Doc 0000151885

The page features a stylized graphic on the left, depicting a vault door with intricate mechanical details and a blue glow emanating from its center. To the right of the vault graphic, bold white text proclaims "THE BLACK VAULT," followed by a larger block of white text describing the document's origin. This text explains that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically referencing the MKULTRA/Mind Control Collection housed there. The bottom of the text block displays a yellow hyperlink to the website "http://mkultra.theblackvault.com" for downloading the collection. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redacted content, or visual evidence of experimental procedures present on this page. • / \ ) r INTOX tO. 10'-J WITH :.C-9 Preliminary Description Of The Reaction Definition. Intoxication with C-9 refers to the sum to}al I '· of mental and ~hysical changes fnduced by ingestion of this drug and ts characterized by slow onset after oral ingestion, prolonged persistence of symptoms, conjunctival Injection, pseudoptosis, tachycardia at rest, postural tachycardia and hypotension, and subjective symptoms which occur Include drowsiness mtxed with appr-e_henston, dryness of the mouth., difficulty in thtnk ing and con c en t r a t t ng ~ va r t a b I e c h a n g e s 1 n me o d ., a n d a f e e t i n g o f i n c r e a s e d sensory perception. Ph~sfcal Pro~~ies. C-9 is an oily resin. It is soluble in organic solvents including ethyl alcohol, but is Insoluble in water. Alcoholic solutions of the drug are stable for at least 8 months. Method of Admintstrdtion. Because of the drugs insolubility tn water, methods of administration are limtted. The drug is effect.lve orally an.d may be given in food, coffee, soft drinks, or aicoholie drinks. It is also effectiv~ when dri.zd '-"'·"·" ~·,-..-h.,.. .".".."..'.-- - and smoked, although the effects are general lv milder and less c 6 n s i s t en t a f f e r s mo k j n g a s co mp a red w it h o r a J · i n g e s no n • Do sa q e • The p r lZ sent de s c r l p t ion is b a sed o n do s e s ( tot a I ) of 0.5 to 2.5 mg. of the drug orally. Def"tnite cardiovascular effects can b~ detected in doses of 0.5 mg. Definit~ subjective effects ,. .. ; .... are reported with doses of I mg. or more. At I mg. level, the effects ar~ usually regarded as pleasant by experienced marihuana users. Wtth the higher doses, effects dis su~jecttve ~ecome agreeable ev~n to experienced addtct~. Wtth doses of 2 mg. or s mo r e , c a r. d f o v a c v l a r e f f e c t s become v e r y prom Tn e n t a dis su~jecttve ~ecome agreeable ev~n to experienced addtct~. Wtth doses of 2 mg. or s mo r e , c a r. d f o v a c v l a r e f f e c t s become v e r y prom Tn e n t a n d fa t n r I ng may occur on standing. T I me Co u r s e • Fo J t ow t n g o r a l i n g e s t t o n b o t h c a r d t o v a s c u l a r and subjective effects appear about one and one-half to two hours after administration of the drug. Maximum effect ts reached four or five hours after the drug is gtve.n. The pea~ effects is maintained to about the 16th hour following administration of the ~ drug. Some effects may persist as long as 24 to 48 hours after a d m t n i s t r a t i o n • I n g e n e r a I , t h e I a r g e r t he do s e o f C-9 t h a t i s given the longer symptoms persist. Subjective S't'!ilptoms. During the height of the C-9 reaction (4-16 hours) the following symptoms, which are listed by organ systems, have been reported. The ltst does not include all symptoms that have been mentioned but only those that are frequently reported. Vis ion. (I) Blurrino of vlston. [2) Change 1n spati.al perception. ( 3 } Oc c a s i o n a I I y, e I e me n t a r y h a I 1u c i n a t i o n s ( co I o red lights, patterns, etc.