Doc 0000151763

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE 9 June 19.59 lbd•al lath11ta ol Mctual Hesltlk A441ctioll llcocarcb. Ct:lltet U.S. hblic Heald~ Scl"'i" Koopiul l.csillPil• ICcNcky ' '(£J~) Under separate cover.we are foniarding you 2 gm of l-(beta diethylaminoethyl)~2-(p-ethoxybeDzyl)-.5-nitrobenzimidazole methane sulfonate (Ba-2068u, ~ITH~7607, ARC I-G-2). This is an extremeiy potent ~3terial and care should be used in handling it; souice was, .of course, the Ciba company. Also enclosing copy of a preliminary report on the addictiveness of two benzimidazole derivatives which was prepared for Dr. Nathan B. Eddy, Secretary of the Drug Addiction Committee. You will note this·report indicates that Ba-20684 is 60 to 100 tiwes as potent as morphine orally in rr3n. Good morphine-like effects were obtained with a total dose of 0.2.5 mg. Dr. Fraser is to explore the dose range, particularly the higher dose range, usi-ng ~the oral route. He will also study parenteral administration. Detailed pha~w2cological information ·is not yet available, however Ciba has indicated to me that they are preparing a brochure for clinical investigators which will contain all the i~£ormation. When this is received it will be copied and sent to you . .. Kindest personal re.gards, Yours very sincerely, ~~ Harris Isbell, H. D. Director· ~~~L~~,~~~ ~~ HI:bws ~ Af4~ dzv {/~ • 77J.....',..'. LFE. /,5~~ ~~ ·. ·.~ The page is a black background with a stylized image of a vault door on the left and white text overlayed on the right. At the top, in a neon-blue, stylized font, is the title "THE BLACK VAULT." Below this, in white text, is a description of the document's origin, stating it was obtained from an online database of declassified government documents, specifically the MKULTRA/Mind Control Collection housed by the Central Intelligence Agency (CIA). The text also mentions that the entire collection is free to download and provides a URL: http://mkultra.theblackvault.com. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visuals related to experimental procedures. The document is a typed letter dated June 9, 1959, from the Public Health Service. It includes an official seal for the Department of Health, Education, and Welfare. There are handwritten notations at the top of the page, including a circle around the number "164" and a symbol that might represent Roman numerals. A large circular annotation with numbers inside, possibly indicating a classification or reference, is present in the center of the page. The bottom of the page features a handwritten signature and title, followed by additional handwritten notes and a reference number "B-279". A small, rotated handwritten annotation "C-267" is also visible in the margin.