Doc 0000151523

June 22 1954 1 Dr. ~is Iobell U.S. Public Rz:o.lth Service Hospital. Le."ti.nstQn Kentucky 1 Dear Dr. Isbell: -- ·.·-· I b.!l...,..~ gotten toscther ::>.11 of the i~1ormstion that ia p~~ently availD.ble on the substance E'J.fcteniz:e. ':i:'...:.e source of th.i3 is nln~:.;t entlrzly co~ir.ed to a tall: given· by Dl· o Ec:~·nrd. EY:1.!'ts o.t t~e !.:::::ric an Che::TI.co.l Sccicty r·~cdici!J.Sl. C~~:.:UstrJ Synpoziu:rJ at S)'-rac~e ·which I attcnd.ad 1" 3t v,.. .,l_. ~ ~ -t::-~. / ~!or:.~ya e.rc rc:;~J. . ~·J:-.f ;~:!.·.~e;J., dooes cf l or 2 ~/"l:;::, of t~;; m5te:::icl I.V. i:.t :0his l~'tel the ani:~l ...J "are r:.w:\ke b::t tot.:\ll)"" ·ol!~cl fo:r c~out c.n hom~. Z·~'..!scle s":c:=!.n.:;t!t c:;~;:la !10:r!1ml 111.~t a :;rc~Clli1~ c~rit;~·:i::. r::~:J\ .. ~::ltn :t va1''-i!l~ o Tl:a vest:tbulnr· ~c'::~~'li~:l :d..c~·sn 1 se.zl!l to l;G· ai'fo =J~~d ~s the c.:.1i:ml 1. . i:;,1-:s 1~.:.~~-:lf ·i~ :)~L:"' ...... ~~ d.t-rln (in t~s b~,~!:. ·1::.:..~:~ t=~~t.s:~l J:~:.n­ •,__•..-_c...y-~ ·:~o .,,~--i-7Q"-~1"'l +~._.,....f-oh_1~_~ ,..~.~- ... ~..;11 ....,10+ 1"'\4+~ f.'-"'~.~.~ .. ~t_T,.>·~•,-.,- -f'i-n_-:-::.!.."_'_..1_" '.':1-.. ·-~re ~-"..- ~-.- --~ ~_..,....._,_,_v f...l..c...o.- ~-- ... 'J '-'-•- _,.. __. ,. fol.. ccd L!to their EOl'.:chs. '?!:e~:" }?C.r3ict i!! thl3 c.tti t1..tlo lo~lJ ";_:~-~c= tm blind.r-csa mii nta:d.n -.;;ea:s off.. Uonl.:~ys whlch 'rere given ::!.bout: 6 nz)kg I.V. died~in con~~l3ions rcse2bling ~hoaa prccuccd by st~JC~~~~o a~ did ·a or:~ do;o ['.t a.bo11t 3 wg/k.g I.~,;. Tl:~ bet.aV:.oar of ~s-csu c..t 1 o1· 2 ~/,~'3 is corwid.e:. . Drbly Ci.f:\;rent 1·~~.::! ·G!.!s.t cf t·l:e =~n1:e~rn. 1-;~1.~:--L~::.~ t;h~ !:!OzL:~c:;s lie q,td+..!tly ~d. are very tl·c~~-:~~2-e, tb;.; C.c:;s hct;l Ci!:i i t"l.-1; ~a.te c.n e:-~­ diztu:-"bed a tate c.: mr1:l. cee~lir~l;,r ccr.c:ntro:ticn of a.ctivc~ ~l. . i.::.~i-;li;. :!.~1 of~::-~ 'b;.-!:~~1, i·~ 1·1·:-d ~~l··~ul~;/;~i t~~·t if, ·tho nun::.l csvit.:;· of a p~:--~~ -:··r~r~ co:::_ple"tcly stu..f'~~d -:rith i.:;:..~::1..!.:ld 1 ~ ... - .. , .:: ; :\ . .. ; .. J. .,...J... ., Frc:1 all that I c:..::!. :c.t:~:.J:-} t!:c c.c;i. ... - :t~::.r of t!1:t!! ::J.terial is q_~li­ tc.ti~.rcly nlr.uost iderl~:!.cZll t·:) t:'"l,-.:lt oi"' tL.e d.:"...:::..; :rou l!!lor.~e b~cn t:oi:'il~ 'b!4~ 'rX~J b~ ~l.i.~~:~it:..ti·v":=:J.y 1-~::;; ·~):'.::.:~::-:. I 1-~.~;:;···':! :~~:1 t:)}. . :l -:1::::- i"; i= :;·:::1tl~ c.r:c. c=..:.1 b.a ;;j:v~n- Cl~ully, ~·;. ~::-:;·~t;:)l :L~ 2\:-e:..:ts 1 e::-~-~!-:.c~'·::::c~, -en·~ I. -"i.,. r::;ut.~ \i"D.S u:; cd" • /, I.- /"1 -- / I I Dr. Iab~ll I hope tbc.t. I 1:m.Ye been aole to !Jro;ri~~- you \rith enou:-)l ini"or::Zl. tion he1•e to n:U·7J ooo..:a prcli=...i:"!~.r:i t:rio.LJ. T'~~ preble~ of st.-rpply nnd This page displays a generic graphic alongside text, rather than containing actual document content. On the left is an illustration of a vault door with intricate mechanisms and a blue glow, digitally rendered. The text prominently features the title "THE BLACK VAULT" in a stylized font. It then provides informational text indicating the document originates from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection and providing a URL for download. There is no photographic content, annotations, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. The document is a typed letter with some handwritten annotations. In the top right corner, there is a handwritten circled number "35". In the bottom right corner, there is a handwritten "A-1". The rest of the page consists of typed text, dated June 22, 1954. There are no photographs, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. ;;j:v~n- Cl~ully, ~·;. ~::-:;·~t;:)l :L~ 2\:-e:..:ts 1 e::-~-~!