Doc 0000151818

- ------ // . \ _ · .. - ·· -· . - . ·· A - ; t. r- (... - < ... · . ... • \ ... ~·· C-102 - . 'l'he oral hypoactive dose-50 was 30. 5 mg/kg as calculated . by the method of Litchfield and Fertig. This level was administered orally and intraperitoneally, respectively, to two group~ of six rats each (three males and three females). The average initial weight of · · the groups ranged bet\veen 87 and 91 grams. "~he number of hypoactive animals, tbe onse.t and duration, are given in Table X. Four animals receiving the drug orally, and all animals receiving the dru·g intraperitonealty, became hypoactive. The orally dosed animals became hypc·;~ctive within 1 to 1. 2 5 hours, while the intraperitoneally administered animals became hypoactive .within 0. 25 hour. Both g-oups remained in a hypoactive state for less than· 24 hours. During the period of hypoactivity, three of the orally dosed animals, and all i~traperitoneally dosed animals, had a decreased respiratory rate. Ataxia was demonstrated 0. 25 hour after. dosing by one animal in the intraperitoneal group and w~thin 2. 5 hours by one animal in the oral group. The administration of C-102 produced a "raised tail" effect in all intraperitoneally dosed animals within approximately 0. 25 to 0. 33 hours. In exhibiting the "raised tail" phenomenon, the animals (3 -: J - 2- did not carry high posteriors. This syndrome was not observed in animals dosed orall:y •. of Three the animals dosed intraperitoneally were hypo sensitive to tough 0. 3 3 to 0. 5 hour after administration. 'When handled, these animals squealed, as though in pain. Hyper sensitivity lasted for about 24 hours. The 24 hour weight gain suppression was zero and 30 percent for females and males, respectively, in the group dosed intraperitoneally. The control group showed a weight gain suppression of 100 and 75 percent, respectively, for females and males. In general, the results indicate that C-102 i.s about twice· as effective when given intraperitoneally as when given orally. ;-]--/ This page features a graphic of a bank vault door on the left side, with stylized blue lighting. The right side of the page contains white text on a black background, stating that the document was obtained from "The Black Vault," an online database of declassified government documents. It specifically mentions the MKULTRA/Mind Control Collection, a compilation of over 20,000 declassified CIA documents. The text also provides a URL to access the collection. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, or redacted content visible on this page. The page contains typed text describing an experiment involving oral and intraperitoneal administration of a substance to rats. There are no photographs or diagrams. Handwritten annotations appear at the top of the page, including a circled number "126" and some illegible script. A small, faint, possible stamp or mark is present in the bottom right corner. The content suggests research into drug effects on animals, detailing dosage, onset of action, and observed behaviors like hypoactivity and respiratory rate changes. The document is a typewritten page of text, likely from a scientific report. There are no photographs, diagrams, stamps, or handwritten annotations visible on the page. The content discusses experimental results involving animals, mentioning "dosed orally" and "dosed intraperitoneally." It also refers to "weight gain suppression" and the effectiveness of a substance labeled "C-102." There are no visible redactions or obscured content.