Doc 0000151546

FOR: THE RECORD SUBJECT: Trip to Lexington. Ky., 21-23 August 1956 l. Dr. Isbell is obtaining supplies of acetyl LSD, 1-rnethyl LSD, BOL-148, an~ the pyrrolidide of LSD·. He will check these compounds in his subjects for LSD-like reactions, for cross tolerance to LSD, and pay particular attention to time course of --- the action in each case and the odd reactions. I agreed to furnish what data we have on the pyrroli.dide compound. 2.. He will chec.k the time course, potency and general ef fectiveness of the dispersed C-9 compound which I furnished in adequate supply. He is looking at the circulatory effects of the C materials in. general. He has approximately 15 pounds of fresh Charas that 'he would like to giye us. This would involve us seeing Mr. Cunningham in Anslinger's office, since .i\'Ir. Cunningham is responsible for the material. ~; 3. Dr. Isbell provideq,.me with one gram of' 1-crorneran tartrate and 0. 5 grains of the phenethyl derivative. The phenethyl ·s derivative is times more potent than 1-dromeran but in all other ways is strictly comparable in its action. It is the most pot~nt e;i all morphine derivatives by far. Dr·. Isbell has no doubt of -it. its oral potency but i.s testing The rado of intro.:nuscubr to oral pote~cy is estimated to be 1. 5 tQ 1. This particular substance probably will never be marketed by Hoffman La Roche because it offers no advantage except the greater potency and is more difficult to make. The antidote for the respiratory depression produced by the compound is Natline. I queried Dr. Isbell on the possible use of o• . a milligrams of this componnd on our needle for use against guards. He thought th:lt ·;cry pt•ssibty the s:~ard in a - .: · h - r · n - · - •+ • + :._ ; , . ; , ,. . _ .. _ ,. . , _ . . • . • . , ,. . , . . . ._ ,l • - . 4 _ " ._ "' , " _ " , ~ . • ., . _ a l ~ -. w , , .. . . v .. . \ . o .. \. . 1 . . - !; - -" - ~L - "' " or U - J ' ! · 1 - ~ ' . · This page features an illustration of a vault door on the left, with intricate mechanical details and a bright blue glow emanating from it. To the right, bold white text reads "THE BLACK VAULT" in a stylized font. Below this, a paragraph of white text explains that the document is from The Black Vault, an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection. The text also provides a URL for accessing the collection. The overall impression is one of secure, hidden information being revealed. The provided image is a declassified CIA document, likely a memorandum, with a date stamp of "24 Aug 1936" in the top right corner. There are handwritten annotations in the top right, including a circled "71" and what appears to be a page number or reference. Significantly, there are several large, solid black redactions obscuring text in the upper left and lower halves of the document; one redaction obscures both text and a signature-like mark around the date "4 FEB 1977". There is also a stamp at the bottom right indicating "Declassified by 187475" and "4 FEB 1977". The document appears to contain typed text detailing scientific or experimental matters, with some handwritten numerical annotations potentially referencing points in the text. ~ . • ., . _ a l ~ -. w , , .. . . v .. . \ . o .. \. . 1 . . - !; - -" - ~L - "' " or U - J ' ! · 1 - ~ ' . · : - > U -' U ·· .1 '· . · _ v , a · ( \ , ( U1 Ul..; ,S r'l; ~ ver .. v ..t possibly be unaware of his surroundings. . 4. Dr .. Isbell finds that t.te R i•:ea ~eeds gi.ven him by :·TE1 produce neurological signs, mydriasis, etc., bm also so mu~~h ... gastro-inte3tin:;:il trcub le {from the resins) that he .::tn tt e;.ralua:e any psychological effects. I explained to him the confusio:t between the two types of seeds and gave him an adequate sa:r.pb of the larger seeds from the 1vie:d.cJ.n mainland fer tri::;.l as he has ti.rne. cy OeclAssifie'd _187475- C:tate ,. · · ., n:e ''?f?1 A -2 J ( ' ~~ - 2 '.J t~~a ~: .. r I also indicat,. hat as soon as it was available,_ I would send him an extract fr< which the resins have been removed. -0 5; 0 Dr • .1sbell has the compoundo2~ 2-dipheny!-4-morpholino ethyl butyrate (note: gamma amino butyrate) which can replace morphine in preventing abstinence symptoms but at the same time produces a rather acute .toxic psychosis of two to three days 1 duration. More information will be available on this compound later. 