Doc 0000151536

----· ---------- ~":J.~J;'\··IIII.IIU.oiU Ul & 1"-r\L-II lt L-'-"'-'....,6\.1 • ......,.,.,·. .•. ~•. •- •• ._..._, • ,.,......_ • •--··- ··--·-·• -~···-- ,:"~•-) .. ,. --I A T l 0 N A L i N S t I T U ~ . . -.: ~- . 0 F H. E A L T H 28 June 195.5 lit RIPUIJIC. AOOIIU' tHit ADDICTtON R£StARCH C!I'ITP:R IIAIIO!Uo\.INn'IVTIS 01' IIIHTAI. HIALTH . tf. L PUtUC HIAU'It SIII'IICI HOSPITAL ao&lOQq .. I .( h\(_) ~ '1 J . )c/ Tha sample of LSD received from ·t a be I ed lS0-25-61, has now been tested •. cxperilnents have b<en done. In cxp~rfm~nt I, four white subjects r~cetved tn ran~omtzed order .. :.· · p·l aecbo, 25 mcsm of LSD-25-61; 60 mcgm LSD-25-61; and 60 megm LSD from our old~stocks. As noted tn the table, average effect ~ In these subj~cts appeared to be j~st as great with the new materl¢l at th~ 60-megm level. as It was at th~ old. · . · .. · s· In the second c~erlment, cx.perl"!nc~d negro subjects rccctv_ed 60 mcgm of LSD-25-61. ln. tab!~/ 2 the r~svlts obtained arc·comp.lrcd with those obtaln~d In a previous 1 r~n with 60 mcgm of our standard material.- It Is again obvious that th~ new material .ts a~ ~ctlve as the old. I n c x p e r t me n t 3 , f o u r- of t he s u-b. j e c t s r e e e 1\r e d t n r a n· d om t zed o r cf ~ ,.. 60 mcgm LSD-25-61 and 60 mcgm old LSD. In thts er.perlment only questlon.natrc ~nd .cttntcal .grades \:lcre used. Agat:t· tt h obvious that the ncw-LSD ts at least as active as the old. In e~ch exp::rtment ther-= was .:t lea.s.t o.ne. lndlvtdual w-ho seemed to obtain more effect from the new LSD than from the old, sugge$flng .: that the new matertal 1s perh~;:>s som~wnet more potent than .the old. The number of subjectt In any of th€ three exper·l~ents I~ far too srna!l for this point to b~ settied, a"d to tesJ it adequatelv.would require preparing fresh· solutions .of old· end n.ew LSD a~ a range of dose leve_ls, u:tng a group of at least 12 subjects. :I do·not b~llev th1s would be wortf,whlie unie~:; tht!rf! ls s.ome reason -to b?.ftev~ LSD-25.:.61 The image shows a graphic with text overlayed. On the left, there's an illustration of a vault door with gears and a dial, suggesting security and hidden information. The text at the top reads "THE BLACK VAULT" in a stylized font. Below this, explanatory text details that the document was obtained from The Black Vault, an online database of declassified government documents, specifically from the MKULTRA/Mind Control Collection. The text also provides a URL for online access to the collection. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures present. The document is a typewritten letter on official letterhead from the National Institute of Health and the Addiction Research Center. Several handwritten annotations are present, including circled numbers like "54" and "(6)(3)". There are also some illegible handwritten marks and scribbles in the margins. The document appears to discuss experiments involving LSD. One area of text is partially redacted. No photographs, forms, diagrams, or tables are visible, nor is there any direct visual evidence of experimental procedures, equipment, or facilities. srna!l for this point to b~ settied, a"d to tesJ it adequatelv.would require preparing fresh· solutions .of old· end n.ew LSD a~ a range of dose leve_ls, u:tng a group of at least 12 subjects. :I do·not b~llev th1s would be wortf,whlie unie~:; tht!rf! ls s.ome reason -to b?.ftev~ LSD-25.:.61 differs chemrcally frcm th~ mab!rlal we _havtt b~en ··usrng. · . •. I hope tt wltl·not·be too long befor~ we can have~ conference about the dlrectlon of the prog_i"4m