Doc 0000151518

The visually prominent elements on this page are a stylized graphic of a bank vault door and explanatory text. The vault door graphic, rendered in metallic tones with blue lighting effects, suggests themes of security, secrecy, and hidden information. Beside the vault graphic, white text explains that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the "MKULTRA/Mind Control Collection." Below this, a bright yellow hyperlink provides the URL for accessing this collection online. No photographs, handwritten annotations, official stamps, forms, diagrams, tables, or redactions are visible. January I -March 3tl 11)54 'I LatorJtory of ?har~acology, 4-119 - . A. · C~!~!tAL or r-..b ~clcilntstrr.ti·1<: d1f'ftculttc~ worth'y uet~ ·::~rtt encountered during tl1 Is quarter • Hand I lng of ?avro 11 tlnd payment of voudi.:~s by the t-.!Jttonal lnstJtu!-e of 1,~.zn:~: t-k.:aHh is now functtoning sr:oorrd-;. Oc:castonal1y, r:1lnor errors h~ve been COr.i.-:llttcd because of the dtj ..... f'ercnc¢S bet~en J-bspt·tal Dtvlsion and NH:'H pra-etle.:!s, but at ttr.".e goes oo tbeJc error$ be ~~ould ell~lnat¢d. CJJntcal stud'tes durfng the quarter \::ere l~rccrly conceroed wtrh contJr.utng search f'or codcfne· substitutes.) the addiction llabiHtv . lntoxlc~tton w!th dJcthvl~ct~e of Jvserglc acid, and the llddlction llabt! tty/ of L-2-t..:.:..~:-tr:t.;:t!;y1-3-hydroxy-r:r:)rp~ l:1Jn and or 4-4-dtphcny!-9-dJocthyi.;;i!lino-hexar.one .. J exceed that of cDdctn~. These clrtigs cannot be rcgard~d a~ safe cccldtne :ub~ r 1 tutcs. . ' each .. - .. , : . .... . , .. , . .t..l."...'..:..n....!..". ~ • . h t. . such =J~turcs 1s 'i Jn nelr - to !era nee to H~-:: addicts. cin the activity of t~c putultGry and aclrcnal Eoth ·-:....: projects ccrrlcd out In colJaboratlon vtth other ~rc bel~o ;~~or~­ ·fori(!S C\:br.:~ster Found.:1r~on for E:x;>cr-lmentaf Biology Shrewsbu,-y, 1 res u t t s are not y;.; t a va II J b I e. TniZ n~uro;>hystofog1c.;d :~ctlon ha~ n0\"1 ~uececded In d~::or.strJtL-:,c physlc.al dependence: on r.tc~crldlne tn clogs. This scc\·Jon ha~ at~o been attempt I no to cor.lpfctely prevent m:>rph tne-induccd depress i<:Jn· fn dogs by ad;nt"n t !..: h•c:: t I on of' ve~ y Ia roe amount~ of Na Jl J ne at Intervals ~r_three bout$. It fs hoped that this expertment utlf constitute a test ot' the nadaptat1on" hypothcsfs of thz d-zvelop~-:l(!~t o; physicul dcpcnccncc. fft;:: The p s vc h o 1o a f s <! c t ion has t n J t I at~ d 4 s t vcl y on· t h:! , . . .. . .. . . ~ .. .. l . . ; , ,J . o • . . t . Y .. • f .,. I : ., _ ~ . to eVrlil~bil Hy of crus ; $~ social; "econor:tle (iiJd cducJtia!".ai status, and outfco~ 0~ add!..:tion tn physic.1Jo~, as comp-ared t~fth ~thcr oddJcts. To;.-o pil:J¢rs b~t wembcrs of' rh€ unit •.«ere publtzhcd during th~ quarter. Seventeen lectures before scrcnttflc v~r= pres~ntzd 1953 to H:c -1 ( .---7 /1.1..- / / \ The document is a typewritten quarterly report from January 1 to March 31, 1954, for the "Section on Addicting Drugs, Laboratory of Pharmacology, NIH Addiction Research Center, PHS Hospital" in Lexington, Kentucky. A handwritten annotation in the upper right corner encircles the number "30" with a "#" symbol next to it. Another handwritten annotation in the lower right corner reads "A-119". The page is mostly white space with some scattered dark marks that appear to be ink spots or document damage. There are no photographs, stamps, diagrams, forms with filled-in fields, tables, redactions, or visual evidence of experimental procedures. eVrlil~bil Hy of crus ; $~ social; "econor:tle (iiJd cducJtia!".ai status, and outfco~ 0~ add!..:tion tn physic.1Jo~, as comp-ared t~fth ~thcr oddJcts. To;.-o pil:J¢rs b~t wembcrs of' rh€ unit •.