S IM 34 , I 0 0 ... I Total I ,08 1,.. 2 ( -l/2 245 '6-1/2 ' . 98 1.95 22 0.6 Av~rage I ; : I t' t i ! RE 0 ! ' 0 . i - ·. .;I 1- co 43 . I i 2 i "· Declassified b date_ 4 FE[ 7wz:18747~ The page is a typed document with several handwritten annotations. At the top, there are black and white, blurry images which appear to be photographs or drawings of abstract shapes or possibly equipment. There are also handwritten notes and a signature, "A-87." A stamp with the text "Declassified by" appears at the bottom, with a handwritten date of "182175" partially visible. Some parts of the document are obscured by black redaction marks. The overall appearance suggests a declassified government document. This document contains a table detailing the results of experiments involving a substance, likely LSD-25, as indicated by the header "RESPONSE TO 75 MCG. LSD-25". The table is divided into two main sections, each with columns for "No. Positive Answers" and "Clinical Grade", applied after 3 days (with two different conditions at 0900 and 2100). Handwritten annotations are present in the "No. Positive Answers" column for "WPR" with a "3" next to "215" and in the "Clinical Grade" column for "Total" with "21-1/2". A stamp indicates the document was "Declassified by 187475" on "4 FEb 1977," and there is a handwritten annotation "A-86" in the lower right corner. There is no photographic content, diagrams, or obvious visual evidence of experimental procedures, equipment, or facilities.