Doc 0000151534

The image displays a large, intricately detailed illustration of a bank vault door on the left side. The vault appears to be made of metal with various circular dials, gears, and bolts, illuminated by a blue light that casts a glow. To the right of the vault, the text "THE BLACK VAULT" is prominently displayed in large, stylized white lettering against a dark background, with a blue aura. Below this, white text provides information about the document's origin from "The Black Vault" and its contents within the MKULTRA/Mind Control Collection, including a URL of "http://mkultra.theblackvault.com" in yellow. There are no photographs, handwritten annotations, signatures, official stamps, filled-in forms, diagrams, tables, redactions, or visual evidence of experimental procedures. lit RS~'H. .. AODKUI TIIC. 2~ May· 1955 ADDic:TIOI't RESIARCH CEMT!R IUnONM.IIonruTn OF II!Jif'l. H~AI.TH · U.s.· PUIUI: HC.U.nt SIAYICI HOSfiiTA~ ~- lOll 2000 . LlliiHTOit, KIIITVCIIT -- Since writing to you on 28 January 1955 we have.compl~ted experiments on the blocking of LSD-reaction with: Rzserpine~ a combination of LSD with C-9, and t~lerance to LSD by prior .·.' administration of .. LAE. Some- further information is avalla'~fe on C-9, and studies desioned to shed I ioht on th~ characteristics C-9 of the m~ntal effects in~uced by ar; underway. Trials for the blockade of LSD-reaction· with "Frenquel" (4-piperdyl diphenyl-carbino~_) a.re in progress and wi I I soon be complete. Ex pe r i me n t s a r e 5~ i n g c a r r i e d o n w i t h co hob a s n u f f , b u t . to d u ~ e no react ion has been observed iff the doses used. More deta i Is of the d~scription~ of the experiments together with tables a r·e g i ve n be I ow. · · . " Reseroir:te tlS LSD/ Block iao Agent. In this exoeriment 12 negro subjects received th~ following combinaticns -of drugs: (I) Reserpinz placebo-LSD placebo; (2) Reserpine placebo-lSD; (3) LSD placebo-Reserpine; (4} LSD Reserpine. Reserpine was given orally in a dose of I mg. ten hours, and I mg. two hours prior to administration of the LSD placebo, ot 60 meg~. of LSD. Placebos used for Reserpine were identicar in app~arance with tablets of the active d~ug. Experi- ment was conducted in doubl~-blin~ fashion. Measurements were those oreviouslv de:>cribed frorn this la!·orator-v CestimAticn ,.,f knee jerk, measureme.flt of pu,:>illa:-v size, meas~remc.:nr of systolic blood pressure, administration of questionnaire, hourly assess ment of clinical grode of reaction). Dota were analyzed by same· methods._ explained in previou:; r..:ports. It can be seen from th~ ta~le that R~serpinc c~used no significant change in any of thzsz rn~asur~s. ~~ therefore concluded that, in this dose, Res~r!"li~·e d0es not ~;lock the LSD-rcaction. It rnight be deslra~le to repeat this work usino a larGer dose of ~eser;:>ine and a longer p:::riod of administration prior to testing with LSD. Of in~erest, ho•.••ev~r, --is the fact that definite side effects were observed even with the small doses of Reserpine used. A-1~ ~·· LAE-32 as Blocker of LSD-25 Eff~ct. Sine~ LAE-32 repeat this work usino a larGer dose of ~eser;:>ine and a longer p:::riod of administration prior to testing with LSD. Of in~erest, ho•.