Doc 0000151540

. ___ _.,.:__ mat ion copy l 13 January 1956 i)r. R •. C. Poggc Dtrector of Medlc4f R~scarch . s. The Wm. Merrell Company • Cincinnati 15 Ohio 1 Dear Dr. Pogge~ We have. completed the cJf'ort to reverse th~ LSD react lon with frenqucl, except for chccktng the stattstrcal constants. I am enclosing tables which show the results. The methods us~d were the same as t~osc described ln the report on the "bloc~Jng" experiment, ~lth one exception - the kneejcrk. ~ Thts was measured by deter.mtntng the dngl~ throueh which a calibrated ham~er must fall In order to ellclt a detectable knecjc.rk. Puptls w~re measured by e.om~o-.r.f.n·s tht1·r diameter wtth those of ctrcJes on a cdrd ln...;"a dark room under conditions of constant light. Bloo~ ?ressure was determined by the ~uscultatory method after 10 mtnvte.s rest tn bed. The mental cff~et$ of LSD wcr~ assessed by admtn~~tratton ~four version of th~ Abrdmson larvi~ qvestlonnalr! fc~ tw~ hours b=fore and eJcht hours after admlnlstr~~ion of LSD 4nd by ~~short psychfafrlc examination in wh!ch particular attention wds paid to ~nxJ~tv, ap~reh~n3ion, hallvcin4ttoru, and Insight -..as .:for.e p~rc~ptual~drstortion, hocrly, and af;o wlthtn a after of f~w mlnvt~s admlnlst~ation Frcnquef. You wt It reca II th«t fn th ts ays ter, Grade I cons tsf~d of n..:rvous n e s s , a n x .l ~ t y a n d ., 1>.P r e h e n s t en c n ! v • G r ad c 2 n a r v o us n e s s , 1 :4hxtety, apprchens(on, and yJsual dtstortlon. Grad~ 3, ~nxtetv, a~pr~henflon, vi:u~! cifstorflon, dnd hailucind~lons wtth m~'~t~~~~== uf :rtai~hr. Grade 4, ;ame as C....r~de 3, but wlth lnslsht lo!6t. T~~!~ observations werq 8lf carried out fer two hours bef~r~ artd e.18~d ho:.Jrs after LSD. Tht_ mcasurabl~ of ttncn:~!entdi'' ~ff·z'=~~ of LSD Jrc c~0luatad by plotting ~~~ da~a on ~raoh pa~er a~d ;:': c d 1 u r i t'! !} t h <:: d r e <1 1_:1 r! d 1 r ~ h ~ t i ;:; -,: - r: :: r l 0 il :: u i 'I ~ \I t t h a p l .,j n i ·-n;; r ~ r • ?ositlve on questlonn41rc were counted hourly and totaled an$w~rs for the entire ddy. ~u.zstlons •., hlcn were :cored oozttiv.,?Jy ::>ricr to LSD were ettmlo~t~d. The provided image is not a declassified CIA document page in the traditional sense. Instead, it is a promotional graphic used by "The Black Vault," an online database specializing in declassified government documents. The graphic features an illustration of a stylized vault door on the left, with bright blue digital-style accents. On the right, bold white text reads "THE BLACK VAULT" in a distinctive font. Below this, in smaller white text, is a description explaining that the document was obtained from their online database, which houses the MKULTRA/Mind Control Collection. The graphic concludes with a website address in yellow, indicating where the collection can be accessed. There are no photographs of people or locations, no handwritten annotations, no official stamps, no forms, no diagrams, no tables, and no visible evidence of experimental procedures or facilities. The document content is entirely descriptive text on a graphical background. The document is a typewritten letter with some handwritten annotations. In the top right corner, there is a hand-drawn circle containing the number "6.5," likely a rating or score. To the left of the circle, the date "13 January 1956" is typed. The letterhead indicates