Doc 0000151526

.TH. EDUCt\TION, AND WE PUBLIC HEALTH SERVICE IN R!!PLY I:>G. AooRE<"..s THs l v. x t n g t o n , Ke n t u c k y . 21 July 1954 Nllv'H Addiction Research Center Could you supply me wi-th an additional amount of Co r y n a n t h i n e '? We h a v e no t b e .z n a b I e t o s how a n y s i g n i r i c 6 n t ---_blocking effect wh<=n IS mg. of this compound were edr:linistered 30 minutes pripr to 40 microgm of LSD-25. We are now giving IS mg. every t'wc hours for three doses. This, of course, means our consumption is rathtr high at this time. We h a v e now c.9 mp I e t e d t h e f t r $ t t r i a I :; o n t h e e f f e c .t s o f CA-I 0 I o n i· h ~~:, c a r d i o v a s c u I a r r e s p o n s ..z r o s t d r. d i n o • A l I 3 p .:: i i e n r s s h o ,•1 e d m a r '< ~ c! · e I ~-- v ~;t i o n i n p u I s e r a t e , a d r c ~ i n both s y s to I i c d n d d 1 as to I i c b I ocd pres sure s, w i t h marked narrowing of t~e pulle pressure. This effect was evident h:0 h 0 u r s d ft c r 2 rn 9 o" o f t he d r u g h a,d b <:en g i v-?. n , a::' pea r tZ d to be maximal eioht hours aftGr the ~ruo h1d be~n giv~n, and r a-n r w .z r e s l I I pres(?~ ( I 6 hours e r he d; u-::. A. ft z r 2..: h.) L; r s . althouch respons~s were in the normal ran~ea they were stili higher ..... th~n / pre-drug controls. The visual content of this page consists of a stylized graphic and text. On the left, there is an illustration of a vault door, suggesting security and restricted access. The text is presented in white and yellow, with the title "THE BLACK VAULT" in a large, stylized font at the top. The body of the text explains that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection and providing a URL. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. be~n giv~n, and r a-n r w .z r e s l I I pres(?~ ( I 6 hours e r he d; u-::. A. ft z r 2..: h.) L; r s . althouch respons~s were in the normal ran~ea they were stili higher ..... th~n / pre-drug controls. T Very 5incer~ly y~urs, !../,!,..,,.: I Y,J./"V v (/V'l u I ~ · • ") r'r . ·1 .w. i l ! · ) ~ L. - . . ~ ~' t , ' l • .~·.'.· • , l .. J ., • Director of R~s~erch Hi: r n The document is a typewritten letter with handwritten annotations. At the top, there appears to be a government seal and header information, including "PUBLIC HEALTH SERVICE" and a location and date: "Lexington, Kentucky 21 July 1954". There is a handwritten circled number "41" in the upper right portion of the page and a handwritten notation "(b)(3)" to the left of the main text. The letter discusses drug trials, mentioning compounds like "Corynanthine" and "LSD-25", as well as "CA-101". The signature at the bottom reads "Harris isbell, M.D. Director of Research", with a handwritten signature above it. There's additional handwritten text "Hi:rn" at the bottom left and another handwritten mark "X-139" at the bottom right. No images or diagrams are visible.