Doc 0000151530

.. ',-..._ DC:PAr-rrr-.1t:.N·r OF ~. ~ / · · - {EALTH, EDUCATiON. AND \1. -FA~L.:. PUBLIC HEALTH SERVICE le~ington, Kentucky 8 December 1954 IN ft&Pt..Y !NG. A.OOAESS nOl Nltvv-i Research Centczr Addlctior~ lb)(J) Subject: I) Report to Q\JR 2) Project Description and Budget for Fiscal Yeor (956 31 Recent Progress --~h)(j) Encl_.,s~d her~wtth is copy ·of the annuol progr.zss report for the Offtii of Naval ~ese~rch, whtch ts being sent to Capt. F. H. Quimby, ONR, as was done in the past two years. ... Also enclosed ts a project description and budget for t·h.e fiscal year 1956. ln forwirdtng this I am assvn't-~il-g- f'-na-t- ~r·rd"rrge-m~nts for continu.'Jri-:;,n of th~ proj~ct wi;!l.be rnede. and that the same p roc e d u r e vd t I be f o I !1' wed. , ~ a s w d s c a r r i e d o u t [ a s t y e a r • . [ am also enclosing two cop-i"·~s of an:abstr:ac~ "·hi.:h ts submittec for cftarance prior to sybmiss ion to the S.ecr~tcry, Soctcty for Pharmacology and ExperTm~ntal Ther~~euttcs. lf the abstract is c I ~ ~ r ~ d and ~he i n f o rm a t ton r e c I as s i f t ~ d , I l :'l tend to p r ~ s en t t h t s paper at the me!t1ng of the Society for Pharmacology and Experiments! Therapeutics in San Francisco, Apri·l 10-16, 1955. Stnce my return from Europe I have compl~ted zome work which may be of inter~st to you. The experiments with Bufotenine were pushed until the subjec~s were r:-ece[ving orally to}al doses of 2 mg. of thfs compound. No di~cerndbfe eff&cti were obtaf~ed. Sine€ work with rhis COi7lpOund did not S~~., at elf! flP"Om!s!ng, ':"!'! di:cc;-:t;ii:.;.;:;:! work with it, at least t~mpore..r~l'l. I think. w.~ s.ll.o.;.LLd..O-t-te."7i;Jt ro obt~in another sample of the material. t~ order to be sur~ we ~rc doing work with the corrc~t compou~d. We hcive ju.sr completed anot:1er serf·~.s with patients who recehed 75 ms~ Ch!:;,r~romdzl~e followed by 60 mcgm. LSD-25. This makes a total of 18 patients who have been studied wi~h this par~Jcul5r combination. Definite blocking of LSD-effects did,!.,£;!.. occur, but . -·-'.,. . ,· ' not as gr-eat as In the pilot expertmerds. We ha\'e now turned to t e s t I The image is a screenshot from the website "The Black Vault," which serves as an online repository for declassified government documents. On the left side of the image, a stylized depiction of a bank vault door is visible, rendered in shades of gray and blue with glowing accents. The text in the center of the image explains that the document was obtained from The Black Vault, that it is part of the MKULTRA/Mind Control Collection, and that the collection is available for download at a specific URL. There are no photographs of people, locations, or equipment, nor are there any handwritten annotations, signatures, or official stamps visible on this page. followed by 60 mcgm. LSD-25. This makes a total of 18 patients who have been studied wi~h this par~Jcul5r combination. Definite blocking of LSD-effects did,!.,£;!.. occur, but . -·-'.,. . ,· ' not as gr-eat as In the pilot expertmerds. We ha\'e now turned to t e s t I n g t h e a b t I t t y o f c h I ~ r p r c.·m a z J n e t o r e v e r s e l S D-c f f e c t s once they a~e well developed. As yet sufficient data are not available to make any statement. l must be in New Yorl; the n tght of February 3rd In order to give a lecture at the New Yor~ Acade~y of Medicine. It wtll b~ convenient to stop ln Washington on either February 1st or 2nd, provfd(d you wtsh me to do so. With kindest personal regards. ·--- Very $lncerely yours, i (\ ... II .-: · - - , '-./../ _,. ,_~ 1.; 11,:.-'i~· . :" ~ ·:_ I. "--:.-"~'-"'---"--~-' ., H a r' {( s"' I s be t I , M. D • . :/ .., Director of Research HI: rn Enclosures:.. Z The document is a typewritten letter from the NIMH Addiction Research Center. It contains handwritten annotations in the upper right corner ("45") and in the middle of the page ("(b) (3)" twice). There are also handwritten annotations at the bottom right corner ("A-153"). The text mentions experiments with "Bufotenine" and "Chlorpromazine followed by LSD-25", suggesting research into the effects of these substances. No photographs, stamps, forms, diagrams, tables, or visual evidence of experimental procedures are present. There are redactions of "b)(3)" which obscure information, likely related to security classifications. The document is a typed letter on plain paper, indicated as "Page 2" at the top. The main body of text discusses experimental findings and a lecture engagement. A handwritten signature, "Harris Isbell, M.D. Director of Research," is present below the typed salutation. Below the signature, there's a handwritten notation "HI:rn" and "Enclosures: 2". In the bottom right corner, a handwritten number "A-152" is visible. The document appears to be a standard business letter with no photographs, official stamps, forms, diagrams, or visual evidence of experimental procedures.