the sender is the Director of Medical Research at The Wm. S. Merrell Company. In the bottom right corner, there is another handwritten annotation that appears to be "4-217" with some illegible text beneath it, possibly a document or file identifier. There are no photographs, diagrams, or stamps visible on the page. r: :: r l 0 il :: u i 'I ~ \I t t h a p l .,j n i ·-n;; r ~ r • ?ositlve on questlonn41rc were counted hourly and totaled an$w~rs for the entire ddy. ~u.zstlons •., hlcn were :cored oozttiv.,?Jy ::>ricr to LSD were ettmlo~t~d. CllnJcal grades w~r~ ~va,uated hcurlv and for the to the describBd tot~l d~y ac~ordlng Syifc~ 4b~vc. - ,- - -~---· . - ·--;-._. - -.., - ----- ..... . Vic had 12 subJcc one of' these. since,.. wer·c- unable to get Into a vetn during one of tha LSD cxp~rlmcnts. All subjec:ta were negro and wer( former opldtc addlc:ts. All ma.l~n ·had had LSD cxperlcnces prior to these cxpcrtmc:nts. None \Jere rc. . psychot LSD was given orally. The mean dose waa 2.4 mfcrograms per kilogram. The dose for each Individual was set by prcltmrnary experiments and varied between 1.5 to 3 mc~/kg. ·The object of Individual dosage was to obtain Grade 3 rcac:tton In every subj~et. T• o of t h e pa t J c n t s , howe v c r, d I d no t h a v c a Grad~ 3 red C: t Ion , reaching only Grade I or·2. LSD placebo waa tap water. Frcnquel was admlnhtcrcd lntr.svc:nous ly, 60 mg. being ·s·lvcn at t·wo hours •fter LSD aad 40 mg additional given thrc hours after LSD • . · .. Patients were nof told what drug. was bctng studtcd or what the object of the experiment was. We carefully avoided asktng any patient how his a~nsatl~n; compared wtth those prior to the Intravenous lnjej:tlon or how they compared wfffi fhc s~n1atlons 1 durtng other weels. So"me pattcnts made soont~neous corr.rnents about changes and • thesc~wer~ r~corded , . Combtnat Ions used ··~re tSD placebo plus F renquel pla~~ba; LSD placebo plus frcnquel; 1.-·so plus ancf LSD plus fr~nqutJ .,lac~bo; frcnqu&J. All tests Houblc-bftnd the code was not ~ire ~~d broken unttl all data had been l~bul4t~d and analy~ed. , . . Results ar~ shown fn the att~ched tables. The t~bfc on th~ "Effects of frenqu~J tn Changing the Total Course of the LSD Reaction~ show~ the analysts according fa our u~ual syst~m. It ts readlly thdt there ts no difference between the LSD ~oparent plus placebo and LSO plus column,. Another fr~nquel Fr~nquel table shows the with respect to questions and The image contains a single page of typewritten text, likely a report or study. In the top center of the page, there is a small, indistinct drawing of a flask or container with a stopper. Along the right edge of the page, towards the bottom, there is a handwritten annotation, "A-216". The overall visual impression is of a research document with a single handwritten identifier. th~ "Effects of frenqu~J tn Changing the Total Course of the LSD Reaction~ show~ the analysts according fa our u~ual syst~m. It ts readlly thdt there ts no difference between the LSD ~oparent plus placebo and LSO plus column,. Another fr~nquel Fr~nquel table shows the with respect to questions and effect~ ~llnlcaf gr(ldc hour-by-hour, Again, no dlff~r€nt:~ tz ep.,:r~n.t. bv of some Th~ s~o~taneous eomm~nts th~ pati~nts wer~ tnt~rest. Stx reported allevtatton of after anxl~ty, nervousn~Js, ~te, the first inject lon of Frenquel pl~eebo; J reported his enxicty o!f4S \:l':lr_sc; c3nd 4 made no CO:"'l::":~nt. Fou;· p:lt icnts re.Jorh:d of enxlety and after 2 aft~~iation ncrvou~ness fre~qu~l; ~ere and 6 made no both ~or$~; comm~nt (on~ re~orted tmprove~ent and worsening. .. t.;~:t_roqc • · ----l-\5.6 ·. "-_/ .. lnd1vtdual analvsts of thP.