••ev~r, --is the fact that definite side effects were observed even with the small doses of Reserpine used. A-1~ ~·· LAE-32 as Blocker of LSD-25 Eff~ct. Sine~ LAE-32 fs a refattvefy impotent dru~ w~ich struc+ur~lly fs closely related -to lSD-25 it Y1as f~lt that prior administrat-ion o( a dose of lAE mtsht bloclc the receptor sites and thereby prevent or modify the LSD-reaction. Twelve negro patients were, therefore, given In randomized order under double-blind· technique: (I) LAE plac~bo fo I lowed by LSD placebo; (2) LAE placebo fo I lowed by 60 mcgm.- LSD; {3) LAE, 500 mcgm. fol r·o~ved by LSD placebo; (4) LAE, 500 meg~., followed In one hour by ·LSD, 60 mcam. The LAE-32 used in thes~ experiments was in the form of enteric-coated pllls rather t h a n i n t he f o r m of so I u t ion t n amp u I e s • S u g g e s t i ve e v ide n c e of very mild lSD-llke effects was observed tn these subjects with thts dosage of LAE. The effects, however, were not significantly different- statt~tically from those ob~ained with placebo (see ta~le} Also, there w~s no signlficant differ~n~e ~etween place~o-LSD and lAE.-lSD, ~I though a mt ld trend toward l"'educt ion of 1-ne LSD re~ct ion was observed which was not sufficiently great ta warrant further · e x p I o r a t i o n • _,. · Cr~ss Tolerance Between LAE-32 an~ ·LSD-25. This experi~en·t. was carried out at the suggestion of Dr. Harold Abramson f!n the hope that one mioht develoo tolerance to LSD without incurring th.e ·unpl~asant side effects' associated with development of tolerance; with administration of LSD. Twelve negro patients, therefor~, reteJved In r~ndomized order ~Y the dou~le- bl ind technique: CI > lAE placeco ·for one week; t2l LAE, 500 mcgm., for 1-hree days, follo~yed by 1000 _mcgm. tAE for four days. Patients were then tested with the standard dose (60 mcgm.) LSD-25. It was not f e I t ·t ha t i t wa . s n e c c s s a r v to do t h e p r a c c bo - p I a The document is a single page of typed text, likely a research report or memo, with handwritten annotations. A circular government seal is visible at the top left, and a date "23 May 1955" is stamped at the top right, with a handwritten annotation "#51" in a circle next to it. There are also handwritten numerical annotations in a circle to the left of the main body of text, "(6)(3)". In the bottom right corner, there is a handwritten annotation "A-18". The document discusses experiments related to LSD and Reserpine. The document is a typed research paper with handwritten annotations. Specifically, there are two faint circular shapes near the top of the page. In the bottom right corner, there is a handwritten annotation "A-18T". The text discusses experiments involving LAE-32 and LSD-25, mentioning randomized order, double-blind technique, and patients. Visually, there is no photographic imagery, stamps, forms, diagrams, tables, or explicit redactions. The content is presented as a continuous narrative of experimental findings. Patients were then tested with the standard dose (60 mcgm.) LSD-25. It was not f e I t ·t ha t i t wa . s n e c c s s a r v to do t h e p r a c c bo - p I a c e bo a n d pl-=!cebo-LAE c_cr(trol's at this time,. since th~y were fairly well covered by the firs.t exp.eriment. ·Methods of measureri'ient of the LSD-reaction and analyzing the data were the same as previously r-eported. Durina the week of ad:nin istrat ion of LAE-32 definite but mild LSD-fike eff'~cts wctr~ reported by the patients .. 'J!e have th~ t::npr~ssic.n thor i'h·ese viere a~ un;:d~=!a~f .J: ~!;~ ~F-Tecrs of LSD-~~, ·given by onz of th~ schedules we have used to. develop tolerance In the past. As can be seen by the table, there was a definite tendencj for the intensfty of the-LSD-reactlon to be reduced f o I I o vn • n g . a weeKr s a e...Jm •1 n •1 s t r a t . • 'o n· o f ' V " - ' ~: - , ~ .. .. .r:.'' 