Doc 0000151841

-- 29 April 1959 52-D COMPARISON OF EFFECTS OF C-9 DISSOLVED IN OIL WITH THOSE OF C-9 DISSOLVED IN ALCOHOL. PURPOSE: To determine if C-9 dissolved in oil is as active as C-9 dissolved in alcohol and administered dispersed in watery solution. METiiODS: SubJects: Five nontolerant former morph!ne.addicts, all male, who were serving sentences for violation of the federal narcotic laws were used in these experiments. All were physically healthy, presented no evidence of the major psychoses, and all had experienced the effects of marihuana in a free environment. Drugs: All drugs given at 8 a.m. with the patients . wer~ fasting. C-9 was available as a solution containing 10 mg/ml in vegetable oil in perles. The perles were opened, the doses measured and diluted with 8 cc of vegetable oil ("Mazola0 ). The glass was rJnsed with 2 additional portions of 4 cc of oil. Vegetable oil containing no drug was used as a placebo. C-9 was 95 also available as a solution of 1 mg/ml in per cent ethanol. The dose was measured and diluted with 8 cc of distilled water, forming a milky suspension. The glass rinsed with two portions ~as of water. Page 2 Design: ·The patients received at weekly intervals, in a randomized, balanced order, the following drugs: 1.0 and 1.5 mg 1.5 per 70 kg of C-9 ~in oil; 1.0 and mg/70 kg of C-9 in alcohol; and a placebo. The patients were unaware of the identity of the drugs cnsingle-blind11 procedure). Observations: The following observations were made at hourly intervals twice before and eight times after the drugs: pulse rate and blood pressure after .ten minutes rest in bed, pulse rate and blood pressure after arising from bed and standing quietly for one minute, and rectal temperature. ln addition, ' patients completed a questionnaire containing 67 items at hourly intervals,. once before and eight times after the drug. Analysis: ln.the cases of rectal temperature, resting and standing pulse rates, and resting and blood pressures, st~nding the values at each hour after the drug were subtracted from the . average of the pr_edrug observations. These values f-or change from control constituted time-action curves, so the areas under these curves were calculated and the usual statistical calcula- t!ons made using the t-test for paired observations. Questions . . scored positively after the drugs were counted over the entire post-drug period, eliminating answers also scored-positively prior The image is a webpage with a thematic background featuring a secure vault door on the left and the title "THE BLACK VAULT" in a stylized font on the right. Below the title, there is text describing the origin of the document from an online database of declassified government documents, specifically the MKULTRA/Mind Control Collection, housed by The Black Vault and comprising over 20,000 declassified CIA pages. The text also provides a URL for downloading the collection. There are no photographs, handwritten annotations, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures depicted on this page. These values f-or change from control constituted time-action curves, so the areas under these curves were calculated and the usual statistical calcula- t!ons made using the t-test for paired observations. Questions . . scored positively after the drugs were counted over the entire post-drug period, eliminating answers also scored-positively prior to the drug. u-J/5 Page 3 RESULTS The results are summarized in table 1. All doses.of C-9 in both alcohol and.oil consistently elevated resting and standing pulse rates, decreased the usual rise in blood r~sting 0 . ( ~) pressure, and caused postural hypertension·; Rectal temperature was not consistently affected. In general, C-9 dissolved in alcohol was consistently more effective than C-9 dissoued in oil, thought the differ.ences did not reach statistical significance. , There was no significant difference in onset and peak time of the changes in pulse rate and standing blood pressures. The usual subjective reports -- change in mood, mild perceptual distortion, dry mouth, dizziness and sleepiness -- were reported after both oily and alcoholic solutions. Four of 5 patients. :fainted on standing after 1.5 mg of C-9 in alcohol, whe;e~s only one o:f 5 :fainted after 1.5 mg o:f C-9 in oil. One patrent fainted after 1.0 mg in alcohol, and none &..P.. ( 7) after 1.0 mg in alcohol. Conclusion: C-9 dissolved in oil is effective in inducing () ( () postural hypertension and subjective effects, marihuana-li~e but is probably less effective than C-9 in alcohol. iJ-1/c; ., . ',) 1 ,, h' Table 1. ~ 1. 