«ere publtzhcd during th~ quarter. Seventeen lectures before scrcnttflc v~r= pres~ntzd 1953 to H:c -1 ( .---7 /1.1..- / / \ i B. CliNlC\l STUDiES Cf ADDfCTI~J 1. Ward S·(vdle:· n· a • Add J c f I c n L I 5 b ti 1 ~ s of t-k w S u h s t e n c ~ s (! l l and 0 2, N-dt~thyi-3-hydroxy-:::or~h tn~n hydrochlorides (~ol-7362 and Rol-7363l. ~urk prevtov~ly reported with these cot:i?ounds vas confirr.;~d during this quarter. Absti~C;)CC was complc1·ely su;>prcssed 1n 2 patient:: -.uho t:er~ strongly addtctcd, when 60 mg. oi the l-lsc~cr wi:S 3dr.inlstcred every four hours. ··' The .g-lsomer was cornpleteiy fnactlv~ t~ suppressing ebstlnc;ClCC a~ thts dose Jcvct. It 'l1ln-;, therefore, concluded thilt the levo-lsor:l·:r b u s h t c h a d d t e t t c n _ It a u l1 It 'I "'; rd d"t e ~ c c c d $ t ha t c: f co c.!~ t n c ; 'Uh c r ~ s ~ ~;.. .·· the _£-lsc::1cr s a vt!r·v tncrt_ e0r,::-.o~~?d; 1.5 (~~·:~rd o·r ac!d!ctton t 1cbi ~ nv-~ . ./ . ':-;~cr~ t.:Hh this cor.:;>O•;:ld ts no\."1 rt:~r;;?t~tc • ·.-In co~es of cO to 75 c:;. every f•.:iur hours, tt has su::mre::scJ u!oost co:.:¥$~b:dy ~b::t!~ence / . . . In S patlcnts strongly acldfcrcd to ~t~hlnc. ft>thercfor~: a~r~~rs ...... ~ ,I~,•.•.u. ·~r·"-'t-iJ.J.. .!,..~ . - ... ... r-~r-~ ... v • ·(3) u~...-_ . .. .. . ; _ .,. . .. , , • • ' • " . ' . · • " . ' r ' t * · _. - .. . . ~ h .. ' J - : ·" w > ~ _ r ...... v ~ . . .. . . t . ' . : ~ r', ' t I" ! ' . .. . . . , .. ~ . ~ ... r This be Jnjcctcd only fn ott. - . o-· -r' ..,..;;...,.-_. . !•."t1 \! tt'\J4 t . , . -~ ., ~ ltt . ' : l . . .. . . . o• ,. ..,..... ...... .a.. .......... , ~ . o:~···--:· r.~~-~ .. ~ . ~ ... r This be Jnjcctcd only fn ott. - . o-· -r' ..,..;;...,.-_. . !•."t1 \! tt'\J4 t . , . -~ ., ~ ltt . ' : l . . .. . . . o• ,. ..,..... ...... .a.. .......... , ~ . o:~···--:· r.~~-~ A--If£ skJa crupiJoos constsitnn of biotc~v ' eryth~~9 .::rid \':h!!a·l~ ... r'e -obscr'i'ed in ~II pfl't t~cts. Scfftef~n.t c·,3te are not yzt at band to p-:rnJt' an cv~ Juat.ton. of' tt; ·addle~ ten r iJhl ~ ~i'v t-1) net.::-dl-:"':l~fiHiCOI (-15431. Tnis COCf.iCVncl is being inveGtioutcd ~t the spectftc request of th~ Cor..t":"lfss!cn~r cf' Narcatlc:. Althouah it can rqaclily be co~vcrtcd tnto bet~-dl-Jc~tv:­ rocth.:doJ, a c-or.t~und with f!nown hlch addiction liabilHy it c1Jnnot 1 lis~ If b~ subjc~tcd i·o the ·controlg cf the Narcottc Act wlthout proof or If$ ~ddictlon trabtl ity. ln dO$eS rongi:,o b~tt:e~n 30 to cclaycd r:1~rphtn~-IH:e qd'fcci: ir. tO nontotc.rt;n·~ adclJet!: .. \.ork is #.;-':·, . :.t!#. not complete and crz yet no .d~f!nlJc opinicn conccrnrr:.:r ~dd:c;fci: - ~ I Tilb il H y c:~n be r':nH.l::rcd,. b. u1o ·i' ' cXt• u-.r ~S • / ft) J to !0 ~l:turc~. · Ss~ p3ttcnts ba~e bezn ,....... ..~. . -~ - '";;"' . ~ . : · - - !r . "" - " : . "' . "a . + ' -.. ~ A-/IJ comtJJctely enaly:cd.· c. t.X>rph1oc Anhtgo~l:lt: .. tl J Lev~ I lor;'):~~ n fL-60 or ~o J-7700). Stud les ulth this cou~ound have been conltrned. It t: extrc~efy pot3nt ·,~ preclpl- tJtlng abstinence froc morphine In ~ddJctcd patfents, recerdfcss cf the route of (subcutaneous or It aiso admlntstratl~n or~tJ. ~ppears to b,1 core potent and ;,ore' to:dc thnn ~,~forphtnc. <, (2} D~xh·o-Nallor::>ncn (P-60). Tht$ co~und Is the. ept Jc~ l fsomer of Lcvallor~h~n ~nd a?pcars aa e~pected, to b~ quite 1 :z..· Inert~ St is tota --· lly lneffcc~tve In i;; " !o!t <3ddietcd person!: fn closes_ a~ h .~s lr.) r. 1. ynlJ; ;on ,r• • .~.:. ::1.