Doc 0000151548

OF HEALTH IN JltCPLY.!.N.,2t!O_!•ESS THS: IIAnOilAL INSTtTUn OF 14~11fAt. HEALTH AOOiatOII RISr.tRCN CCNTIR U.S. PUIUC HIL\LTM SIRYIC( HOSPITAL P. o. Bo• zoao LlliiiiGTOII. KINTVCIIT (h)CY) ---~ 50 On checking I find that 1 have only mg. of the drug MK-57. Chemically this compound is 6-methyl-A-6-desoxymorphine. I am writing Merck and Company to see if I can obtain an additional supply. l Meglmide is_being shipped under cover. separat~ ~, ·' I am enclosing three·reprtnts on suggestibility by V. H. Vogel. . - / . I am·also enclosing tables of the preliminary tabulations on C-9 and r\1~. These experiments y.:ere preceded by preliminary titration in which· it was determined that 0.6 to 1.0 mg. of Y'..-< for each 70 kilograms·. . of. bodyweight induced definite cardiovascular changes. Thereafter, a comparison was carried -out in J5/subjects, using the randomized Latin Square design. The drugs tested were placebo; 0.6 mg MX (per 70 kilos); 1 mg MX (per 70 kilos); and 1 mg. C-9 (per 70 kilos). Measure ments including reclining pulse rate (after 10 minutes in bed); standing pulse rate (counted for one minute after standing for one minute);_and number of positive responses to a simple system check-list based on our earlier work with C-9. Two tables are enclosed. One shows the time course of the with different drugs. In this table it is evident ~ffect t.hat the effect does not begin the s·econd hour and u~til at least until the twelfth hour. p~rsists . - r , . • . '-. __ -2 .. 3 .. - · 5 ··-- 6 --- ·--.......... ·Page 2 .v~r .----\ ~ . . • ,,r- The second table shows the average changes with the four differen! combinations. You will notice that there is a distinct difference between both doses of MX and placebo, as well as between C-9 and placebo. There is also a definite dose response between the 0.6- and 1.0-mg. level with 2:1X. There may be a tendency for cardiovascular effects of C-9 to be more pronounced in the overall ccurse. I cannot be certain of this until the statistical analysis has been completed. \Vhen this is accomplished I will send you another· report and wi·II also work up tab! e showing the details on the cardiovascular measurements made in the older work with C-9. .... . Sincerely yours, ·r M.D • · . HI:rn Enclosur-es / : 5 ' " ~ ·.TIME The image displays a digital graphic representing "The Black Vault," an online database of declassified government documents. On the left, a stylized depiction of a vault door is visible, complete with intricate mechanical details and a blue glow emanating from its center. The right side of the image contains text explaining that the document originates from The Black Vault, specifically from the MKULTRA/Mind Control Collection, which houses over 20,000 declassified CIA documents. A prominent yellow hyperlink to "http://mkultra.theblackvault.com" is also presented at the bottom. There are no photographs of people, locations, equipment, handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. The document is a typed letter dated October 23, 1956. Handwritten annotations are present in the upper right corner, including what appears to be a name, a date or code, and a number circled in red "(73)". There is also handwritten text and symbols to the left of the main text, enclosed in parentheses "(b)(3)" and a symbol that resembles a 'w'. A circular stamp with text and an image is at the top left. The text discusses drug experiments, specifically mentioning MK-57 and its chemical properties, as well as experiments with MX and C-9 drugs on subjects, detailing measurement procedures like pulse rate and subject responses. There are no photographs, diagrams, or structured tables visible within the main body of the document. completed. \Vhen this is accomplished I will send you another· report and wi·II also work up tab! e showing the details on the cardiovascular measurements made in the older work with C-9. .... . Sincerely yours, ·r M.D • · . HI:rn Enclosur-es / : 5 ' " ~ ·.TIME COURSE OF C-9 EFFECTS ? ------------------ ~ - --"-----·- ·-- 1 ~\SU~ ·: DRUG HOUR BEFOP.E OR AF n: t? D~·I.-'G I 1:1~~~ ~?.1 Bl HI ~J~51 ~.~ al +ol ~-~~R-;-;2~~23~ - ... - -- -- ~-.r -----------+------------- ~-------~ I i Placebo 61 66 6/f 63 6? 