Doc 0000151817

...,.. .. ,_. C-102 Sixty rats were divided into ten. comparable groups of three males and three females each. Only six animals per level were used due to the limited amount of material. The average initial weight of the groups ranged between 77 and 84 grans • C-102, suspended in ~ 20 percent solution of polyvinylpyrrolidone, was administered to nine of the groups at logarithmic dose levels oflO.O, 17.8, 31.6, 56.3, 100.0, 178.0, 316.0, 553.0, and 1000.0 mg/kg. The tenth group served as controls. Animals were weighed (.1\ppendix) and observed for symptoms as required (Table VII). Symptom dose-50's were calculated by the method. of Litchfield ·and Fertig (Table VIII), where warranted, and a 24 hour weight gain suppression curve was determined (Figure V). No objective symtoms were observed at the lowest level. C-102, administered orally, produced a hypoactive effect at all but the two lowest levels within 0. 5 to l. 5 hours. The number of hypoactive animals increased from three at the 31.6 mg/kg level to six at all levels above 100.0 mg/kg. Animals remained in a hypoactive state for about 6 hours at the 31.6 mg/kg level to as long as 48 hours at the 1000.0 mg/kg level. Although hypoactive, the animals at all but the 1000. 0 mg/kg leve~ were easily aroused and .. ·•. _..._ - 2 - alerted by. e xternal stimuli. Handling the animals, or a sudden movement or noise, would cause an increase in activity for approximately 1 minute, after which the animals would again return to their hypoactive states. Hypoactive animals at the highest level became lethargic and were not easily aroused. DUFing the periai of hypoactivity, one to three animals at all but the lowest level were observed to intermittently wash themselves more than . - normal for periods ranging from 1 to 5 hours. An excessive chewing phenomenon was exhibited by two animals at each of the 31. 6, 56.3 and 100. 0 mg/kg levels, three animals at the 178.0 mg/kg level, and all animals above 178. 0 mg/kg. This symptom increased in degree of effect as the dosage increased until one-half the animals per level at the three highest levels would come to and chew on paper held six to twelve inches away. Hypersensitivity to touch was observed in two anc;l one animals .. respectively, at the 31.6 and 56.3 mg/kg levels. A maximum number of five hyp-ersensitive animals The page displays a graphic simulating a vault door, with a large circular lock mechanism and intricate gears, suggesting secure storage of information. To the right of the vault imagery is text overlayed on a dark background with a blue luminous glow. The text indicates that the document originates from "The Black Vault," an online database of declassified government documents, specifically the MKULTRA/Mind Control Collection. It further states that over 20,000 pages have been declassified by the CIA and provides a URL for online access. The page contains no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence related to experimental procedures. The page displays typed text with some handwritten annotations. A number, "# 135", is written in the upper right corner of the page. There are no photographs, stamps, forms, diagrams, or structured data tables. No redactions are visible on the page. The typed text details an experiment involving rats and a substance referred to as "C-102," describing experimental procedures and observed effects. until one-half the animals per level at the three highest levels would come to and chew on paper held six to twelve inches away. Hypersensitivity to touch was observed in two anc;l one animals .. respectively, at the 31.6 and 56.3 mg/kg levels. A maximum number of five hyp-ersensitive animals was observed at the 563.0 mg/kg level. The hypersensitivity occurred 1 to 4 hours after ad.II)inistration and. lasted for 2. 5 hours at the lowest observed level to a maximum of about 24 hours at the higher levels. A decreased respiratory rate was observed at all but the /] -!; ---- -3- 10.0 mg/kg level with increasing frequency a~d duration, and with a decreasing ohset time. One animal at the 17.8 mg/kg level was· observed to haye a decreased respiratory rate within 1. 25 hours, while all animals at the 1000.0 mg/kg level had slow respiration . . within 1 hour. The symptom persisted for 4. 75 hours at the 17.8 mg/kg level to more than 1 day at the 1000, 0 mg/kg level. Ataxia, while it did not appear at the three-lowest levels, was present at all levels abo!W 31.6 mg/kg. While only two animals showed the inability to walk the dowel rod at the 56.3 mg/kg level, the symptom increased in frequency until all animals at the three highest levels were ataxic. Animals l:ecame ataxic 0. 5 to 2. 0 hours after administration.· The duration of ataxia increased from 1 to 2 hours at the 56.3 mg/kg level to 24 hours at the highest level. Poor equilibrium was presen·t only at the four highest levels, . . with two animals at the 178.0 mg/kg level, five at the 3\6.0 mg/kg level, and all animals at the 563.0 and 1000.0 mgfkg levels showing the symptom. The duration of effect was shorter, and the onset time slightly longer, than for ataxia. Animals at the four highest ~evets staggered within 0. 75 to 2 hours after receiving C-102. In addition to staggering, the animals, at levels of 100.0 through 1000. 0 mg/kg, walked witth awkward gaits, such as: 1) walking with all limbs in a stiffened position; and 2) dragging [)-! .. ~! --- the hind quarters of the body with forelimbs in a stiffened position. These sYt:nptoms increased in frequency and amplitude as the dosage increased and were exhibited by animals at the 1000. 0 mg/kg level for as long all limbs in a stiffened position; and 2) dragging [)-! .. ~! --- the hind quarters of the body with forelimbs in a stiffened position. These sYt:nptoms increased in frequency and amplitude as the dosage increased and were exhibited by animals at the 1000. 0 mg/kg level for as long as 1 day. Animals exhibiting the awkward gait would stop in unusual positions with forelimbs. extended anteriorly and hind- limbs extended posteriorly. Both diarrhea and diuresis were observed in one to three animals per level at all but the dosage level, but were not lowe~t proportional to the dosage. A low peripheral temperature, observed in one animal at the 178.0 mg/kg level, increased. in frequency to a maximum of five animals at the highest level. The low peripheral temperature occurred from· 2. 25 to 5 hours after administration and had a duration of less then 24 hours in all cases. No de'at!t& occurred at any of the levels tested. Symptom dose _,/ 501s (Table VIII) were calculated by the method of Litchfield and Fertig. The 24 hour suppression of" weight gain {Figure V) determined as described in the April report, varied ~etween zero and 188 percent for females and zero and 198 percent for males.· The 24 hour 50 percent weight gain suppression was 27. 07 mg/kg with a slope of 283 for. femalesr and 63.1 mg/kg with a slope of 288 for males. The suppression of weight gain was proportional to dosage level up through the 316. 0 mg/kg level. 0-/~ The declassified document page is a typed report with a page number "-2-" at the top center and a handwritten annotation "β-/" in the bottom right corner. The text describes the effects of a substance on animals, detailing behaviors such as increased activity, lethargy, and hypersensitivity to touch. There is no visual content beyond the typed text, handwritten annotation, and a few small, faint ink marks scattered across the page that do not appear to be significant markings. The page itself is a scanned document, exhibiting a rough texture and faint discoloration consistent with aged paper. The body text is printed in Portuguese, with the exception of a handwritten annotation in the bottom right corner that appears to be "D-1". There are no photographs, stamps, forms, diagrams, tables, or redactions visible on the page. The overall visual presentation is that of a standard typed document. The document is a single page of typed text, numbered "-4-" at the top. There are scattered black ink dots and smudges throughout the page, indicating natural imperfections in the paper or printing process. A handwritten annotation "D-1" appears in the bottom right corner. The text discusses experimental observations including animal symptoms, dosage levels, weight gain suppression, and statistical calculations, suggesting a scientific or research report. There are no photographs, diagrams, forms, stamps, or redactions visible on this page.