Doc 0000151782

,--~ .o. -•~ ---- DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLJC HEALTH S.ER. VICE 3 January 1961 NaU..al botltlllc o( Meatal HuJIA A44!atoa l.escucll Ccater 11.S. PUllc HnltA Scroi« Hoopital l.ca!Apa, JOeaaacsr .· . -- ---···-------- ·----------- -·-- ' I am enclosing herewith copies of three tables: 11 Comparison of the total course of tl].e LSD, mescaline and psilocin reactions, " 11Mean increase in pupillary diameter over control, 11 and "Mean increase in number positive answers over control. '1 All dru.gs were given intramuscularly, a de~arture from our previous practice. The 10 subjects used received all drugs. The methods used were those that have become standard with us for psychotomimetic stuqies .. The experiments were done partly to get - equivalent dosages of LSD and mescaline, and also to get some information on psilocin (dephosphorylated psilocybin}. As expected, the effects of all three drugs were quite similar quantitatively. All three induce the same sort of autonomic changes inciudillg pupillary dilatation, temperature elevation, blood pressure rise, etc. , and all induce similar mental-changes including alterations in mood, body image, sensory distortion and hallucinations, chiefly of the visual type. The chief differences relate to potency and time course. As is apparent from the tables, the onset of the psilocin reaction is , quite rapid, nearly maximal effect being attained in t.1-!e first half-hour. After 2-1/2 hours the psilocin reaction is already declining sharply, and after 3-1/2 to 4-1/2 hours has declined to negligible proportions. It is of some interest that psilocin is the most consistent agent we have studied, insofar as the induction of hallucinations is concerned. All 10 men who received a 150-mcg/kg dose had hallucinations and 9 of them lost insight. Despite this, psilocL."l seems less unpleasant than either LSD or mescaline, perhaps because of the short time course."' -~. Page -2 The calculation of relative potency presents something of a problem of because the marked differen'ce in the time courses. The relative slowness and long persistence of the mescaline reaction should be noted in this regard. However it is apparent that 1. 5 meg/kg of LSD is equivalent to 75 meg/kg of psilocin subst~ce ant;l to 5000 meg/kg of mescalL"le hydrochloride. - -Currently we are ~ning a small study on the relative p:Jtency of psilocin and osilocvbin. Psilocin is of course_;nore ootent in terms of weight, .b ut probably there will be very little aifference in terms of moles. The page displays a digital graphic with a dark background. On the left, there is an illustration of a bank vault door with intricate mechanisms and a blue glowing light. To the right of the vault, stylized white text reads "THE BLACK VAULT". Below this, in white, is a block of text explaining that the document was obtained from The Black Vault, an online database of declassified government documents including the MKULTRA/Mind Control Collection. A yellow hyperlink directs to a website for downloading the collection. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. 75 meg/kg of psilocin subst~ce ant;l to 5000 meg/kg of mescalL"le hydrochloride. - -Currently we are ~ning a small study on the relative p:Jtency of psilocin and osilocvbin. Psilocin is of course_;nore ootent in terms of weight, .b ut probably there will be very little aifference in terms of moles. ·J Cross toler~"'lce between me~caline and LSD is,well along and I feel almost certain that a high- grade of cross tolerance will exist. .Amphetamine is next on the agenda insofar as cross tolerance is concerned. / It was very pleasant to see you during my last trip to iAiashington, and I am sending kindest personal regards for the New Year . . Sincerely yours, !~ Harris h"'':bws Enclosures Tables (3) ., ,',I i C(),..... , ~· -r:'"-•\ z·~...