Doc 0000151812

• --·· ., Janua,r.r 6, 1958 Dr. Rarris I:Jbell A:!d.iction Center F.c3~areh u. s. Public l!ealth Service Hospital P.O.~ 2COO I.e%1 ngton, Kentucey IY-"..ar Dr. Isbell: 'l'l:lan1t you verJ much for you:r: interesting a.nd belpt"ul. report on the effeets of epinephrine. Your f'1M1Ilgs in this re~ agree Co::!!pletely with others that I Gm f'~liar vith. or We ere e.t present involved with ths problem aseo.:yin.~ clinicall;r the posoible psyehotcmit:letic effects of an alcoholic e:.'traet of a. certain t~ ~ :f'Ull.:,-us. T.oe chemist vho .is doing tb.e iaolation vork ori~lly u.ced hi:ls~lf as guinea -pi,;, but is ncv willing to turn thia over to more ~le:lted. h:"tx1s. ~ found. tbt 10 gram:s at tba dried f"~ prcduced a state of t=ntal. contusion involving Visual Ulusio:lS and. :possible ~llucim• sane tio.."\S alo!lg Vitb. nti~ling on the skin and -periodic brec.tl:ll.eaanass ll. To ey lmowledge, he bas taken t~ ~s, both i'resh aZJd dr!ed, a.t lee.3t or f~ di£ferent times ee.ch frc:m a. diffo:.-ent collecticn the aam ftm,..i7.US, including t= sa:c:pla tllat he is j?resently' working vith and each time ho.a experienced. the ocw:ce effects. Further, he. bas pre!)ared nn ethanolic extract of th!s dried flmgus a.lld. lyophilized it. 0.15 grams of this e.."~Ctrne~ is cquiv o.lent to 'l.O grams of the orit.,~l dried ful:lgus. Our chemist tried a dose of thia e.."ttra.et equivalent to o. ·10 gram dose at the ~""US and re!)orted ef'fects equal to cr ;reo.tor tban those he b.a.d preViou.sq experi- enced. · I am eendillg you e.~rcrx!:stel:y' 20 gra:c:s af the el.~:rn.ct \Ulder se-;o....-..e.t~ cover. You will find that tb! m.ter:tal is '\Yf!r'J byg:-oscopic ar..d. sca:rewtba.t sol':lble in wter. \:a baw on band. a su.ffic:ient supply of the row :r.:::.tcr.ic.l to Ca..rr.J cut extensiw isol.sticn e:q:er:tments a.s aoon as -n-o have wrificd the ncth"ity or thia proli:li%l:3.l"y extract. We inte!ld to follC"'.t tl:e extrccticn.:.:: prcce3s reutirely by s..--til::al testing backed up Vith an ccca.sionnl c.bbrevi.:lt.ad. clinical trial. I ac enclosing a. copy of the a.n!I:ln.l work tba.t has so :l:'o.r been en_-ried ou.t on this mterial c.lcng ...~. th a. report on "unknom" LSD-25 i'rC!!l th~ aa:::s l!looratOI'jl' f'Ol.• ca;:pari3cn purposes. 'l'he lar~e dosca requirtZO. fCl" t1:o "~!-:n~m" LSD-25 arise fl'"~ the i·a.et th:l.t \.~ supplied the a.asay le.":)orntory "'·ritb. a. \~!""./ dilute ~ru:xple of col:id r:.a.teria.l. Tl~~ ~thcdD ar:.d. prooe::!::.t.?"OG uaed. in tee 1..o.boro. tor.r doiiJg thia vm·lt 1'or us o.nd Im.l.Ch of tl:e _-, /3 '- The image displays a stylized graphic designed to promote the website "The Black Vault," which houses declassified government documents. On the left, a detailed illustration of a bank vault door with intricate mechanisms is visible, rendered in shades of gray and accented with a bright blue glow. To the right of the vault image, white text in a handwritten font declares "THE BLACK VAULT." Below this, more text in a standard font explains that the document was obtained from The Black Vault, an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection. The website address for this collection is prominently displayed in yellow text at the bottom of the image. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures on this page. f'Ol.• ca;:pari3cn purposes. 'l'he lar~e dosca requirtZO. fCl" t1:o "~!-:n~m" LSD-25 arise fl'"~ the i·a.et th:l.t \.