Doc 0000151533

v:· __ / p:!rtm!nt oL HEALTH. EDUCATION. ----··~o· .:ARE • Public Health Semce NATIONAL iNSTITUTES OF HEALTH 28 January 1955 Ill IIIATIIIG. ADOIIISS TM• ADOICTlON RESEARCM CENTE!t · NATIOIIAI.IIITITUTIS OF !IIUTAI. HIALTM U. S. PUII.IC: HIAI.TK SCRVICI HOSPITAL • · 801%000 (.b)0) Since wrtttng to you last Dtcemb~r ~th we hav~ completed a ~umber of ~xpertments ~htch are described below. Bufotenine. No further;"wor::k has be.en carried out with t!'!ts I, s u b s r a n c e due t. o t he [:i"1f~cf ~of e f f e c f s of do s t s ran g i n g up to I 2 mg. or a I I y • L e t t e r r e c ~ I v e d. from Dr • E v a r r s of the Na t i '' n a I ~ i 1.15 t i t u t ~ o f !vie n t a I He a l t h t n d l c a t e s t h d t no s i g n i f i can t e f f e c t s .. other than o transient drop in blood pressure occurred after as ! , much <3$ f rr.g.~Jnt·ravenously to normal volunte.zrs. The lnstttuh: a p~ e ~ r s t o b ~ ··t u r n i:1 g U s a tt.,.e n t i c n t c o t h e r s u b s t a n c e s found in the cohoba b~ans at.~d I wttl await with tnten:st a'ly infor.na tton from this •·our-c~,. The lnsti~u~es hav~ kindly a.gre~d to supply me with cohoba~snuff so that ~c can ascert~t~ wheth~r then: is anything ln ,-this .bean that t.nduc~s suffici!nt mtntal change to be of Int,er.zst. · Chlorpromazl<""l~ as an Anrtdote to LSD-25. ~'/./e hav~·now complet:d sevtn expe""r Im~nt:. The ftrs t h1o of these were rep.~rted on September IS, 1954 •. The remaining expertmenb are described tn ord~r and are nu~b~red 3 to 7. tn general the effects of chlorpromazine have not been as good as would hdvc b~en an+tci pated from ~he two original experiments. Although, in g~neral, th~re is a tr~nd indic.at·ing reduction of the LSD-~ffects the only c"ns ist.~r.tly s t~n!fic!nt c!'loln;<: h,H be.:n ~n pup! llary $ izc. Ex:') € r The image is a graphic representation of a digital document's landing page, rather than a scanned page from a physical document. A large, stylized title, "THE BLACK VAULT," is prominent at the top. To the left, an illustration depicts a stylized vault door, emphasizing security and hidden information. The right side of the image contains explanatory text about the document's origin from "The Black Vault," an online database of declassified government documents, specifically mentioning the "MKULTRA/Mind Control Collection" and its source from the Central Intelligence Agency (CIA). Below the descriptive text, a yellow hyperlink, "http://mkultra.theblackvault.com," is provided as the access point for the collection. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures present on this page. The document displays a typed letter dated January 28, 1955, with official letterhead for the National Institutes of Health. Handwritten annotations include a circled "48" and a parenthetical "(b)(3)" in the upper right and center sections, respectively. A black stamp obscuring text is present in the upper right quadrant. Near the bottom, there is a "Declassified by" stamp with a date of "4 FEB 1977" and a reference number "137475". Another handwritten annotation, "A-17", is located in the lower right corner. general the effects of chlorpromazine have not been as good as would hdvc b~en an+tci pated from ~he two original experiments. Although, in g~neral, th~re is a tr~nd indic.at·ing reduction of the LSD-~ffects the only c"ns ist.