Doc 0000151545
CIA
A 1956 letter from Harris Isbell, M.D., Director of the Addiction Research Center at the U.S. Public Health Service Hospital in Lexington, Kentucky, discusses the erratic effects of orally administered L-3-Hydroxy-N-phenethylmorphinan in postaddicts, suggesting poor absorption and less promise than another agent.
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Ask the archive about this →-~ . ...,.. of HEALTH, EDUCATION, AND . .::LFA,.~~ NATIONAL INSTITUTES OF HEALTH 24 August 1956 IN .-&~L'nNG ADOIIUS TH& NATIONAL INSTITVT& Of' lfiNTAL HULTM ADDICTION RISUIICM CINTIII U.S. Pueuc HIALTM SIRYICI HoSPITAL '· 0. 80:& 1000 I.UINIITOII. KIIITUCKT On checking my files I find that we have some informa tion on oral administration of L~3-Hydroxy-N-phenethyl morphinan.,, Data indicate that the effects of the drug . are erratic when given org.lly:.r as contrasted to being . .. very It has been con._si_~-tent~··when-g1ven-sub<;_u1-a_rl~9-~SJ.Y> ~glven in doses rangin·g between -0.5 to 5.0 mg (total) f to adult ~ale postaddicts. Detirtite morphine-like effects ( 1{~.!:.;;- -' (were observed in same ingividuals at every dose level. l ,,.,v~ J These ranged from ext renfe ly mi 1 d to very intense. Onset ,.;- ...... tv.. ·:r··"',...Z _?1) of action was also erratic, appearing from one hour to las long as twelve· •. ~ • 7 .. / ' ,... '-r .,.... /' ~.:;..r-- .-.:> 4-.... ---,..- .._,.'.I.· I fear this indicates that the drug is erratically ---/ absorbed. This may hnve some connection with its limited solubility. Although I will check, 1 now feel that it is probably net as promising an agent as 1-dromoran. Very sincerely yours, .-. '· .., : · .....~ Harris Isbell, M.D. Director· . HI: r.n - ..
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The page is a typed letter with handwritten annotations. At the top, there is a government seal, indicating official correspondence. Several handwritten annotations appear on the document, including circled numbers, a signature, and notes in the margins. A circled "70" is next to a scribbled signature that reads "HANK". Another handwritten note, enclosed in a circle, reads "must refer to the oral trics / since". There are also handwritten numbers and letters in the bottom right and left corners of the page: "A-234" and "2646". The text discusses the oral administration of a drug and its effects.
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