-J ! J 01 ,. r • n • c dt '- J•r I on,:, l l nsr~ J r ' u;LC. OTto ." -\r' rt·n rt. r• l :i u11c . ; • . . . • .; ;; • r {:- "" bo it c D i ::; c a t c i t n the h o pc t h a-;' I The image is a scanned document, appearing to be a page from a report. The text is printed in a somewhat faded, sans-serif font. At the top, the title "QUARTERLY REPORT" is clearly visible. The document's content appears to be typed text, discussing clinical studies, addiction liabilities of certain drugs, and their effects. There are no photographs, diagrams, stamps, or filled-in forms. The only handwritten annotation is a signature-like mark in the bottom right corner, "A-11&". There are no redacations present. l l nsr~ J r ' u;LC. OTto ." -\r' rt·n rt. r• l :i u11c . ; • . . . • .; ;; • r {:- "" bo it c D i ::; c a t c i t n the h o pc t h a-;' I ;· t.:o u. t d be o :-~ I I y c f f;; c t : v.:: u n cl . both ond orally. it ac.n cars to subc~teneously b~ ~or~ C4l interest sJnce, /1r. -{/./ :;: / t:i'f.!c·;s wfdch 6r~ cbout eqts~l to tho$e of C'!~?~<:rldlne In micr:. Sc far. only dats cooccr~tng the std~ r~~ctJonz In oan arc av51fabit. fn do:;es of 4 to 0 ;;:g. it lttduce$ glcld;ncss, dl::::l~zssJ p<tilor, nc:.~sccS and sl<!epJr:~s:;. Thes2 eft<!ets ur~ quite mae-ked wlth the B-~ .. - --dose. The co~ound a~:>~ur~ to be ouch Jet~ aet tve .ora fly, sIn~~ equ i vu 1c nt cff ~c t s we r~ not obt.:ll n~d \tl th doses of 50 to 60 r.rn • .... --- d. - Dtethylamtcl\! of Lvserotc Acid tt.SD-251 •. .• . CI .) :: ·D o ! . i e e f f" e . c t r c . Ja t Jo n s h . t? s • T h ~· c e pa t r c n t s · . -. . J J ~ .. . , . . , ., . . 0 • l v ' - - n • 0 •-n.. .t>"' • 0 a5 ' 0 •. ,.. : ~ ; , l 1 e 0 '# •,· e:. : > - , "" . . " , . r . i . ... .. . ., . .. , ~ . . .. ' " - '""t# n · ·• /.'...'.. : . ... ~ . • ,'.-." .·t:• ·.,t. . S .r".' ) -. n _ r J :- • ,,... -~ half-h:Jut b;:f-.,rc ~nrJ f.!fict" :(HJ~tn~sh~JtJ ..n t of i·he dtucr ovc~" ll!l :J-hour . ., .· ,.! ....... r· ., ~ ."....,f," "'"-~ ~ ...... - An!<ict\' r: i 1 ho vi' :. "' .i jl .,,.. 1 .. ·"' {- y ,..., ... " '" W 'J V "'- I ... '-" • ~- •• . .,.. c.:-~ ··.~.'. :I 4t '.J. 1a ·"·· ~.., !""". ~- A-JIJ these changes were slgrdftcant The document is a scanned page of a typewritten report. There are no photographs, diagrams, tables, forms, or redacted sections visible. The text is accompanied by a handwritten annotation in the bottom right corner, reading "A-117". There are no official stamps or seals visible on the page. The entire page is dominated by text describing a research project on drug addiction. The document is a typed page with a top margin that appears to have a curved line, possibly representing a header or indentation. The content is organized into numbered and lettered sections, discussing clinical studies of addiction and the liabilities of new substances. There are no photographs, diagrams, tables, forms, or stamps visible. The only handwritten annotation is a signature or initial in the bottom right corner, appearing as "A-116". There are no redactions or obscured content on the page. ~ ...... - An!<ict\' r: i 1 ho vi' :. "' .i jl .,,.. 1 .. ·"' {- y ,..., ... " '" W 'J V "'- I ... '-" • ~- •• . .,.. c.:-~ ··.~.'. :I 4t '.J. 1a ·"·· ~.., !""". ~- A-JIJ these changes were slgrdftcant stat!si·fc.lfl·t Jt unty three of thz of the ·fuse and the d;crcc of €ffect obtained In the cnse of ~a; pupi I Jary sl:ze and bfood pressure. S tmJ lar cut"v~s t:ere obta tr~(~d of dose or the c:tntcal of mcnfol effect. c$tlmat~d oraJ~ . . correfatfcn bet~cn pu~tl(ary, blcod pfZ$SUri' and ~enfal crfccts jg.' .· . io data. cvrd~nt th~ v/a hav~ now $tudted the subject I v~ ,#.;. .• -.:! ¢CO::•nC::<iC statu~., and p'!fSOn.;d li'y rypCSct ~~ Orh:;r t_;crdz~-·J!1~ cff..:crt / of lSD-25 a~pear to bz s~ecJftc a~d are not rcf~ted to any cf ~he sine-:; b:cn studied ~cr~ (2} T~lcr~nca to lSD-25. To JcrZ~ r.c~ we hav~ conifrm~d ;-/I Jr -,! ("-/ <_, a t~tsnfficeitt cicar:;e·of tolerance c.a!'l b~ obf-aln<:cl by adrdnlltz;·fllg 10, ~0 ~~!d 30 r.::o. of LSD-2.5 i'vdce d.:~ Jfy fer -JS I fri· Jc ilS three day~~ Doses oJ thfs order tnducz only ~ifd effects. 