Doc 0000151796

The image displays an illustration of a vault door on the left side, rendered in a metallic gray with glowing blue accents. To the right of the vault, text overlays a black background. The title, "THE BLACK VAULT," is prominently displayed in large, stylized white lettering with a blue glow. Below the title, a paragraph of text in smaller white font explains that the document was obtained from The Black Vault, an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection. A yellow hyperlink, "http://mkultra.theblackvault.com," is also present at the bottom of the text block, indicating the source. '.!:H.~ ADDICT!mt LL".:3!LI'~S Or;t S'71~T.dE'.t'IC SlmS'n:TUTES FOR CODZI1S F..arris Iabe ll ~~-m Addiction Research C.;;nter., PHSJ Lanngton, Ky. H.F. Frasor~ A.rlikler \i.R. ~lart1n and A.B. Wolbach 1 RAonr 21-61 -~ To dcve~op eyr.thetie substitutes for codaine~which are as e.t"f'ective ·as codoi~ tor rclie1~ of pain, cou0h and diarrhea., . but which :ha.ve l~s o.ddietivc :oropertie!} • , . Test~ o~ the addictivcnass of fiv~ potential codeine tJUbstitutea uas CCl'n1)letod during the year. One of these, 1-{p-Chlor-phenethyl )-2-rnethyl-6·, 7-dimethoxy-1, 2,3,4-te tra hydro-isoquinoline Hal (!-K-1), was describad ~ l~st year's ab3tract. ?urther te3ting of this asenc 5upportcd pravious. results .-- it r~3 little or no add1ct1ver2S3 even when t;ivan intravenously. Since tho oocpound has been reported to be as ef~eot1ve a3 codeine as an analges1c it is o~ 1 great interest. . . ._ 1~2-D::tmethyl-3-phenyl-:;-p!'opiono:cy- pyrrolidine Hcl (!·0-lJ also ~roved to be lesa addictive than codeine. The or analg~sic effects I-0-1 hot~var, can be questioned and 1 clinical toxicity is high. Ethyl l-(2-Carbaroylethyl)-4-phenylpiparidine-4-carbo~~­ late Eel (I-D-20), an antitussive agentJ 13 devoid or a.ddi c ti\ --ene sa • Tiio other drugs, 2,2-Diphsnyl-4-{1-[4-(U-pipericline )- . 4-earboxa~~d~]-piperidin~}-butyronitril~ (I-D-21) and · d-3-Dir~thyla~no-1,1-diph~nylbutyl ethyl riulfone Hcl TI-C-26) proved as, or more, addictive than codeine and ara being dropped £rom rur~~r L~estigaticn. !3 -J 70 -~ ..... ·"J• PLAlt3 FOR FOTURE . . (a) Long rar..ge ~ Project will bs continued until the Co::m.i ttee on Drug Addiction and Ua.rcotics, Nat1or..n.1 F~search Council, i'eels thAt adequate subst:1·tutaa for codoino 1n all therapeutie "applications are available. (b) Ir.m!d1ate. Druz~ to be tasted dur~!S the coming year include: d-Phena..-r9r-ol'!!id (I-J'-:;) { 1-2 • -!!.;rdro;cy--2, 5, 9- tri!:Cth~,rl-6-., 7-benzomorphn.n HEr (.I-H;..2H-l-Dimthylamino-3- ~he11j"lindane Hcl (I-N-1); .;t-!Iyd:roxycthoxyathyl-4-phenyl- 4-prop1onyl-~ipe~idina Hcl (I-D-22). '/ CURHE:l:r REPORT~ AUD PUBLICATIONS (a.) 1I. F. F~ner an:i H. Isbell' (1961)" "HurrAn ~~r~aology and addictivcness of Ethyl-1-(3-cyano-3,~­ pr~nylpropyl)-4-piperidine carboxylate (R-1132 Diphenoxy 1 lata). u l3ull. l~areocics., 1:;., 29-43. :a. (b) H. F. Fraser,,- W. R. lo!art1n, A. !ofolba.ch and . R. Isbell (lS(?l )·, "Addiction l1o.'b111ty ot: E~.!l isoquinolina annl6~sic~ l-(p-Chlorphcn~thyl)-2-ccthyl-6~7-di~~~ozy­ l,2,3.4-totrahydroisoq~;.oline." Clin. Ph.arn-acol. Tb.erop. 2. 237-299 ; (c) H. F. Fraaer and A. B. Wolbach, Jr. (1961), "~~~ addiction li~bil!ty of Alpha-dl-3-ac~toxy-4,4-diph~nyl-6- moth-:;la.tlino 'heptS4'1.a hydrochloride (HII!-7667, ..' \110. !-C-25) and 6-Acecyl-3-etho.:.ydlli~"d.roreorphir..•:l (lr.t!I-7623, A..~C I-A-38) .a Eull. D~~ Addiction and Narcotics, Add. 2, pp 1-3. 