1" 0 n :1 ~ 1 •1 c.; n 1 1 . . r ~a_uI ·: Lr •; o n i n k n e e ·-jerk s , pup i l r a r y s l z e a n d s y s to I 1c b i o o d pre s s u r e '.'!-:! r ~ observed and there were nearly slgnlficant reductions in the number of answers to quest lonna ire and ln the clinical grade of effect. tt 'ltould appear that some degree of tolerance did develop. Toiet·ance, howevel'", was far less than that· induced by repeat'ld administration of LSD. This m~thod, therefore, does not seem to .be a very practical way of inducing tolerance to LSD. A-lf7 .;. ~~ ., ..... Reproducrbtl ity of LSD-25 th~ ~esponse. In th~ course of the experiments described abov~ three trTais of th~ eff~ct o£.60 m~gm. 6f LSD wer~ carri~d out on the same 12 pa f I en t s u n d e r n e a r I y t de rd ; c: a I co n d i t ro n s • A s · c a n · be s This page is a typed document with typed headings and text. There is a handwritten annotation in the bottom right corner, "A-186". There are no photographs, stamps, forms, diagrams, tables, or redactions. The document appears to be a research report detailing the effects of LSD-25 and a drug identified as C-9. LSD wer~ carri~d out on the same 12 pa f I en t s u n d e r n e a r I y t de rd ; c: a I co n d i t ro n s • A s · c a n · be s e e n f rom th~ tabte on reproductbtftty of the LSD-response, the LSD-reactio~ Ts an·extremefy consistent blologtcal phenomenon. Reproducibiltty ts, of cours.-:,· ·very important _tn testing the effects of vartous -- _ a n t i do t a l d r ug s • Combln~tton of lSD-25 with C-9. The purpose of thts experiment was to study possible enhancement of blocking of fhe LSD-response by comblntng the drug with C-9. The same 12 patients· who were used in the LAE and Reserpine experiments received in randomized order according to the ind technique:· dou~le-bl Cl) C-9 placebo-LSD placebo; (2J C-9 placebo-LSD-25; (3) LSD place~o- ... 0.5 mg~ C:-9; (4} LSD, 60 mcgm., -0.5 mg. C-9; (5} LSD~ 60 mcgm.~ -I mg. C-9·;--- :.'· ln addition ·to the usual ~SO measurem~nts (pupillary stze, estimation of knee Jerks, of resting blood pressure, measur~ment LSD assessment of clinical grade), the pulse rate questionnaire,:.-~nd and systolic blood 'pressure of th~,se patients were measured at one minute intervals for five assuming the standins ~inutes'after position. AI I measurement~ were made prior to administration of the drugs and once per hour hours administration of the fo~:eight a~ter drugs. It was realized th-at the observat~on period was not suffici~nt!~ long, but 'prevented of the observation period circumstanc~s e~t~nsion for more than eight hours after administration of the drug. " Results are shown in the tabfe. It should be noted that a ·s:igntfi·cant number of answers on the qticstionna ire occurred wnh ·administration of C-9. Analysis of the ans-wers showed, however, o very different pattern from that seen after LSD dose. High scores were obtained on a group of symptoms resembling those seen after a-dmrrris-trat ion of Atropi'ne {decreased sa I i vat ion, dryness of mouth, d r v t a s t ~ i n mo u t h } : ,. n d on ~ u c h que s t i o n s ! s i ncr e a s e i n e u d i t e l"' y ·a ~c~ ,.~... y, .:' :.rc·.