Doc 0000151521

@ J'une 11 1954 1. Dr. Ear::is Isbell united States Health Scirvice ?~blic Lexington, Kentucky Deur D.:.:. I::;bell: In continuntio:l of' our CL.-ug a..."l.tagonisn progre.:n., \ie b.D.ve recently perfor::!:.ed QX!X:r~ents to test the a.ntOGonism bstvc;en t"he effect::; cf' coryr:.n.nthine hyd.rc~h1o:-ide, :&lnthine, Md LSD-25. \·Te f"..:~e send.ir..g you a. ac.:::p1·3 o:r corr~~thine in case you 1-li:.::h to r~pect O"'..ll" c:~el"'j r-c; nts. B::mthir:.e is, of ccurae, uvo.il.:~.ole on p=~scription. -- In surr.-"'~), a 15.0 r:t.:::n• dose of co:r.rrJ:mthine tai;;e11- or.o.l1y 15-30 minutes bcfol-e u dose of l;Q nic~_o51·~ or: LSD-25 S.3e::..zd. to C.:l.r.:.ini:Jh or p::-event ~'.OGt Of tb.-~ n:.ent3l a.r:.d :pzyc:holcsico.l Sj•l:QtC::3 U'JU:J.l1:t I·:"viuce:i by LSD-25; c.t the s.:r..e ·ti:le, s~~ctic c.:ld .,;c~e'Co.ti v·~ sy~tcza c-~~i ci[;ns CJf LSD-25 1.rcr.e lo.r(;ely 1.uic.ffectcd. or 1:ere ,increased in inte'ilnity. TL.!.e ..:.:.!,-._r.,.,.....',·..~.·.,..-..i.-,4-!_ •re " _ '" . " ... ' " _ "" _ "C -: . - J Cf , ., , " . - ..o .. · ~ - .; ' " . ' ... : .. ~ "~ . "' · · J ~· · h- - 1 • · - ~· - "' . , ,. t ., · < - , • -· ~ ,. ~ ;c -'" v9~., • .(> . 0 . . . .. , ., . v . -. . . . . . J . . , . 1 :_ • ;j • 1 to - ~ . - : 1 : : : . t . . L . ~ C .... l 1."_'" '.·.. ,' )• su~Jne..::_-..;.. .:!::~ 15.0 ~. do3eo of cor·:li'l::.nthil:~ Gcc=:.ed to !Jrcduce l~~s pl~c­ tec:t-icu tt.=..n 'iid the fir3t t"!.ca~, fer c. s110l"~el· ~~ricd of -'~be. P.,.:~:tni­ st~tior: ~ 1;cryn::!r.th!ne after LSD-25 hc....1 t~en t~~en p:ve lit·i;le pro tection from the effects of' LSD. Jl..dro.iniGt:-ation oi' :&.nthine (100 n:..::;n. :per OG) c...."J.d co1-ync.nthine (15 !!!.?• per 03) 15 to 30 nim1.t:~s \:Jefore LSD- 25 (L!-0 micro.c:;:r2.:..-.s} s~err:-ed to !'~vent even th~ sc::-atic c.r:d ·Jis~er::-.1 sr- :ptc::t:J •~s1Ui.l1y ;.::c.iuccd. by LSD. Tlre c.d:ii tion of B:3. .n t;hinc to the r;,;gi...--:.c, hm;aver, ;rc:.'.. uced a. '~aec..vy," '0.ru:.:;cd" fce1L"lg in tho;; su·o,;~:::ts. Cc:~'­ nnnthin~ g:1.·i~n alor:e in doses up t.o 45 tlz:::l• p-er os, h.':'•l r:-:- not!.c'::'::.bJ..e , S!'J.c,ulcl you ¥i:;:h to i.."l.·;ca'ti;c:te m.:.c'h <LT"''..tg c<r.:tbin:-.tion3 as t!:i.:!S~, "e vou!-~1. ::PJ~::3~3t tl1.:1.t :,..-cu first =.·:::t.:=:.~:;>t to ccr.d'ir:J. c~.1.r r~::~l-::-.; ~J:;i:'.. ·: ·~~e <l=UZ3 8~~ d~~e ac~eQul~s si7en uCov~j it i~ The image is a webpage with a black background. On the left side, there is a graphic of a large, round bank vault door with glowing blue accents. On the right side, there is text in white and yellow font. The white text states that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the "MKULTRA/Mind Control Collection" containing over 20,000 declassified pages from the CIA. A yellow URL at the bottom provides a link to download the entire collection. tho;; su·o,;~:::ts. Cc:~'­ nnnthin~ g:1.