23rd r:eet., Col!ml. Drug Addiction a.'"ld ~/areot1c3, Na.tl. Res. Couneil, Wanhingtcn D.C. Natl. Acad. Sci. 1 ..,..... __ _ -~ r'}a ...~ ., / l This document is a typed research paper with several handwritten annotations. At the top right corner, there's a handwritten circle around the numbers "201" and a handwritten number "B-370" at the bottom right. The text itself discusses the addiction liabilities of synthetic substitutes for codeine. There are no photographs, official stamps, diagrams, tables, redactions, or visual evidence of experimental procedures or facilities. li~bil!ty of Alpha-dl-3-ac~toxy-4,4-diph~nyl-6- moth-:;la.tlino 'heptS4'1.a hydrochloride (HII!-7667, ..' \110. !-C-25) and 6-Acecyl-3-etho.:.ydlli~"d.roreorphir..•:l (lr.t!I-7623, A..~C I-A-38) .a Eull. D~~ Addiction and Narcotics, Add. 2, pp 1-3. 23rd r:eet., Col!ml. Drug Addiction a.'"ld ~/areot1c3, Na.tl. Res. Couneil, Wanhingtcn D.C. Natl. Acad. Sci. 1 ..,..... __ _ -~ r'}a ...~ ., / l November 1961 ADD!C·l'J.ON LI!~n.:tTY OF ~C 5UBSTI'!U':BS POR COD~nre (Project Description) . or Paq;J.~Gt to th.e Ot.!•!ce .cf Na.\~ Rer::ear:--...h t:cr f~~..ewal C~ntracy !:tJt.onr 21.-61, H.R. 101-149 ' 1. E..'.l cl-!r"S,rom1d L"lf O!'!l".:l ti? ~ SL."'lCo 1931 the National I.'Wtitute oi: ~!ental Health Addiction· Reneo.rch Center has 'been carry-'~ on a. project \lith tha objeet · . a.s sara as tr.!lt c.L'"I..tG w.tth re5pe.ot to toncit:r and addiction l:1a.b1llty, and ;thioh al$0 1-iould 1:-e aa effoctive ao codeina an P~ssa..~h. T!Ua c!aecrlp~ion c~nstitutas a roquest for raneiro.l ' Of the pr0j0eb f'or the. period 1 Ju.l-7 lg62 to 30 J'Ul1~ l$6} • .. re.o projeot 1nit 1all7 undertaken beea:u.ee codoine \-n\3 l':SS tho t""~at widely used tl!l.reot!c drug 1n both civilian and trl.l:!b-.7 practice. Since codeir...-3 ia derived ·.rrom opium, or n:ad!'! tro: morDl1!ne dorlved from opium# !t t~a.n n.aaec~a:oy for tto United State~ to stockp~le op.i. um in orj~r to j_~ura n supply o~ codeine 1."'1 tr.s evont of' yar. 'fho f'acil1t1es of tha lm·:H A.a.dic'tion Canur t:ere not sutfie:!ont to ca.""17 r&~a.arch out too \1ork \:11thout tu.rthor t'inanc1r.g_ by the Departrcent of i. Aceo:r::Jlish:;d ., :-- Appl'O~tG17 70 qollllJoundo h:~:;c been e:mcln..~ in the 10 ycn.rs t.'to proj.l~t llas b;:;en op3roting. · '!-wo nor.addictive., . . anti tu.ssiv e devclo~d.- .. tr.a isoqu.inol!na drJ..g knoi;'Il cthcheptaz~ ,9.-pt·opo;eyph~~ ar.~d a~ I-K-1. D.ip.~eno~ylate (R-1132) is a potent antid!.arrheal .. "; c!.or1va.tive- (~-K-l) ws co:pletea. not ind1.teo aubJactiV@ e.f£octz; it 1a 1r..e.f!"eetiva morphin-e-11.~ 1n supprGtlSi..'l.-5 n.'betinence from corpl:.ineJ and dee:;, not create ph;raical de~end.<J-nce when givea ehrcnical17 i."i m!r:.ally tolernt.ed doae5. Uvnetl1cleas it ha.o been roportad. to te aa effocUvo an .:L"'l relie,;-i. ... pain in .. ¢lin!c al • cedeir~ "lr~ ~11-controllod ~:t~d!es ~ insol~bility~ .8-J:- 7 .) ' A pyrrolld1.r..a deaic;;r..a ted by- t...""le eerial number ccmpo~ I-o-l ii:l.::l otv.d1e.d- durin;; tr..a :rQar. It i.~duce2 only a. partial or 3!;)eat..~.l:u ~ri)h.ir-.2-li 1~ ef.t\::~ta in f~l"::'lSr atldic ts a.