Doc 0000151881

D~pa.r--. of HEALTH, EDUCATION, AND --,:LFAr{. Pul-~4 Heah~ s·ervke N A T I 0 N A l l N S T I T U T E S 0 F H E A L.T H 31 January 1957 IN ltCI"I.YlNG AODIIISS THC NAnONAL INSnTUn 0, MENTAL HIALTN ·A ODICTIOII RISIARCH CINTER U.S. PII81.1C: HIALTN SIRYIC:I HOSI'ITAL ~· P. 0. 8o:r zooo GJ·· The information··on F-230 which you sent on January 25th is most helpful. Do you have any information about _ of this compound? su~plles Since our dogs run between 7 and 20 ki-lo-grams and s !nee the dose in dogs seems to be in- the order of. 100 mg./kg. we would be using approximately an average of 1 gram per trial, we could, therefore, test about 10 dogs. This number might be insufficient. I woulC:: like to obtain more of the compound. Meanwhile we·wtll begin some very simple pre l!minary work with the amount on hand •. I am getting into about the same situation with BOL. Preliminary work with this compound indicated that mild LSD-I ike effects began to appear in human subjects with 4 total doses of about mg. I have written the Sandoz Co asking if tney could supply more of. this compound, and am withholding attempts at blocking the LSD-reaction with BOL until 1 hear from them. Results with trte second batch of 01 iol iqui seeds were identical with the results obtained with the first lot. With doses ranging up to 5 grams total there was no evidence .of any p_sychosomimetic activity._ Doctor Wikler will be in Washington from February 4th to the 8th. He is on a promotion board and could probably be located at the PHS headquarters, if you desire to see him for any reason. Very sincerely yours, . , IJ - . : ··- _·, __ - ·/ ·• ': ,/ f .. I : . ... .• / ·. ./ L ... ~ .' -··· , - 1 .. . - - v ,- , { - ; . L . - ' i -'1 . / ,, - --'"y ... ,.~-"--·"' ·• Har~is Isbell, M.D. Director HI:rn - . ' . ... The image displays a title card for "The Black Vault," an online database of declassified government documents. To the left, a stylized, metallic vault door is shown with intricate mechanical elements and glowing blue accents. To the right of the vault, white text explains that the document was obtained from The Black Vault, specifically from the MKULTRA/Mind Control Collection, which contains over 20,000 pages declassified by the CIA. A yellow hyperlink to the collection's website is also visible. There are no photographs, handwritten annotations, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. This document is a typewritten letter with several handwritten annotations. A circular seal and text indicating "NATIONAL INSTITUTES OF HEALTH" are visible at the top, along with a date of "31 January 1957". Several handwritten markings appear in the margins, including what looks like numerical notations and acronyms. A signature and typed name "Harris Isbell, M.D. Director" are present at the bottom. There is also a handwritten notation "A-266" on the right side. Finally, there is a circled number "82" at the bottom right corner.