3. Ch Jorpror.:azfnc (Sf~F-2601). T!i Is com;>Ound ts va.r to::s ht known as LaroJcttl~ ThorazJn.:, and by other n~.~s. Chernfcelly H· ts related to the p~enothta:ln~ grou~ of antlbJstarnlnlc druos. tt has been re::Jort~:~d to b.z ~n.ecl~ct!clyttc; parasyr::pa~·holyrtc, ~ntf­ c:letlc, and highly $cdotlve drug whtch, In edcitlon, _mark~dfy pc.tcn tfutcs th~ ef'fccts,·ot' Ot)iutc:, ba~l,ttur£des und gencrtti eilC~thefic~. -- It rs under tntcnslv~ invcstto4tion os ~ sedative agent for v~rloua optaf'c/ s rclat2d sy~ptom3 o~ wlthdra~~~ frc~ ~~d drucs~ 'I I t ~ •. - .;; ;:) ' f . I ! . i t. l (..:. I , ., ~ ... a 1 •• i J ,. - ._U • ! I . t J ' ,. " . ; . ) fl Ze:au~~ of r~oorts ~f the ~otcn~Jction ~: n,.. ,, '., .~. .~ r ~ ~ · ...... . ~ ;..; ,. ~- .:1. ~-·.; bocy noh:d with d •. co~o • f t ne VJrn t ~ ~ v ..... ~~- ! I .:*, - ~ - . .·,-.....~, c, - .,, i ,i" I l . f 4 . u . . ~ . J 'r : ~ , - ... - .... : ... This page features typed text on a white background, seemingly from a declassified document. There are no photographs, diagrams, or forms. Handwritten annotations are present in the bottom right corner, including the text "A-115" and some illegible scribbles. Some ink smudges and stray marks are visible scattered across the page. There are no official stamps, redactions, or visual evidence of experimental procedures or equipment; the document appears to be a purely textual report. with d •. co~o • f t ne VJrn t ~ ~ v ..... ~~- ! I .:*, - ~ - . .·,-.....~, c, - .,, i ,i" I l . f 4 . u . . ~ . J 'r : ~ , - ... - .... : ... t . w ·• , J · ' r - l -~ 2 Bloche~lcaf StudJc~ 1 \1• ..C l1ni·cJt ~·ndocrinoiogy cf·l\ddlerio~l (l) Lack of effect of chortonfc gcnadotro~Jn af}cr ·onfc gonadotropin bcT'ore and durfr.g a cycle of addiction to r~rphtne:r or odr.1Jntstrntion ICOO unit$ of' chorJontc gonacotropin da.~ly f<:>r ftve day$ did not Induce 4 stgnfflcant rts~ in 17-ketosterolds. This was JOt ju~ to ~ccr~ase In ~=tivity of the preparation used. .. . ._., since tt Induced the tn fndfvlduofs who cx~~cted rts~ h~d n~t b~~n ----- readdicted. An ad~lttcnal pJtle~t \lras, therefore, put through a ., Th\! reason for thls ·cha~~·-e .Is ~bscure. _, ( f')' ~ddtcti~n nn excretion of - Founcatton for Expzrlr:ie~tnl Blo!o::v, frn.:¥bna{·ion of tha sh:rotds t are ' . • ! o ar1c~~TaCg .d C I CT . f . V Z on:I'.y ;,.·, r-:1:1 jl j (~ It'- 1 tj excretion durrr., cycles olf addtc~·fon .:re b:-tng c~rrlcd out, ustna 2 e1aie iubjcct$. Th~ ~Jl~,H Addiction l!::~curcb Center coll<:ct~ urtnas precfp1t4fes thz gonadotropin)· dries extract$ and th~ 1 fot•-rards tn(!r:1 to th~ Ndtlonal Cuncer lnstttut:: where the assay!~ llr~ made. A:: yet th~ rc$ults erz net avatlable. b~ Studtas ln Matebollsm of Ethyl Alcohot. A con,lcler- or 4ble nu~ber dct=r~lnattons of t~a rate Dt which ethyl alcohol .. df:- . ~r>p~ars from th<: blood $'.'ere carrlzd out early In the quarter •. T·.;,<O dcferntnatton of of in the concentratJ~ns ~lcohof th~ bre~~ht ether~ ~ ~ c~tcrr::In~tton c·'? hlcod clc:;;hol c,tl~·.;:.ci·!y~ ustr~a dlch.rc:.-Jafc O}dcurion ~ / l) . .. l,f,~ lr",'_ .~. 1 11 - -::. ~ ~ t !_ , .. ti_ ,',• / r.\.,;. ....~.. ,,.., l• . ! i • . ., , . '';'"f'".- . " ! "· 0 ~ # , v . , : ! ~ " '\ . _ ~ .. ,l . .. ~ . . , . . . .. . . , , " - ' ! ".. lt . ~ar •,• ·•~ " ~a - ~ . ~ . br"' .... } . u • · l l ~ ... . ... - .. _ ~ .. ,l . .. ~ . . , . . . .. . . , , " - ' ! ".. lt . ~ar •,• ·•~ " ~a - ~ . ~ . br"' .... } . u • · l l ~ ... . ... - .. . . . . . . . . .. ~ . . - .... r , / unie.:;s It Yt~s coflbrch:d .daily. Un<!!{pblncd di~cre~·3ilcies ccc.:urf"cd / tn the cichrcr.1~te tttt·ation method,. which 'i<er:: prcb,d:dy reldh:d fo dtfflcuitte! 