-:.c~'·::::c~, -en·~ I. -"i.,. r::;ut.~ \i"D.S u:; cd" • /, I.- /"1 -- / I I Dr. Iab~ll I hope tbc.t. I 1:m.Ye been aole to !Jro;ri~~- you \rith enou:-)l ini"or::Zl. tion he1•e to n:U·7J ooo..:a prcli=...i:"!~.r:i t:rio.LJ. T'~~ preble~ of st.-rpply nnd st~bility, etc., vould ce v~3cly si=~lifici if this ~~~ cc~ld b~ used in lieu of the one you been h~v~ invcsti~tir-g. I 'n loo:dng for.mrd to you vhen a.rc do.m he1e ne..xt se~in.:; yo~ 1 :cnth. ., . .· ' ~·· LSD DOSE-EFFECT ·oATA - - DOSE M:G/KG - :::_r- . Mean · , . .. . . I . •· f J .i· ~ ~ -r;.(_.af -(..?,: :; I -' 7.,, :l. ?~l of 0.25 () c; n 7.S I () I c; ? (1 Measure NlJviBE R OF SUBJECTS ... ,.., 8 8 0 7 8 6 I 'Respiratory .. Rate • ' Q. IS o.or 0 • .:~3 0 2 0 ()3 ') I S Body Temperature -0.48 0.39 0. 3 3 0.21 0. IS 0.39 r Knee Jerks ·-· -- "=1' I • 28·::-::· 1 I • 2?. I • .S 2 I • 7 I~:· '1.43~ .52·::~:-i -- .... f S'!stolic ~ / -Glood Pressure : I . 07 1 • 1 r I -:-2 • I 8 ·::· 2. 56·. . - ~ .. , ( .. ) . .. o ,.., - - r ~ ·:~ . . . : ., J. I I , ~: . ·· . : . : .. . I i ~.7--2-lr .. f /H:·I Pupillary Size I . • I " CJ 8 . ~ , . , - ~ .. ! 3.:17 ~~·~;. : 3. I 3.87·,;-~·., ;~-. 3.!.Q""- I Number ' i / - -· I .. Po s it i ve • ' I 35·. .. ·,\· ., , . . : 34·." .· 60· , . , . .... 4 ,.... Answers •2 ( 50 ~: r I I .. :·-·~ Clinical Grade 0.2 I, 0.75 ·,,· l I • 0 •\ f ·~ \ • 7 ,·::- ·r~o'2 -~:~z.. I. 33 .... l, _ " ·~;. S i g n i f i c a n t a r S ;~ t eve I • - ·::··::.. S i g n if i c a n t a t I;~ I e ·~ \ • 7 ,·::- ·r~o'2 -~:~z.. I. 33 .... l, _ " ·~;. S i g n i f i c a n t a r S ;~ t eve I • - ·::··::.. S i g n if i c a n t a t I;~ I e 'te i • .4-/2. {, i No t e s o n L SD Do s e - E F FE C T T a b e I • Data on respiratory rute, body temperatur~, knee jerks and . systo I ic blood pressure were graphed. The pre-dose values "for each.measure were averaaed ~nd averace drawn as base line. Area under curve ove; 8-hour peri~d past-dose was measured with a plani~ 1 cter. Thi~ yiel~s ~ rf' 1• sure •1 n squarz inches ("effect hours ) which reflects the tota I time-action course for the eight-hour period. c s. s 2 • A v e r a 9 ,z r s u l t o n 2 p l a c e bo s f o r e a c h i n d i v i d u a ! we r e u b- tractcd from result with various LSD fisures, giving a figure reflecting only LSD effect. These figures were then analyzed statistically, using the 11-t:r test for paired observations. The significance ratios are all in terms of that dose against a -- p I c e b o • A s y e t d i f f e r e n c e s be t we e n LS D do s e s h a v e no 7 bee n analyzed. r 3 • l'b t e t h a t r e s p i r a o r y r a t e .f. b o d y t e mp e r a t u r e c h a n g e s a r e n c t significant~ / 4. Significant changes,.;·iere o~ncrhred i·n ktf·ze-fe'rks, systolic blood ~ressur~, + p,upi I !ar'l s! ze. The pupi llarv change is the most sensitive and signif_tcant measurement. Although average changes in .knee jerks· were '_alwa•;s in the some