} on closing the eyes. Taste. (I J Increased acuity of taste. {21 Dry taste. Touch. ( I ) Numb ne s s o f o ne o r mo r e e x t r em i t i e s • A---3Jj (2) Paresrhesta (hot or cold feelings on the sktnl. . ,.,. ..... ' -~ F • :-. ) Sme t [ • NO symptoms reported in this area. Gas+ ro i n t e s t t n a I • ~· The document is a typewritten page with handwritten annotations. At the top right, the number "#86" is circled in red ink. Further down on the right side, a handwritten annotation "X-332" is present in blue ink, written at an angle. The document refers to an "INTOXICATION WITH C-9" and discusses its preliminary description, definition, physical properties, method of administration, and dosage. There is no visual evidence of experimental procedures, equipment, facilities, photographs, stamps, forms, diagrams, charts, or tables. The content appears to be purely textual information regarding drug effects and administration. The page contains text from a declassified document, likely a report, detailing effects of a drug, potentially C-9, on users. There are no photographs, stamps, forms, diagrams, or tables visible. The text is presented in a structured bulleted list format under headings like "Time Course," "Subjective Symptoms," "Special Senses," "Vision," "Taste," and "Touch." The handwriting of a person named "A-331" appears in the bottom right corner of the page, which is the only annotation. There are no visible redactions or obscured content. em i t i e s • A---3Jj (2) Paresrhesta (hot or cold feelings on the sktnl. . ,.,. ..... ' -~ F • :-. ) Sme t [ • NO symptoms reported in this area. Gas+ ro i n t e s t t n a I • ~· Dryness of·the mouth (f) l 2 J o·e c rea s e d sa I i va t l on • (3) Dryness of the throat. 14) Increased appetite (consistently reported). (5) Nausea and vomfttng (only wl+h the larger doses}. Cardiovascular. ( I J 0 i zz i ness (2) Palpitation (3) Weakness and fatigue (4) Fainting on standing ---·- .. Resoiratory C I) Sense of ehok rng (2) Air hunger Rc na I No symptoms reported. Neuromuscu I a r (I) Dizziness '· (2) S lurr- tng of vis ion (3) Paresthesia ·(4) Drowsiness ( 5) Sweating (6} Weakness Mental Reaction. Ideation. Ideation Is reported as being impaired. Patients • haye diffictrlfy in thinking, find rt hard ro concenrrare, and are bothered by at~~mpts to carry out set tasks. ~bod. Wood var.tes. Individuals whq are not habihjated to marihuana or who dislike the effects of the drug, are depressed --------- - --------- ------------ ·- ------- - --- --- - ---- -- - ./ by C-9. They become fearful, and frequently refuse to take the drug agatn. Unpleasant effects are accentuated by nausea and vomiting, fatnfness, dtzztness, and weakness or{ standtng. In experienced marihuana users, effecls on mood.vary with the situation·. If patients are observed in small social groups and not intensively examined there Js a strong tendency for elation to appear. The patients laugh, giggle, tell point a less jo~es, play records, and generally:be.have tn silly • fashion. Under condtttons of intensive examination, tendency ts for patients to withdraw, and act in~· guar~ed fashion though they remain quiet .and cooperative. When doses of 2-2~ mg. are given, experienced ma~I.huana users become fearful and- somewhat withdrawn. They state that they are afraid of "going too high" and that they wt II .be unable to ttcome down.n !r Affect usualty·ts appropria.te to the situation. and the ' stimuli being received. Stream and Content of Thought.· No gross lmpa trment of abstract thinking occurs. So far as one can ascertain, there is no abnormal thought content~ Paranoid ideas have not been ~romlnent tn our experience. Psychomotor Activtly. Like mood, psychomotor .a.cttvity varies The document on this page is a typed report detailing various physiological and psychological symptoms categorized by bodily system, such as gastrointestinal, cardiovascular, respiratory, neuromuscluar, and mental reactions, likely related to drug experimentation. There are no photographs, diagrams, organizational charts, or tables present. However, there is handwritten marginalia on the right side of the page with the annotation "A-330". There are also some small ink dots and smudges scattered across the page, but no official stamps or redactions are visible. to the situation. and the ' stimuli being received. Stream and Content of Thought.· No gross lmpa trment of abstract thinking occurs. So far as one can ascertain, there is no abnormal thought content~ Paranoid ideas have not been ~romlnent tn our experience. Psychomotor Activtly. Like mood, psychomotor .a.cttvity varies with the situaHon and' wtth the individuals. In social situations, outgoing individuals are prone to laugh, dance, giggle and crack many jokes. Patients usually remain detached .. .. . . .... ,,....