1 • ! • 1 " .. w , t V .. • .. ' . l . . . . . t . L " J ~ i '1. , , .. . - .. . . < . . , . , . . !. , _ ~ r . - :: - ~ 1 I t • ~. .. J . ·~ r· , t , t ' -. . - ... s . !,., #~.' .,_,. . t . r w ·" • "' f . : . , _ , . .. . . i'~? ,\.I.' -, .'.; '-""" "'"'' r t ." '" - ' d ,,.. t .. l . . ' t; t i' _ ~ . v ..... i.,~t·-'"'s''"' q,~ it ·...- f .~""" ,. I ii • ~. .~_-" "..' ..\,.. f-..-"".'._\. •J. : ~ - . · . " .. " , ' u'1 ."'I1 . . I \\~.:-r 5: · I R t h is f' I e J d Is ·- eon t . ; n u J r.c. It now app~ar; that t~c ral lo of . early ~·encls to fnc:re~sa durt::tg ti:!/Ph6sz __ -morphine. This phenomena rnay possibly be Jtnl:cd to tb~ eT'fect of --- C. -f.X?E21MEl'..fiAl N!tRO?SYQ;JATRY f. N:urophy~lofogy a. Rt .!bo,Jnd Lc ':.'~r I no of Tn:-ct; hoI d whIch Uncle.-I ! e s Con- ··' vvfi1on$ Produced by El~ctrfcal Sttmutatton of Thalac!c lntr~lactnar Nvel~f Ia Cats D:Jrlng r:lecovcry t'rco::1 Pentobarbital Ancsth~!sla. ln cats In vJhtch btpohr cf~ctrodc: were lm;Jir.tilh~d irr tn.e. thal.;mte tntralc;r:1inar nuetl:t under d~cp pentobarbff-91 cnesth~.sia, progrcs$iV¢ :/' / deere as~ In the am~ u . n t of . , 0 c I ec tr lc<J I st tr~u ioa ·H't1 n r~qu irzd to I nducc . convulsions ~cs ob~ervaci ~0 t~ 30 h6urs after Induction of tha ' anzsth;:s!ll. Tnts. The document is a declassified, single-page, typewritten text detailing research on morphine antagonists. A handwritten annotation "A-114" is present in the bottom right corner, possibly a page or document identifier. The text is clear and legible, with no visible photographs, stamps, forms, diagrams, or tables. There are no obvious redactions or visual evidence of experimental procedures or facilities. The document appears to be a scientific or research report due to its content and formatting. The document is a typed page of text with a handwritten annotation at the bottom right corner. The text appears to be a scientific report or study detailing the effects of a drug, possibly LSD, including dosage information and categorized effects. There are no photographs, diagrams, tables, stamps, or forms visible on the page. There are no apparent redactions or obscured content. The primary visual element, aside from the typed text, is the handwritten annotation "A-113" in blue ink. d~cp pentobarbff-91 cnesth~.sia, progrcs$iV¢ :/' / deere as~ In the am~ u . n t of . , 0 c I ec tr lc<J I st tr~u ioa ·H't1 n r~qu irzd to I nducc . convulsions ~cs ob~ervaci ~0 t~ 30 h6urs after Induction of tha ' anzsth;:s!ll. Tnts. low~rlng o7 thre.$iiclci p·::rststed fr;;- abou} 42 f~ours . - a:icl hcd c:J:oiliJf~d"rcd ·aftero72 houT~. 0 Thfs ~'Cirk Js to b.~ extended fo other area3 of the bratn. b. crossed. • . . rct-i.. cx 1l s ~~~~nsor 0 pr=duccd by ~eprc$sto~ Of fo,!.,.l'j ... ,., .,:..; ··~ ..... 'f.r cr 21 dcvs addictten, 0 ~o ,., A-1vr I .!1\ : \ii f ~ . "';i~~ t Th:l r~svlt$ to far !i!HJ<~ort the 'ad,pt.lti.H~r: theory of phy~Tcal d~~=:::1:, ..... . , .~..1.. ~-~ ~nee and refute thc,:Ju.JJ. act !on:' theory. c. Oiphaslc Actton \-:tth Cos-.:s of' M.. '. !pcricltn~ tn Do~1c• Stnole d~sc~ of' 75 r::g./kg. produ~e typtca! me~phfnt:-!tl:e effects ln tha hlndllr:-.b reflex of chronic s:ptnal dog:. After 6 to tt hours rcv~rsel occurs anda tn addtctlon "'tryehnlne-llken effect~ ep~earo 1 ·These rescr.1bla In every respect. the hvper-1rritabtt Hy seen during chrordc adm1nlsrratlon of mcf).erldtne Jn smaller doseJ. d •. 1-.~p.ertdin~· Addiction In C-ogs. ~. .e art.: now <1ble tc consistently prectpltate abst1nence from ~pcridtne fn doos th~t ~cr~ receiving rnepel"ldtnc chron1cat!y.· Tnfs h-.1: ~~~n rn_sr:,!:: _p?S.$Iblz by ad!:tlntstcrtng rnet)~rldlne every thrze hourz-· .rnd· r·~-r~rrt;; rfie cio~cs t~ ~:, the lc ... -:f ju$t sh6~t of i·_hat t?hl~"ch Induces r;;;~nd waf cc.;wulstons. of nepcrt<!!n / c V~ - i ~ · • ~ · c t v .. ... . . .