Doc 0000151811

·~.- - ·- ~~ ADDICTIOS ti.\Ditrri!S 01 SY!a'tHE?IC SUDSTITU'l'ES FOR COt:.::tiZ: Harris n~ell lOJ.'1 . 1 Ad41ct1on Ruea.rch Center. fll3, Lexi-ngton. '!::1· a. a. i'. haaer. A. ~~er. V. l!artin and l). E. Rosenl::erg .:' !Q davelop ssnthbt1c substitutes ro~ codeine which are less a~dictive than co4e1M. ·J ~stins tor ad4iet1veness vaa completed or 1s 1n pro::;ru:s on the tollow1!l!I lUna compoun~ c!Uri.ng the reporting p.ar: (l) 1.2'-B':t·dro::o::r-2,5.9-tri=th7l-6,7- benzcccrphan (I-n-2); (2) 1.2-H;droxr-5.9-d1ceth:l-2(2-pheneth7l)-6,7-~n=o=or?h~ (I-S-l) gir-n oral~; (.}) l-Et1drox¥ethoxyethyl-4-pheeyl-4.pr<r;)ioeyl-P1,er1c11:le U-D-22); (4) ~thotri=epraz~ (levomf!promaz1n.e, VI·C-5}; (;} l-~t~la!Wlo-3- ph~li~dane (1-~l); (6) 2·AcinD-~9 (I-S-2); (7) =iXture ot I-P.-l (:es above} and II-<!-l (5-allyln.orpheca::oeine}; (8) 2j,.,icyd...-..ox;r•5 ,9-dir.athyl-20 .:5-di:~tl".ylallyl )- 6 .7- 'ben.t.omo1"9han ( !.I..C-2); · (9) 2e\,"'yclopropyl.Jr:;eth;rl-2' •hyd..'""OXl-5 p9-~t~l.-6. 7- ben:=orph.a.n (li-e-.)). Of these. t-l:I·l (crs.lly) an-d the mixture ot I-H-1 and U..C·l p~ve4 to have ad614tiv~ness gre~ter than codeine and have been dr¢pp€d ~ further consideration. I-D-22 (an allt1tus=1vs) an4 II·C-2 had lees addiet1venes21 tr.an codeine. n..e-2 d:serves t'Urther 1J1\o·e=t1gat1:m as an analges1::. I-~-1. I-n-2 and VI-C-5 bad no add1etiveness. I-H-1 and I-fi-2 are prebnb17 too tone for ellnieal u:se. VI·C-5. a ehlorpro:a:!ne ~onzener. de$erv9a extensive inveat1~t1on in chronic pa.in. II-C-2 bu eon.si~rable theo~t1eal int"reat, sinee 1t is :::orphine-l1ke behaviorally and creatc3 nild p~a1oal addiction but will not 5uppress a~st~nee trom PJOr?hiM. u-c-) 1.S st1ll ~1ng studied. (a) tons n%1.';8• •,;or!c V1.ll be continued bu-t 'v1ll be tiniah~d a.f~l"' l Ootober 1962 bJ th• iat1onal Ir~t!tute~ ot Uealtb rather than by orr1ce of ~~1 Reacareh. (b) ~dinta. Drug~ to be tested du.~ng the cca!n; yea~ 1neluda II-C-' (~ aboTe) • l4-hydroxr-i-all3l•dihjc!rOt:Ot'Ph.1ne, and sueb otlnl"' ocs;:toun(!s aa !U'8 rec0f"..m=n4o4 by tha Co=ittee on Drug Addiction a.."l4 liar0ct1es. ~t1or..al fu!~a.rcn ., CoUncil. (a) Praser, !. P •• ~aa1g, c. 1.~ and Hol~=~· A. ». (1961), •t7al~t1on ot caruopl."'dol and pne~dol tor ac1d1et1nneso.!l :8111. ~reotica, '1:5, 3-i. r. (b) V.ol~h, A. D. and ~ser, B. (196~), "Addiction 11ae111t7 or EthYl• l-(2-ca~tnyl)-4-?hen7lP1P~ridine-4-carc~X1l2tO ~dr~hlorida." ~llctin Drug · Add1etio.""1 and Na:ocoUca, ~t1onal aeiearch Council, 'Jashi~ton, D.c. (t::.,:l. :-..~ .. ,.-:.:. ·., ...... . ..._:_. ) \..'-"--" ~. The image displays a graphic header for "The Black Vault," an online database of declassified government documents. On the left, there is a stylized illustration of a vault door rendered in shades of gray, silver, and electric blue. The text on the right explains that the document is from the MKULTRA/Mind Control Collection, housed at The Black Vault, and provides a URL for downloading the collection. The overall aesthetic is dark and technical, with the vault imagery suggesting secrecy and unearthed information. The document is a typed research paper with some handwritten annotations. In the upper right-hand corner, there is a handwritten annotation "223" circled in black ink, along with a smaller annotation "M". In the lower right corner, there is a handwritten notation "B-402". There are no photographs, stamps, diagrams, tables, or redacted content visible on the page. The document appears to be a report on synthetic substitutes for codeine. This document page contains typewritten text organized into sections titled "PLANS FOR FUTURE" and "CURRENT REPORTS AND PUBLICATIONS." There are no photographs, diagrams, or structured data visible. However, there is a handwritten annotation in the bottom right corner, "B-401," that appears to be an identification or filing number. The document also has some small, scattered dark marks and smudges, but no significant redactions are apparent.