Doc 0000151517

The image is a black background with white text. On the left side is a stylized image of a bank vault door. The top of the page features the title "THE BLACK VAULT" in large, stylized font. Below the title, a block of text explains that the document was obtained from The Black Vault, an online database of declassified government documents, specifically relating to the MKULTRA/Mind Control Collection. The text also provides a URL for downloading the entire collection. There are no photographs, handwriting, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures visible on this page. DEPARTMENT OF~· LEX KY 477 HEALTH. EDUCATION. AND '•• ELF.l-. ffErR~--r=-~s21illRib)k;:;£!3t=~:mE-~= PUBL.IC HEALTH SERVICE LEXINGTON. KENTUCKY IN "IU't;YING, ADCR£'SS THIC ·29 March 1954 fM~jf;~'(i. :t~~l4 ~.~:d'ti~ ~ PUBLIC: HEALTH SER'IIC E HCSPIT4L NIWH Addtctlon Research Center .. /-_L;!_~) \_ ·- ·-------- . As you undoubtedly know, ( had a vis it week before last from Mr. Kornetsky. We went over the data obtai~ed so far, and ar~ In the process o( mak tng duplicates of the graphs tn the dose effect experimenf. .... ' . Since Mr. Korn~tsky has been her~, we have completed another tolerance expirl~ent. In thts experiment pati~nt~ we~e given LSD for eight days i"rt doses increasing from 20 meg. to 75 meg. ouc~ d a i I y a t 9 a • m • 0:-~ the . n i n t h d.-a y , t he 7 5 -m c g • do s e was rep' a ted • The results a,:>pea~ In T9"ble 1. At. exp<Zcted, c1 considerable d::gree of tolerance was developed to the subjective effects of LSD-25. Pc:d ients g!Y"•? an Jvcrag~/ of only iS pos=it ive answers, as compared to 88 positiv~ answer.s after three doys.-of water. The clinical· :.:?: grade after eight days was esti~~ted as 0.625 as compared with l.7 after three days of weter. In scoring a number of positive answ~rs and cltntcal~grades, the same criteria were used as described in my prior letter. The grade of tolerance, however, taking into account the individuals concerned, does not appear to be any greater than that developzd after three day_s on hto srnall doses da iiy (see prior report}. Moreover, patients on the elght-day schedule reported more side eff~cts as tole~ance was developing, .more par ticularly in the middle part of the schedule. · We have some preliminary information on att~mpts to break through th~ LSD-tolera~ce by lncreJs ing the dos~. The number of patl~nts is not~yet ~ufflcient to permit any conclusions but, howev~r, t~e informa_tion is being submitted for what it is wert~, since n is not li~cly that I will be able to do more pri:>r to the Fcderdtion mer;:ting. In one expertm~nt, 4 patients w~re mdde tolerant by the three-day schedule CtO, 20, and 30 meg. LSD-25 at 9 ~.m. and 9 p.m.), the test dose being given on the fourth day. Two of the patients r e c e i v c d a to the Fcderdtion mer;:ting. In one expertm~nt, 4 patients w~re mdde tolerant by the three-day schedule CtO, 20, and 30 meg. LSD-25 at 9 ~.m. and 9 p.m.), the test dose being given on the fourth day. Two of the patients r e c e i v c d a ! CO mc g • t ~ s t do s e { i ncr e as e of 33 p ~ r c en ~ ) a n d 2 i e c e iv e d I 2 5 m c g • { a n i n c r ~ a s e o f 6 6 p e r c e n t ) • No s i g n t f i c a n t ;'b r e a ~ - t h r o u g h 1 ' occl:rred Tn an-: of_ these 4 patients. 0? Ma r c h 19 54 __ ,.,--.' Poge 2 I ,, . .• .. ~ ... :,1. .-; .. ):·. ..- < . (.. ,Jiil~ ). u( ) - . 2. ~-J/ "" ?