• . \ " : 0• .1'· r~~c.:oer 1d l nc-t.tJ II f ~'iC An 7 ~~-:o l11 sm o • v mep~rtdinc, no cntacontsttc aet1on of Naliinc "flO'""""'u t, rn ... · . ···---r' ~ 1-1 ....." 1 ' A-1o - In Dogs. ln 2 dog~;,.c'~:.<l~~ of ;.':''Jrphfn~ w~s rapidly fncte~u~d from S to 12 mg./r~g:· in a 6-day pzrlod. On rh~ Sth diHt'of acidJctlvsl 1 I S r:g /kg • of ~-!,d I : ne p r c c rp it~ h: d !-yp l c a I a b· s t t nc nc ~t s ym p tom~ c I n or --.2 addttJonaf dogs, do~ag~ methJdooe WJS Increased to 17 ~g./kg. ln lJ 6-dil\' ;.:H:tccl. 0'- ~-h~ 8th day, IS ~..g./kg.of Nal I r c c rp it~ h: d !-yp l c a I a b· s t t nc nc ~t s ym p tom~ c I n or --.2 addttJonaf dogs, do~ag~ methJdooe WJS Increased to 17 ~g./kg. ln lJ 6-dil\' ;.:H:tccl. 0'- ~-h~ 8th day, IS ~..g./kg.of Nal I fne preclplta~·ed tyPtcaf abstinence. These rasults indicate th~t tt is very 1tkctv that a shC"rt, :Jr.:~I;J fc.st)' ·.1htch ccuJd be used by ~l:\'!;m,scok.gtcoF houses for f dciermlnatlon-of phystcal dcp~ndence ltabJiity cf ne~ analgesics, c~n be developed. ,., • .;·d • .li"U ICS or ~nd E~tloetJon A!pha -- Merrell h.!s repor({>d th~t i'ovh,•tlan '7~xt!nctfor.n f;; du.z to c•:>:--ticli / '/ lnhfbltton. The the . ory a.,d vanced by fhfs tnvesttgator ts based on th~ bloc~ad~ bv l!ght and non~rclnforcc~~nt of voluntary hand rcs~onscs Y-:- Jl, ! " . n .. v " • Z U, • . - t'1·~.· - "! u -" : 1 lr ' - "'~.'1r .. l . ! 1 ., - Q . 'u ~ - "· t " . "' ~ - - '\ 1 .. • . G " • ~ _ ~ &l - : ~ • :.;....~. . " .) " t;, " e .• ~ ~· - ..,._ t' . ' .. · .. - . ~ ~ • 6~.-, • _t - ~ *,·.·1 .. . ¥ .. . ~ i 1 - " . ? .-d . v ~t• .,. - ·~ · : Q !'-- '} 1 1 ·::> ,. 1 . 4 . ct ' .. ' .. ' ~ ~ . . , ' ' C Lfi b J ! "-": -,-. . f . . . :,:.'.>..' . ~ ..... ' • • ,,.. cas~s by a iow tone. 1 hi~ fast we& rn~c~ en ~ suIo Jccr~ sa .d jP / 11- J {.;- r·:,~·\-­ .:.~~ . " ~·· ~ • L ~~$ult"s Jndt~n,i ~·- ~ ·.; ~ / ~ j . ' h~r slp}Hl bfcel:ace. tz 1.1n or tcr.rtng1 ' ~~··'. A~ rc • pons e and o s .$_u<:h noJ b<: <o ;1<!1 t I one d. the c t lr..u Ius ,-!JI c b o·r Induces the c'l!pha blcd:adc f$ conf·intNo, bloekl:::; alp~1a oradu3l:y dtvapp~~r&. Thrs 1:1 tt"u<!, r4!o~rdlcss of' the noture c1r the stl r!'lulus - light or sound Induces th~ same effects. t; the stimulus fs dis continued, alpha This document page features predominantly handwritten text that appears to be a research report on the effects of LSD-25. There are no photographs, stamps, forms, diagrams, tables, or redactions visible on this page. The handwriting is dense and covers the majority of the page, with a handwritten annotation "A-112" in the bottom right corner. There is no visual evidence of experimental procedures, equipment, or facilities. ;1<!1 t I one d. the c t lr..u Ius ,-!JI c b o·r Induces the c'l!pha blcd:adc f$ conf·intNo, bloekl:::; alp~1a oradu3l:y dtvapp~~r&. Thrs 1:1 tt"u<!, r4!o~rdlcss of' the noture c1r the stl r!'lulus - light or sound Induces th~ same effects. t; the stimulus fs dis continued, alpha blocking reoppeers when the ts reintroduced, stl~ulus only to aga1n slowly di$appcar. 2. · Psychology Exp~rlcental a. Hospital .Project fer Evaluation of Pr;ychotherar:>vQ The explrl~<ental psychologist \'las 11 !oanedu to the cl inlcal dtvJs!on of the to asstsf Jn plan; for of hos~ltal forcu!-~tlng ev~)uation th~ effects of psychotherapy on the C"e iapse- ra:tG- in addJ.c4--G-.,.. A{"';;ui' h~·o -· ..:.~ \! n d on c - h a I f mo n ~-h li of t h ~ q.u !J r t e r., r...-t r e s p z n t I n l· h t s fa s ~ • Th ;1 " ~..... . . ptlnt study It bclna carried out by c!tntcal prclt~Inary wh1~h th.z aozn~b~c ln ~ll admls~ions ts curr~ntiy und~rw~y. . . / . . . . .. . . b. ~Minnesota 1-/uHi?hi!r.lc Per.sonut Hy lnv.zn·t~o,"Jc~ of .. . . I . t • . • t -• • . • ror phys ec Jns. an , rhe grcu;' .L •. t•u o:•: : 1. r an ..