--_ ) ) .\~, from th<! sttuaf'kln. They tend ro laugh qut,ztly at the outgoing fndlvtduals. When the situation ts not social, tendency Is f~r all types of patients to withdraw to thetr rooms and take naps. Halluernations and Delusions. Hallucinations and delusions have not yet observed. Occasionally hal1uclnattons, be~n ele~entary Jtghts, patterns on closing the eyes, have been and·e~lorings reported. · General Characteristics of C-9 Reaction. Atthough the ·menta I ef:fects Induced by C-9 seems somewhat vague, they are deftnitety_marthuana-ltke and are so tdenttfted by experienced who are well acquainted with the effects of marihuana. ~ubjects Such patients state that the chief differenccs are slow onset long persistence of the reaction. Essentially the drug seems ~nd to induce a mental state characterized by a peculiar mtxture of pleasant plus which has no sed~n apprehens~~~JX definite basis. A sensation of or being~~d fl~attng~ f~equently reported. Distortion of time sens-e- Is often mentioned; ------.....:.---~ .. . ttme seems to pass more slowly. Some-difficulty in vtslon is present. This is usually described as consisting of slight blurring of vision plus spatial distortion. crdinarity Distan~~s ----------~·- appear to be greater; distortion in form, shape or color is unusual. ln addition, ther~ is .a sense of heighten~d sensory perception·-- all things fook better, feel better and tasre better. In th.e proper situation there ts diminution in ego controls which, though not as great as seen wfrh large amounts --·- --.--- 4-]2r- .... ........... --~---------- of alcohol results tn somewhat stlly, uninhibited behavior~ 1 Th~. patients stafe they are able to enjoy mustc more, to . , appre.ctate ta.ste of food more highly, and. to appreciate colors and so on more. than they would without the drug. Although the fest ~Jtuation has precluded ~ny direct observations on sexual ·drive all patients consistently state that sexual urges would ·be e~hanced in a proper situation. Symptoms induced by C-9 differs sharply In overall pattern . . This is a typed document page with a handwritten annotation on the lower right, reading "A-329." The text discusses the effects of marijuana on users, including their mood, thought content, and psychomotor activity. There are no photographs, stamps, forms, diagrams, tables, or redactions present on this page. The image reveals a standard typed document, suggesting it's part of a report or study, with the handwritten annotation likely serving as an identifier or reference number. to appreciate colors and so on more. than they would without the drug. Although the fest ~Jtuation has precluded ~ny direct observations on sexual ·drive all patients consistently state that sexual urges would ·be e~hanced in a proper situation. Symptoms induced by C-9 differs sharply In overall pattern . . from those induced by LSD-25. In the LSD reaction, nervousness, anxiety and anorexia are prominent. In the C-9 reaction, ... ·drowst~3s_Calthough mixed with some mtld apprehens.ton} and h-.u-nger_are commonly reported. Atropine-ltke ~ffects Cdryness __________ of the mouth ......e.. _.t..c.-....-)- are prominent with C-9 and not promTnent wtth LSD. Characteristic visual-perceptual distortion, which is so prom J n e n t i n t he l S D rea c t to n , I s s c a r c e f y me n t i on e d b y t n d i v Td u a I s under c:..9. Depersonalization (a feeling that onets body or so part of it rs not one's own J ts common with LSD, rare under C-9. ObJective Effects. These include: (I) Inject ion of the conjunct tvae (red eyes} (2) Pseudoptos Ts {crocpy ! !ds -- a : !.:epy upp.zorant=e I • (3) Tachycardia (fast pulse} (4) Very fast pulse and marked drop tn blood pressure o n · s t a n d i n g·. No ·effects of outstanding_ s tgniftcance have been observed on rn .b.od.y temperature, resting blood pressure, respirat-ory rate, or a n y ph a s e of the n e u r o I o g i c a I exam i n a t i o n • Pup i l s a r e no t d i I a t e d • - There is no gross motor ataxia and no g.ross.. c.ha.n.g.e on sensory -· • / examination. No laboratory evidence of damage to the I tver. k