·-· In another expertm~nt 6.pattents were made tolerant, using a nine dose schedule· (one dose of LSD-25 daily at 9 a.m., increasing frc:n 20 to 75 meg. on the eishth day). On the ninth day, one patiint was tested with ICO meg. ·and 5 were tested wtth.l25 meg. There was nos isnt.ftcant break-through with either of these doses, although in one patient (DEll partial break-through was achieved. These series of experlmznts wi II be completed as soon as poss fbi e, after which we wil I go on to even hisher doses. At the moment, the trend appears to indicate that the dose must be increased more than 66 per cent to restore the original effect of LSD-25, once tolerdnce has been developed. I I I think. it ts. of some interest and some pr~ctical irnport'Jnce that we have now tested fuore than 50 former ~orphine addicts with LSD-25 Cthis number includes the group tested in 1951}. The .. •·. I ' II t·mportant thing seems to be that the mental effects observed In I f this population ~re, so far as I can tel I from the literature, ;I I' identical with those obser'!ed in other populations, despite the ; I fact that my group differs so greatly with respect to The document is a typed letter on official letterhead from the Department of Health, Education, and Welfare, Public Health Service, Lexington, Kentucky, dated March 29, 1954. It features several handwritten annotations, including numbers in circles and a fraction, as well as a circled "29" and a number "37" in the margin, and a signature "A-96" at the bottom right. There are also several stamps, including "FEDERAL SECURITY AGENCY" and possibly others that are difficult to decipher. The letter discusses an LSD-tolerance experiment conducted by NIMH Addiction Research Center. This page appears to be a typewritten document with handwritten annotations. A date is handwritten at the top, as well as some pricing, and a name. Another handwritten signature is present at the bottom. There is a letter "A" and a number "95" handwritten in the bottom right corner. The majority of the page is text, with no photographs, official stamps, forms, diagrams, tables, or visual evidence of experimental procedures, equipment, or facilities. There are no visible redactions on this page. II t·mportant thing seems to be that the mental effects observed In I f this population ~re, so far as I can tel I from the literature, ;I I' identical with those obser'!ed in other populations, despite the ; I fact that my group differs so greatly with respect to race, ' l I I I ' economic and educational st~tus, personality characteristics, I a c t n d p r t o r r u g tis e • _-! • I I would Iik.e your advic~ conce~~ing our plans for the immediate f u t u r e • I h a v e 8. p a t t e..n t s c h e c ~ i n g i n t o t h e wa r d n e x t we e k • This group is made up o!· individu:als who have been in the dos.-: effect experiment and tn the previous toier~nce experiment. My objectives are, (I J to corrcbcro-re the'results obtained with questionnaire and clinical mental examination, usir.g our objecth·e measurem..:nts, _...(2 J to determine the break-throush dose, us tng thcs~ objective me-asurements, (3) to t·est the SKF metabolic bleeker for enhancement of the LSD effect, and for tts effect durtng tclerence, (4) to determine the speed of less of tolerance, and (5) to obtain data on the effect of LSD on the fv'.\\P I and Rorschach tests. The main thing is tha·t to attain aii +hese- objeethres ~rill !"equ!:-~· fo;;r (:;.d viri:-hulf ~v fiv" mcn1·hs; or in ol:;~r worcs rh~ ~xperim~r.i':s will continue until August cr·September~ The decision thet must oe made is whether these are the most i~port~nt things for us to do at·this time. '· Sincerely yours, ' . r ·lJ . I~· ": /· 1 \) / ., t .. t~ I ,;· ..,~_;;<.' --t.A.,·\ . H u' -r". ' ~ r v . 1 • : ./ : . •. .,. 1• ·' ~ s .....1 , b e I l , I' f· < ~ ' t • ur. • ' Director of Research r HI: n At ta chmen ts A-95 cc: M1·. Kornetsky ...-JX\;1- ~ ; : ; 1 tt ~ l f [~'I TABLE I r~-"'LSD-25 TCLERANCE. -- E tght Day Schedule '": . 7-S. meg. Test Dose ., l j : ; After 3 Days H 2 o :l .. After HI: n At ta chmen ts A-95 cc: M1·. Kornetsky ...-JX\;1- ~ ; : ; 1 tt ~ l f [~'I TABLE I r~-"'LSD-25 TCLERANCE. -- E tght Day Schedule '": . 7-S. meg. Test Dose ., l j : ; After 3 Days H 2 o :l .. After 8 Days LSD PAT lENT I 20 mea. tnereas. in . r . . . ._ to 75 m c~ r ~ ~ No. pos it i ve No. pos i t tve Answers Grade • Answers Grade SJM j; 34 .. 