Doc 0000151551

C .. - .. ~~~l--e-e---------------------- --------~ ·~-, r ~. obta.L{~~~ lle recently a. smal.l supply of an interestir.g substsnc" in ·~~h pote~~. the cannabinol series appears to be extrenely I have nov given 11 subjects dcse!~~ 1 to 2.5 mg. of this drug. Tne first tvo _ patients promptly. iden~ied the effects as being like those of marihuana and, naturally, all patients since the first tvo have expected marihu~na­ like effects. Patients begin to report the subjective effects Within 2 to 4 hours. Effects appear to be most :prominent 6 to 8 hours after the drug is administered and are still present 24 to 36 hours later; and in some cases e·ven longer. Description of the subjective effects is very vague, except that the subjects are ver.J positive they resemble those of marihuana. They say the effects of 1 '!!lg. are equal to one or t"Wo ciga-:-ettes of the best marihuana, except that they appear and persist for a sl~~ly very long period of ti.I:le. They are described as consisting of a sensation of mental relaxation accompanied, hm;ever by "physical" tension, increased 1 appreciation of music, jokes, other things. The characteristic ~d behavior observed in marihuana smokers (giggling, silliness) has not been seen, but the experimental situation has not been conducive to the ap~~arance of such behaV'ior. No hallucinations, perceptual distortion, etc., have been reported. ., "" With larger doses (2 to 2.5 mg.) the symptoms became quite unpleasant in 6 of the 11 subjects 6 to 8 hours after admi~istration. The u.~pleasant sycptoms included di~i~ess, feeling of ~reat wea~ess, rearkz~ dx~·siness, nausea and vomiting. · rleakness has :pers_tsted for 48 to 72 hours after administration of the drug. One patierit feinted on going to the bathroom the morning after having recei-yed a 2-mg. dose. / neurological exa.mina.tion.-in these patients so far has been negati·1e vith the dose used. Ho·,;ever, 3a.it could.-_not be tested in some patients who beca.oa so weak they refused to get out of bed.. There is a very definite tendency tor the pulse rate to become rapid and a tendency for the blood pressure to fall. The results suggest that some cardiovascular disturbance, possibly postural hypotension, may occur. I hope to investigate this in the immediate future. Because of the appearance of these toxic reactions, I am not planning to in~rease the dose beyond 2.6 mg., in the future. ~iate It is that the patients the The provided image is not a declassified CIA document. Instead, it is a graphic that advertises "The Black Vault," an online database of declassified government documents, specifically highlighting the MKULTRA/Mind Control Collection. The graphic features an illustration of a vault door on the left side and text centered on the right. The text explains that the document was obtained from The Black Vault and provides a URL for accessing its collection of MKULTRA documents. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures present in this image. The results suggest that some cardiovascular disturbance, possibly postural hypotension, may occur. I hope to investigate this in the immediate future. Because of the appearance of these toxic reactions, I am not planning to in~rease the dose beyond 2.6 mg., in the future. ~iate It is that the patients the characteristic marihuans note~crtCJ• sho~ chierly of reddening and r~~leB, ~hich consis~ ~arked conjtL~ctival pseudoptosis. ~. The page is a declassified document containing typed text with some handwritten annotations and a circled number. The typed text appears to be a research report detailing the effects of a substance on human subjects. There are no photographs, stamps, forms, diagrams, tables, or visual evidence of experimental procedures or facilities. The handwritten annotations appear to be marginalia and a circled number "78" in the upper right corner, which may indicate a page or document locator. There are no redactions or obscured content.