-.1.. c~n·zf"a ~T1: ow~ro /l.o.cl.:..e.r-~cn u,I~ n r• n• c (- \ p-os.,tlv~ f'c:·'bt.;r!l- in7J:c·( · t:nd nonuddlci< phy$lclanJS. Should tb~ physicians post-ad:ficlfnuve profile~: \"JnJeh are similar to those or th¢ av~r"g~ cddlct In the hospital population, It ~lght be Jnf~rrcd'th~t per- of addiction th.sn are the avaifobJ!ity of drugs or special group aftitud~s. To d~te, 13 profttcs.havz be~n obtarncd on phy,fefan addicts. As patlenti beco~ av~flable a group sufrlcfent to pcrmft JIJntflcant com~arison wfth the hocpltof proputatton wrtf be bulft up. PsychologfceJ Dar-i Durfng Chronic Alcoholic lntoxi-. cation. T~a d~t~ obtatned durfng· tha cbr~nfc o!cohoftc tnto:Scation study has been fui ly ana lyz.:d. The r.tO:{· interc~-st-i!!; frndlng is ---: " ~ . . concerned Tl th nark~d c I cvt~!- f()r: -.. o f a I I e I in 7eol sea fcs. i.r: th~ t-S.!? f during chrontc rnfoxic~tlon. d. Psycho los / ie.:ll Ch.lngcs Dv·~ Jno I n r , o x . 1 c: ~ l ~ , c n \'1 1 .. r , . ;1 To date th\: most s1gnifica~t flndtn9s This document is a typewritten page with handwritten annotations. The main body of the text discusses the effects of chlorpromazine (SKF-2601) as a sedative and its potential interactions with other drugs. There are no photographs, diagrams, stamps, or forms visible. The only handwritten elements are marginalia in the bottom right corner, consisting of an "A-" followed by "111". There are no visible redactions or signs of experimental procedures. The document’s visual content is limited to the text and the minimal handwritten marking. The document page contains typed text that appears to be a research report, discussing biochemical studies related to morphine addiction and its effects on hormone excretion. There are no photographs, diagrams, or tables present. The only handwritten annotation is a number "A-110" in the bottom right corner of the page, likely a document identifier. No official stamps or redactions are visible. The visual content is solely the typed text of the report. I e I in 7eol sea fcs. i.r: th~ t-S.!? f during chrontc rnfoxic~tlon. d. Psycho los / ie.:ll Ch.lngcs Dv·~ Jno I n r , o x . 1 c: ~ l ~ , c n \'1 1 .. r , . ;1 To date th\: most s1gnifica~t flndtn9s in fhfs $i'udy r,~.,z been chon:;cs ~ tn l':'lany oft!:~ r.l.U'f &coles. T~znty-f'ive patJ~nts tJ'I'·Z cvrrerd·fy beir.g tested. C.-, ,.. c1 ~ r• : ("\ !" ' ••• •· .. f) "' • f.- -~ ' ""' .• b . .. . . . . j . , • . · , : : . ; . J . c"' .. ~ . " . ' . · .. " "•:':'J"--'"4' r''" •J ' r - ~• - . i! betna lowe:cd by ( loglc~J sttnulatcr. ~~ w~s found ~hat the output Impedance of th8 previous stir.:ulators '3as so htgh f·har the output dropped to -1lr.t:st drop sttll resulted tthc:n th.z le-ads we~c conn€ctl!cl to fhe anir:tele Thts·-can be obviatc.d by monttorlog the stimuL~tor with un oscill~ · I\ ~ ' c. Cons id~rc:blcr ~qutp..:ent we$ con~tru,ct(!d {'~r. us~· h1 ~~ '~......____.../ on the relatio1sbfo fo th-~ stud~~s ~£ ~f~ha bloe~cde favfovt~n ' " • ,., 1 ., ~. /1 . 71 /t-/~)3 M~dlcal Director Hur-rJs bb~~tl: "Citn~cal Cha~~ctcrlst%~$ cr·or~g Add!ctlon." D!~::ress Ucnfnf As3oc1Atton, lc~tnoton, Ky., January 27 1954. 1 --. nC l i:-d ~.; isl Ch ~ r a c h: r t s t f c s of l ~~o r t a n ~· Dr u 0 ;\ d d I c t t o n z • !;~cdlcol and i'lursJng ;.>tJff, St. ·bseph Hosp"i~al, lex1ngton Ky. February 2, 1954. 1 •. ~ ncnronfc Afc!)noiJc Si"'ltc~icJtfon." Dc?-t. of thor:J~eo!.,.. Ui1(v-::-slty of Cinc:trml!tt C?licaa of t~:e-:trctn(!, Cincinnati.! L.hio, ;.:arch --3, l9S··J. ... ... '·- a ,_~I c·r - '~n;1.,. er "/u1 Lp-zraf fona I Vtc~:t of Cau~4 f t~:")fJnat fen:: C!!nlcal PncnJ;.;.;zna ln Pzv·:hiJtrJc. P.::~C.Ji:-c:). 