· records from a qualftattvc point of' vteu hour-by-hour 4lso showed ~o difference. H~lluclnattons and ocr:c~tual distortion continued to be present after the Frenqucl and clc.cllned at the usual rate. This· point ts best exemplified by ease report on the patient ·whom Dr. AIUn law durlng hJs vtslt here. · LSD . . December 9 1955. ISO mcgm/tl.S mcg/l:sJ at 8 a.m. At 9 o'clock., 1 nervous, confused, n4useated, body 1s expanding dhd contractlng, bands and feet look big, eyes are blurred, object~ ar~ changing stzc and sha·p~, ~kln melts off hands l~avlng only bones., tnseets are erawltng under hts s~tn, colors on wall runnlng toscthcr like melted wax and forming plcturca of people and ghosts. Ptcturcs are hc;>.rr·tblc but n-ot d lsturbtng, bccauJe h~ ~no'i'IS they arc due to LSD. 10 o1 clocl~: !~x, nervous and appreh<:ns ive, confused, feels as if in a nlghtmar8, has been floating tn the atr, people and obj~cts at~ changing slz~, shape and color. He can see bl~~d v~ssels under the skln, thlng~ ~re cr~wltng u nd c r t h t s t 1 n·; h e ad Is . d r 1e d up a n d s h r u n k en , a n d p l e t u r e s o n the wa IIi are o~rts of peop li~ an 1m~ Is • dev tIs, a-nd ~o on. Insight :nalnta!~~d • .At JO a.m. recetved 60 mg. i:rznqucl Intra venously. After lnJec1lon, ;>atl~nt r.e;::>ort~d to th.e Aide that all LSD efftcts had d.(S<l'JP~4red. Dr;.AIIin and t· frn:ncdtately went to s~e about t-hfs 4nd IIi are o~rts of peop li~ an 1m~ Is • dev tIs, a-nd ~o on. Insight :nalnta!~~d • .At JO a.m. recetved 60 mg. i:rznqucl Intra venously. After lnJec1lon, ;>atl~nt r.e;::>ort~d to th.e Aide that all LSD efftcts had d.(S<l'JP~4red. Dr;.AIIin and t· frn:ncdtately went to s~e about t-hfs 4nd on.~etaile·d qu~sttoning found the patient still had marted vl!ual dtstortlon, halluctnatlons of the type desFrlb~d above, but $t11l maintained 1ns1ght. At II a.m. patient rccct1~d 40 ~g. Frenqu~l 1ntr~venovsly. He reported nervousness was less, but still was obvtously confused, vlsua! distortions In aize shap~ and color w~re !til! present, flesh still mzlt.d off hands and ha could sc~ blood vQs~cl~ and bone$., I loo~ed v~ry small, very small, and v~ry horrible. lnslght w4s stilt pr~Jent. · lw~l¥~ to 4 o.~. ~ymptoms graduallY d~creased. At 4 ~.m. ~as stilt se~lng colored ttght3 which, however, formed na dzftnlte plctur~s, continued tens~ and $trang~ until 2 D~m., aft~r which h•· w~nt to sl3cp. · Decz~ber 30. !9.'i5. At q ·'l~r.~, ~atl~nt slven 150 :o!CS':"l L::) CI.S mcg/~g·}. ld· 9 a.m. nervot.:sncJs, walls arc se~n through 4 fog, m4ny ltght' and colors se~n wtth eyes clos~d, feet .and hands seem to melt, look old and sktnny, felt strang~, confus~d a.::.._ and lost. At iO stl t! confused; feels stror:cz and lest, orientation ls ma~frtalned, v~rv n~tvou$ 1 peo9lc and obJ~ct= . are changing slzer shape and color. Hls h~nds an& my h~ndt Or. P~·::.