directioil! char.g~s could not be sho•,yn _t_o be si·snificanr at all do$e levels. This probably was dr;e to rhe·"fact that kr.ee jerk \'/5S graded c·!Jnically/ rather than being measured quant-itatively. The document is a page from a typewritten letter, identified as Page 2, dated June 22, 1954. The main body of the text discusses preliminary trials of a drug and its logistical implications. A handwritten annotation "A-12" is visible in the bottom right corner, and a different handwritten notation "HW3/mk" appears in the lower left. There is a dark, horizontal redaction located in the middle of the page, obscuring some content. The page also contains scattered dark specks, likely due to the document's age or handling, and a faint, possibly ink-related, smudge near the top. The image depicts a table labeled "LSD DOSE-EFFECT DATA" displaying numerical results categorized by "DOSE" and "MCG/KG." It includes rows for "Mean of Measure," "Respiratory Rate," "Body Temperature," "Knee Jerks," "Systolic Blood Pressure," "Pupillary Size," "Number Positive Answers," and "Clinical Grade." The data entries are numerical values, some accompanied by asterisks indicating statistical significance at the 5% and 1% levels. There are no photographs or diagrams visible. In the bottom right corner, a handwritten annotation "A-126" is present. No official stamps or redactions are visible on this page. llarv change is the most sensitive and signif_tcant measurement. Although average changes in .knee jerks· were '_alwa•;s in the some directioil! char.g~s could not be sho•,yn _t_o be si·snificanr at all do$e levels. This probably was dr;e to rhe·"fact that kr.ee jerk \'/5S graded c·!Jnically/ rather than being measured quant-itatively. - 5 • S i g n i f i c a n t c h a n g e s we r e o b s e r v e d i n a n u r.; be r o f po s it ·i v e answer-s and in clinical grades at doses of 0.5 meg/kg and above. Although time has not yet permitted calcuta:J-ion of correlario;: coefficients, it appears that both tbese measures wil I correlate with each other end with blood pressure and pupillary changes. I n o t h e r wo r d s , f h e d e 9 r e e o f p up t I I a r y d i l a- t a-t i o n r e f I e c t 5 the c-e'2ree>. of' :n'<rd~! d:~:-:s~ ~~d vic-: V{;:"~a. T;-;:;~, .::;r,.;; ,,.~a;;u,·-G serves as a check on the other. 6. T~ Irregularities in the results at I.C and 2.0 meg/kg are -ro due in pa.rt or.1ission of one very sensiti•te subjec~ fror.; this e clo sac e I eve I s • T h i s res u I t s i n a d -z c r e a.s e in the r1e a n effect at lhes~ doses. 7. Very good dose respons~ curves were obtained (considering the sma II nunber of subjects J when mean responses were plotted a ,g a i n s t I o g o f do s e • Va r i a t i o n s f r o r7l s t r a i g h t I i n z .,., e r e c h i e f I y at those dose levels which did nor inctur3e the one exfremzlv· sensitive individual. This page is a typed document with handwritten annotations. The typed text discusses LSD dose-effect tables and experimental results, including measurements such as respiratory rate, body temperature, and knee jerks. Handwritten marginalia is present in the form of numbered points and a signature or identification code "A-125" at the bottom right. There are no photographs, stamps, forms, diagrams, tables, or redactions visible on this page.