here. l should be able to under take 4 new ser.tes of exper lm'!nts. in August or Sepf~mber •. l wil I be away from Lextngton from july 7th th~.July 13th ~nd wfll b~ 4way .from Lexington on September 9th.and- l-Oth and aga-tn on NOvtmh~r 19th an6 19th. I expcet tc be ln Chtce~Q_ln botb S~ptcmbcr dnd . t-.!o~:ernbcr and could contc;ct ou~· friends th~r~ on e Hhtlr or both Slneer~ly yours,. A-f?G hi: rn Harr I~ ls~ell, M.D. - . r .. . ·_, ·- '·. ,. . · Co.tPAR I SCN Of N-EW AN). -OlD LSD No. Exp.erlm~nt ,'~ . ..../ 25 megm 60 megm 60 megm MEASURE' PlACEBO New LSD New LSD Old LSD o.os Knee Jer" 0.16 1.68 1.87 Pup II s . 0.36 0.45 2.48 2.77 , . . ~ ; .•. Blood Pressure 0.03 I .2-4 1.94 1.86 .. :·· Qucs t Ions I. 0 2.0 76 48 Clinical Grad~ 1~- 0 0 1~12 1.25 ~/ ., Averages of 4 white subje~ts .· A-!95 - ·COMPARISON OF NEW AND OLD LSD · Expc.r fment· No. 2 '· .MEASURE 60 mcgm 60 mcgm Old LSD New LSD ---- Knee Jc rk 3.68 2.83 Pup tIS 4.63 5 •. 76 ..... Pressure 2.72 2.43 Bto~~ .;-:· , ... Quest Ions 9.3 83 ~ .. ... Clinical Grade I .2 : ::- 1.7 ., / Averages of 5 negro subJects. / "· - - -- -- - -- -· - -- -- - ·- -- --·- - -- .· . .... ~ .• ~~ COviPAJH SON OF N - EW N-D -OLD LSD ~ Expcrtmcn~ Nb. 3 . . MEASURE 60. mcgm 60 mcgm New LSD Old LSD Qucs t tons 152 I 1 l Gllntca I Grade·' 1.75 I .5 ~ .it. 1,? ;;< ., . . . . MEASURE 60. mcgm 60 mcgm New LSD Old LSD Qucs t tons 152 I 1 l Gllntca I Grade·' 1.75 I .5 ~ .it. 1,? ;;< ., . . . The document appears to be a report or research paper containing a table of experimental data. The table presents measurements for different physiological responses like "Knee Jerk," "Pupils," "Blood Pressure," "Questions," and "Clinical Grade" across various conditions, including "Placebo," "25 mcgm New LSD," "60 mcgm New LSD," and "60 mcgm Old LSD." There are no photographs or diagrams present. The document includes a handwritten annotation at the bottom right corner: "A-195." The page also features a title "COMPARISON OF NEW AND OLD LSD" and a subtitle "Experiment No. I." The text seems to be typed, with some handwritten modifications or additions, particularly in the "Clinical Grade" row where a symbol appears next to "0". Additionally, there are some faint lines or marks that might indicate page divisions or edits, and some scattered black dots that could be ink smudges or dust. This page displays a typed table comparing "NEW AND OLD LSD" as part of an "Experiment No. 2." The table presents numerical data under "60 mcgm Old LSD" and "60 mcgm New LSD" for measures including "Knee Jerk," "Pupils," "Blood Pressure," "Questions," and "Clinical Grade." Below the table, a handwritten note indicates "Averages of 5 negro subjects." Another handwritten annotation in the bottom right corner reads "A-194." The page also contains some smudges and occasional stray marks that might be from the original document or the scanning process. There are no images of people, locations, equipment, or facilities, nor any official stamps or formal forms. This document presents a table comparing results from an experiment involving "NEW AND OLD LSD." The table has three columns: "MEASURE," "60 mcg New LSD," and "60 mcg Old LSD." Under "MEASURE," there are two rows: "Questions" and "Clinical Grade." The corresponding entries are "152" for Questions under New LSD and "131" under Old LSD, and "1.75" for Clinical Grade under New LSD and "1.5" under Old LSD. There are some handwritten annotations, including "A193" in the bottom right corner. The document appears to be typewritten with some imperfections due to the age and nature of the document.