Doc 0000151553

--------- TITIE Cf ?CGjECT: /v·Ml!!~'l.of\ &..lft!:dltth!'S·Cif Syttth~~:tle Svbstttvtes f-r Cwr~~tne., . - Gbl~~ttv~. T~ fl~d ~ cyath~tte 4nelo~~lc ~nd ~ntltu~~tv~ . /........ drvg \'thlch •.wld t: \lS tefe frc.rn U·.e poln~ c;( vt:w <~t t~Sctty and cddtctl~ft llobltlty ~u 1: ec~tetn-t~ t. ~l"~~ ~tart of ~rot?.~• Th.l$ ?ortton gf th~ s~~a~v eovcrs the pe:rlc.r.! fr~ t. J•JlY t·;:t t~ 31 D~e~tmb¢r tv5~. At ,tatcd. 4b:.ve, the c~l«et!vo Qr tr~= prwj~et Js t~ lind., ·.· ----- co-d~ in e. At th~6.? Qh ad~q~(l t. e syt\th~t lc sv~s t Hutt$ f ~r ·~ur)h tne '/' / •r~ 4Vt.!!~bJ~, su::b 4 c:c·!~ttt~ Si.•b::d·tit:. . -!:.:. ~t;; n~.s:..i.arl b..:.~.i\oU~ ni..) . ., ' . - - - - --- -· ------ --- A-26 - . d«;erl.}ttons ~r• ...t 1~ ;)f'~"VJ~us. ;)f"•.i':-"r.:ls rq:)e;rta,. 1:1d T!tl l{u~ b!€ ,. ~ ;.><: tl • ~ ·! • -- Ourirtg the o~rlod I July 1?51 to JS D~ce~b~r 1955, ~5 or of for dr~ss ~t~tur~' drv~~ h~v« h~«~ f~st~d. dcf4ll~d tnf~r~tfcn e~necrntnn rht1St: avbsf-arH~'l!$ $~~ Anfiu41 'e:h:.Yt: f~,r - t~_b<t r;ut,i-:'i.odlns ~~ ;)os:tb1~ S\.":;~tttuh~• f~..- Ci~<ieto~ f\,;;r IVPPtll~S14;n of ~fuGh llt~ft: f\;.~.m·H s.· ( l J n. .. J-.;..:tt:th~.xy..J-,U,.~~Th1flt~~iJt>)n1!'T~n~ (d~~rrcm~f}H.;f;J~nl~ J. . ' . -:· t 2 ) r ~ r e ~ t t:n •:-• . /~ pro~r;:m h-arl de~eh~~,..td tr~o drvn• terhi·d't 40Pft~r~d tY b~ p(Jt~nttatfv \U«ful ec·lttfrtlf $U!:stthJres f"r tup;>t"~s~l~n cf ec-v~h, :'J¢ CO!':l;JQUi1-d W~l <t•IOJI.abfe f,r r«li~tf of ~~~d gr.arle-s of crrvo; ~In whteh was 4$ S4fc a$ Cvd~Jnq, olnri '41Vt:i'l \fl}h ~ ....: ll'if pos;JbiJtfy 4J p~•~~tt4t e~d~lne substttvt~, u•r~ 1t~t~d. r ... Rtt~crt r ''55 6f$O e~ntelnl!d Jnti:.TC\attc.;.r. eortc:t:rnlng i:l:;tHl >it-2-PrQ;>Jcn~y-4 ..d im-:tny I.Jmtno-1 ,2-d l:>iu:ny J-3-r.·H:thv JbvtJtn~: fprQpo~ypb~n~J. Pr~lt~ln4r~ eltnlc51 trtaf, cGn~lnu: to Indicate: that b.;;th the rge~~t~ ant:! th.: dextr~rcttlt'Ciry Isc.~~r , reodffy ~~caus~ ~f th:~J~r~~ dgt~ requJr~~ and b~caus~ tbay - Whi 1e f:) ~ v~ry high de.$¢ thc•1 ~U1;:tr":s ~tat fnent:c ;,..~!':'1 f:lGr~tl h~~ fer · A .• J f w .,. \..- , ( . . • . . , ._ ,. f y~ tf ·.-. ~ , '.-.•. " 7 ' A-20/ ---------------------------------- / r --- ·' 2. ~esul t, t"tn· tn.-,. th~ Cut·r~~ t ~~:::lort ~~~ r~r ~· Ovr lnc the c:urrt.tnt ttl;')ort tnu ~~s-rtcd Cf Janv4rv to 31 Deee~b't' 195<:~ J t tur add i c t J v 11 p r QP.f r t t c;. c f l I ~ ew The image displays a stylized graphic design, not a declassified document page. A digital illustration of a bank vault door, with its intricate locking mechanisms and a gleaming blue light emanating from behind it, dominates the left side of the frame. To the right, the words "THE BLACK VAULT" are rendered in a large, white, distressed font against a dark background, with a faint blue glow. Below this title, white text describes the source of the document as "The Black Vault," an online database of declassified government documents, specifically mentioning the "MKULTRA/Mind Control Collection" and the Central Intelligence Agency (CIA). A yellow hyperlink indicates the website for this collection. There are no photographs, handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures, equipment, or facilities. --- ·' 2. ~esul t, t"tn· tn.