~r.tly s t~n!fic!nt c!'loln;<: h,H be.:n ~n pup! llary $ izc. Ex:') € r i me n t 3 • I n · t h f s e x o e r I me n t t he a n t i d c t a I e f fe c t s o f I 00 m G • ch·i~r~romazine oive~ 30 m~nu~es before 60 meg. of LS~ were stuc!'fed in 7 po3rients, lncludi.1g 6 whtt~s O.:'ld I negr«). 7he purpQse 6f the exp~rime~t· was to study the dose rdng~ ov~r whlc~ antidotal effects could b~ ~x~ected. The dose of chlorprc~azlne was ele11ated 25mg. above that given tn ExperJ.11ent ~,and the dos~ of LSD was elevated 20 ~cg. Observ3ti=ns inclu~~d kne~ jerks pupillary siz~, systolic blood pressure, end questionndire. ,;fl these measures \'l'?.re cbtair.ed hourly f.:H two hovrs prior to administration and for etght hours after administration of LSD. /1. -!! ."Declassified by _1,~4 .... t" I , ~ date· 4 F'EB 197Z v, ·'s_ "'-' I• e (, Chlorpromazine was gtven orally 30 minutes before the LSD. Co n t r o I s r n c I u d e d a d rn in i s ~ r a r i o n o f a do u b I e P. f a c e b o ; p I a c e b o ~plus LSD; and chlorpromazine plus d placebo. Measurements of ~n~e jerks, pupillary size, and blood pressure were plotted in the usual way and the area und~r the curves d~termined with a planim,~er. Th'! number of pos ttive· answer/s on the quest ion- naire was coun7ed over the observation period and the cl inica! --- 9rade assigned on the bas is of the ques f ionna ire plus the attendant's notes. The results for the placebo and LSD, and .for c:htcrpro~azine plus LSD were corrected fer placebo effects and the di-fference behvee·n the conditions analyzed by tn~e "t" test. The results. arc shown in the· table. ,\lthouch all.rhe. res u I t s . a r ~ i n H. e d i r:e d ion o f c h I or promo z inc fer placebo effects and the di-fference behvee·n the conditions analyzed by tn~e "t" test. The results. arc shown in the· table. ,\lthouch all.rhe. res u I t s . a r ~ i n H. e d i r:e d ion o f c h I or promo z inc red~ c i n g the lSD-effecrs, the only s JgnifTcant changes were seen in pupi I ld·iY stze and in the gra~e of the reaction. -----Exp• eriment 4. ·.! This.experim~nf was carried cu~ in tt:e same way, us l n s 6 w h i t e and t negro p a f i en t Ca d t f f e r en t group f rem t h a t used in Experiment 3). Rzsulrs are shown in the table. lt is noted that ttqs·was the 11cst successful exp~riment, significard an t i dot a I e f fe c t s be t n g o b s e r v e d on knee jerk s , pup ·i I I d r y s i z e , number of questions,.~nd nea--fly significa·nt- results being or obtained on blo . , ,d . pr . e ,'ssure and cl tn.i.cc.l srade r~spons~. ExperimentS. This was essenfi.JIIy'J repetition of Exoeri~e:"lt 4 , u s i n s a n e n t i r e J y ·· n e w ·s r o up o f I 2 : n e g r o p c. t i e n t s • T h e o n ! y s i g n i f i c a n t e f f e c ~ ''a s o n p u ~ rl I a r 'I s l z e • N e a r I y s i g n i f i c c n f effects on cli:1ical grcce w~re observed. · / Exoeriment 6. This experiment was de~rgr.ed to rest fne effects o f c h I o r p r on o z t n e i n r e v e r s i n g t h e ~ f ( e c t :i o f LSD • T h ~ I 2 n e g r o p a t i e n t s r e c e t ., ;,! The page is a scanned, typed document with some handwritten