- r ~ v " ' 'n C ' f tt • l ( . ' . ) , l" ..., ' t " a ' l C .,. O 'l r C I! . ' . - .. P ~ • Of t' . ~ , o , n ~ . . .l . . .~\ r ... · .. r l,. , .. ,. J' ; ' l ~ •~ n ~ ~ { · .. · t. " J. l . tr . . l ~ ~ • , ! c : .. t . n ..,· : .• f 1 l' . ) • ~ . t , ! t . J' - ~ . ' . -. , · , . . ... ~ . ln - r - · " · " ~ " " '" ' ', · . · ; t. 1 4•-'t•"-·-·>· ------------·----------- * ,.._.......,....,_ .. ..,_ .... _____. ....... .. .... Pt! n·vnct~r · · · ·ri..r?·:.,l ..... :-r-- · -.~-··e-t-,-p~l-------------\-.(1-o--.-.t- -....;,;_·; ::;..;;. __.t ·· · ~·u~ . p p_1_1;1 ~ ! 4· .• -;-.;;~::-t,-.;;-·-----c7'i-;-,;~ -- ~~~I.::gq r11ne f>, ~ C .tr." . ' } • f'ah:~ 1 ... J w f.. ·J ~ U . ra 1 (m:.~) C7t~11 ..1 .. . . . ; K ..t p ~ 'C p .. : j ., c -'. r 1.-. ~ ..o~ l L '.J f .t . · : D " . ' . ... : , : ~ ~ . ~ . : a L . .. • U '" . :.:_ . ___G -'" . ' r -" : : The page features text formatted as a formal letter, including a header with "DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE" and "PUBLIC HEALTH SERVICE." Handwritten annotations are visible, notably "186" circled in the upper right quadrant and a marking that appears to be "(B)" or "(63)" positioned centrally near the top. Another handwritten annotation, "B-337," is located in the bottom right corner. The document's layout includes spacing for potential tables or structured data, indicated by dashed lines, but no complete tables are present. No photographs, stamps, forms, diagrams, or evidence of experimental procedures are visible. This page is a typed document with handwritten annotations. There is a circular handwritten mark with the numeral "6" inside it on the top left, and "Page 2" is typed in the top right corner. A handwritten signature, "Harris," appears below the typed closing "Sincerely yours." Below the signature, "Harris" is typed again. The document also contains handwritten initials "HI:bws" and the heading "Enclosures Tables (3)". A handwritten alphanumeric annotation, "P-33", is present in the bottom right corner. There are no photographs, official stamps, forms, diagrams, tables, or visual evidence of experimental procedures. : j ., c -'. r 1.-. ~ ..o~ l L '.J f .t . · : D " . ' . ... : , : ~ ~ . ~ . : a L . .. • U '" . :.:_ . ___G -'" . ' r -" : : . . .. : . l : \ : . /·-...... , J . .'...• tf ). .. " (., 5 , . 0. 75 ·mcq/k;: ·.f-3. 4.1 :f; ·:}. 41 .. rr:>. 15 :tr 10. 19 ... 4..~. 50* 12. 413 ... 7. ua ~ o. u9 -5!. 25 -i. 11.01 3'" .J ' • . l . r .. ' 4•• : 4.G7 1 . , , ..: . ,.· , ~ . ) ~ - I ? I .' • . L .. ~ . O) 1. fYJ mcg/~g +4 .• 31 :11: o. 49 +58. 05 * 7 .. 70 +i35~ 20 j: 10. 10 ·+ 12. 9·:> :t! 1. 61 -51. co :!: 0 . " ~ -' ' . ' - " ~, '7 i , , . ; , , . •• . • • . . ' 1 . (, } . . . I ... . .. 1 ·~ 1 ' . • .. . . J .. / . ) ; ~~~ {3 I . ' "'r•?c~\.llna 2. 5 rcq/tg +3. 4;) :l 0. 41 +33. 40 * 9.27 •45. 45 :fs 13 .. 53 +lO. 4·J ~ 1. 02 -C5. 5'J .1: 15. (:G 35 . '1.. :) "·"-' 5. 94 1 r , , , 3 • · .,.. .,..~.., \ . ,. . o t - ., ::u • tna u .:; . 0 .•"".t;,~,g fl,-· ;\.. g +4. 56~ o. 32' ··71.10 ~ 17. 7J +76. 65 :h 12. 45 +17 .. 33 :h 1. ~HJ -7). QiJ : 1 !3. GJ ' ~...·, .~I . 1 • . ~ _ . ' . · . J: : 1 •. 2 • . • . J , 3 • c . . , . . 1' .. 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Tho dgns lnJ1cat.~ lncrcaso;:;; (+) or dc~CI'CG.SCS (-) in the rncr..-~;·J::::: ..: : '~!~t~~- l1 ( e 2. · ~J:t:ans :t: star.dar~. errors or mAmb~r of qUf!sUons ccorcd pos1tlvel]ln. lh~ '7-1/2 r;Jurs after th~J c!r.:.g . c 'l.;rJch t':u;re not sc~>r,:t:! po~;iUvcly l:ieio1·~ lh:3> drt..!."J~. \ 3. ~-~E:.t.ns ~: .clan;:lnro! errors o! tnt~msll;; of mentv1 rcactlon o.n a :Jcalo or 0-4. e) - .......... In .Pupilla..'"":{ 1.:1a:r.etor (mr:-J over Control ~;;ean !ncre~s: ~:-:~·:)urs after A~c1t"J5"trat!·'n c! C:ru.::r ... ... Drug D~ce ··- l " ~-, ' . 3 4 5 0 7 ::-) .,. . . ,. ... ... !..S~-25 0.75 r:!C!'J/Kg +1. 