Doc 0000151816

. . lr C-102 C -102, suspended in a 20 percen.t solution of polyvinyl- pyrrolidone, was orally admini~tered to albino rats at levels of· 10.0, 31.6, 100.0, 316.0 and 563.0 mg/kg. Due to the limited amount of material, two animals were used at the· lowest level and one animal, each, at all higher dosage levels. Two animals served as controls. The initial weight of the animals ranged· between 88 and 104 grams. Animals were weighed {Appendix) and examined for symptoms as required (Table II). No objective symptoms were observed at the lowest level. Hypoactivity was apparent at all levels above 10. 0 mg/kg within 0. 25 to 1. 0 hour and lasted from about 3 to less than 24 hours. The animals, although hypoactive, were not lethargic and were easily aroused by such external stimuli as sudden move- ments or noises. During the state of hypoactivity, the animals were observed to wash their faces more than normal. The male at the 316.0 mg/kg level and the female at the 5S3. 0 mg/kg level, chewed excessively during this period. The female at the 563. 0 mg/kg level was hypersensitive to touch after 1. 25 hours and remained hypersensitive for about R-1 /J ' \ --- ' -2- 24 hours. The animal became belligerent when pressure was applied to its tail. Slow respiration was observed ·for long as 24 hours a~ in all hypoactive animals at the three highest levels. Ataxia was observed in the female at the 100.0 mg/kg level and in all animals at higher levels. The onset time decreased from 1. 75 to 1. 25 hours, while the duration increased from 2 to about 24 hours as the dosage was increased from 100.0 to 563. Omg/kg. Poor equilibrium was observed at the two highest levels 1. 5 to 2. 5 hours after dosing and lasted from about 5 to 24 hours. Staggering was observed in both animals at the two highest levels. The animals walked with awkward gaits 1. 5 to 1. 75 hours after receiving C-102. When walking, they dragged the hind quarters· while the forelimbs were stiffened as in tetany. Although the animals would not allow their limbs to remain in a g.iven positioQ, they stopped in awkward positions with their hindlims extended posteriorly or . forelimbs extended anteriorly for periods of 10 to 15 seconds. Both animals at the two highest levels had a low peripheral The provided image is not a declassified CIA document itself but rather a header or footer that appears to be attached to one. It features a graphic of a bank vault door on the left, rendered in shades of gray, silver, and blue, with intricate mechanical details. To the right of the vault graphic, white text on a black background reads "THE BLACK VAULT" in a stylized font, followed by several lines of text explaining that the document was obtained from a declassified MKULTRA/Mind Control Collection. A web address, also in yellow text, is provided for accessing the collection. There are no photographs, handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures, equipment, or facilities within this specific image. as in tetany. Although the animals would not allow their limbs to remain in a g.iven positioQ, they stopped in awkward positions with their hindlims extended posteriorly or . forelimbs extended anteriorly for periods of 10 to 15 seconds. Both animals at the two highest levels had a low peripheral temperature 2. 75 to 3 hours after administration. No deaths occurred at the a bove levels. The visible portion of the document is a typed page of text, likely a research report, accompanied by an image. The text details an experiment involving albino rats and a substance called C-102. There are no photographs of people, locations, or equipment. However, one section near the top of the page features handwritten annotations: a circled number "124" and a dash mark. There are also several small, dark circular marks scattered across the page, possibly artifacts from the copying or scanning process. The document includes a page number/identifier "B-1" in the bottom right corner. There is no other visual evidence of experimental procedures, equipment, facilities, or redacted content. The page contains typed text detailing observations of animal behavior, likely from a scientific experiment, with a page number "-2-" at the top. There are several small, dark circular smudges in the upper portion of the page, which may be ink blots or dust. In the bottom right corner, there is a handwritten annotation in a dark ink with the characters "B-1" followed by a dash and what appears to be a partially obscured stamp or inscription, potentially indicating a document identifier or classification. There are no photographs, diagrams, forms, stamps, or clear evidence of experimental procedures visible.