11 ttpoln ~ncl ;\naic~sla- f·!~urophy~fclogJcal Funcrlons~'1 "Pc1tn and Anu7cc:fa- Pscyhofoglcal funcrloas.n Consctousnes$ - ,..\nosognosla.'1 nChun~cs in Coascfousn>!S!;- 'Afte:-atfon of Se~ccttve Rccotlcctiont 4nd =Lc~rn1ng of lit~rpretctions1.~ ___ _ ., ~. ?a~crs P....~.....b... fi~hirl _...__.._~~ lo~er Li~b Rcr:e~~~ C - 1 "'""' r...-......~ . c.,: : ! ~ . . ' .. ~ ~ ' • ,. . ~ _ - _ . •1 n ~ ; . a . ~ ~ ~ ~ !'!. of lit~rpretctions1.~ ___ _ ., ~. ?a~crs P....~.....b... fi~hirl _...__.._~~ lo~er Li~b Rcr:e~~~ C - 1 "'""' r...-......~ . c.,: : ! ~ . . ' .. ~ ~ ' • ,. . ~ _ - _ . •1 n ~ ; . a . ~ ~ ~ ~ !'!. •f'lo•. , ,.- ~ .! A.-cb. t.\:urv:. c. ;·svc:-~ i-Jt. / /.1: ' ./> "I'7 --- v I I _ ... 4. P~r!~tHH:-1 H.)nor!; I sbe II : r.:t. lnvi-i'~d to pJri·icl;Jnte Jn $\':".'!;:>~stun cr, Alc:ohof~ -ori~r to cr= e~Jt~ of l~ter~Jjf~n~l Health ConnressA loronto anada",J 9 Auaust 1954. w ., 1 -~-- b. Invited to ~Jrtfc!pote In Sy~postum on Atc~hol, Joint C-:;:n.'":1Jttce on i'd~chol and i\lcoh-ofis:n, '-~or!d HzaHh t.:rsunt:atton, Unth:d Naf'Jons, Geneva, S·t;-!tzeri:):t Scpt~::1bc r 1954. Assistant Attendtnn Ncurofoatst, · Pro~t~d fro~ C I n. c i n n J t J Ge n c r o l Ho s ~ J t ~d , to r\ H· c n d l ng ;· ·~ u r o I o 8 ( ~ t ~ ~ 1;·5-e!. M~rc~ / /f-;oo 4 l • , :J' J ' ·" - ' · · • 6 , ! • ' \ .. ~ .. . f i '. \ . j ' .. · tr 1. - ... 11 nacutt . ~ • · , · · . n . n ,• : rc • :s • ra • rt ons of Drun Addlctloo.~ V~nd~rbf!t U:dv~r::lty, Dept. of PiH:r·~ecol •• Nashv:!r~s Tenn.· . Clty of' D~trolt, NJrcofic:s Cilnfc, Detroit, Uich • .. ---- • 1(1. Harvard L!ccltcz:f Schoof# Dept. of Pharl':7acofcgy, Bo s to n ::'<3 s s • 1 BLuczrazs Dental A~socfatlon~ L~~tng~on~ ~enfuc~y ·' ----- V~nd:::rbllt Untv<:r!:ity Sd;ool of }.:Cd., NJ~hvJIIe~Tcnn. Dept.,,of PhJrr.:;Jc:~:d. _e, C!:~r.1istry, Sou·(hcrn Co: fcc:: of Ph~ rr.-:oc>J !-::cv: ; ·• t f ~ nt a, Go).. . . r• r . ...l ...... . '/ T~t!: ~~.s'i·it·Jrg·oi Pcnns.y1·.;anJa Hozpiti)l, Philo,d~I:Jht\l, Fa. of l•.' -•' •ea• t. c ! .ru~, "· (...' !, nc ·~• -..... --!... • L: .... • : : ''41 1.. . ·'i: . ,;1.··.·. lr_' ·~ ~ c : ? . ' . " . '\ ... .-' , ·" ... . & , v r :i r ~ ..: ' • i) ~ • · o ;; l _ c .., r , , , . .:· r. Nat~:irres Ml:~. The document is a scanned black and white page of text, likely from a report. There are no photographs, stamps, forms, tables, or diagrams. The content is entirely typewritten text, with some additional handwritten annotations at the bottom right corner, including a number "A-109" and some smaller scribbles. The text appears to discuss scientific research, specifically mentioning "pituitary gonadotropin," "alcohol metabolism," and "analytical methods." There are no visible redactions or evidence of experimental procedures or equipment. The document is a scan of a typewritten page with some handwritten annotations. The content appears to be scientific or research-related, discussing "Electrophoretic Patterns in Addiction" and experimental procedures involving animals. There are no photographs, diagrams, or official stamps visible. The only handwritten marks are at the bottom right corner, appearing to be a number or identifier "A-108", and a few small ink marks scattered throughout the page that do not obscure any text. There are no visible redactions. ·'i: . ,;1.··.·. lr_' ·~ ~ c : ? . ' . " . '\ ... .-' , ·" ... . & , v r :i r ~ ..: ' • i) ~ • · o ;; l _ c .., r , , , . .:· r. Nat~:irres Ml:~. "tinle, City of D<?trolf, Detroit, t;~ l'n~rstty Prlar~col-"C\{,- of \'1vemin;J, Schoof of .. lar.;:imlc 'flyo. . 1 D r • . J r w . :~ Y " 1 ! · Fo" V ' d ~ ~ D· ~ · . ~ . ~ - 1~ • ' - - -. 1 .l - iHe., Mrnnc~polis, Minn. Untv~rstty cf Ut~h., Col lege of Phert~acy, Saft