Doc 0000151759

• . \ j • \x..'"~.:;\' ,. 43-Y 2,-Dihydro-lyser_gic acid diethylamide (V-A-24}. These experiments were carried out to determine if £-dihydro lysergic acid diethylamide (V-A-24) has psychotomim€tic properties, and to assess roughly its potency in_this respect as compared . " with LSD-25. V-A-24 Is known to be about one-half as potent as LSD in blocking serotonin-induced contractions of- the isolated uterine muscle of the rat. No previous human trials were kno~~. METHODS Subjects. All the subjects were nontolerant former morphine addicts who were serving sentences for violation of the Federal narcotic laws. All were physically healthy and none any of the major psychoses. pre~ented ··General Conditions. Subjects entered a special ward on the night before experiments were conducted. During the ~xper­ imental day they could remain in their own rooms or mix with other patients in a common day room • ... R ... ?L u """'/' Pag~ 2 Druos. ·£-Dihydroiysergic acid diethylamide was given in solution at 8 a.m. with the patients fasting. Preliminary - experiments were conducted in which single patients received V-A-24 0.5 ·5.0 in doses increasing from to meg/kg. The proper J.0-5.0 dose range was found to be meg/kg, so that all 12 patients were given. these in a randomized balanced ~ses order. Placebos were not done. For comparison, data on 9 patients who received 1.0 and 1.5 meg/kg of LSD-25 in aneth er experiment are included. Obser~ations~ Observations were made at hourly intervals once before and eight times after administration of the drug. The standard routine_ of th.e Addiction Research for drugs Cente~ of the LSD type was used. The observations included systolic bloo~ pressure, ·pupillary diameter, and threshold for the ,, The change after drug was by subtracting kneej~rk. calc~lated the average of the pre-drug observations from the values at each hour after drug. The areas under the time-action curve composed .. of these areas was calculated by the method of Winter and Flataker (1}. The number of responses on the questionnaire which were not scored positively before the drug were counted. "Clinical gradesu were assigned by _the system of Isbell ll ~ (2), and were based on short psychiatric examinations performed at intervals after the drug. --- _ Pag~:: RESULTS The results_are tabulated in Table 1. They show that V-A-24 induces·a pattern of change similar to that caused by . . . LSD; but is, of·course, less potent. From the data, it appears The image displays a graphic header for "THE BLACK VAULT," a website dedicated to declassified government documents. The header features a stylized, illuminated text accompanied by an illustration of a heavily secured vault door. The text on the right explains that this document was obtained from The Black Vault's MKULTRA/Mind Control Collection, which contains over 20,000 declassified CIA documents. The visual elements of the vault and the prominent title suggest themes of secrecy, security, and the uncovering of hidden information, which aligns with the nature of the MKULTRA program. No further visual elements such as photographs, annotations, stamps, forms, tables, or diagrams are present. The document is a single page of typed text with some handwritten annotations. At the top right, there is a handwritten number "160" circled. In the top left corner, there are a date "12 May 1959" and a code "43-Y". At the bottom right, there is handwritten text "B-24". The document appears to be a research report, detailing an experiment involving "d-Dihydro-lysergic acid diethylamide (V-A-24)". The text describes the subjects, their selection, and general conditions under which the experiment was conducted. No photographs, diagrams, or official stamps are visible on the page. and were based on short psychiatric examinations performed at intervals after the drug. --- _ Pag~:: RESULTS The results_are tabulated in Table 1. They show that V-A-24 induces·a pattern of change similar to that caused by . . . LSD; but is, of·course, less potent. From the data, it appears that V-A-24 is roughly slightly less than one-third as potent as LSD. The mental after:V-A-24 were similar to those pheno~ena reported after LSD ' and included nervousness, anxiety, a sense of strangeness, haptic sensations, visual perceptual distortion, and, in sensitive patients, visual· hallucinations. 