annotations and stamps. There are no photographs, diagrams, or tables present. Some areas of the document are redacted with black ink, obscuring portions of the text. There are official stamps indicating that the document has been declassified, with a date of "4 FEB 1977" and an identifier "187475". Handwritten text at the bottom right appears to be an alphanumeric code, possibly an accession number or reference. i n r e v e r s i n g t h e ~ f ( e c t :i o f LSD • T h ~ I 2 n e g r o p a t i e n t s r e c e t ., ;,! d l S D c n e <l n c o n e - h c I f h o u r s p r t o r t o r e c e i v 1 " G chl·::>rpromazinrz. ihe results are shown in the table. The only s lgnificant effect .was on pupillary s izc. C ' . " ;. " oer·, ·· . ·· , ·~ ~ nL f 7 •. Th ' ·s·- ~ x - . , . . . . . . . ·~., ;r f · , " ., · o 4 ' .. " . ' ~ . · .. · . - . - - . _ . . , ; _ ., , .. ~ , - , . . J ... O .. v . lL "A--<..1•1•' 7• •a• .. was E xoerl!i • l .l!~ t 6 1 IZXCZC1~ t"L i l - ~~ 1- I4"'J~ ffiCco C..L;t I orr:;rOIT'd·7. • 1 0e WdS Q • l Ven • J n~ ,rc- l!lU~CUfdrfy one and. one-haff ho~rs ·dfter a largz ir.di~Tdc.;dl iz::·= c r do s a o f LSD ( de s i g n e d t o o b t- a l r, a g r d ~ 2 ~ s p on .s e i n a I I r r ; p d t i .z n t s 1 • The r o2 ·"'.: s ~ s i g n i f i t d t. de c.; e e s e : n pup i I ! c r 'I d i : .J t c and 'in t1ie clinical Grcde of th~ re.:ction. • A--17 I Disc~.~ssion. As stated above, the·orrglnat prcmi~ing experirtenfs o n t h e e f f e c t s o f c h I o r p rom a z i n .z ·i n b I o c l-: i n g t h e · e f f e c t s o f L SO have not been born~ ouY to~ The page is primarily text-based with some handwritten elements. There is a signature and a typed name with a title beneath it, indicating authorship and position. Official stamps are visible at the bottom right, including a "Declassified by" stamp with a date and a reference number. Additionally, there is a handwritten number in the top right corner. The document appears to be a scientific or research report. f e c t s o f c h I o r p rom a z i n .z ·i n b I o c l-: i n g t h e · e f f e c t s o f L SO have not been born~ ouY to~ ~cl I by add.ttional experiments. Although the .. exp~rtn•ents show an ovtralt trend to reduction in the LSD-reaction, it is doubtful that further work with chlorprcmaztr is indicated. Part of the difficulty is probably due to the fact that the re~ponse to both LSD and chlorpromazine is highly indtv~duat The best experiment would b~ one in which the dose of both drugs was Individua I ized. CA-101. Another lof of thi!: mafertal was obtained and the eff~cts 1r compared ·;;ith those of the original lot. The second lot proved ! to be jusr as potent as ~he first in inducing typical marihuQna- I 1 ike subjective effects, plus. a marl::~c degree of postural hypote-ns ior: fn doses of I to 2 mg. ora fly. \. In experiments using 6·subjects, the effect~ of smcking tobacco i en-which the drug had been dried were studied anc ccmpared with \ thost seen in th~ same subj~cts after oral administratTon of I I i i t h ~ c em p o u n c . I n gene r a I i t i s c e r t a in t h a t t h e drug i s e f f e c t i v e when smoked in thi~ way. Larger amounts are requir~d dnd the I ' \ results are more~er'ratic. For exampfz., ill 2 patients, definit€ \ I ! subje~tive 5nd c~rdiovascylar effe~ts were &~en •fter s~okin; !I ;' o n I y I m g • o f t h e d r u g • : I n s or:te o-f t h e o t h e r tl a t i. e n t s. , o n 1y m i I d \ \ effects were obsz~ved after smoking as much as 4 mg~ of t~~ drug. Attempts to improve cons·i.stence of th:: effects by morl careful ! distr!