-·~ .. dceai 4nd turn lnto anlm~l cl~ws, walts arc cov~red with p1cturcs resembling melted wJx, pictures arc of shosts, pretty women and se onl hfs body has dls~pp~arcd from th~ chest do~n. 10 a.m., given rr~nqucl pla~cbo. After thts, reported he w~s much more rclax«d;and LSD effects were less. He was obvtously attll confused and on looking at the walls atlll Jaw the pictures, hands~stlll decay, stomach ts gone, effects arc due to LSD. II a.m. frcnqucl placebo was repc•tcd. P1ctures attll on wali, sees t1ghts and color~ with eyes closed, people •nd obj~cts arc very distorted, tns tght- matntalncJ• 12M to 4 p.m. Effc~ts, which persisted throughout th1s ttme, graduJI ly 6ccamc weaker. At 4 a.m., ttTII saw 11ght$ with qye$ tlo$cd, - and nervousness and halluclnatlons continued until about 2 a.m. .... I would be pleased to have your. r~actlon to thh. I can eonclud~ only that, tn the doses uied, frenqucJ had no st&nlfteunt~ effect on the This document appears to be a typed report, possibly from a medical or research setting, with handwritten annotations and a stamp in the upper right corner. The text describes observations of a patient, detailing their experiences and reactions to LSD. There are no photographs, diagrams, or organizational charts visible. One handwritten annotation in the bottom right corner appears to be a page number or identifier. The visual content is primarily textual, with minimal supporting graphics. graduJI ly 6ccamc weaker. At 4 a.m., ttTII saw 11ght$ with qye$ tlo$cd, - and nervousness and halluclnatlons continued until about 2 a.m. .... I would be pleased to have your. r~actlon to thh. I can eonclud~ only that, tn the doses uied, frenqucJ had no st&nlfteunt~ effect on the LSD reaction• . . --; I believe that J have told you Reserplne ma~es th« LSD r~actl~n worse, rather than amc~lora.~tln:g -if •. Thit means that the effects of a drug on the LSD rc;actton car.not b-= used to pr\tdtct tts possible cllnlcaf usefulness as a qulettng agent tn th~ "n~turaln psychoses. Our expert~~nts, fh~~cf9r~, hJve no b~drlng on the po~eotiallties cf Fr~~qu~t ln ~~e~e condttlons. & was very lnter'!stcd tn Hzmwtch 1s n:port of rts use tn se~lzophrenlc~. tf thts 1~ eo~ft~med, th~rc c~n b~ no doubt th~t Frenqu«l would be a v~ry us«f~l ag~nt because of lts cxtrcmelv low toxtctty. Wlth personal klnd~st reg~rds. rt1 r r t s I s b -z .t J , M. D • · .Director HI: rn Att~ch:ncnts 3 ' ,_......__,,.-...,_~!-(' ror C~SE. Cf THE LSD 2EAClfCN LSD ? fae<!bo J. tso·=z- Frenque I LSD PI aee J. lSD* fx) + re t:.ea sure- P14C:ebo F oque .-~-;:- Freaquel Plueebo J. frenqt:~ I~ 1 + + + Knee Jerk 0.12 0.60 1 .. 90 J. 1.47 I Pup I f t a r v S t ze + 0.69 + 0.69 + S.SI .. 5.31 J 1 , Sv s to f Je B f oo 1 + .a. + + Pressure --~ .61 0.79 3.25 3.32 •', 2l N:>. ot ?o s t t I~~,I· An s we r s o tl I Questlonnalrw 87 3il I Cl tn ica I Grade C.f 0.2 / Figures 8t'e f!l4!ans of \'a~ues oo II subjec:~s. r.hnc of t~e dtfier~nczs LSD+ Franquel or LSD ara • betwe~n plac~bo '~r¢n~uel ~igntfica~t . . •...• I • Exprcsied as square tncb~~ under cfrccf curve~ ~ - . " .. • " . " .. " . • - J, . 0 ~ 2. "' 3·. eas"!c Oil see tc "~ t-4 Csz~ f.,;x:) a D ~ ~ f·. s .., 0 ,~"' 1'.-g ·C .. ~ - - ..;; • r-~ 1 "" • 4----J.; J :. . . . . _.