Doc 0000151813

-- Department of HEALTH, EDUCATION, AND WELFARE • Public: Health Service NATIONAl INSTITUTES OF HEALTH 14 January 1958 IN ACI'LY1NG ADORISS 'Mil! NATIONAL IIISnTUTI 0, MIIITAL KULTM ADOICnOtt RISUIICM CIIIT'III U.S. PUIUC KIUTII SUYICI HOSPITAL P. 0. 801 lODO l1111118TOII, KIIITUCIIT I J. . ! j . • ' . I ! (b)~) I . : . . _....._____,..' _____:, __, - ---...L·-- 1 am sorry 1 was a;,vay when your 1 et ter of January 6th arrived so 1 have been delayed in ra~lying. The information and the :'!latarial arr!vec safaly and 1 will get startec! as soon as possible. It will take two or three weeks before the tests currently in progress will be co=pleted. 1 am a~suming that first priority should be given to K-302 since is<blation and extraction .,rocedur~s wi 11 depend on .the test •. It seems there will be only enough material li~ely for exploration. prel!~inary S-5 will be. piaced in second priority and we will, of cour3e, explore the dosage range first. Could you send me the structural formula of this compound! With respect to phar:1acolog!cal work which shou1:i be done prior to clirii::al testing, it would !:>e nice if we could always have acute toxicity in two or three species; a state ment of the effective dose for given effects as compared with a similar material, if one exists; and a description of symptoms noticed with toxic doses, and an opinion as to the cause of death at toxic levels (e.g., convulsions, respiratory depression, pulxonary edema, etc; so~ething about the aross and microscopic pathology in the· animals that died). If we are to do anything other than single dos~s, chronic toxicity would also be required. The drug should also have a general phar.11acological screening. This would include effects on blood pressure; heart rat.e; te·mperature; respiratory rate, pattern and volume; central /}- ~ e -- f£;(~ ~ --·--. - . • !.-~ ' · ~ .. -:) r : '' _ :"J ) nervous system effects by gross observation; and other simple measurements ·such as activity cages, coordination measureoents, tests for analgesia, etc. Chronic toxicity studies include, in addition to ~hould the above, studies o~ blood,. bone marrow, urine, and liver function, as well as gross pathology and microscopic pathology on all organs. As you see, most of the above is covered, partially at least, in the infor--:nation you have sent n:a - The visual content of this page consists of a dark background with a stylized depiction of a safe door on the left. The safe door is rendered in shades of gray and blue, with intricate mechanical details like gears and a combination lock. Prominently displayed at the top of the page in a bold, white, stylized font is the text "THE BLACK VAULT". Below this title, white text explains that the document was obtained from The Black Vault, an online database of declassified government documents, specifically from the MKULTRA/Mind Control Collection. At the bottom of the page, a yellow URL is clearly visible: "http://mkultra.theblackvault.com". There are no photographs of people, locations, equipment, or subjects present. There are no handwritten annotations, signatures, official stamps, forms, diagrams, tables, or visible evidence of experimental procedures. The page also does not contain any redacted or obscured content. Chronic toxicity studies include, in addition to ~hould the above, studies o~ blood,. bone marrow, urine, and liver function, as well as gross pathology and microscopic pathology on all organs. As you see, most of the above is covered, partially at least, in the infor--:nation you have sent n:a - except for the chronic work. Could you send me infor~ation on Abood 1s ~aterial? I will have to be in Washington on February 6th. !f you have any time during the afternoon of February 7th I could drop by. With kindest regards, pe~sonal Slnc ere ly yours, HI:rn /]-J -~-- The document is a declassified letter on official letterhead from the Department of Health, Education, and Welfare, National Institutes of Health, dated January 14, 1958. Handwritten annotations include a circled number "121" in the upper right corner and "(b)(3)" written mid-page. The rest of the page contains typed text detailing information about drug testing. There are no photographs, diagrams, stamps, or filled-in forms visible. There is no visual evidence of experimental procedures, equipment, or facilities. The page is a typewritten document with handwritten additions at the top. A circled notation in blue ink with the numbers "6(3)" is present, along with a handwritten date "-1-11-58". The text includes official headers like "Page 2". There are no photographs, diagrams, tables, or forms visible. The document appears to be a standard memorandum or report. A handwritten signature that reads "Harris" is present at the bottom right, with the typed name "Harris" below it. There is a handwritten initialed note "HI:rn" on the bottom left. A handwritten annotation "B-3" is present at the bottom right of the page.