-;:: • : :-:~:::, an.:.' ' The page is a typed document with handwritten annotations in the margins and bottom right corner. The text describes experiments involving LSD and a drug called "Frenquel" (later identified as C-9). There are no images, stamps, forms, or tables; the content is entirely narrative text and handwritten additions. A section of text near the top right appears to be obscured or redacted, indicated by a dark, vertical mark. The handwritten notations include a small circled "C" at the top, and an alphanumeric code "A-185" at the bottom right. mo u t h } : ,. n d on ~ u c h que s t i o n s ! s i ncr e a s e i n e u d i t e l"' y ·a ~c~ ,.~... y, .:' :.rc·.-;:: • : :-:~:::, an.:.' ' · •ung~r.. T 11 ' iv. T,. afu• l•' ., .;r •L .""."J""U -!Jdt' 'r ern or,. ~norex 1 , nervousness, insomnia, plus visuaf perceptual distortion was not observed • The ~ar~Jovascular effects o/ C~9 were aoo~rent even with t~~ a. a 0. 5 -mg • dose ( see tab I e 1 • 1 n sot' c t a s the ~at pe r"m it an I y s is : C-9 did not block or accentuate the effects of LSD on the pupi Is, knee jerks or resting blood pressure. G-9 did !::lock tn pa·rt rhe fn blood pressure on standing after LSD alone. tSD, on rhe ris~ other hand, pdrtial !y blocked the drop in blood pressure on standin~ seen after 0.5 mg. C-9 alone. ·"~ .. • ~~· .. tt may be desira!\ when conditions permit to study the c:ombtnat ion> of' lSD an :J, 9 more intensive I y, us tng larger dost!s of LSD and prolongi~!J· ::-.period of observation· to-at le~st 16 . hours. Before this c !:H~ .-done, it wt I I be nec~ssary to develop a method of dif'fe"ient tating between mental effects caus~d by C-9 ~nd mental effects caused by LSD as well a~ a method ~f grading the eff~cts of' both. "Frenquel" ~s Intravenously as a Reverser ·of the lSD-Reacrion. . A few pre I iminary experiments of this kind have been carried out. Four patients received in randomized order: (I) 60-75 mgm. fof lowed in two hours by 15-25 mg. Frenquel lv; f2l 60-75 meg. LSD followed in two hours by a freng'Uel placebo intravenously; (3) LSD p[acebo followed .in two hours by 25 mg. o·f Frenquel intravenously. F~enquel alone induced no measureabfe drug effects. There were no obvious differences rn the intens Tty and course of' the lSD-reacr Ton In tf\.ese pa.tients on the Frenquel trial as compared \'lith the placebo t :r i a I • Wh i I e the n u171be r of p a t i en t s i s s rna I I , re s u I t s do no The document is a typewritten page with a handwritten signature and accompanying text. The signature, "Harris Isbell, M.D. Director of Research", appears in dark ink on the right side of the page, below a handwritten "Very, sincerely yours,". There are also some faint pencil markings and a handwritten annotation in the bottom right corner "A-184". The text discusses the "Cardiovascular Effects of C-9" and "Mental Effects of C-9", with section headings numbered (3), (4), and (5). There is no visual evidence of experimental procedures, equipment, or facilities, nor are there any official stamps or redactions. Ton In tf\.ese pa.tients on the Frenquel trial as compared \'lith the placebo t :r i a I • Wh i I e the n u171be r of p a t i en t s i s s rna I I , re s u I t s do no t j us t i f' y e x t en s i ve e x p I o r a t t o n o f' t h e a n t i do t a I e f f e c t o f "F r e n que r • " Admintstration of Frenquel· Orally for One Wee!{ as a Blocker io'1: ·. of LSD-React Twelve negro subjects ricei ve<t the to I lowing combinat to.ns of drugs: {!) Fr~nqu~l p_lacebo,..