·i~n alor:e in doses up t.o 45 tlz:::l• p-er os, h.':'•l r:-:- not!.c'::'::.bJ..e , S!'J.c,ulcl you ¥i:;:h to i.."l.·;ca'ti;c:te m.:.c'h <LT"''..tg c<r.:tbin:-.tion3 as t!:i.:!S~, "e vou!-~1. ::PJ~::3~3t tl1.:1.t :,..-cu first =.·:::t.:=:.~:;>t to ccr.d'ir:J. c~.1.r r~::~l-::-.; ~J:;i:'.. ·: ·~~e <l=UZ3 8~~ d~~e ac~eQul~s si7en uCov~j it i~ 3U~~e~tc2 t~t the Z~nthine r:.:.!.,sht teen be triei; for e:.:c.:u:?le, th0 use of other s.~lrer:~r;:ic bloc:.::.:1g d..... .J .Zs, o---::-::.~r p~r~.o~r-:.1pc..thetic blcc?.it1g a,s~nta {3t1Cll c.s ti:.::cttu·e c1"f.' :;:!.lc. dcru~ 01~ Sl.t!. . c:;tiD.(;) c~ e~;z~tl c:~T\:lic::ic blcck:t!:.3 c.g.~n.:--s ( sl~:~h r-.. 3 1:~:-::-.::~.:~-t~­ c!'lit::.:l) ::,_t:;l:t b~ t~·:J::.... . -:,111:-~.:tle. :Ic\li~"ico.·tr.:Lc:l of t;l13 d~:'J;;•.;::; U3C:l i~1. o:;~~ -=G:.·!.::ls a.ci tu~ til:·~ rel::..tio.:1z~i:ps bet1•~·.::n doses could., of cou:c:}o, be r::::·i~. A-'i! -/) ;-.... Dr. Isbell \Te J.o~': fo::r:c:'i to bcc.rir..:; ti~e results o'£ a.:1y such ''c.nt.'J.;onism e:-.."?:n:•i.:lents '' ouch ns tne!::e vci.':h you r:·i sb'c ·c.e o.bl:! to 1)~:-:f··~·:-.::::1. It t;o:.Q~l. b-~ !l?lTr'.:lcic.ted :L~"' yctt ~tould. ~~::·1 t~~ U3U::!l l·~~tte:::- to tb.·':! e~:>Ye (i.rl--'tr\~GS' in O!'J.~~r to 1". . .:::'/C'l•t r.z:y r(;GU.lto Cf: the::-..o ~"ltid.oting e.XJ?~=".:ri:-:-~nts ~ In c-.dd::.ticn., it would bB n:riJ?re~io.to;d 5.-:f ycu trould. send. an c.ri.;i11~l or.d a cnrbo~ of such reports. Sincerely yours, ... , . This document is a typewritten letter dated June 11, 1954, addressed to Dr. Harris Isbell. A handwritten annotation in a circle with the number "33" is present in the upper right corner. Another handwritten annotation, "A-12", appears in the lower right corner, likely a page numbering or reference. The text discusses drug antagonism experiments involving corynanthine, Banthine, and LSD-25. There are no photographs, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures on this page. The document is a typed letter on a plain white background. It contains a date, sender/recipient information, and the body of a letter. There is a handwritten annotation at the bottom right corner of the page that reads "A-122". There is also a black marker-like mark obscuring some text in the central-lower portion of the page. The writing and layout are typical of a formal letter from the period.