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e) 43-Y 1-Methyl-d-lysergic acid butanolamide tartrate (uML-491, V-A-23). Investigation of the psychotomimetic potency of~this compound (methyl methergine·) was undertaken because it is 2.5 '/ approximately times as p;tent as LSD in blocking serotoni~- . induced contractions in the isola ted rat 1 s uterus and is 4 .~. times as potent as in blocking the serotonin-induced ~SD ede~a in the rat}~paw (1) •. It was, therefore, of interest because of the hypotheses relating the LSD· psychosis to serotonin blockade in the central nervous system. METHODS Thirteen adult, negro male former morphine addicts ~Subiects. significant physical or mental disease volunteered fer wi~h6ut the experiments. All had experienced the effects of LSD in previous experime.n ts. ·· .• ... - n a . ·':'::Y • ...... . ~.- Page 2 Druos. Were given in solution at 8 a.m. with the patients fasting. In preliminary experiments the dose of V-A-23 was 0.5 5.0 elevated cautiously from mg/70 kg to mg/70 kg. In the final experiment all 13 subjects received 5.0 mg/7~ kg of V-A-23. Observations. The following observations were made at hourly intervals eight times after the drug: twic~ befor~·and pupillary diameter, blood pressure, threshold for the s~stolic a kneejerk, the and short status LSD-q~estionnair~, m~ntal examination. Methods followed were those described by Isbell / Al ~ (2),.as were the methods of analyzing the data (J). RESULTS In the preliminary experiments no psychosomimetic effects were_ reported or observed with doses of 0.5 to 5.0 mg/70 kg of . V-A-23 (8 subjects) •. In the final exp~riments, 2 of the 13 subjects reported psychotomimetic effects similar to those of LSD. Their visual perceptual distortion, S}~ptoms i~cluded depersonalization, and optical hallucinations. Both were, however, very sensitive to LSD and both were regarded as being suggestible. One was a consistent placebo Significant r~actor. pupillary dilatation did not occur·in either instance. Symptoms in the remaining patients were not LSD-like and included sleepi (4 ness (6 of 13), nausea of headache {l of 13). 13),~a~d -~ -) Page 3 ·The observations are suminarized in Table 1 and are compared with data obtained on 9 subjects in another experiment after placebo and 1.0 ~nd 1.5 meg/kg of LSD. Significant elevations in blood pressure and pupillary diameter were observed, but the change in the pupils was small, even though significant. A significant decrease ln·the for the kneejerk also ~~reshold occurred. DISCUSSION / The results are somewhat puzzl.ing in that the The image displays a dark background with a stylized title "THE BLACK VAULT" in white, outlined font with a blue glow. To the left, a graphic depicts a heavy vault door with a complex locking mechanism, rendered in metallic tones and accented by a bright blue light. The text on the right describes the origin of the document as being from The Black Vault, an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection and providing a URL for access. There are no photographs of people, locations, or equipment related to the MKULTRA program itself, nor any handwritten annotations, signatures, official stamps, forms, diagrams, tables, redacted content, or visual evidence of experimental procedures. The visual elements serve as a generic thematic introduction rather than content from the declassified documents. after placebo and 1.0 ~nd 1.5 meg/kg of LSD. Significant elevations in blood pressure and pupillary diameter were observed, but the change in the pupils was small, even though significant. A significant decrease ln·the for the kneejerk also ~~reshold occurred. DISCUSSION / The results are somewhat puzzl.ing in that the pattern of change in the objective measurements was LSD-like, but was, with the exception ?f the 2 patients mentioned above, not correlated with mental changes of the LSD-type. It seems safe to state that if V-A-23 is a psychotomimetic, it is far less ' potent than LSD. Thus another example is added to the list of compounds that ar:e potent ln.i-libitors of peripheral actions of serotonin, but are not_potent psychotomimetics. SUMJ.AR.Y 1. ln doses of 71 meg/kg (5.0 mg/70 kg), 1-Methyl-d~ lysergic acid butanolamide tartrate did not consistently cause psychotomimetic although significant elevations of ~ffects, blood pressure, decrease in the threshold for the kneejerk and dilatation of the pupils did occur. ~-· Page h REFERENCES 1. DOEPFN£.1:{, W. and CERLETTI, A.: Comparison of lysergic acid derivatives and antihistamines as inhibitors of the edema provoked in the rat's paw by Internat. Arch. Allerg. seroton~n. and Appl. Immune!., ~: 82-91~ 1958. 