tdA-ey or hemopo ted tc system has been observed after single i. !I ~ ----- dcsisr of the. drug. ' Cardiovascular Effects. The cardiovascular effects of C-9 are also induce·d by the members of the marthuana group (marihuana Itself and parahexyl compounds}. They consist essentially of tachycardia and postural hypotenst~n. Th~se effects are evident In two hours and may be present 24 to 48 hours !a-ter. They may be present for 24 to 48 hours after the ingest ion The image is a scanned document featuring typewritten text. There are no photographs, stamps, forms, diagrams, or tables. The handwritten annotation "A-328" is present in the bottom right corner. Some faint, scattered dots and smudges are visible throughout the page, but they do not obscure any content. The document discusses the effects of "C-9 Reaction," including hallucinations, delusions, and sensory distortions. induce·d by the members of the marthuana group (marihuana Itself and parahexyl compounds}. They consist essentially of tachycardia and postural hypotenst~n. Th~se effects are evident In two hours and may be present 24 to 48 hours !a-ter. They may be present for 24 to 48 hours after the ingest ion 9f doses of 2 ;to .2.5 mg~ The cardiovascular effects arc most evident on quiet standing. The resting pulse rate and pulse rate after one and two minutes standing plus blood pressure after one and two minutes standing are very useful Indicators of the drug's effects. Va r i a t i o n s • As ts the case with at 1 drugs, the degree of - effect obtained with a given dose of C-9 vartes from tndlvtdual . to .tndtvJdual. In some patients, intense mental effects plus cardiovascular effects, resulting ln fainting on standing, may r • o c c u r w it h do s c s a s I ow a s 5 mg • · I n o f he r l n d i v Td u a I s r e c e- i v i n g I • 5 mgm., or even 2. 0 mgm., very few subJect i ve s ymp toms and only mild changes tn pulse rate and blood prl'.ssur~< wi II be -observed on standing. c-9. Psychosis Afrer So- far, no ·toxic psychosis has occurred after ingestion of _C-9. It is, however, known that other marihuana- like dru~s sometimes trigger a toxic psychosis, usually of paranoid type, in susceptible individuals. It Is very likely -;: ... ·• ... -~ .. -.· i /) that when a sufftctent nu~ber of patients have had c~9, toxic j ~sychoses ~ay be reported In a few. l . 'Dtagnosls. At the· present ttme ther~ is no absolutely certaJ.n way of.dlagn·oslng-C-9_(·or· marihuana intoxication) in -·an unknown sttuatton. The diagnosis should be sugge.sted by the ._.. combination of conjuntival tnjec.tion, pseudoptosts, tachycardia, postural hypotension, plus the· subjective effects of dryness of the m?uth, blurring of vision, drowsiness, change tn time sense, spat tal_. perception, and heightened auditory acuity.·. --·~--- Negafive potnts of Importance includ~ lack of neurological .... changes and absence of significant effects on respiration, temperature, and resting blood press·ur~. o-rfferentra·tton from LSD-25 should be ~elatively easy (unless a mixture of drugs ts given) since pupillary dilatation, accentuation of tendon reflexes tal_. perception, and heightened auditory acuity.·. --·~--- Negafive potnts of Importance includ~ lack of neurological .... changes and absence of significant effects on respiration, temperature, and resting blood press·ur~. o-rfferentra·tton from LSD-25 should be ~elatively easy (unless a mixture of drugs ts given) since pupillary dilatation, accentuation of tendon reflexes and marked visual perceptual distor~ion arc not~present during the C-9 reaction~ lack of pupl.fary dtfatatton serves to differentiate C~9 from Scopolamine. Alcohol and barBiturates induce definite ·neurological changes (nystagmus, ·ataxia in gait and station, bu.t. do n.ot indu.cc ds:"yn.