-LSD placebo; (2) Frenquel ;:>lacebo- 60 mcgm. LSD; (3) Frenquer-tSD place:-o; (4) FrenqU·:!l-LSD. Frenqucl (and Frenquel placebo) was ;~dministe~ed orally in doses of 20 mg. thr~e times daily for six days prior to'ad~lnistration of LSD or LSD olacebo. Procedure VIas carried-:out in dou!;le-bl ind fashion. The ~urpose of ths experiment was not explained to the p~ti~nts. One weeks ttme was allowed to elapse between admtnistr·atlon of Frenquef ,and FrenqveJ. placebo to perm.it ."washout 11 _of. any frenquef that mtght have been given previously. Methods of assessing the LSD-reaction were the same as those reported above. Although the experiment is not yet complete and the code has not been broken, results so far strongly suggest that we wil I be u~~~~~ tn ~istfn~uish ~etween Frenquel and placebo. Another report wtll be submitte~ as soon .as possible when the work is complete. MisC"e II aneo·us lnformat i.on-- on C-9. (IJ Stability. Th.z alcoholic solutiof1 of rhc original lot of C-9 has~en kept for almcst a year. ihis mar·zr-ial is appare:-~tlv a-s effect i ve as when f i r s t r e c e J ve d • (21 Method of Administration. C-9 apoeers to ~e equally e f f e c t i ve w n e n g i vc n o n f o o d , i n co f f ~ ~ , i n· so f t d r i n k s , o r i n alcoholic drinks. It is also effectlvz when smoked (see leth:r of 28 January 1955), although larg~r amounts of tn~ drvg are required and the The image displays a table of experimental results, likely from a scientific study. The table is presented with a title at the top stating "EFFECTS OF 1 MGM. RESERPINE 10 HOURS AND 2 HOURS PRIOR TO 60 MCGM. LSD-25". The table includes columns for different drug conditions: "PLACEBO-PLACEBO", "PLACEBO-LSD", "PLACEPO-RESERPINE", and "RESERPINE-LSD". The rows list various measurements such as "Knee Jerk", "Pupillary Size", "Blood Pressure", "Questions", and "Clinical Grade". Accompanying the table are textual notes at the bottom that explain symbols like "P" and indicate the method of analyzing data. There is a handwritten annotation in the top right corner of the page that reads "A-183". d , i n co f f ~ ~ , i n· so f t d r i n k s , o r i n alcoholic drinks. It is also effectlvz when smoked (see leth:r of 28 January 1955), although larg~r amounts of tn~ drvg are required and the re;ults are mor~ erratic. A-ll'S - _.,.,,fiij • ··~ . .. . . . ..,. ·. . - .:·. ·:l~t' .. . - 'ff ~"-. - (31 Comoar-fson ·~ Cardfovdseular Effects of C-9 with Hl·:>s.:::· or Ma r t ft u a n a a n d P a r J x v • he sa me k J n d of c. a r d i o v a s c u I :! r e f feet s Uachyc:ardia at re-s ·. :aehyeardia and po$tura I hypotension on standingt_ occur .afte. a·dmfriistratfon of art a tcohollc extract of marthuana orarly, after smo~tng of marihuana cigarettes, and after 45- mg~ of parahexyl orally, as after the admJnJstratron of C-9. The. cardtovdscular effects of C-9 ar·e probably common to all active members of the cannabinol group. (4) Mental Effects of C-9. Effort Is now underway to obtain a be t t e r de I i n e a t i o n of t h e e f f ~ c t s t n d u c e d b y C-9 • T he s u i:; j e c t i ve sensations induced by the marihuana group have long been or.scure. The descriptions in most of the writings on marihuana with respect to the occurranee of vtvfd, depersonalized, hallucinatory or c:atalept Je states have seldqm been observed when these drugs have been studied under controlled institutional conditions. Ordinarily the subjective effects Induced by marihuana in such circumstances appear to be rather mild, and so f~r descriptions given by ·tnstltuttonaltzed p~tients have not shed a great deal of' light on