-,. th~ Cut·r~~ t ~~:::lort ~~~ r~r ~· Ovr lnc the c:urrt.tnt ttl;')ort tnu ~~s-rtcd Cf Janv4rv to 31 Deee~b't' 195<:~ J t tur add i c t J v 11 p r QP.f r t t c;. c f l I ~ ew t ·; n f h ~ t t c d r v v 1 tJ arc -·· evaSuGtt!d wholly or ln P1)rt. Tb~ tqsulta arc presented b~lou under lndlvtdual h~~dlns:. •• ~-4lpha-t,J-Dtm~rhyl-4-phenyl-4-prw~lonoxy- i> lv~r ld 1n e fa: t>h4~rQ£.! i rnr, NtH. .. 34f.t2 I. Tb 1$ ec."l'tpcund ln. do5 <:! -- of SO to I 00 ~n. subeut~ncouslv tr\duc~s def.ln l tt.r but sllQrt- IJved ~ubJ~ctlve eff~ct$ r~sembllng thoeq-c&vscd bv mcperidt~~. ,.,. r"ur ISOans. <,;t th~ druo ~very h¥t.trs p~rttall•t SU0pf~,,~, In abstloen~e rr~il_ morphln~ str"'ngty ad1'i'et\rd- ~ttl'!'nts. The L drur.h ther.:fcn: --~ . Jws . ~:H·L:t l . ~~/ llabtJ l ty i'!;:·pr~ch tnr; thot ~f r:t¢p~rldint: !Hirl· J~ not f;"t'!r:{'H"Cird ~~a pr~tsfng ecd~tN:t $VC$fltu-fe. / . . b. !i!,.- c.~ t~-1· ,3-D t ~."1-:!th_-,d -4-?i1~~'/ 1. .. 4-;;>rG~ i :;n ~·XY•· ~ L}~ r 1d l ;-,;: lbeta~t'o.d inz, tHH-340'3l,. r~,~~~ty· . . flt-''! t~ 30 mg. of this / sub:sta·ne~ s~vbeut~n~:.f..':ly t!'i(!ve~s t."l'iir~~d mor;Jhttt~-~i~eo tuoj~crt~~ J t l t'• • 1 ., t -_., "- • •- I '0 "" L ~ f if .. ,~ t . .;; .... $:1 ··~~·, ' c~dclna =~~~tttu!~. A-2G [ c .... ¢ .. plp.:t>tditt<f U~~H-731"5 ). ·ttl d~$el of 20 to J:J mg., fhtl co:'!!~ound 1ndv~cs mar~ed nor~ht~e-ltk~ ~upharta 1n fGr~ar ~or~htne Qr •ddlcts. fllty m;. cvttry hcvrs th~ d~ug r~ur ~uo~res$~1 avm~t.;.ns ~r obstl.n"Jneco f'r~...~ nor~bfn(l c:0"1~1ehdv~ lt~ ·3ddletlcn llltbtltty ll1, tht!rcfcf'(\!' ~q~l to th.2t of mQrphlnct clnd tt ls 1 not A pr~tslng ccd~ln~ substitute. d. ~-4 $4-0t p!'l ~J~Y t -"-P 1; Jr:r td 1n.;-3•h!Zp tarr on~ ti-:.J t,,~r- t .. dylm~th4d~,~,, NIH-7343 Jot · tn dosq; of 100 t\,) 150 "':J• £ubcutanecuslv . I of th ls. e\iS.}~U~H! •-wb~utan:!;.·v~ tv ttv::rt ·r::..ur to slx hour3 c~u~~d ;t",;., plittt~l, b~t ·+elt::th:.~ ~tJ:"J)r:tt,t~n cf -.\lh3ttn;:nc-e tn 5 str~n'ilV l$ a ¥erv addtct~d ~ottznt~~ Tht~ tnf~resttn~ r~&vff stn~~ . . / ~1~xtr..;,;-~f~f;;ry !S.c-;";'lCri' ·in th~ ~~th;;cl;,;.a~ 3-:!ri~S g~n~r-il fy 4f~ , / conti~1n4tcd wlth ~~411 ~~ounts of 4 very pcttnt J~vcrQtat~ry 1$;;..