~s..S: o.f the mouth and the cha'racteris tic menta t cha.oge.s caus..e.d by C-9. The C-9 r~a~tlon is not likely t6 be confused with any of the. major ·ps·ychoses; it might however be confused with anxiety reactions or panJc ~t~tes. ·--·----- --- --------- ~ A-Jz) ·- '# . ~ ~· .' ~--~;-.;: ·~· '--::' . •'. . ~ ~ I fLSD-2~ ACUTE INTOXIC>\TIO.l WITH THE DIETHYLAMIDE CF lYSERGIC ACID ' ; I Definition. Acute intoxtcatron with thc~diethylamide of lysergic acid refers to the physiological and mental changes produced by the ingestion of that drug. Acute LSD intoxi- cation ts characterized by dilatation of the pupils, increased systol tc and diastolic blood pressures, Increased deep tendon reflex~s, decreased superficial skin reflexes, retention of the pupt lla_ry reactions to light and accomodatron and abs~nce of changes tn tests of motor coordination and sensory function. In addition, the drug induces a characteristic train of »ment~l" symptoms which include, in rough o-rder o.f app.::a-Pa-n·ce·, sensation that something is happening to the individual, nervousness and anxiety, peculiar sensations on the skin (electric shocks, hot and cold sensations, insects crawling on the skin,. changes 'in the texture of objects (a blanket feels like a buffalo robel,_ difficulty in concentrating, rapid rush of thoughts, changes tn mood which vary from great elation to severe dipression, ., changes in visual perception tthings and people appe~r to be blurred; people and objects change in size, shape and color}, tt e I e me n t a r y" h a I 1 u c tn a t i o n s ( p e r c e p t i o n of I i g h t s , co I o r s , diagrams,. patterns rapidly changing form, shape and size w~tch are most prominent on closing the eyes, or going into. a- darkened room), and -in extreme The page contains typed text describing the effects of LSD and another substance, possibly C-9. There are four numbered bullet points detailing observed physiological effects, and a handwritten annotation "A-327" in the lower right corner. The document appears to be a declassified item, with no official stamps or redactions visible. No photographs, diagrams, or evidence of experimental procedures or facilities are present. ( p e r c e p t i o n of I i g h t s , co I o r s , diagrams,. patterns rapidly changing form, shape and size w~tch are most prominent on closing the eyes, or going into. a- darkened room), and -in extreme cases, true hallucinations (see.ing persons or things that are ncr really pr.zsent). A-J:zty . . .. . ~ - "·a /--...:_, ) ·-··' Despite these expefienc~s, the subj~ct knows who h~ is, where l I. -he ts and the date and tim~. -· 1 Variations. The dzscrtption of LSD intoxication set forth in the definition above includes symptoms observ<.!d in indi- -vtduals who experienced maximal effects from LSD-25. tt must be borne in mind that, as ts the case·with all drugs, the effects of Identical doses of LSD vary widely In different lndtvtduals. A dose of 75 meg. may induce only slight nervous- ness tn one tndtvidua l, wh Tl e another ~ rson wi II experience marked visual distortions and i·rue haltucTnatlons. In the· ,,. . same tndividua I, the effect may vary, deperrdtn'g upon. environ- mental circumstances. At present, however, all the. reasons for the variations tn the d~gree of effcaoct in different individuals are not completely understood. Effect of dosage. As is the case with other drugs, t~e larger the dose of LSD, the greatcaor the effect in the same individual~ under the same circumstances. A person who experi- ences only mild effects after having r~ceived a dose of 75 meg. of LSD would b € expected ref exp{:!rience moderate to rr1arked effects with a dose o1 125 meg., and marked to severe effects with a· dose_of fSO tc (7~ meg. T\e dose of LSD also affcc}s H1 .: t t 17, e co u r s e o f f h e i :1 to x i c a t i o n • T h e z ~ ; e c i-s a p p € clr mo r e quickly and persist longer vdt:, t:1c larger doses. Time co rJ r s z • Th e •" • 1 r s t s . 1 g n s a n {J .. s yi,l p ' r on: s o r ,.. LSD in r 0 X i- rs cation appear _to 30 mfnure.s af}~r- ir.8est-ion of the drug; - . i -- \ The page contains typed text detailing the effects of a drug, including "Cardiovascular Effects" and "Psychosis After C-9." There is a handwritten annotation in the bottom right corner that appears to be a number, "A-324." Several small black dots are scattered across the page, likely from the printing or scanning process, and there are some faint horizontal lines indicating previous staple or binder marks. The document does not contain any direct visual evidence of experimental procedures, equipment, or facilities, nor does it feature photographs, stamps, or forms. Th e •" • 1 r s t s . 