the ~xact nature of the sensations experienced. For thts reason, 12 patients we-re given a sente~ce-compiet ion tes~, consisting of incomplete sentences chos~n to yield information with respect to menta r status (aff~~f; mood, bizarre thinking, etc), and soma+ ic sympto (dryness of' the mouth, blurr.ing -:>(..vision, changes in auditory acuity, etc). Validating questions and g-zneral drug questions are also included. tncomolet~ sentences which elicited conststently posit t ve- responses were se!ected frofTl th i ~ with respect to menta r status (aff~~f; mood, bizarre thinking, etc), and soma+ ic sympto (dryness of' the mouth, blurr.ing -:>(..vision, changes in auditory acuity, etc). Validating questions and g-zneral drug questions are also included. tncomolet~ sentences which elicited conststently posit t ve- responses were se!ected frofTl th i ~ or fg ina I test and a new tru?.-false test consisting of over 300 tte.ms constructed. This true-false test is now being admint~tered.to 30 men. \:ihen the results are in, item analysis wi II be carried out and furthzr work ·conducted base'!_ 01l leads obtain·zd from the? high scoring items. · · · · ( 5 ) Pre· I i m i n a r y C I t n i c a 1 Des c r i o t ion ·of" the C -9· React i·o n ; · · ·· · A descriost ion of th<:: C-9 reaction based on observations made ·in 3 3 t r i a l c f I to 2 • 5 mg • of C-9 o r a II y i n I 7 s u b j c c t s h a s ~ e e n prepared and is appended. It should be born~ tn mind that this description is preiTmina·ry in nature and may have to be modified .~-... ~. ~..~.. •.. '.. '•' / -·...~... ~• u~• tLn ~..._ ·• ·., n•~-~•- ..m '~"' tt~-r.• ·~ ~ ~ w ~ . ~ . c· ~; • ;, - ui . ~ .. L j - - d • Future Plans. tn ;dditio~ to stud·tes o~ th~ C-9 ~ea~t!on 1 future plans rntfudc. studl~s of the effect of c~m~fndtions of s~n~o!ami"~ end LSD-25. the us~ of ~es~!roin~ as a onie~in0 dr:Ja, ~rd. the testin..., ny of new. substances from the Un i v~rs of Illinois a:; they ~...~come a va ira b l e. •.v Ve 1 s in~ ere '(\ your-s , Jr " .. ( J ' _fJ I IJ.t!J'tlti<J ~..Ll)l- ~-'a r r is I· s :.e I I , r·Ti .D. Di;ector of Research HI: rn Enclosures . . \) il ··. c~ "f- ~- EFFECTS OF J MGM. RESERP lf\IE 10 l-DUP.S AND 2 HOURS PR lOR To 60 M:C-M. LSD-25 '· . .. . c '- : : • ). I ,•,• r..:. t>RLG •. \ ' ·· • . ,I ' The document displays a table summarizing the effects of LAE-32 and LSD-25 on subjects, with data organized by drug and measurement type. The table includes columns for "Placebo-Placebo," "Placebo-LSD," "Placebo-LAE," and "LAE-LSD," with rows for "Knee Jerk," "Pupillary Size," "Blood Pressure," "Number of Questions," and "Clinical Grade." Numerical values, some accompanied by 'P' indicating statistical significance, are presented within the table cells. Below the table, a note explains that 'P' indicates a statistically significant difference from placebo-placebo, and mentions that certain differences were not significant. A handwritten annotation "A182" is present in the top right margin, and there are some minor smudges and spots of ink throughout the document. The document is a typed report containing a table that compares the effects of LSD-25, placebo, and LAE-32 on various measures, including knee jerk, pupillary size, systolic blood pressure, questions, and clinical grade. The table includes numerical data and symbols indicating increases or decreases. Below the table, there's a statement indicating that the figures are averages on 12 subjects and that the method of