~ supplied the a.asay le.":)orntory "'·ritb. a. \~!""./ dilute ~ru:xple of col:id r:.a.teria.l. Tl~~ ~thcdD ar:.d. prooe::!::.t.?"OG uaed. in tee 1..o.boro. tor.r doiiJg thia vm·lt 1'or us o.nd Im.l.Ch of tl:e _-, /3 '- --· < - ..... ___ a.ctual tr:l.ining of the tecbnicians involved w.s direct~ supervised by Ed Felib'n, vho continues to follo.l the work done there 0:1 a consultant bc.nie. I feel that knCYin; this, you vil.l be better able to decide he-W" '1:1Uch confidenco that you wish to :place in these results. If I cs.n sum\LY you Vitll e.ny other inf_or:ntion about the mterinl vhich vill help you · :_ to get it to the point ot clinical tri&l I'll be veey glad. to do so, an,., j we c.re 1:10st flll:d.ous to get sane expert evaluation c"f these effects. !> • I am alae sending you five gre.:!:8 ot synthetic mterio.l in vhich ve are interested. This l:l.tter substance is the nitrogen a.nnlcg at tetre.l"..ydrooa.nn.abinol (fi·.--e-cerbon side-cio..ain). It is a pure ca:poulld and although it exists as the hydrochloride, it i3 not very- solubla in ve.ter. We call the material C-5 and as YO".l Will see by tha a.ttnched lnb crator:r reporto it bas DQ;!O interestillg proporties. I am including pharl:a. cological re)?Orts on "unl-':Ilcwn1 C-9 (di='"thyl-heptyl) fran the a=ra l.abors.torJ ' for can:parison. As you vill note frCll the doses, the "unknctm" C-9 a33c.yed ws supplied in very di.lute form. A question that occurs to me in connection w:l. th cllnica.l ·work on these canpou:ads is whether it vould hel:t? ycu 1f ve i:Sde a routine aaoa;r of the card.io-vuec:ular ef'fects of such mter1a.ls prior to se:nd:!.ng them to you. I. could probably get Carl to do this if you feel tbat 1 t vould. serve a uae:f\J.l purpose. U you thi:ok of o.:J:J:3 other procedures that w might run, ;,our uuggestions would be e.P.Preciated. Ca.rl ia sendi.'"lS m soce samples of tba 'mteri~:~ol teat Abood. reported aa ba.~; h&llur:in~-e%!ic effects at o.bout- 6-10 millio""'%"al:S per dose. Carl feels that he has confir!r.ad this effect in his subjects a%ld ao I am going to c~"'"e it vith sane of the stl.Uld.ard catcri~ls in e.Djxr:ala. If you would like a sample, I could easily ser.d it a.long vben it arrives here • . vl: hope to be Gble to This document contains a typed letter dated January 6, 1958, addressed to Dr. Harris Isbell. There are handwritten annotations in the top right corner, including numbers and what appears to be a circled number "120". A handwritten notation "B-2" is present in the bottom right corner. No photographs, forms, diagrams, tables, or redacted content are visible. The visual elements consist solely of the typed text and the handwritten markings on a blank page, suggesting marginalia or some form of internal tracking. feels that he has confir!r.ad this effect in his subjects a%ld ao I am going to c~"'"e it vith sane of the stl.Uld.ard catcri~ls in e.Djxr:ala. If you would like a sample, I could easily ser.d it a.long vben it arrives here • . vl: hope to be Gble to vi:sit you in the near future. Sincere~, /)-/ The page is filled with typed text. There are no photographs, diagrams, or tables. There are no official stamps or forms. There is one instance of handwritten annotation in the bottom right corner, which appears to be "D-1". There are also a few small black dots or smudges scattered across the page, but these do not appear to be intentional markings or redactions.