3:! ~1.73 · l • ;., " ; S .;..;J qq :..,. +J . ~'"''"J' ... J.53 +.'.\., .-.(;!c<.:;. . : .. . - "" . '~ J • fI' ? : .~ j T .. ..f".';'ll-...J -G ,., 5 1 • O-<v"\ c·.r... ."... g-.. /~·t·'4! +- t -- ~ ~ - / .~ __ . ~ ., 5 +2.40 +1 ·~ C . ," , '\ +. . l . 4 0 - •1. 20 -+-1.15 +.J . ~ _ - . " .. \ , :iescnl tnra .¥.). . o- rr..q/;aq +1.55 + 1 - ~ ... ~ .. +l.CS + 1 • . - o - ~ The image displays a declassified CIA document from the MKUltra collection, featuring a table of experimental data. The table, titled "Comparison of the total course of the LSD, mescaline, and patiocin reactions," presents numerical data under various parameter headings, including "Temp.1 (P.C.)," "Pulse," "Blood Pressure," "Pupils," "Threshold for Kneejerk," "Positive An," and "Clinical Grade." The document also includes three numbered footnotes explaining the data and measurements used. There are no photographs, handwritten annotations, or official stamps visible on the page. The bottom right corner of the document appears to have some content that is partially obscured by the image's edge. The page contains a table presenting quantitative data from an experiment, likely related to drug effects, showing mean increases in pupillary diameter over time for different drugs and dosages. The table includes columns for "Drug," "Dose," and "Hours after Administration of Drug" with numerical entries. Below the table, a handwritten asterisk notation indicates that it represents items with a negative sign, and a handwritten alphanumeric code, "B-334," is present in the lower right corner. The top portion shows a title for the table, "Mean Increase in Pupillary Diameter (mm) over Control." There are no photographs or official stamps visible. +1 ·~ C . ," , '\ +. . l . 4 0 - •1. 20 -+-1.15 +.J . ~ _ - . " .. \ , :iescnl tnra .¥.). . o- rr..q/;aq +1.55 + 1 - ~ ... ~ .. +l.CS + 1 • . - o - ~ +1.25 • l - . ' , W •, ' s -1 ; + 1 . .. ·. . . . l . '. . . . .. . J • . l • V ... . . . .. ; +., ,.,_.'; ~.fascallne 5.0 ; .. . . .. . . . . . .' . 4 .. l'~. g +.":;' ...'.".''.'I. +2.75 +2.75 +2.55 +2.15 +.4.. • •...',.\ . J ... ..... ..., +1 •.3 5 - : c : , - :;\ u o ' . w .. . i . n . 37.5 mc:q/l!..::; +1. 93 +2.02 •1. 09 + , V .. .~v' 3 +'J.52 +. · . " J '\ • . " . ~ 8 +0.02 ) . :."..'\, ):>!' -:; ~ ', ~silocln 75.0 ."...". . ' \ C' ~ "' /':.tt J .... f~'t. 4" : ' j +2.33 +l. 63 ..."..'. . s· . ' ; -t-0.48 ... ~.32 +0. 3-3 • • . ., , ; c 1: , . . . r.. , - . 1 +3 ,,.., Psilocin .1,:;·".'y1 mct1/kq· ( ~ +3.82 .;{~.".' 7u2 +1. 7-3 +1.12 +0.63 +-~. -43 +:J. 33 * 8epr-asents onl:,' item ln ta.!)le with negative sign Incrca::e ln ?-:umber F:os!tlva Answers over Control !.~ean N= lJ . Eours a:ft;:r Ad:-:lini strnUo~ o~ Crw.a .. . ... 7 ;: ... 0 ., 0. 75 rr..cg/t-7 4. 20- · 13.l::J 11. ?0 0 1. 5:'J :::.cg/k-;; 11~. 10 22. TJ 21. CJ · . " . ' ; . :iJ"''-·."1' . ' . - ... ' . · · C ,. · v "\ / 2. 5 r:;g /i~g 9.10 12.30 7.::.(J 4.10 2. 2~ 1• • L":' ~J 0.40 J.2\) c. so o. D.30 15. ~j l A .... . 1' . " ,;/ 13.00 7.50 3. 3.) ~.) Psilocin "1". o . mcq ;· 7.0-J 3.50 0. 60 0 0 c 0 -v '· ~g 1 -· . - ~ - · ~-o 8.CJ 0 0 "' so ,.. . Psilxin 30. 34. 9'0 6.40 0 v 0 " ,;/ 13.00 7.50 3. 3.) ~.) Psilocin "1". o . mcq ;· 7.0-J 3.50 0. 60 0 0 c 0 -v '· ~g 1 -· . - ~ - · ~-o 8.CJ 0 0 "' so ,.. . Psilxin 30. 34. 9'0 6.40 0 v 0 This document page contains a table presenting data on the "Mean Increase in Number Positive Answers over Control" for different drugs. The table's columns represent hours after drug administration, and the rows list specific drugs (LSD-25, Mescaline, Psilocin) along with their dosages. There is handwritten marginalia in the bottom right corner, reading "B-333". No photographs, stamps, diagrams, or forms are visible on this page. The content is entirely composed of tabular data and handwritten annotations on a plain background.