~d ia more potent nhen given orul:r tr.an when s;1ven il'ltrov:enously. It SU!),?I~S:las aostinenca t•rom t:l-Orphino to only a olight degree. ld.thd:-aii frc!Zl tha e~ri::ent. '1!he drus thers:rora has low . a.dd1ct1veneaa The page contains typed text in English, organized into sections labeled "PLANS FOR FUTURE" and "CURRENT REPORTS AND PUBLICATIONS." There are no photographs, diagrams, tables, or forms. A handwritten annotation "B-369" is present in the bottom right corner. No official stamps or redactions are visible. The visual content is limited to the typed text and the handwriting, with no visual evidence related to experimental procedures, equipment, or facilities. otv.d1e.d- durin;; tr..a :rQar. It i.~duce2 only a. partial or 3!;)eat..~.l:u ~ri)h.ir-.2-li 1~ ef.t\::~ta in f~l"::'lSr atldic ts a.~d ia more potent nhen given orul:r tr.an when s;1ven il'ltrov:enously. It SU!),?I~S:las aostinenca t•rom t:l-Orphino to only a olight degree. ld.thd:-aii frc!Zl tha e~ri::ent. '1!he drus thers:rora has low . a.dd1ct1veneaa bu.t it~ s tox.icit7 na7 clinical use. p:eelud~ / . compound in th¢ aeries by --\net~:" zr:;!peridi.~ de51~tcd nUl:ber I-D-20 induced no mo:-ph!ne-liko t~ se~-al a~bjoctiva or or er..recta rega.-d.less the· route aQinistrat!on. It did .. not 5-unureas e.l:sti..--wnce. J:t thercrore :Us not e..."l ad~ctive eomponrA a.."ld rt:a:~ ievrs~ant ~"la third uaerul S..."'ltitu.3siva deverloped in t.~ prog..~. 1-i.~O o£ t..i.e CO..~OundG knO'Wn as I-D-21 (a -w::t!lzdon.a derivative) and I-C-25 {a. mathado!"~ dsr1vat1ve) both Pl.""'Vad to be at least :l:). addictive a5 c~ine and r. . a :v~ bt!en dropped r.rom. ~rt..'1cr eonn1dera. ti.on !.~ tho. program. Although a g,.."""eat daal ~ prcg:-eos has been made, ~~ still no :;in.cle drug t•hich iz a.3 oi'fect!va &"ld ucnto:.ic aa poases~ code in~ for all th~ purpot\03 tor ... ¥ .hich codeine in uood • codeine in i.•"".ducing a..'lalgeait!.., and both a..~ mON t-o..."d.a. I-K-l ~;3 auitabla _or.l;r tor cral u%1e. In addition, da.tca are naadad on ~~e a.b'sor,tion, e;te:-ation, distribution and f~te or ., 30 r=et~ l J'uly 1962 :md Juno l$6;i wa proi)Ose to test '1 tha clinical pha.~ool?S:! of rour drll3_~; £-phel"...ru=?rorrdd (I-J-3).; as a.~other ~perlclir'..e S:~titu.snive knovm I-D-22; an ir..dane It the gas chro!:!Eltogra.ph, wlUch !a en crder, 'beco~s a.~-Uable, 11crk w.1ll bs initia~d on the t:=3tabolism o£ codeine .. tuid e.vantunll;t this 'dorlc will be oxte~ed to the :::ota.bollsm cf I-K-1,. ~--$JAtr"....methol"'~~~ and ~..e o~ tl"'..!l a."ttit-..u H~ivcs o~ 5. Hcthcd!l ~~thod~ uzad a.~ atar~rd ~dic;ion liability tgstino canter. =thod:J ~- tha tl1:'1H Addictj.on P.osearch Tlla-~~ test:1 aro accept3d e.a s-tandards for lgg3J. acf;ion by' tha C~.ittce on Drus Addiction and 11areot!c:n., 1!at1or..al r-esearch Ccuncll,_ ... nnd cave been daacr~bod in previo.u s p~ojGct d~~cr1pt1~~ - eolYents at va...~9uu p~., separation r-rom il:puritias by rA.per e.ll.roca.tozraphy, and 1dentll'1cat1on bl' a· variecy or end rea.ot.!or~ inel~1ns gao chro~tcgra!)hy1 ultraviolet sp-sct·ro- ~-. r.a.:l Er-luat!on of tho data been ¢0'"/ered in proviou~ de5oription3. - / 1.. Location or the P!'o.jeet provideo t-1~ ~o XlSCi)Ssa.r".f i'ae1l.1tiez for the t:t""F~ ~ work to be undortal'~nt (1) a pcol or yjatunts lrllo uUl voluntoer tor e~~ rizr:.enta with CL-ugs_. end (2) strict enviro~ntal control The document is a typewritten page with a handwritten annotation in the bottom right corner. The annotation appears to be a series of letters and numbers, "B-368," possibly a file or reference number. There are also two dark circular stains near the top center of the page, which might be ink blots or smudges. No photographs, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures are present. The content is solely text and these minor visual anomalies. sp-sct·ro- ~-. r.a.:l Er-luat!on of tho data been ¢0'"/ered in proviou~ de5oription3. - / 1.. Location or the P!'o.jeet provideo t-1~ ~o XlSCi)Ssa.r".f i'ae1l.1tiez for the t:t""F~ ~ work to be undortal'~nt (1) a pcol or yjatunts lrllo uUl voluntoer tor e~~ rizr:.enta with CL-ugs_. end (2) strict enviro~ntal control ~.iell p:"$v.enea int...