Doc 0000151794

.oe --- ~· ~-}~) -- DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLlC HEALTH SERVICE 27 September 1961 Madoaal l~utlue o( Muca1 HeaJc.b A44iclloo llctc&Rll Ccoter u.s. hblic Kcaltll :.Cmcc Hoapital l.csiDJtOII, ~lli'IICir.T .. ' ~){;;) ·; . :I I ' ! ! . . •. : . ! • r '* • ~ ¥ ·------·-- ____. L_._:_ _ : -1-... :·--"-·. !i_ ··~ ... ·- ...~ called me .on this date concerning diphosphopyridine nucl~otide and.alcohol. I promised him I would write him concerning the information I have on this. I have the ninformation for Clinical Investigators" prepared by Abbott Laboratories. The material is undated and consists of an introductory section which attempts to build up a theoretical back ground for the use of DPN. T.he second section is on the chemistry of the material; section 3 on the pharmacology, is blank; section 4 on clinical studies, deals with hangover-in nonalcoholic subjects. Tne studies were done on only 2 men, and apparently there were no measure ments on blood alcohol or blood acetaldehyde levels. Section 4B deals with treatment of alcohol withdrawal and section 5 syndrorr~, with dosage recommendations, references, precautions, and aft~~mich contraind.ications table, and suggested forms are given • •. I also have a paper, "Pyridine nucleotides in the prevention, diagnosis ·and treatment of problem drinkersn by Paul 0 1Hollaren, £2: West. J. Surg., (2) 101-104, 1961. · The material in both of these reports is unconvincing, but possibly some little work. might be indicated. Since the theoretical background is hypothesized, more rapid removal of acetaldehyde, determinations of blood alcohol, and blood acetaldehyde levels should be done if behavioral changes indicate any gross effects on drunkenness ei~her or hangover. ) -·"' ': .· . .;. _ .,.}.,, t \ As I also told Dr. Treichler, I am embarking on a ·study of cross tolerance bet1·1een scopolamine and JB-318 and I.SD. We are just beginning the first phase, \'lhich will involve determination of proper dose range for scopolamine and JB-318 intramuscularly. Following this, comparative potency evaluations Will be made, after which the chronic tolerance phase would be undertaken • . 0 Sincerely, I , , ! I ,!J ;'tft/.;':.Jl/----;:/J";..t.([f / Harris Isbell, M'.D. Director The image displays a digital representation of information regarding declassified documents. Dominating the left side is a stylized graphic of a circular vault door with intricate mechanisms and glowing blue accents. To the right, white text describes the origin of the document from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection. The text highlights that the collection contains over 20,000 declassified pages from the CIA and provides a web address for downloading the entire collection. The overall presentation is digital, aiming to inform the viewer about the source and accessibility of the declassified material. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, or redactions visible. 0 Sincerely, I , , ! I ,!J ;'tft/.;':.Jl/----;:/J";..t.([f / Harris Isbell, M'.D. Director The document is a typed letter on official letterhead from the Department of Health, Education, and Welfare, Public Health Service, dated September 27, 1961. Handwritten annotations include a circled number "199" in the upper right, a circled "(b)(3)" to the right of the letterhead, and handwritten notes regarding the content at the bottom. Additional handwritten notes include a signature and "Harris Isbell, M.D. Director B-360" on the lower right, and a scribble that appears to be "0-211" below a paragraph concerning blood alcohol levels. There are no photographs, diagrams, or organized data tables present, nor is there visual evidence of experimental procedures or facilities. The document appears to be a standard correspondence with minor handwritten additions.