~vtion in drying :-/ftl're drug en r~e tobacco are underway. - -· Combined administration of LSD an·d CA-101. These txp~r toTlents are curren!·ly in progress •. Parients,are r~ceiving orally 60 meg. L/i of This document is a page containing a table with experimental data, likely from a study involving drug effects. The table is titled "EXPERIMENT 3" and presents "EFFECTS CF 100 MG. CHLORPROMAZINE GIVEN 30 MINUTES BEFORE 60 MCG. LSD-25". It lists measurements such as "Knee Jerk," "Pupillary Size," "Blood Pressure," "Questions," and "Grade," with corresponding values for "PLACEBO + LSD" and "CPM + LSD," along with "DIFFERENCE" and "SIGNIFICANCE OF DIFFERENCE." There are some handwritten annotations and stamps, including "Declassified by 187475" with the date "4 FEB 1977," and a handwritten label "A-172" in the bottom right corner. Portions of the document are obscured by a heavy black redaction, particularly in the lower center of the page. The text below the table explains that the "Figures are means on 7 patients, 6 white and 1 negro." as 4 mg~ of t~~ drug. Attempts to improve cons·i.stence of th:: effects by morl careful ! distr!~vtion in drying :-/ftl're drug en r~e tobacco are underway. - -· Combined administration of LSD an·d CA-101. These txp~r toTlents are curren!·ly in progress •. Parients,are r~ceiving orally 60 meg. L/i of LSD plus mg. of CA_-101. Controls tncl·ude a placebo; LS:i rns. alone; and CA-101 arone. Re:;ults so fJr indicate tl) Even 0.5 CA-r 0 t w i I t induce de f in i t e m i I :i s u b j e c r i v e e f f e c t s i n t h c m a j or i t y o f s u b j e c t s ; ( 2 ) 0 n e - h a I f m g • o f CA-I 0 ! i n d u c e s d e f l n i t e c d r d I o - vascular effects Cbut not great wzakness or faintlng) in all the s u b j 1Z c t s ; ( 3 J L SD . do e S· n o t b I o c '< t h e c a r d i o v d s c u I d r ~ f f e c t s o f C·\ - ! C : (4l CA-101 dc~s not b:oc.( the subjecttv~ <?ff~::_ts of L~~; \5 i The :# u b j ~ c l i v e e f f e c t s o f I /2 m g • CA- 10 I a r e. s ·O m ~ !. d p, d i' no a c c .z ,.;t u a ~ i o r. of the effects of the LSD are.cbserved when the mixture is givz;-,·. The s ~ ~X p? r i m-<: n t s W. i f I ,;: 'I en t u d f I y be eX rend' d. r 0 i n c I v de c 0'11 b i n :J t j C· ~ s ·Of a la-rger ·dose of CA-!01 with LSD. · .i S i n Ci·:Z r e I y you~ - ~ ' . j ·._ ,1, / } \ < I ~ d; v. •j ' ?~/'v/ i This image is a scanned page from a declassified document. It features a table with experimental data, including measures for "Knee Jerk," "Pupillary size," "Blood Pressure," "Question," and "Grade." Each measure has corresponding values for "Placebo + LSD," "CPM + LSD," "Difference," and "Significance of Difference." There is a handwritten annotation at the bottom right indicating the document was "Declassified by _ 187475" on "4 FEB 1977" and signed "A-171." A portion of the top right of the image contains some illegible, scribbled-out content, appearing