-ner~ U ~lll bz: r~tn ..J e3t1:,ted u~1ng1~;-,~et•llty o'.1r!fi(:rl tot 1~ ~~ !: ~ ~ " The image is a scanned, typed document with some handwritten annotations. Top right corner has a circled number "80". Bottom right corner has handwritten text "A-26". There is also a horizontal line with a dot near the bottom. The document appears to be standard text, without any visual components like photographs, diagrams, or forms. There are no visible stamps or redactions. 5 str~n'ilV l$ a ¥erv addtct~d ~ottznt~~ Tht~ tnf~resttn~ r~&vff stn~~ . . / ~1~xtr..;,;-~f~f;;ry !S.c-;";'lCri' ·in th~ ~~th;;cl;,;.a~ 3-:!ri~S g~n~r-il fy 4f~ , / conti~1n4tcd wlth ~~411 ~~ounts of 4 very pcttnt J~vcrQtat~ry 1$;;..-ner~ U ~lll bz: r~tn ..J e3t1:,ted u~1ng1~;-,~et•llty o'.1r!fi(:rl tot 1~ ~~ !: ~ ~ " ! ' -1 -~ ~:~ ·t f -! ~ i t ~ · ~ ·~ ~l l n ~..; f 0 -vr i~~ h ~ ~; ~-: 1 i ~~ ~ 5 ') t~ l c r: f t ~.l ~ ~ f f' ~ ~ f- ~ 1 ~~ J ~~ ~~ n~ tLn~- {f . r e•._-,, ""'". . ;... •." ,. .. vi t.i _-, A-2.'> .l..li.jj - '':~ ~~:·hcxv-N...pheuthv 1-mor~b .' r. l-3· . loan , , , •. . _ .. , . ft- t .1 , .... ~ , 1 .1~ - , : , . ! /. " . ' , ' • . as b'itna ~net of th~ nt•.;:lt P'~t+:nt mo:"';)hlnc ... ttl:e c;;.r.p~urdtt fi!'l~,. dhe.;?t~red. In d-u<lt!S cf d~ IJt~le 4s 5 m~. ·lt lno~et:5 ir.t<!r~s<:, Five t<J lO ~:19 • .;f t!t~ c·~i·)vvnd clth::r svb~t.~tan~ously vJ· vrfltfy aup;)ress.:d wbsttnence fr'-l!l ~Otf'h1nc il1~o;t e~~~~de:y when_ give~ =v=r~-stx t~ ~~~ht h~vrs to str~nsly cdd1ct:d pati~ntiu • .i-1-'·A?.t ~ hi.i-~Y-~. .~ ·h enc thy t -;ncr~h Jn Jn H·~i H-72';>.;.;_:, J. J . 1 ..~ ,,. .. r... ..,.. . ,·.;'fl .'J '."..l f·... .... ~ t t. ;- . .., .~.. .., - 1tr4,..n~h· ~cdicre·! ··1at1znrs, ~1hsttnen::{t frc;.~ r.1cr:hln~ W<ill ~ ..1 rt1~th, . .t,-_' '·rT ~. • h. !1_. . 3-!· · · ·:-~y:-1'4-;Jfurn~thyl-mor:;,h 1n.an · lh!H-7:.?.t;5A J. Lt~c tr.c- ",'-t"~c~dlas c~-)ovttd, thft rlrug· 11 t"o lns~lub'~ ~nt! too Irritating to be Injected. In dv$C' ~. . ~1'\glng up t~ 250 r:o:g. orally lt dtd n~t Induce any ~~llnttc subjc~tlv~ effacts cf mor~hl~c-tlke n~tur~. Dcsq4 ;I 333 mg.-orally 4¥~ry st~ h~ur' had no cffeet en th~ Snt~nstty ol 4b,ttn~n~« fr~~ mor~hlne In ttr~~ly ~ddtetcd patteots. Th~s• ffndtn~s tndtcate a ic• · d¢grt'~ cf cddictfGn 11abt-1tty .. 'f th¢ c~fl~und Is ~lth~1' an ~freetlve antitus,1ve ~r 4n ¢((eettve 4nalgcs1cJ ct w~u!d be 4 p g t c n t i a I e od q l n d sub a t it u t e • 'ubcutan~~usly ln4vc~d J' ntcnie 1ubJ~etlv: cff~cts whlch verq drug Svl-~uf(iru:;../; ;;b;!y ¢very r.~r hour; cr..:.m;J;~t~ty SV;;:t~)r¢J~~d The page contains a typewritten document with a handwritten annotation in the bottom right corner: "A-262". There are also faint, scattered marks that could be ink blots or smudges. No photographs, stamps, forms, diagrams, tables, or redactions are visible. The document text discusses the addiction liabilities of new analgesics and the use of certain substances as substitutes for codeine. This document is a single, typewritten page with handwritten annotations. The text discusses the development