analysis is the same as in previous reports. There are no photographs, stamps, or obvious redactions on the visible portion of the page. A handwritten annotation resembling a kite shape or a drawing with a line and arrow is present in the bottom left corner. HI: rn Enclosures . . \) il ··. c~ "f- ~- EFFECTS OF J MGM. RESERP lf\IE 10 l-DUP.S AND 2 HOURS PR lOR To 60 M:C-M. LSD-25 '· . .. . c '- : : • ). I ,•,• r..:. t>RLG •. \ ' ·· • . ,I ' ( PLACE BO-P LACE BO PLACE BO-l S(? PlACE 1:0-P. ESE RP INE RESERPINE -LSD ;·, .. ~ : nee J erfc .... 0.62 . ".i'3.31 p< ... I .02 3 .I 0 p .•. up II I "r y SIze .&. 0.35 .. ... 3.02 p J. 0.31 3.35 p I oori Pressure ... 0.75 '· ... ~-.39 p ... 0.60 I. 99 P \\. uest oh$ 12 . 93 P:. . 14 I 01 P .. p .· p I Ink .,1 Grade 0 .. . .. I • 5 0 1.5 ' ':' .. \ d~~,.-f re;~-~ bf anal ;n I ng data same as In pr ;or ts. ' . . ·. ' ' . ' - lndlc~tes !lgnfftcant difference st~tasttcally from plac~bo~ l ' . 1@of dtff'ct"4tnces be.t~een Placebo-lSD and Reserpfne-LSD are :·stgntftcant •. • . ~ ' to\ t ' • ~ •• _.'' ':""•'""' rl ol ~ ,- .... ~ EFFECTS OF LAE-32 (500 M:Gvt.) GIVEN CNE HOUR BEFORE 60 lll:GM. OF LSD~25 '· - __,\ . DRtG "· '\ - !---- ·. ' ~.r ···URE PLACEBO-PLACEBO PLACEBO-LSD P lACEBO-lAE LAE-LSD \ ·. -· . " Kn~ : Jerk ... 0.62 ... 3.32 p "- . I • 26 • .&. 2.46P p Pup I I~ ry S t ze + 0.35 .. ... 3~ •, 02 "" 0.67· + 2.9rP . f· nlo ·d Pr~ssur~ . ~ o. 75 ' ... 2.40 p ... 0.56 · .a. I .96P '\\, '· . Num,I -;::r of Qo~st Ions· . 12 1o r P 3?. 78p .. o· p C I f tic~l Grad~ . . 1.. • 5 ·. 0.3 I .2 P : - . . . .. , ' ., .. -- -- --- - ---------- - -~- -- 4.E ~:'lr Plac~bo given at 0700 a.m.; LS.D glve·n at 0800 a.m. Figures are averages on 12 subjech. l)( stattst"~":ally 1ndlc:atet .difference significant from pl-.cebo-placebo. • I Dlfferehcts-bet~een placebo-plbcebo and placebo-LAE not stgnlft~ant. brrrerehctt betw~en placebo-LSD a~d LAE-LSD not slghllicapl. . " I . . \ ·. ..~. ..... • ••. t The image displays a table titled "STATISTICAL REPRODUCIBILITY OF LSD-25 RESPONSE". The table is organized into columns labeled "MEASURE", "TRIAL 1", "TRIAL 2", and "TRIAL 3", with various physiological and psychological measures listed in the first column. Numerical data, including means and standard errors, are presented for each measure across the three trials. In the bottom left corner, there is some handwritten annotation, "A-180", oriented diagonally, and at the bottom center, a statement indicates "Figures are means of values on 12 subjects ± standard errors." There are no photographs, stamps, forms, diagrams, or apparent redactions present on this page. Plac~bo given at 0700 a.m.; LS.D glve·n at 0800 a.m. Figures are averages on 12 subjech. l)( stattst"~":ally 1ndlc:atet .difference significant from pl-.cebo-placebo. • I Dlfferehcts-bet~een placebo-plbcebo and placebo-LAE not stgnlft~ant. brrrerehctt betw~en placebo-LSD a~d LAE-LSD not slghllicapl. . " I . . \ ·. ..~. ..... • ••. t •-; . ·t ..1• o . . . OF 32 (~. C<lli\PAR I SON lS0-25 EFFECTS .AFTER A WEEK OF PLACEBO AND AFTER A '\Y/EEK OF LAE ... . ·:..., ., " -· .,.~, ~ .. .. --' DRUG. ~ 'Ill~ ~"-!t "' :.!"· MEASURE PLACEBO-LSD LAE-LSD DIFFERENCE DIFFEREi . '· ...;; .. , I ' •· __ ,.._.....,..... Knee Jerk ; ... 3,01 + 2.18 . - 0.83 ,. 0,05 -,\ + .r Pup t I 1a r y S I ze 3.73 ·.'- 2.46 - I .27 ~0.01 .. Systolic Blood Pressure ... 2'.30 .1. I .03 . - I • 27 L.O,OI - . Quest·lons - 97 ... 