Doc 0000151830

- _ . October 19.58 REPORT ON C-5 (TETRAHYDROCANNABINOl, NITROGEN ANALOGUE) Experiments were designed to dete.rmine the dosage range c-5, required to obtain effects with to assess type and quality of subjective effects, time course, and to compare with effects of C-9. METHODS. Subjects. Were 15 Negro male former addicts in good physical and mental health. All were experienced marihuana users. None knew type of drug being given or effects to be expected. Measurements. Following observations were made at hourly intervals once before and eight times after a~~inistration of drug: Pulse rate ) ~~ter 10 minutes 1. ) in bed and after Systolic and diastolic blood pressure ) 1 minute standing 2. ). Rectal temperature . 4· Pupillary. diameter 5. Threshold for elicitation of kneejerk Questionnaire containing items reported after marihuana 6. and LSD Notes on behavior. 7- General Conditions. Patients entered the ward on day before and remained overnight. They were awakened at 6 a.m., and drug - was given with patient fasting. Patient re~ained in ward through out observation period; free to mingle with others between observations. IJ-3 Page 2 9.eport on DruQs. c-5 was dissolved in alcohol in appropriate concen tration so that patient did not receive mor·e than 30 cc. with o distilled H and was drunk. Placebo consisted of starch 2 suspension in water to simulate appearance. Initial dose of c-5 was 0.1 mg./70 kg. This was increased in step\oJise fashion in subsequent trials until last patient received 100 mg./70 kg. Forty-two trials were carriad out on the 15 patients. In 18 trials dose was 10 mg. or more (to lOG mg.) per 70 kg. Results. No distinct effects were. observed or reported with any of the doses used. Changes in measurements were indisting uishable from those of placebos. Because of the negative results, no comparison with C-9 was made. Conclusion. C-5 appears to be a relatively inert drug in man. Future Plans. None. HI: tkh !)-5 . ~ ' The image is a graphic overlay placed on top of a black background. On the left, a stylized, metallic vault door is depicted with intricate gears and mechanisms. The title "THE BLACK VAULT" is prominently displayed in a white, graffiti-like font at the top center, outlined by a blue glow. Below the title, white text explains that the document was obtained from "The Black Vault," an online database of declassified government documents. It further states that this specific record is part of the "MKULTRA/Mind Control Collection" and details its origin from the CIA, offering a URL for download. The overall visual presentation is designed to convey the theme of classified information being accessible. The page is primarily text-based, with a document title, date, and experimental details. A handwritten number "139" is circled in the top right corner, and another annotation "B-5" appears at the bottom right. There are no photographs, diagrams, stamps, or forms visible on this page. The content describes experimental procedures related to drug administration and observation of subjects, including pulse rate, blood pressure, temperature, pupil dilation, reflex testing, and behavioral notes. The visual elements are limited to the typed text and handwritten annotations. The page is a typed document titled "Report on C-5". It is page 2 of the report and bears a handwritten annotation "B-5" in the bottom right corner. The document details the administration of a substance labeled "C-5" to patients, including dosage information, trial numbers, and observations. It mentions that C-5 was dissolved in alcohol and administered to patients, with placebo trials also conducted. The findings indicate that C-5 had no distinct effects and was indistinguishable from placebos. There are no photographs, diagrams, or forms visible on this page.