to be part of a larger diagram or note. A blurred image resembling handwriting or a smudge is present in the lower center of the page. The document contains a single page of a declassified CIA report, likely related to the MKUltra program. The visual content includes a table presenting experimental data with columns for "MEASURE", "PLACEBO + LSD", "CPM + LSD", "DIFFERENCE", and "SIGNIFICANCE OF DIFFERENCE". Below the table, a short explanatory text describes the figures and methodology. Handwritten annotations are visible at the bottom right, including a "Declassified by" stamp with a date of "4 FEB 1977" and a number "187475," along with the marking "A-170". There's also a smudge that appears to be an ink stain or a photocopy artifact. No photographs, diagrams, or organizational charts are present. de c 0'11 b i n :J t j C· ~ s ·Of a la-rger ·dose of CA-!01 with LSD. · .i S i n Ci·:Z r e I y you~ - ~ ' . j ·._ ,1, / } \ < I ~ d; v. •j ' ?~/'v/ i ui?~ ·' ~ H· d - -, I J ;r • I . / S v, I S ' ~ - .. ' , e ·1 . I , i . ' l! ' • : " _ " ., • Director of Research HI: r n Dec/assjfied by d . -----187475 - 4 FIE ate-,. 1977 .- .. :-- · ..· ! . . .. . . :-' EX?ER l;\'iENT 3 .: . EFFECTS Cf I 00 ft:G. CHLORPRQviAZ INE. GfVE..N 30 Mlt\UTES BEFORE 6C lv'CG. LSD-25 -- . CP:..-, ?LAC 80 · lv1EASURE 4-. lSD. + LSD DlfFEREN:E I Knee J cr~ : I I .4 7 1.44 + 0.03 N• . s. I .,I Pup i I I a ry· ·size r 2.72 .' ' 0.22 + 2.50 <O.OI ,._. . I ! Blcod· Pressure 1.1 0. 0.75 I + 0.35 I. N.S. :;,. I / ; r I i : ;/' / I Questions 32 ,., 2C 12 N.S. { ! I... I l i / < Grc1 d~ I • I ' 0.5 0.6 o. 05 \ / Figures are means .. on~ 7 pot. i en t s , 6 w-.'1 t t '! and .I negro. Declassified by -1874'75....- date 4 FE 8 1977 /f.4 - F1'7 I<._... 1 r'._ \·· ' 4--- :.·· EXPER H,:ENf 4 -. ' ~.,' : 75 lvr;. Cf CHLOR P!HJ/~Z INE GIVEN 30 MINUTES BEFCRE 60 MCG OF LSD-2S: PLACEBO CPM SIGN IF ! CAl\CE MEASURE + LSD .&. LSD D I F FER E1 \CE "trt CF D IFFEREl\.CE Knee Jerk 0.95 -0.08 I .03 4.68 ( 0.01 1 ?upilJary size 4. 78 ,, . 2.80 I I .98 3.91 ( 0.01 f I l . I I Blood Pressure 3.07~ 1 .sa I .29 2. 3· < • ro ;> o.o5 / f . j ,I 135 Quest ion ' i . 4.0. i 95 5.25 . <O.O! ~• ; . r .o l '· .-l < . Grade 2.2 1-.·2 ~ 2.36 I 0) 0.05 / Figures are means of 7 patients~ 6 white The document displays a typed table detailing experimental results titled "EXPERIMENT 6". The table includes columns for "MEASURE", "PLACEBO + LSD", "CPM + LSD", "DIFFERENCE", and "SIGNIFICANCE OF DIFFERENCE", with entries for "Knee Jerk", "Pupillary Size", "Blood Pressure", "Questions", and "Grade". Below the table, explanatory text describes the figures and measures. A declassification stamp is visible in the lower right corner, marked "Declassified by 187475" with a date of "FEB 1977". There are also some handwritten annotations, including a number "A169" in the far lower right, and a dark, smudged area in the lower center resembling a scribbled note or marking. 3· < • ro ;> o.o5 / f . j ,I 135 Quest ion ' i . 4.0. i 95 5.25 . <O.O! ~• ; . r .o l '· .-l < . Grade 2.2 1-.·2 ~ 2.36 I 0) 0.05 / Figures are means of 7 patients~ 6 white and I negro. Figures for knee jerks, pupillary size, and blood pressure represent area under time-action curves {8 hours). )uest ions show number of positive answers in 8 hours. C I i n i c a f grad .z s on I -4 b a s i s • Oeclassified by -1874~ /f -{7( date 4 FEB 1977 __ "~--. ·. . ._ ... -..