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..... _.-~. FURTH:i::R ATTEi·'l'TS TO BLOCK THZ LSD R.2ACT!ON BY PRSTR.S..O..TE3NT ·~·liTH BOL ( ;;;:xper iments 56-D and 56-2). Ginzel and i--'!ayer-Gross reported that pretreatment with 3 mg. of BOL for one day attenuated the reaction caused by 40-.50 mcgm. of LSD, and that t\vO days pretreatment tvi th 3 mg. of BOL blocked it completely. Concomitant aruninistration of BOL \vith LSD had no effect. In previous experiments, we v1ere able to confirm the latter finding but were, however, unable to confirm clearly attenuation of the LSD reaction by two days pretreatment with BOL.. In one experiment, 8 subjects received 1 mg. of BOL orally for two days, and an additional milligram on the third day. T'.vo hours after the third dose, these 8 subjects were challenged with 1.0 to 1.5 mcgm./kg. of LSD·. A strong trend toward reduct ion of the intensity of th2 LSD reaction was observed, but the reduction did not reach statistically ~ignificant levels on any of the measures used. The experiment was not regarded as conclusive since.4 of the 8 subjects proved to be resistant to LSD. ln a second experiment, 10 subjects received 3 mg. of BOL three times daily for thrze days and an additional milligram on the fourth day. Two hours after the last dose of BOL. these patients were nchallenged11 with 1.5 to 3.0 mcgm./kg. of LSD. Again a trend to reduction in the LSD reaction was observed, \vhich did not reach ~--·:$. statistical significance. In this experiment, the ~artial cross tolerance bet\veen BOL and LSD ;may have. been obscured by the relatively la-rge dos·e of LSD used. _further. attempts T~1o to blo.ck the LSD reaction \'lith BOL havt?, therefore, been carried out, using a dose of 1 m~gm./lcg. of LSD, an amount cor:;>arable to that employed by Ginzel and Fayer-Gross. I··!ETHODS Subject_!. subjects were Negro male pr i sonars who i~.11 vrere serving sentences for of the Harr.ison narcotic vio~ation laws. All were abstinent from opiates for at least six months, and all were in good physical and mental health. All except 2 of these had previous experience LSD. In Experiment wit~ .56-D, 8 subjects \vere used; in Sxper iment 10 subjects 56-~, \vere used; 4 patients in both experiments. serv~d Drugs. Here given orally in solution. In Experiment .56-D, 1 mg. of BOL tartrate administered orally at 8 a·.m., 4 p.m., \oJaS and 10 p.m. for two days prior The image is a graphic with a stylized title, "THE BLACK VAULT," set against a dark background. To the left, a detailed illustration of a vault door is depicted, featuring intricate mechanical components and a glowing blue accent. To the right of the vault, text explains that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the "MKULTRA/Mind Control Collection" and providing a website address. There are no photographs of people, locations, or equipment, no handwritten annotations or signatures, and no official stamps, forms, diagrams, or tables. The visual content consists solely of the graphic illustration and the descriptive text. Experiment wit~ .56-D, 8 subjects \vere used; in Sxper iment 10 subjects 56-~, \vere used; 4 patients in both experiments. serv~d Drugs. Here given orally in solution. In Experiment .56-D, 1 mg. of BOL tartrate administered orally at 8 a·.m., 4 p.m., \oJaS and 10 p.m. for two days prior to challenge with. LSD. An additional dose of 1 mg. of BOL given two hours before (at v~s 6 a.m.) on the day of with LSD. Pn identical ~~allenge schedule was used in Experiment 56-E, except that BOL given 'l.~s for five days prior to challenge with LSD instead of for three -- days. In both experiments, the challenging dose of LSD was 1 mcgm./kg. g.iven orally in solution to patients who were fasting. [J-J ·~- l The document page contains typed text, with a handwritten annotation in the upper right corner that reads "127". There are also some minor dots and marks scattered across the page. In the lower right corner, there is a handwritten annotation "B-3". No photographs, stamps, forms, diagrams, tables, or evidence of experimental procedures are visible. The image displays a typed document page, likely from a research report, with the header "Page 2". Notable visual elements include two circular black ink blots near the top of the page, possibly from a stamping mechanism or accidental ink spills. There is also a handwritten annotation in the bottom right corner: "B-3". No photographs, forms, diagrams, tables, or evidence of experimental procedures are visible.