2. ISBELL, H., BEl.LEVILLE,:R. E •. , FRASER, H. F., WIKLE.q, A., c. and LOGAN, R.: -Studies on lysergrc acid diethylamide: I. Effects Ln former morphine addicts and development of tolerance during chronic iritoxication. A.M.A. Arch. Neural~ & Psychiat., -76: 468-478 (Nov.) 1956. 3. ISBELL, H. -and C. R.: Studies on lysergic acid LCG.AL~, diethylamide (LSD-25). III. Attempts to attenuate the LSD- in man by pretreatment with neurohumoral blocking agents. rea~tion A.M.A. Arch. Neural. & Psychiat., 81: 20-27, 1959 • ... - t \ ; ,',I .. "-" :_).... ,/ \ ·~ t ····· "J ri I ~ Table 1. Comparison of the Effects of 1-Methyl-d-lyserglc acid • butanol amide (UML-491, V-A-23) wl th Thos·e of LSD-25 • .DRUG AND DOSE Placebo I tsn1 tso1 r1EI\SURE 1.0 1. ~ ~~~======~============~ Pupillary Size 0. 2 ± .1 .1~ 10.2 ± 1.18 15.0 ± 2.1 + ~--0 ± 1.1 I .s Blood Pressure +15.6 ± 13.5 61~. 8 ± 10.9 +94.6 ± 17 + 81. cf ± ·1 0 • 1 .. -so. Patellar Reflex +2Q .1 ± 11 .1 9 ± 31 ... 72.9 ± 21.7 -·. 55. 8 ± 11 .l~ Humber of Positive Responses 0.1 ± 0.) 51 ± 23.2 The document contains typed text, including a date and a four-digit identifier. Handwritten annotations include a circle around the number "161", and "B-241" in the bottom right corner. There are no photographs, diagrams, or forms visible. The text discusses an investigation into the psychotomimetic potency of a compound and mentions experimental subjects and procedures without visual representation. The document page contains typed text detailing the results of an experiment involving V-A-23 and LSD. There are no photographs, diagrams, or forms visible. The only handwritten annotation is a designation "B-246" in the lower right corner. There are no official stamps indicating classification. The text discusses drug administration, patient observations, and a list of reported symptoms. +15.6 ± 13.5 61~. 8 ± 10.9 +94.6 ± 17 + 81. cf ± ·1 0 • 1 .. -so. Patellar Reflex +2Q .1 ± 11 .1 9 ± 31 ... 72.9 ± 21.7 -·. 55. 8 ± 11 .l~ Humber of Positive Responses 0.1 ± 0.) 51 ± 23.2 . 98 ± 26.6 16.) ± 7.6 on Questionnaire Clinical Grade .. 0 '±. 0 22 ± 0.)8 2.8 ± 0.17 0.46 ± 0.33 ---------~-~------- -~------------- ---~----------- ---- ~------- ---------- ------- ---_,.-----~----~---- .e ·1. Means± standard errors ~f observations on 9 subjects. r· ' 2. Means ± standard errors of observations on 13 subjects. . ..... The document is a single page containing typed text. It includes a page number "Page 3" in the upper right corner. There are no photographs, diagrams, tables, forms, or official stamps visible. The page does contain handwritten marginalia in the lower right corner, appearing to be initials and a number, "B-23". There are no obvious redactions or obscured content within the text. The document appears to be a bibliography or reference list from a scientific paper, with the heading "REFERENCES". It is numbered as "Page 4" on the top right. The text is printed, with no photographs or diagrams visible. There is a handwritten annotation "B-23" in the bottom right corner of the page. There are no official stamps, forms, signatures, or redations visible. This page contains a single table presenting data on the effects of LSD and other drugs. The table is titled "Table 1. Comparison of the Effects of 1-Methyl-d-lysergic acid butanolamide (UML-491, V-A-23) with Those of LSD-25." It lists various measures such as pupillary size, blood pressure, and patellar reflex, with corresponding numerical data under different drug and dose conditions. There is a handwritten annotation in the upper right corner that appears to be "B-23:1". No photographs, stamps, diagrams, or filled-in forms are present, and there are no visible redactions. The layout is clean and organized, suggesting a formal research document.