Doc 0000151804

--- ... --..- DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE 21 March 196 2 lCau ... u l ..d tllla ol MoAtal Hoaltll U.S. A P 4 1 4 1 k bl t i l c o a H c l a l l c tl u l a S "' c l " l ic C o c a H 1 o et a pltal .. , .. t.eziap11 lteancky 0 • (bJ0~ -~ I I / a bottle labeled 3,4-tetrahydro- received~today 9-Amino~l,2 acridine. On checking my stock I find that I have 5 grams of the material which was obtained in October through Dr. Ray Shelton, 1Villiam S. r·1errell & Co.,.·and which is labeled tetrahydroaminoacrine. This presumably is the same material as that used by Samuel Gershon ("Blocking effect of tetrahydroarninoacrine on a ne\1 psychotomimetic _agent, 11 Nature 186: 1072-1073, June 25, 1960). In that article tetrahydroaminoacrine is designated 1,2,3,4- Tetrahydro-5-aminoacridine. The structural formula given in the however is identical with the structural formula on a~ticle the bottle I received from the Applications Development Company. I presume that both the compound I received from Merrell & Co. and the one you sent me are the same, and that the difference in naming is due to some differences in the conventions for numbering the ring system. However, would you please have the chemist check this for me? Dr. Utterback spent yesterday and today \'lith us. I have tried to impart to him my philosophy about clinical testing of new drugs, including the necessity for measuring things, estab lishing the reproducibility of the measurements made, doing dose-effect curves, and making proper statistical designs. Kindest regards, ;ltv,~ Harris Isbell, r<LD. Director HI:rn /J-)7!' The page displays a dark background with a stylized graphic of a bank vault door on the left. The text "THE BLACK VAULT" is prominently displayed in a white, brush-stroke font at the top, with a blue glow effect. Below this, white text explains that the document was obtained from The Black Vault, an online database of declassified government documents, specifically referencing the MKULTRA/Mind Control Collection. A yellow, underlined URL, "http://mkultra.theblackvault.com", is provided for downloading the entire collection. There are no photographs, handwritten annotations, signatures, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures visible on this page. The document is a typed letter dated March 21, 1962. At the top left, it features a circular official seal with the text "DEPARTMENT OF HEALTH EDUCATION AND WELFARE." There are several handwritten annotations: a circled "2=f." and "(6/3)" near the top, and a signature "Harris" above the typed name "Harris Isbell, M.D. Director" at the bottom right. A numerical notation "B-378" is also visible in the bottom right corner. Throughout the document, there are scattered ink dots, possibly from a typewriter or age. No photographs, diagrams, or evidence of experimental procedures are visually present.