- . __ . ;:: ....... _. . ,~ ... ·~~ ..... .~· f :.-. -......· . • - t EXPER H.iENT 5 7 5 k'G.t • Cf CHl CR PR O v'A Z I f\lE G l VE N. 3 0 MI NUT ES 8 EF rn E 6 0 tv:CG. Cf l S C: - js PLACEBO C?M I IGN IF ICAN:E . tf.EASURE +·LSD + LSD DIFFERENCE ·!> IO F DJt.:F ,. c D ." C .. f . 'I , C C .... I "· Knee Jerk ~00 . 2.02 -.02 f N .S. • ' I Pup I 1 l a r y Size 2.96 0.90 2.06 I l. : · "' - > -~ .(0.01 .. ' ! I I l ' I Blood Pressure 1.35 I l • 12 0.23 f f N.S. I .- J r ':~ i . Questions 76 I .56 ~~- ~ 20 l I~ N.S. f : ! ' 1. ·. C I i n i c a I Gr a de I • 3 !. / 0.8 < .IO> 5 I -· ~ Figures are means o( observations on 12 nesro patient-s . .F lgures .in knee jerk, pupillary size and blood pressure. ,resent areas under curv~. Question~ ~amber of positive answers in 8-hour period af · drug. Clinical Grac;les on 1-4 basi.s •. . --1S74'75---- Declass•fied i~ 1311 - j--/1 0 date \ • f ... - ~-... -.·., . .. : ,..,.:.. _ . l · ~ , - ~-..· - ~ ~ ~. .. ·. .. -· EXPER lf.iENT 6 EF FECT S . OF 7 S. UG. CHL CR PR Q .·1A Z I r· ..! E C'P.A L The document is a declassified CIA report page, likely from the MKUltra project, featuring a table detailing the effects of chlorpromazine and LSD on patients. The table presents various measures like "Knee Jerk," "Pupillary Size," "Blood Pressure," "Questions," and "Clinical Grade," with corresponding data for placebo/LSD and CPM/LSD conditions. Handwritten annotations include "EXPERIMENT 7," a smudged section potentially over a photograph or diagram, and a "Declassified by 187475" stamp with a date of "4 FEB 1977." There is also a handwritten annotation "A-160" in the bottom right corner. The page also contains text describing the experimental setup, including the number of patients and dosage ranges. \ • f ... - ~-... -.·., . .. : ,..,.:.. _ . l · ~ , - ~-..· - ~ ~ ~. .. ·. .. -· EXPER lf.iENT 6 EF FECT S . OF 7 S. UG. CHL CR PR Q .·1A Z I r· ..! E C'P.A L L Y GIVEN I -1/2 HOURS AFTER 60 WCG. LSD-25. Figures are means of observations on 12 negro pat iznts over 6-1/2 hour period after CPM given. Figures r~present area under time-act ion curve (knee jerk, blood pressure, pupillary size). - · ''1.,- .. ~·,on~ S~'O"' ;"'Ui.lb""• 0~ OO'"i~·,,.,... ,....J. urt• ng o"' hours. "-'V '\!.oil ' • I ~ il f4 t tt V l • I , v t If'\,. Ciinicai grade on basis·of i-4. Declassified by _ '75-- 1874 n e (late .t· ' 1977 • A-/t • • . . . ·: . ~ • . f ·-~ :· . .. - ·~ , ·: .• ~\· .... ,.-·' /" EX?ER~ .-. ··.: EF FE.CTS OF 25 r1:G. OF Q;tORI'ROvtAZ lt'-t'E t .lvi. GIVEN 1-1/2 HRS. AFTER VARIABLE DOSE. OF lSD,..25. C?iiwi . t 0 IGi'-J I r lC..:... W.EASURE .&- LSD OIFFEREN:E D t F FE2ENC£ OF DlF.f. i I Koee jerk I ..6 6 1.90 -0.24 I N. S. f I < ;~ P. PP i I I a r y Size 2.57 1.35 1.22 2.62 0.05 Bfood Pressure 1.23 0.90 0.33 .N.S. -- ' ~~ Questions 74 _63 t l I N .S. ,, i I ,_.. i· Clinical Grade t.9 I It ' ., 1.4 l I ! o.s. 3 ~I l \ I ( 0. OS F . / ;' Flgur~s are averages of observations on 12 n~gro patients over 6-1/2 hour pertod administration of CPM. aft~r Dose of LSD varted between 60 and 150 • ~cg .D eclassified by -187475.- n:e Cfate ~ 1977 I