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Doc 0000151783

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This document is a project description from the CIA's MKUltra program requesting renewal of a contract to research synthetic substitutes for codeine, focusing on their safety and potential for addiction.

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The full page is black in color with a large image of a bank vault door on the left. The vault door is gray and silver with various dials and gears. On the right, white text on the black background reads "THE BLACK VAULT" in a stylized font. Below this, there is a paragraph of text explaining that the document was obtained from The Black Vault, an online database of declassified government documents. Specifically, it states the record is part of the MKULTRA/Mind Control Collection, housing over 20,000 declassified CIA pages, and provides a URL for download. --- 1'ffi! ADDICTION' L!t~o!tJTY OF SY~ITEET!C ~1JBO!"TITUTES FOR CC·DS!NE (?rojeet. Descrl... ptlon) 8e-Tu.~st to the Of!l:e ct r:a.m:U Fesea.l"Ch for the Rene<¥'lal o! C.,""ntract NAO!l.r-25-59. !fEflOl-10 .. ~ t.. C-ente: b.as teen ca.reyin;r on a project wtth L.1e object of discoveri.nq Sj'!!L~tic / substitutes for~ codeine which vto-ald be G.S safe as that c'~.g with respect to descri?t.J.on conclitutes a request for renewal of the project !or tbe perlo? 1 JUJ.1 ifml to zo :r-~~-:l 1002. Is !rorn opiu!n, or reada from moQhine derltted £rom opiu::n, eodeir~ dcri1.~ event. of war. The i:!e.iliUes o! Uw N!11ll Addiction Reseo.rcll Centor we!"e ~t .) to c:J..-ry out tho in addition to a":aluatlon o! potent new sui.f!~ier.! wor·~ analgesics !r~:nittad b7 t.hs Cot::'1":.itt~ on D:-.1q Addiction ar.d !c7arCotics of . ' ., been .. ha~ o;;~ratL"lq ~ and wera na~'Otin~) :~d. tet~-d..'""Oi!'::-Oq"J.i~li~ (Y!l-1-7:17:-~t\. or J.,sc- J .. :~:-1) is of grc;at bt~re::t. Clln· /] .. )s;.~ ,; ..; .) \ / its analges-ic ~te.ncy L'1 ~"li"'1r-ls !s cl.c:ost eq~ to that o! ccdeir~. In ior::1er !clletVing or..J. ad!?:~nistr.illon of as much as eOO mg orally- or 12J mg intra- _.,·. • I ~;.-pre!:.!'-!r:.·J' e.octi-:1ence fro~ morphine-: Foll'?',•.rin~ a!:J!"Upt wit.'ljnwal c! .. whic..1. not yct obtained. Amcnq the objects o! ths are to ~r:::tph h~ b~e:n proj~~~ '\ ,,-·~ ! •, . - .. . '---=~ ..:i_., .;., .. ..~· T....:, ar;!... ~'-""'n•• ~~• d c·-t.~. ~.o,....c..,..t_.ra .-l.~.... Q.., ., a_ , 1'"'P ... o ,. . n A.e ot n ••~. c .... z . .~ - l . ~ .J : " 'i "" : " t '" " "' : l ei" • r . e cUu ..,. a c.s !s ~-- ... t .._ - _ ~mo - · I cl . h .... • J " n to:- cl / 1 My 1951 1 Jul7lGG2 we to test the clinical E~een a~d 1'ropo~e ,, ·been recorm::l~ad tor study by tha Committee on Dru.q Ad:i!ct.icn and e) !"ollowmq this, ct'..1dies on the and !ate o! ope~tton. m~h.c!1sm I-~:-1, . . R-1132. acd propox:rph~ru) will be i.~iatcd. ' _,'. . 5. / descrfue-j !n project descrlpUons which should be for pre~.cuz con:~ultc.-d de taUs. ' pu. various ~epa.~t!on ircm bpuriUes by pa;e . r ch. ". "'mctcgraphjr, :uld . 7. . - t..vlll volunteer for e:-:v-~rlmen~ with d:f'iJgs, a..~d 2) strict env!rom::.ertzl cor:trol, . , . 8. . '."!.:_....,.. .. ~ The page is a declassified document, likely from a report or proposal, with a handwritten annotation "187" circled in the upper right corner. The typed text discusses "The Addiction Liability of Synthetic Substitutes for Codeine" and references a request for renewal of a contract with the Office of Naval Research. There is another handwritten annotation in the lower right corner that appears to be "B-346". No photographs, diagrams, or evidence of experimental procedures are visible. The content is primarily text-based with minimal visual elements beyond the handwritten annotations. / descrfue-j !n project descrlpUons which should be for pre~.cuz con:~ultc.-d de taUs. ' pu. various ~epa.~t!on ircm bpuriUes by pa;e . r ch. ". "'mctcgraphjr, :uld . 7. . - t..vlll volunteer for e:-:v-~rlmen~ with d:f'iJgs, a..~d 2) strict env!rom::.ertzl cor:trol, . , . 8. . '."!.:_....,.. .. ~ ~·· .... 1 . .l..• t"e~l", ·I -) G. E:::Umated Cost I. Tiarl'l.s !sb~ll, M. D. Ci.re-ctor 12-28-60 ... The page is a typewritten document, likely a report or memo, with handwritten annotations at the bottom right. The text discusses new drugs and their effects, mentioning analgesics, antitussives, and their addictive properties. The page appears to be numbered "Page 2" at the top right. The handwriting annotation, "B-245," is located in the lower right corner, indicating a possible file or reference number. There are no photographs, official stamps, diagrams, or visual evidence of experimental procedures visible on this page. The page is predominantly text, with very little visual content beyond the typed words. There are no photographs, diagrams, tables, or forms. The only non-textual elements are two dark circular ink marks near the top of the page, possibly from a binder or loose leaf punch, and a handwritten annotation at the bottom right reading "B-344". There are no visible official stamps or redactions. The overall impression is of a typical, unadorned page of a research document or report. The document is a single page of typewritten text, with a few handwritten annotations. At the top right, there's a handwritten note "Page 4". In the bottom right corner, there's a handwritten annotation "D-343." The text discusses the need for continuation of a project related to codeine substitutes and outlines proposed work involving the testing of various chemical compounds. There are no photographs, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. The document page is text-heavy, with no photographs, diagrams, or forms. It contains an official "Page 3" stamp and a handwritten annotation "B-342" in the bottom right corner. There are no visible official stamps related to classification, and no redactions are present. The text describes the project's methods for studying the excretion, metabolism, and fate of codeine and other substances, as well as the biochemical methods used for separation and identification. The document is a typed page with some handwritten annotations. A handwritten annotation in the bottom right corner reads "B-341". There are no photographs, diagrams, or official stamps. There are some dotted lines and smudges scattered throughout the page, which appear to be incidental to the printing process or document handling. The text describes the "Location of the Project" and "Experimental Personnel" for a research study. This page contains typed text and handwritten annotations. The typed text includes a page number "Page 7", a section heading "9. Estimated Cost" and accompanying text describing estimated costs and money requested for fiscal year 1961. Below this, "HI:tkh", "Attachment", and a date "12-28-60" are typed. Another typed section indicates "Harris Isbell, M. D. Director". Handwritten annotations include what appears to be "B-340" in the bottom right corner. There are no photographs, stamps, forms, diagrams, tables, or redacted content visible on this page.

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