~du.otion of d..~tZ5 ot.."l.er than thoec .. a. -- ·rield. E3 will 1:,e aesi:stad 'b7 t1~0 oth~r e,Aper1anc.ad ph:1d~ia,n.:;s1 Drs. ll. P. Fresar and Abroliam. Wiklcr~ both of whom h~va det".e r.;sc~h in a.dd.iotion and have r::m::1 publ.icationa. and recaar~'l psvcllolcr:;i3t are aloo o.~~1ablc. ~~~ . . ·;,.~ F..a.rrla ~bell~ M.D., DUwcator "· ~ttkh. At tachlra..Y"J. t ( l) . . : /3-)/~ ·I The document is a typed page with a handwritten annotation and stamp at the bottom right. The annotation reads "B-367" in dark ink, and a partially visible stamp appears next to it, also in dark ink. There are no photographs, diagrams, tables, forms, or official stamps related to classification or routing. No visual evidence of experimental procedures, equipment, or facilities is present. The page contains primarily text detailing the progress of a research project. The provided page is a typescript document with handwritten annotations. It features the title "Project Description" and "Page 3" in the upper section, along with three circular markings, one of which is filled in. There are no photographs, diagrams, stamps, or forms visible on the page, nor is there any evidence of experimental procedures or facilities. A handwritten annotation in the bottom right corner reads "B-366". The document is a typed page with handwritten notes. Two dark, imperfect circles are at the top, and a page number "Page 4" is in the upper right corner. There are no photographs, diagrams, tables, or official stamps. The text discusses the "Project Descrip'on," specifically the "Work Proposed" and "Methods" related to drug testing, including codeine and other synthetic drugs like I-K-1, I-D-22, I-N-1, I-H-2, and levomepromazine. A handwritten annotation "B-365" is present in the lower right corner, suggesting a document or item identifier. The provided image is a scanned page of a typed document. It features dark grey text on a white background, with a few dark circular bullet points at the top. There is a handwritten annotation in the bottom right corner that appears to be "B-364". The text discusses experimental procedures, facilities, and personnel related to drug research. There are no photographs, stamps, forms, diagrams, tables, or redactions present on this page, and no visual evidence of experimental procedures, equipment, or facilities is discernible. This is a typed page from a document, likely a proposal or report, with some handwritten notations. At the top right, "Page 6" is typed, and a handwritten "B-363" appears at the bottom right. The text discusses personnel and facilities for research studies, mentioning physicians, a biochemist, and a neuropharmacologist. It also refers to an "Estimated Cost" and an "Attachment (1)". A signature block for "Harris Isbell, M.D. Director" is present. There are two dark circular dots near the top of the page, which might be part of the original document's binding or a visual imperfection. No photographs, diagrams, or evidence of experimental procedures are visible.