1. acid diethylamide is a psychotomimetic ~-Dihydro-lyserglc drug. It is about one-third as potent as LSD. •\ Page 4- REFERENCES 1. WINTE.tt, C. A •. and FLATAKER, L.: Stud! es on_ Heptazone ( 6-Morphol ino-L~, 4-di ph.eriyl-3-heptanone hydrochloride) in Comparison with Other Analgesic Agents. J. Pharmacal. Exper. ~ Therap., ~: 305-317 (March} 1950. 2. ISBELL, H., BELLEVILLE, R. E., FRASER, H. F., WlKLER, A., / and C. R.:· Studies on Lysergic Acid Diethylamide. LOG~~~ I. Effects in Former Morphine Addicts and D·evelopment of Tel erance During Chronic Intoxication. A.M.A. Arch. Neural. & Psychiat. -76: 468-478 (Nov.) 1956. -\ ·--:· i i ,',I .. ~L C) ~ Table 1. Comparison of the Effects of acid diethylamide and LSD-25 • &-Dlhydro~lyserglc • MEASURE DRUG AND .DOSE -(mcg/l_{__gl_ __ 42 . Placebo! LSD-251 LSD-251 V-A-2 V-A-21~2 s.o 1.0 1.5 3.0 . - I - ....... ± Pupillary Size 0.2 ± 1 .;1.~ 10.2 ± 1.18 +15.0 2.1 + 8.0 ± 1.7 +12.1 :t 1.7 FJ J ood Pressure 15.6 ± 13•5 + 6!t .• 8 ± 10 • 9 + 91+. 6 ± 17 . 5 + 69. 1 ± 2l~. 1 8?.6 ± 12.1 J'ntellar Reflex + 20. 7 ± t' i . 1·. -50.9 ± 31 -72.9 ± 21.7 -68.7 ± 15.4 91.1 ± 22.9 '-_ , Humber of Positive n~~~ponses on Questionnaire . 0.1 ± 0.3 57 ± 23.2 98 ± 26.6 15.5 ± 6.4 38.7 ± 15.6 Clinical Grade ·• 0 ,.±_. 0 2.2 ± 0.)8 2.8 ± 0.17: 0.83 ± 0.27 1.5 ± o .Lt.D -· ----·-- e 1. Figures are means ± stan~ard errors of observations on 9 subjects. 2. Figures are means ± standdrd errors of observations on 12 subjects. ( "· ' . ' This is a declassified page from a document, likely a report or study, based on the presence of typed text and the "Page 2" notation. The page contains a significant amount of text detailing an experiment involving drug administration and patient observation. There are no handwritten annotations, signatures, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures, equipment, or facilities; the page is entirely text-based. The only non-textual element is a handwritten numerical identifier, "B-245", in the bottom right corner. -· ----·-- e 1. Figures are means ± stan~ard errors of observations on 9 subjects. 2. Figures are means ± standdrd errors of observations on 12 subjects. ( "· ' . ' The page is a typed document with a single handwritten annotation in the lower right corner, "B-24 -". The text is formatted into sections labeled "RESULTS" and "SUMMARY", with a page number "Page 3" at the top right. There are no photographs, diagrams, stamps, forms, or redations visible on the page. The document discusses the effects of a substance "V-A-24" compared to LSD, and a summary of the drug d-Dihydro-lysergic acid diethylamide. The page contains a list of references, numbered 1 and 2, with the heading "REFERENCES". Both references appear to be scientific journal articles. There is a handwritten annotation in the bottom right corner of the document that reads "B-245". Additionally, there is a handwritten mark near the top right corner of the page, resembling a line with a small diagonal mark, which may indicate a page number, though it is not clearly legible. No photographs, stamps, forms, diagrams, tables, or evidence of experimental procedures are visible on this page. The image displays a declassified document titled "Table 1." which presents data on the effects of d-Dihydro-lysergic acid diethylamide and LSD-25. The table contains measurements for Pupillary Size, Blood Pressure, Patellar Reflex, Number of Positive Responses on Questionnaire, and Clinical Grade, with values presented for Placebo, LSD-25 at different dosages, and V-A-24 at different dosages. Handwritten marginalia in the top right corner reads "B-242". Two numbered notes are present at the bottom, clarifying that the figures represent means plus standard errors of observations, on differing numbers of subjects. No photographs, diagrams, or forms are visible.