23 ! ~ ' . ;~ .: . ~ ti DEL . 97 3 ! i ! 16 l i l~ : ; \. WEl; · i i . ' • l 167 3 ! ' ; : i. 38 I• !i ti. 'l " I' FO ri\ ,. I 8 1/2 t f • ! l ~ 2 0 .... ~ -' ~ : !.; . , SM ui, 251 3 ~ ' 24 f· ~ ~ i! _J ;, vi GR t: 5 0 ~ .~ 5 0 .. ., ·;, i. ' DO ' 32 - l l : ; 31 ' .i . ' . AU / j ( ~ I 0 I .. I l i I. 2 ': . i ', l i 4 I i l ! 0 ~ J ' '. 1i Tot a l !~ ; :; 705 ( 3-1/2 . i 143 5 {; Average L sa· I .7 • ~ l ! f8 0.625 :: '' !.,i l H,. ~ . ; I i ; '. i ' ~ : 0 0 Hu·:.t- .; , ~ . ! li SH~~ 2 0 d l ~=· Co n t r o I no t y e t o b t a t n e d TABLE 2 n BRE.A:~-THP.CUGH"- l SD TOLE. RANCE. 3-Day Schedule -- ,, I \ . I ~ ~ After 3 days H 2 o ll After 3 days LSD ! l I l After 3 days LSD -PAT lENT i~ f ; Test Dose H 75 meg. Test Dose Break-thrc-ugh - 1J ' 100 me~. Test Dos~ i! No. pos. Ans. ; Grade ll No. pos. Ans ., Gr. ;j No. po~ Ans. Grade ,l.i i i !I i GR ii 5 0 l II l 0 9 ! l/2 ·' AU 'I The image is a scanned page from a document featuring a table of data titled "TABLE I Eight Day Schedule". The table contains columns for "PATIENT", "After 3 Days H2O No. positive Answers", "Grade", and "After 8 Days LSD 20 mcg. increasing to 75 mcg No. positive Answers", and "Grade". Several patient codes and numerical data points are visible, along with a asterisk note stating "* Control not yet obtained". At the bottom right, there is a handwritten annotation "A-94". There are no photographs, stamps, or diagrams visible on the page. Dose H 75 meg. Test Dose Break-thrc-ugh - 1J ' 100 me~. Test Dos~ i! No. pos. Ans. ; Grade ll No. pos. Ans ., Gr. ;j No. po~ Ans. Grade ,l.i i i !I i GR ii 5 0 l II l 0 9 ! l/2 ·' AU 'I I 0 I 2 II 10 0 iII 2 I 0 I. p :1 !l 125 mcs. T ~ e st Dose HU-"~ )•,f ·II l; • i 'q 7 1 - /2 ~ -· ··' - - DO · 1 I - Is 0 III 32 i p(I 2 0 L ?, /1-93 . . ( r· - ~ TARLE 3 ~ - - n BREAK-THRCt.GH" LSD TOLERANCE - - ·- B-Day Schedule . - ... - ' After Days H 0 ,: After 8 Days LSD il After 8 Days LSD .;) 2 L PATIENT Test Dose 75 li Test Dose·7S Test Dose ICO ' -~ ·~ No. Pos •. Gra·cre No. Pos. Grade ;I N0. Pos • Grade ~i Answers ; I' : Answers : Answe-rs ~ SM 1 ; 1 I I 251 ! i I I 3 i ! •" l ; ~ 24 i i ' I i d l 0 ! ; 0 ·- ;i . i . j i l , I l , I'' I I . I ! j I ' l . .. I ·I i ' I t H ':I I~ I I : J l - - ij j qt. H l I II I !I Test Dose 1'25 l I I·' . I !I I; FO l l ~ 1 a I )/2 2 0 ii I i ' 0 .. SH* ~ ; l ! I f I ! . H 2 ! ' ' 0 H ' ,. ' 0 . : 0 BEt I I 97 l I ... 3 I .I ' 16 I I I ' i . : i 53 ; 2 ! ' ; #;,.. i S IM ! 34 i i I . _j ! ; ~ ~.:23 I I l ~ I 5 l I li l ' VI'E I • i 167 - I 3 ., I l I i 38 i,, I I i 35 I ' I I / ,_. d - ! - .. ' / - "' . ' . .. - The image displays a table titled "TABLE 2 'BREAK-THROUGH'- LSD TOLERANCE 3-Day Schedule". The table contains columns for "PATIENT", "After 3 days H20 Test Dose", "After 3 days LSD 75 mcg. Test Dose", and "After 3 days LSD Break-through 100 mcg. Test Dose", with sub-columns for "No. pos. Ans.", "Grade", and "Gr.". The last row includes data for "125 mcg. Test Dose". Handwritten marginalia "A-93" is visible in the bottom right corner. There are no photographs, official stamps, or diagrams present. The content is primarily structured data within a table format. I I l ~ I 5 l I li l ' VI'E I • i 167 - I 3 ., I l I i 38 i,, I I i 35 I ' I I / ,_. d - ! - .. ' / - "' . ' . .. - . 1-9~ . .. ' The document is a declassified CIA table titled "TABLE 3 'BREAK-THROUGH' - LSD TOLERANCE 8-Day Schedule." It presents structured data in a table format, detailing test results for various patients under different LSD dosages and conditions, including "After 3 Days H2O Test Dose 75" and "After 8 Days LSD Test Dose 75," as well as "Test Dose 125." The table includes columns for patient identifiers (SM, FO, SH*, DEL, SIM, WE I), "No. Pos. Answers," and "Grade." There are no photographs, diagrams, charts, or official stamps visible. One handwritten annotation, "4-92," appears in the bottom right corner.