75 22 : /Q, I .. . .. . , , CliniCal Grade f·~ I 0.8 - 0.3 70, I ) ---~ ---- - - ----------------- ~-- -~--------- ----- ---~ --- --- - -- ~----- ----------- ------ --------- ----------- - - --- ----- -~- Figures are averages on 12 subjects. Method of on~lyzlng dota $ame as In previous report~. ~ -:!.. II .. " c.,r ' STATISTICAL REPRODUCIBILITY OF LSD-25 RESPONSE ~ ) ~ .... ~ ····~' ·' MEASURE ' TRIAL I TRIAL 2 TR lA~ '3f :-:.f ~.) ,, ...:. ' ' .__....,.._.,. Knee Jerk 3.32 3.01 3.31 .:! 0.47 ±·0,38 ! 0.52 - ------ P - u - p -- i - I - - I - a - r - y - -- S - I - z - e -- ----~--------------------------------------3 .02'~ . 3,73 3,02 ! .. 0.20 ! 0,27 ! ·o. 1 a •j' Blood Pressure 2,40 ' 2.30 2.3? ... 0,36 --1.0.18 -... 0.39 . -:-· Questions I 01 97 93. ... ) -1. 24 -1. 29 19 Clinical Grade 1.5 I , I I • 5 :{ ! 0.32 --1- 0.3 - -1- 0, II . . /"-"t-. I ., f \ ') ----------------~----------------------------------------------------------------------~-------------------~ Figures are means of values on 12 subJ«cts .S. standard errors, ~ ~ .. ~-.) ( \ -· ~ NG.A. EFFECTS OF COv'\B IN lNG ~0 lv'CGM. LSD-25 WtlH 0,5 MGM., AND 1.0 C9. - ._...,_ · ibrnn This document is a table presenting data on the effects of drug combinations on various physiological measures. The table is divided into sections for "MEASURE" and "DRUG," with columns detailing results for placebo-placebo, placebo-LSD, placebo-0.5 C9, LSD-40.5 C9, and LSD-1 C9. Below the table, there are legends explaining notations of statistical significance (P, C, L) and a description of the experimental methodology used for "standing" pulse rates and blood pressures. Some handwritten annotations and a date stamp are visible in the margins, along with a classification stamp. -1- 0, II . . /"-"t-. I ., f \ ') ----------------~----------------------------------------------------------------------~-------------------~ Figures are means of values on 12 subJ«cts .S. standard errors, ~ ~ .. ~-.) ( \ -· ~ NG.A. EFFECTS OF COv'\B IN lNG ~0 lv'CGM. LSD-25 WtlH 0,5 MGM., AND 1.0 C9. - ._...,_ · ibrnn MEASURE ,, . '. PLACE B0 -PLACE 80 PLACEBO-LSD PlACEB0-0,5 C9 LSD-.a.o.s ~9 LSD-I ,p':C .. ' / 8. .Knee Jerk; .a. ·o.62 • ... 3,32 p .a. I •. 41 . ... '2 '89 ... 2~96 p ! ' Pup I I I a r y S 1 ze . · .a. O,.JS ... 3,02 g. . :- o.oa ... 2.70 c p ' .lr 3, )P ' . . . p . . p Resting Blood Presstir~: "" 0.75 ... 2.40 . ... 0,49 .a. 2.19 c~' .J..2.10 ' Questions 12 ' .. . ' JO . .I P 56 p. 94 p .•, 37 r:. , . ! Clinical Grade 0 I • 5 ' 0,3 ' I • 2 .P I. 2 •, St~ndlng Pulse Rate 90. ' 99 112 p 105 p 1 16 r· ' I '\\~ p l.·. Standing Blood fressuri · 109 .,l. .. I 19 197 ... 1o 1 ·c~ 102 l - P- Flgur~ slgnlflcant·ly d.lffer~nt from PlacebQ~PI~cebo, ~ C- Figure slgnlflcantl.y dlfferent from.Piacebo-C9~ .) l- Figure significant It different from Placebo-LSD. Figures are means of results on 12 patl~nts. Placebo-Placebo and Placebo-LSD figures .also used in LAE experiment • . . Da.ta In top 5 measures ana lyz<;d as In previous reports. Da t a o n us t a n d I n g" p u I s e r a t e :: and "s t a n d I n g" b I oo d pre s s u r ~ s o b t a 1 ned once pe r m I nut e for 5 ' . . · minutes after standing.· Valu,~s totalled for 5-mlnute period. and then totalled for each ob$ervat ion. final figure divided bv number· of minut~.J (5)x number of observations (8) to attain averao, for· day. Means of dally averages then (:alculated·. . as usual. 4.~ ~ .. - '',J I' ~-.... observations (8) to attain averao, for· day. Means of dally averages then (:alculated·. . as usual. 4.~ ~ .. - '',J I' ~-....