~ ( EFFECTS OF •••• t-JJli2 AFTE~ LSD · O~lGS s s I 3 7 The page is a typed document with handwritten annotations. There is a handwritten note at the top left indicating "Dr. Pre" and a handwritten number "4-36" at the top right, alongside the typed title "Page 4." There are also handwritten lines underlining portions of the text and a handwritten annotation "12 M to" above the time "4 p.m." in the main body of the text. Towards the bottom right, there is a handwritten annotation "A-214." There are no photographs, stamps, forms, diagrams, tables, or redactions present on this page. Oil see tc "~ t-4 Csz~ f.,;x:) a D ~ ~ f·. s .., 0 ,~"' 1'.-g ·C .. ~ - - ..;; • r-~ 1 "" • 4----J.; J :. . . . . _.~ ( EFFECTS OF •••• t-JJli2 AFTE~ LSD · O~lGS s s I 3 7 lSD-pl4e~bo ~ j Frc~quel-?facebo I I l f I 0 0 0 ~ ------------------~----~----~----~~----+-----~------~--~-----111 ~ lSD-p face bo J. · Z C.." ) ··F·rcnque J J t I I 0 0 ·o < w > - LSD J. F r ~ nque: I ro J- Placebo _,II 13 9 5 4 3 V) 0a . ------------------~----~----~----~~----+-----~------~--~~--~-"-11 LSD + Fr enque l rs 10 t7 J3- g 5 5 -- ... . LSL'-o Ide&.: bo ~ Frenquel-?lacebo ., b. t o.t 0 0 0 0 0 ~c:.I -------------------+----~--~~~--~~~--~~-----+------+-----~----111 < lSD-oi acebo .& e~ F renqu~ I o.r o. f 0.2 o.~ 0 0 0 0 -z lSD .&. Frettquel P f ac~bo 2.2 2.S 2.3 I .5 t 0.7 C.7 ' lSD .f.. Frenqu~l Z.4 2.7 2.7 ! . _2.4 0.? 0.9 ~ I or figures are--.o-e-dns oD tl patl¢nts~ ~~a.n d-ose LSD 2 .. 4 r::cg/!:g. C·os<! three hours ma. ot Frenquel 60 r.19• f.v. 2 hour$ and 40 f.v./aff'er LSD. f ..... ~- f ~ 0 0 f 0 J &\nf' , 0 .f. 0 0 cl'f rr 0 0 =- ~u - J. 0 ~ 1 .t 11, t - + '/ J 'I + ' ~..... ".,l 'I 6 4 I 4 6 ?- ten~ m.o rt repor- tred t-oth ways) # .. .. _ .- _, 4-.2.;/ I This page contains a table presenting quantitative data, likely from a scientific experiment, with specific measures such as "Knee Jerk," "Pupillary Size," "Systolic Blood Pressure," and "Clinical Grade." The table includes numerical values and indicates that the figures are means from 11 subjects. Below the table, there are numbered explanatory notes referencing experimental procedures and dosages. Additionally, a handwritten annotation in the bottom right corner reads "A-2.13," potentially a document identifier or page number. The header of the document, partially visible, mentions "EFFECT OF FRENGUEL IN CHANGING THE COURSE OF THE LSD REACTION," suggesting the experiment involves the drug LSD and a substance or condition named "Frenquel." This page is a scanned document from the MKUltra collection. It is primarily a table with numerical data related to drug experiments. The table is titled "EFFECTS OF FRENC IN CHANGING LSD REACTION HOUR-BY-HOUR" and presents data categorized by "DRUGS" and "HOUR AFTER LSD". There are also handwritten annotations, most notably "A-2/2" in the bottom right corner. The document appears to be a report or a summary of experimental findings. There are no photographs or diagrams of people, locations, equipment, or facilities. Some columns and rows appear to have been redacted or obscured. The document is a scanned page from a ledger or data sheet, featuring a table with columns labeled "FRENDUEL A" and "FRENDUEL B." The table contains rows with various symbols, including "0", "↓", "+", and "↓ (?)", suggesting some form of data entry or experimental results. Some cells are obscured by black redactions, most notably in the leftmost column. Handwritten marginalia at the bottom right reads "A-211". The top of the page features the text "SPURIOUS COMMENTS ON FRENDUEL". No photographs, stamps, diagrams, or evidence of experimental procedures are visible.