6. I queried Dr. Isbell on the possible use of orinase to potentiate and/ or prolong the LSD reaction (based on information that orinase lowers the: capacity of the liver to perform its normal detoxifying function). He felt that a considerable amount of informa tion could be gotten about the feasibility of this through some- animal work with the compound prior to his human work. He suggested use of Dr. \Villter's technique. If the animal work indicates that this is a feasible he will be very glad to do the human approach~ work with the material. ~~ 7. Dr. Isbell is_ v-ery int.erested in testing. the French com- pound if we can furnish him with the substance and some animal data. His interest in 'tI he compound comes from its possible con- nection with the active 'compounds ·found ~n nutmeg, etc. 8. Ill connection with the problem The page is a typed document with handwritten annotations and official stamps. There are no photographs, diagrams, or structured data visible. The document contains an official stamp indicating it was "Declassified by" an individual identified as "187475" on "4 FEB 1977". There is also a handwritten annotation at the bottom right corner that appears to be "A-236". The page also includes a few small, smudged black markings, possibly indicating redactions or stamps that are now illegible. 7. Dr. Isbell is_ v-ery int.erested in testing. the French com- pound if we can furnish him with the substance and some animal data. His interest in 'tI he compound comes from its possible con- nection with the active 'compounds ·found ~n nutmeg, etc. 8. Ill connection with the problem of checking the effects of drugs on su,ggestibility, Dr. Isbell felt: that a standard procedure .could be worked out which would not necessarily require the use of a hypnotist. The technique he suggests consists of the production of a standard tape recording which suggests that a person. is sway ing on his feet. The subject is placed in a sway meter. There his tendency for normal swaying and swaying under suggestion will be measured at different times in order to determine repro ducihili.ty !.~the sc.:r.ie individual. Later the drug is introduced to determine whether the subject is then more susceptible to the pl'!fing of ~he tape •.\ Ve a.lso discusosed tho· problems of arriving at objective tests for depth C?f hypnosis. In relation to this, Dr. Isbell felt that it might be instructive first to aflf.llY whatever tests that we decide. ar-e germane to the problem to somnambulistic .subjects in states such as rigid suspension between chairs or complete anesthesia, etc., in order to eli..-ninate as far as possible ~elas~lt1ed· b1 -l87475-- 4 FEB 1977 - . ---- .. -- ------···· ·- -- - ·-~- - - .. ..._ ·__ (·:..,_ ) r - -~--. --,--- . - ·#- · ·- -0· - 3 - ; . __.,. -- ./ doubts as to the genuineness of the arrd to get as large condit~on a change in the subject as is possible.· . 9. Dr. Isbell that the problem of an anti- suggest·~d . interrogation mat1!rial t:.ight be solved by the injection of between 30 and· 60 m illigrarns of d, l acetyl rneth·adol (alpha-d. l-4, 4 diphenyl-6-dimcthylarnino-3-acetoxy-heptane}. The effect would be profound, not too dangerous and would follow the time cou,se indicated below: Effect Begins Peak Effect Mild Residual Eff~cts 1- 10-15 mins .: ll/2 - 2 hrs. 24 hours d- 3-4 hrs. 12 hours · 72 hours· ,. ---- Nalline will only antidote the respiratory depression, ·not the . analeesic effect, the emetic effect, nor the psychological efft~c:t .. be Therefore, it would poss\ble to keep the person alive in the event of an 9verdose by the use of d- 3-4 hrs. 12 hours · 72 hours· ,. ---- Nalline will only antidote the respiratory depression, ·not the . analeesic effect, the emetic effect, nor the psychological efft~c:t .. be Therefore, it would poss\ble to keep the person alive in the event of an 9verdose by the use of Nalline, but it would f\Ot be possible to put him in ~ condi~/ion for interrogation •. . ~ . 10. Dr._ 'Wikler has finished his review on the electro- physiology of the central nervous syste:ID and Dr. Isbell: will send us a copy of tbe rr.,anuscript s:,on. Dr •.~ Isbell Yrill be in \Vashington part of the week o! 20 September and will be glad t9 tal~ to us then. Chief, Branch II TSS/Chemical Division Dist:-ibuticr.·:. Orig & 3 :. TSS/CD . - ' 'Declassified by -187475-- aate ---::---:;:""7.:':::;;"_ ___ , 4 FEB 1977 This page is a declassified document with several visual elements. At the top, there is a "SECRET" stamp with "-3-" indicating the page number. A table presents data on "Effect Begins," "Peak Effect," and "Mild Residual Effects" of a substance, with numerical and time-based entries. There's a handwritten annotation in the bottom right corner: "A-235." Additionally, there are several black ink redactions, obscuring content in the middle right and bottom left portions of the page, along with a date stamp indicating "4 FEB 1977" for declassification. The document also includes a heading for "Chief, Branch II TSS/Chemical Division."