and properties of potential codeine substitutes. In the bottom right corner, there is a handwritten annotation, "A-26/". There are no photographs, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures apparent on this page. an ~freetlve antitus,1ve ~r 4n ¢((eettve 4nalgcs1cJ ct w~u!d be 4 p g t c n t i a I e od q l n d sub a t it u t e • 'ubcutan~~usly ln4vc~d J' ntcnie 1ubJ~etlv: cff~cts whlch verq drug Svl-~uf(iru:;../; ;;b;!y ¢very r.~r hour; cr..:.m;J;~t~ty SV;;:t~)r¢J~~d . r:l~r;'>hin~, ~nd h nvf a i"">Oh!ni1\oil e.:.d~lr•~ ~vl::).tifuh:. tt i~* A -2) r- I - ·Insoluble ~nd cau,~d lnt~nse irrltatt~n when a Golutlon m~da tn ,.,r(,uolyn~ · gtyeol \1.ts InJected subeutan~~Ul \y. No ~or:)h tr.f!- 1 tk41 ci!c-cta tt~rcr sc¢n with d.;.:~s r4not.ng b¢ht~.en 5 h,; tSO e1g. subeutcsnc..;us1v tn IS ;:;atl~nts. NQ suppro;atcn of ebstlntnc.: • .,, ~bs~rvad wh\!n ~200 mg. w<trq gh'!R subcuttln\tcus ly 4t tn-: tw~nt,<~th hwr ~~ ab$t1nfne~ frc.~ m~r~htn~ to 9 atr"r.otY addlctad rNtlent~ .. Addh:tl~n l14blllty of tbLs e•.:::t;:J;;;.und ts,. thcr-tfor~, quit~ ,lew, lo 411 pr~bablltty, tt lS a c.;.mPI!!t\!IY Inert drug. k. !!-4":1 ph" -t..n 1r.::et hy l i n<~-1 ,~::-(j l ;?hen v l-3·.n~ thy 1-2- !H!l protl hmvxy but.1~q ':i:u;r~p{;~y0hine !.. Tn l s Is th~ t ~et tvc- ::"tO$ ~f the ls"-n~r:l \;-t • pt·~>·;•Jx' y;.. . h.::n<:t$' ~ud ll!os !.3er.t1(j~td Gbvv~. lt / . f~.. ,-r-·). ,... . -. ,..~....- .... ~... ..l..!..\. . - .. - ~ ;- did n..::.:t ~ \ Cot.mel t ft'ldt f!,~ et;r.t;lound h~d vary fc.~ aJdteflvtt I i;3bt! Hv. eltalc4l th4t It Is a' Sine~ ~r~lt~tn4ry r~~~rts tndte~t~ eff¢etlve &J e~~clne 41 un 4~~~c~si~1 further studt~$ w~r4 t" rc:qu<:'~tcd by 'th~T Drr.ro. Addretton C~Jtt~~ ln cf'der determine (jr more ex~etly the oddic:tton•su;tGJAl:lg :)~t~ffey tfH! e.:;m-:,zvnd. Thts Is be1nr; 4ee~l?lhh«d1 ustng 4 "double blind,. erQS$cvqr d4slnn ln which addtet Grc to fcrm~r v~tunf~er~ addlct~d m~~h1n~, after ~hle~ they 4r« ritv~~ ~lthcr evd¢tn¢_~ i~'rc~~xyphene In e~ded ccpsul¢s so th~t th~ ld~ntt•v of the dru~' ra vn~no~n to th~ gb$erv~rs. After ten J4yl of $ubst!tvttcn ~ed nlth~ut the know!Qdg.:! o7 th~ ~servars ldentte~t placebo cO;')JUfct ar~JZ &vbt:t Uutcr.J.. ;a~{t~Pt.$ ~H l );i:.!' \7.1Hdr-;twn one~ fr<-7l c:~cl..-;.t.~.: en.d o:tce- fr.-..~ pr~:"'~v~y;;h~nc.: f,c.lH.dfi oi thh ~:li~rlm.znt $h.;,t;L! b..z ., PlAr.U ·rH£ fG~ ~UT~'(E / _t.~r: -t{!:il~f>! :")t.a~:;. w lllr • • ._.., :..• ~·c 1ntend f;.;,. e~.<nt-tno~ th~ seJrdt fc·.r $-ub,tltutfi r~r c...dc1n~ until a druo or an dru~' 4rt fcund ~hTch arc JU~G~d by th: C~tttc• on ~ru~ Aodlct1cn and N~r~cttc~. Nl)tlcnlll R~st!~tc:b Cc.~ncl1, to fu1f1lt all ~eec:s4ry r~quSrcrnent,. P.