67 7 ll 6 5 I 66 6 4 7 I~ '7 ( ..1 6 ~ ' i ~l \ If\' INS ~lx 0.6 61 65 66 67 66 70 7?. (if') 67 68 73 1. 65 {;') t : i- SE lv'ax I .0 62 66 70 7?. 6Q 74 75 73~7~ 71 74 1 7? ·I f.? 61 .. 1r C-9 I .Q 61 66 75 73 69 7 I 1s 7A · 74 74 11 12 6n 6s i\ ~=--"-~ -~J_,;,==•= ~··L· ·~ i ' , ,_ .. - 1··~·-- 1 -:--!Oo&-~ ~=-:.~~~ 901 i \ ,., PL,cebo BS 91 89 85 P-9 9J . ~?. 91 r.rt fl(' 8(, p ~) t'l') i\N)I:·-;• Mx 0,6 U6 85 93 9B 03. 97 102 !('() 97 QJ 07 95 87 l')r ' 1 ~~SE Mx 1.0 90 BB I 06 I C6 107. 100 110 I r,.,( '> . I 06 97 100 99 ~0·'? 9 . 5 !fE C-91.0 90 06 IC2 II 0 Ill 107 lf-2 1,..13 114 I 05 I 0~ ?? 97 1 ~= ;:0~ " I = -J. -f=·•-?- 1'111_11 , - J,=-J~-·_1--== -::=e:::J~.· 1 PI ace bo 0 0 I I I 0 tv'rx 0. 6 0 0 2 3 l:-sr 1-· -- ._,,.. . Mx I .0 0 {) 2 ~£4 'J. 5 · 5.o 1l' 5 5 5 tT 't2l . 'f3) (0I )L . I~ •J •C-91.0 0 0 2 4 ··4 ~, s ~ s _.~ 4 __ 3 ~ _ .. _._. :.:-:..'!..!.!'..::..::.::::..:!::_:=:- - - - - - - - ,.;._. .... ~ '·~ Doses ~xpr.~ssed as mg/70 ':g (e.g. 1.0: 1.0 mg for 'each 70 ~g ':lody _wctg'd J. · Counl ed fo'r minute after st~ndlng qute~ly for I mlnute. /' \ ('· , ./ ' ' . \ The document is a typewritten page with handwritten additions. At the top, there is handwritten text with a date and "Page 2," suggesting it's part of a larger document. Below the main text, there is a handwritten signature and typed name and title: "Harris Isbell, M.D. Director." There are also handwritten additions including "HI:rn" and "Enclosures: 5" in the lower left. Additionally, a handwritten numerical notation "A-242" is present in the bottom right corner. The document has a slightly worn appearance with some minor smudging and speckling consistent with age. .. _._. :.:-:..'!..!.!'..::..::.::::..:!::_:=:- - - - - - - - ,.;._. .... ~ '·~ Doses ~xpr.~ssed as mg/70 ':g (e.g. 1.0: 1.0 mg for 'each 70 ~g ':lody _wctg'd J. · Counl ed fo'r minute after st~ndlng qute~ly for I mlnute. /' \ ('· , ./ ' ' . \ . _. ·- ---··-.. ~-/ - - - .. - . - ..._,\ -- -------~---------- -~ ( - ·, _./ ...... AVE~AGE CH\ I'G E S -l. STJ\NDA?.D ERRO~S AF iE~ C-9 AI'O l\.IX rN r 5 ~ "" US Jr._::,r_-,r.~) . ~ . . . PLACE SO MX C-9 MEASU~E ~.lX .o 0.6x I I I .0 ' ·I I .. RE C l ! N l I'C f PULSE RATE 590 -+ '2 611 - ~ I I 642 -~ 16 654 -.J -· 22 J ! I i 2 sr.~r-.o tNG PULSE -R.A; TE 804 - ~ 16· 859 .! 20 9'27 .! 13 945 - ~ 31 I 3 + QLJES T ICNS 13. - 7 3'3 .! II 46 - I 8 45 .! 10 ::..· -~- . "" ..... ~ / . /_.-'/ ., . I R-:prez.znfs su:r. of rates obt:~fned a:t one . to ntn~ hours aft~'"' . drug. / -.- - - 2 Counted for one m nut e aft,!r standtng one minute. Repr-zsents T .. a v~ rage sum ~f'rrates obtained ~ t one to nTne hour~ '"'f'ter d r 'J9. .., Represznts tot a I of po s T t T ve rzsponszs Tn 23 hours. - . ... h Dose til H , I~ • for <- ... C . _ '- .._ " 70 k ; - :;, of bocy wz r gh r • I ~ •· -- . - -- -· - - -. - - . o A,..2'i . - -- - -- - --- ... - - < . ' . - The document contains a table displaying "Time Course of C-9 Effects" under "Hour Before or After Drug" with numerical data organized by drug type and dosage. Handwritten annotations are present, including the numeral "1" in the upper right corner, possibly a page number, and what appears to be a signature or symbol near the top right. The table includes rows labeled "Placebo," "Mx 0.6," "Mx 1.0," and "C-9 1.0" across different experimental conditions or time points. Below the table, there are two lines of text containing further experimental instructions, including dosage expression and measurement duration. The document presents a table detailing "Average Changes & Standard Errors After C-9 and MX in 15 Subjects." The table categorizes data by measures such as "Reclining Pulse Rate," "Standing Pulse Rate," and "Questions," across different "Placebo," "MX 0.6x," "MX 1.0," and "C-9 1.0" conditions. Below the table are enumerated explanations of the superscripts appearing in the table, indicating what "sum of rates," "counted for one minute," and "total of positive responses" represent. A footnote marked with an "x" clarifies that the dose is in milligrams per 70 kg of body weight. The page also contains a handwritten annotation in the bottom right corner, "A-240".