Doc 0000151535

'_r"'ant of HEALTH. EDUCATION. Ar--.._ WE(- 1E • Putlic Ha~!th Sert!~~ 1---------------------------------------------------------------- NATiONAL INSTITUTES .OF HEALTrf I June. 1955 lit lllft.QII&. AOOIIasS Till ~ ADi:ltc:tiOit R£5£ARCH CENT£P N&YIOIIAI.IIITlTUTIS Oft MIIITAI. HUI.Tif lY U.S. PUaU~ HUI.TII. SElMCI HOSPITAl. Boll ~000 . I.UIIltTCIIt. KIIITVCIU l w a ! away from Le x 1n s ·t on I a s t vt e e K s o t h e p r e I t m t n a r y description of the C-9 could not be completed unHI my r~turn. Thts has now been finished and Is attached to t h e o r i g i n a l I:~ t t e r • Since writing~you on May 23rd the work with Frenquel orally .as a block~r of LSD has been completed and table giving the results is at~_,.ach.zd. You will note that the d lffercr.ces between placcbo-LSD and frenguel-LSD are insigntftc3nt. It Is concluded that tn:the doiage used Frenquel is Ineffective 1n altering the LSD~reaction. l am, of course, sending t h e s e d a t a o n t o t h e Jim • S • Me r: r e l I .Com p a n y , who s o l:: i n d I y supplt~d me with th&"drug. l am als~ thinking of s~nding a short note to Science conce~nlng these negative results. Trials of s~nthetic LSD are underway. Mlld but deftnite LSD-Iike effects have been observed w1th this material ln doses of 25 mcgm. Trials of larger doses $hould begln next week. Very sincerely yours, r\ f.j·I I\ , I _ ~ 1\ 11 l . () /..) tff..t:0r/L,U ~~·~--. Ha r r l s · l s bet I , M.D ~ Di·rectcr of Researc~ HI: rn At t a chme n t - ( ~- -----------~-------,.--·- ' ~ - - ·· " . ' . .. .. ~ ( ' - .. - ..J ~ .C.-:.·. ,...-..., ,J ( ' - J ~ · : - , - · : .. - - .. .. . .. .. \1 . . " f:'' ~]'."' EF.FECTS OF "FREI\OUEL," 20 rv'GM. T.l.D. ORALLY '. ON REACTION INDUCED BY 60 MCG. OF LSD - .. .. MEASURE . DRUG . .. . frenquel • f r enqu.e I Frenquet J:renquel ' .P Jd cebo + LSD Pl~cebo "" · . ; This page displays a graphic with text overlay, not a declassified document itself. The graphic features an illustration of a vault door on the left panel, illuminated by a blue light. The text on the right states that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically the MKULTRA/Mind Control Collection. It provides a URL for accessing the collection online. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. \1 . . " f:'' ~]'."' EF.FECTS OF "FREI\OUEL," 20 rv'GM. T.l.D. ORALLY '. ON REACTION INDUCED BY 60 MCG. OF LSD - .. .. MEASURE . DRUG . .. . frenquel • f r enqu.e I Frenquet J:renquel ' .P Jd cebo + LSD Pl~cebo "" · . ; . ,:: .. LSD Placebo P J acebo LSD LSD "' ... ... • Knee Jerk 1.24 0.57 3.14 3.28 r "' ,. Pupillary Size +. 0.34 ~,. " ' + 0.65 "' 3.68 ' 3.56 • • S vs to I i c a lood Pressur•l -~ 0.63 1.0 I .... 2.49 2.24 / : . ; No. Po!t:·ive Answers I ' On Qucstionnofre ; 9 • -·1 7 ! 76 69 I I Cfinfeal Grade - / 0 0 '~2 I I. 3 . . . . . . . . . . I . ~. : . - .. . . . . - -· . -·--- . -· ... . /1 if-· . .. - -· - -·- .. . ... .. .. ' . . The document is a typewritten letter dated "1 June 1955" from the National Institutes of Health, Institutes of Health. It contains a handwritten annotation "(6)(3)" next to the date and a small circle with "52" inside it to the right. The body of the letter discusses experiments with LSD and Frenquel and mentions trials of synthetic LSD. At the bottom, there is a printed signature "Harris Isbell, M.D. Director of Research" and below that, "Attachment - 1". In the bottom right corner, there is a handwritten annotation "4-190". There are no photographs, diagrams, tables, or obvious signs of experimental procedures shown. This is a page from a declassified CIA document, likely from the MKUltra collection, featuring a table of experimental data. The table is titled "EFFECTS OF 'FRENQUEL,' 20 MGM. T.I.D. ORALLY ON REACTION INDUCED BY 60 MCG. OF LSD." It presents measurements for "Knee Jerk," "Pupillary Size," "Systolic Blood Pressure," "No. Positive Answers On Questionnaire," and "Clinical Grade" under different drug conditions. There are handwritten annotations on the page, including "MER 17" at the top and "A-18" in the bottom right corner. There are no photographs, diagrams, or stamps visible in the provided image. The content appears to be typed data with some handwritten notations.