£P~~TS ~~ ?UutiCr\ilct~ tnorlna curr~nt r~~~rt p~rtodJ. The document is a typewritten page with handwritten annotations. There are no photographs, diagrams, tables, or official stamps. The document is a report section detailing the results of drug testing by the MKUltra program. There are handwritten additions in the margins. The document is marked "A-260" in the bottom right corner. Some text appears to be underlined, and some words are circled in red. There are no redactions or obscured content. w lllr • • ._.., :..• ~·c 1ntend f;.;,. e~.<nt-tno~ th~ seJrdt fc·.r $-ub,tltutfi r~r c...dc1n~ until a druo or an dru~' 4rt fcund ~hTch arc JU~G~d by th: C~tttc• on ~ru~ Aodlct1cn and N~r~cttc~. Nl)tlcnlll R~st!~tc:b Cc.~ncl1, to fu1f1lt all ~eec:s4ry r~quSrcrnent,. P.£P~~TS ~~ ?UutiCr\ilct~ tnorlna curr~nt r~~~rt p~rtodJ. 1. l•b~t1, H.: ic~tqdtc::~l ,\sp~et.t Qf G;JtQte AddleJic.<n. Bull. t4itw York At:ad. Med.·, 1!.: ( 12 l SB~-901 (D.-:c. J l?5S. 2. fr4ser, H. F~. Van H~rn, G. D., ~nd ~:bell, H.! studles ,,, ~n N-41tyloor~Qrpidna ln ~~~en: Anti!r;"nhm to ~.~ctpldn£' ~nd Herc1~ 19~6. '..-'/ 3. frDs«rj' }~.f. ~nd tsb.!ll* ~~&t Addir:ttv<t ~uf·~nti'1tltle~ (;t Ho!X~~~thy\:!~Hth~lnt:S·/·fed~rutlcn ?r~~., 12.: t t J 4·::;3 (''•lrch J r~d~rJt h .. n r:-ce.p J1..: t t J 442 L.:.:;rch l 1'?36. S • h b •d t , H • : The S ~ ts r <: h f.:. r G t•J c n ~ d d 1 c t t n o f'\ n;: ~ c < ? $ t e • . . . c hmit J V.i5o . -- ' . .. . , 7. Fr3ser~ H. f ... a~.:-J t,b~ll. H.: ,v!-:J~ndtlt.l to fbq Mlnubzs of the· t7th :.~eqt.ti'\~1. Cv.~-.,1 ttee en Drug A.~:-Hc:t l~n ·lnd c.J Narcctl~$, N::tt"nAI r:c:careh C;~uncl_l• ·~.'4$hir.gt~ft,. D. JO.JI' Jilttu~r\; \9-5~. · ~¢p.orts ~n Addletlon ll~btlttv T~$t$ cf N<;w Subs tanc:es.. . p;l 1-& 7. ·t ... A-Z)j This page is a typed document containing scientific information related to drug compounds and their effects on test subjects. The text describes various chemical compounds, their dosages, and observed reactions such as euphoria, lethargy, and suppression of withdrawal symptoms. There is one handwritten annotation in the bottom right corner: "A-25". The rest of the page consists of typewritten text, with a circular symbol at the top left, suggesting it may be an excerpt or continuation from another document. There are no other visual elements such as photographs, stamps, forms, diagrams, tables, or redactions. The document consists of typed text on a white page, with some faint stains and smudges. There are no photographs, diagrams, stamps, or forms visible. The only handwritten annotation is a number, "A-258", written in the bottom right corner. Some of the text appears to be slightly obscured by shadow or uneven printing, but there are no deliberate redactions in the form of black ink or white-out. The visual content is primarily the raw text of the report. The page is primarily a typewritten document with handwritten annotations. There are no photographs, official