52-D ln 'f Comparison of Effects of C-9 in Alcohol with Those Oil. ~ MEASURE DOSE AND VEHICLE Placebo Oil Alcohol 011 Alcohol ·(Oi 1) ( 1.0 mg) (1.0 mg)' (1.5 mg) (1.5 mg) e Resting Pulse Rate +45.6 ± 19 +51.6 ± 16.5. +6). 6 ± 18 +72.8 ± 10.3 94.3 ± 19.6 St :ilng Pulse Rate -1 0 • 2 :t 30 • 9 +81.6 ± )6 +95. 3 ± 45.6 +87.1 ± 2.5.8 +118.7 ± 46 nesting Blood Pressure +64.8 ± )J. 6 +15.0 ± 33 +)1.9 ± 18 + 34.3 ± 11.5 +22.7 ± 17.8 Stand lng Blood Pressure · +40.1 ± 1~. • 8 +19.) ± 35 -38.8 ± Jl~.l -93.4 ':t 2).2 -uo.6 ± 39.5 Temperature + 1.9 ± 0.6 + 2. t!~ ± 0. 35 + 1.4 ± o.5 +· 0.9 ± 0.9 + 1.04 ± 0.2 Number of Positive 1.6 The document is a single page of typed text with handwritten annotations. At the top right, a circled number "151" is visible. There is also a handwritten date "29 April 1959" in the upper right portion of the page. Near the bottom right, there is a handwritten annotation that appears to read "B-116". The document is a declassified CIA file, with no visible official stamps indicating classification level, but based on context, it relates to MKUltra. There are no photographs, diagrams, or tables present. This page contains only text, with no images, diagrams, or tables. There are handwritten annotations in the bottom right corner, which appear to be a document identifier "D-115". The text describes the design, observations, and analysis methods of a study involving weekly administration of drugs or a placebo to patients. It details the types of measurements taken, such as pulse rate, blood pressure, and rectal temperature, and the statistical methods used. 17.8 Stand lng Blood Pressure · +40.1 ± 1~. • 8 +19.) ± 35 -38.8 ± Jl~.l -93.4 ':t 2).2 -uo.6 ± 39.5 Temperature + 1.9 ± 0.6 + 2. t!~ ± 0. 35 + 1.4 ± o.5 +· 0.9 ± 0.9 + 1.04 ± 0.2 Number of Positive 1.6 ± 1.2 11.0 ± 4.2 11.0 ± ).1 8.0 ± ).1 18.2 ± 6.55 -· Responses on Questionnaire Figures are the.means (5 subJects) of areas under the time-action curves for the various measures ("beat-hours," 11mm-hours,··~ etc., except 1~ case.o'f number of positive responses e on the questionnaire). A positive sign indicates an increase ln the measurement, a negative sign a decrease. \ The document page contains typed text, a handwritten annotation at the bottom right, and a page number at the top right. The text appears to be a section titled "RESULTS" followed by a discussion of experimental findings regarding the effects of C-9. The handwritten annotation is a series of characters that looks like "B-114". There are no photographs, stamps, forms, diagrams, charts, tables, or redactions visible on this page. The visual content predominantly consists of typed experimental findings. The image displays a scanned page of a declassified document, focusing on experimental data. It features a table titled "Table 1. Comparison of Effects of C-9 in Alcohol with Those in Oil." This table presents numerical data, organized by "Measure" and "Dose and Vehicle," with categories like "Placebo (Oil)," "Oil (1.0 mg)," "Alcohol (1.0 mg)," "Oil (1.5 mg)," and "Alcohol (1.5 mg)." Handwritten marginalia in the upper right corner reads "B-113." Below the table, there is explanatory text describing the figures as means and the interpretation of positive and negative signs in the measurements. The overall layout suggests a scientific report detailing experimental results. No photographs or visual evidence of experimental procedures or facilities are present.