stamps, forms, diagrams, or structured data visible. The document itself appears to be a scientific or research report detailing the effects of various compounds. The handwritten annotations that are visible are primarily part of the chemical names and numeric entries within the text, suggesting they may be corrections or additions made during review or data entry. There is also a handwritten number "A-257" in the bottom right corner, likely a document identifier. The content discusses drugs and their effects on addiction and withdrawal, hinting at experimental procedures without explicit visual evidence of them. The page contains primarily typed text, with two distinct sections marked by lowercase letters 'j.' and 'k.' indicating different chemical compounds. There are handwritten annotations in the bottom right corner, including the number "4-25." The document appears to be a declassified government report, with the absence of any official stamps suggesting it is no longer classified. The content describes chemical compounds and their effects on subjects, hinting at experimental procedures related to drug addiction and withdrawal. No photographs, diagrams, or forms are visible. The document is a single page of text, handwritten and likely typed with a typewriter. There are two circular symbols at the top of the page, possibly representing marks or annotations. In the bottom right corner, there is a handwritten annotation that appears to be a document identifier, "A-255". The page also shows evidence of age, with some yellowing and faint lines. Some areas of the text are slightly smudged or faded, contributing to the aged appearance. There are no photographs, stamps, forms, diagrams, tables, or redactions visible on this page. The document is a typed page with some handwritten annotations and a stamp. In the top right corner, there is a handwritten annotation "A-25". There is an official stamp in the top left corner that is partially obscured. The text is a list of "REPORTS AND PUBLICATIONS" from "Isbell, H." and "Fraser, H. F." concerning drug addiction and analgesics. There are no photographs, diagrams, forms, or tables present. The content appears to be a list of academic publications. The document page appears to be a scanned or photocopied page of text, likely a bibliography entry or a note from a meeting. It contains a few handwritten marks, including a circled 'C' at the top, the words "Hlalw:tkh" and "Harris Isbell, M.D." at the bottom, and a handwritten annotation "A-253" in the lower right corner. There are no photographs, diagrams, charts, forms, or visual evidence of experimental procedures. The text itself details a report on "Addiction Liability Tests of New Substances" from the 17th Meeting of the Committee on Drug Addiction and Narcotics in January 1955.