1 g n s a n {J .. s yi,l p ' r on: s o r ,.. LSD in r 0 X i- rs cation appear _to 30 mfnure.s af}~r- ir.8est-ion of the drug; - . i -- \ ..... -..... _) ~ ma x t ma I e f f e c t s a r e u s u a I I y e v i de n t w H f. i n t \'!O ho u r s • T h e effects rematn maximal unttl the 4th hour of the infcxicatian 't ! . ,• gradually decline. and signs greatly and~ th~reafter, Sym~toms abate after eight hours and are usually completely gone after "!6 hours. Occasionally, s~vere reactions may persist un~il the or 12th 16th hour after t~e .drug is ingeste-ds a_nd, in certain individu~ls, symptoms may be reported f~r several days after tnge·stion of a single dose of the drug. Tyoical LSD reactions .. Typical· LSD reactions ma-y be described as mi fd, moderate, marked or severe on the bas is of the mental symptoms experierrced. Mi I ci r e a c t i o n • .~ m I f d r e a c t i o n co n s i s r s o f a p e r c c p t i o n on the part of the subject that so.r,--e thing has happ~Gn~d; some cheil(;e, wrdch js·djfficulr to ci·ncribe, has oc-:urred in th~ way the subject feels. This c~ange consists chiefly of sen- r sa t i 0 n s 0 f a p pre he n s i 0 n , a n X t e t y a n d n e vo us n e s s • Co n cam it a n f ! y ' the subj.ect may experience fe..:Lings of tremC..ling inside his· body of uncomfortable sensations in H~e stor1acn or chest, and heaviness in various muscles, n particularly the peck. T h e s u b j e c t !i a s d i f f i c u y i n co n c e n - . . tratrng andcarrying out .tasks involving inrellech.tal effort. He is, however, able to .o erform these tasks, thouch some0het " more slo~ly than in the undrugged The page contains typed text from what appears to be a declassified government document. In the top right corner, there is a handwritten annotation "A-325". There are also several smudges and flecks of what appears to be dirt or debris scattered across the page, as well as some faint horizontal lines, possibly from the scanning or printing process. No photographs, stamps, forms, diagrams, tables, or redactions are visible. j e c t !i a s d i f f i c u y i n co n c e n - . . tratrng andcarrying out .tasks involving inrellech.tal effort. He is, however, able to .o erform these tasks, thouch some0het " more slo~ly than in the undrugged state. r.. :oo d' i n t h i s c. f rea c t i o n , i s mo s t f r ·z que n r I 'I one of mi I J ·d a t i o n a n d e a s y I a ug h t e r' • V is u a I . ~ r c e p t u a I d i s to r t i o n s {c ..h a n g e s i n s '1 1 p <:: :1 - --- .. -~··. .. r-·· ·~ srz~~ color.. ·of person: or objects} do not occur. "Eler11cntary" . ff ha~lucinations and Hfrue hallucinations ~re not present. In- , ~Jght_ is jetaincd- the. subj~ct realizes that the symptoms he ts experJencing are due to the drug. Exampll of mild LSD reaction~ A negro male, age 40, received 138 meg. of LSD-25 orally at 8 a.m. At 8:30, pupils had .increased I mm. in diameter; deep tendon reflexes were unch.anged. No subjective symptoms were reported at this time. ·· B - y · 9 o'clock~ pupils had increased 2 mm. tn diameter and ~eep tendori reflexes had increased from a barely perceptible -jerk to a vigorous, rapid twttch. At 9 o 1ctock, patient reported s~n- sattons of unsteadiness, nervousness and increased s~livation. At 10 o'clock, pupt Is nad increased 3 mm.· a-s compared \'rith the pre-drugged state; the knee jerks remained hyperactive. Tne patient continued to report increased nervousne~s, unsteadiness a n d t n de s c r i b a b f e s e n sa t i o n s t h a t t h i n g s we r e d i f f e r e n t • No change. in his overt behavior was obaer:\!ed. At II o 1ciock, pupils had increased 4 mm. in diameter; knee Jerk had become rep~titive on a single I iofd tap. The: p:·ri-ent conrinu~c to repcrt nervous- .• LSD· was·.' .t.a ken, pu.pils w-zre ·3 rnm._._larger tha;'l prio.r The document page contains typed text from what appears to be a medical or scientific report about the effects of LSD. There is handwritten marginalia in the top right corner, including a circled "30" and the text "A-324" in the bottom right. There is a black ink scribble obscuring a portion of the text in the lower middle of the page. The page also shows evidence of a hole punch at the top, suggesting it was part of a binder. n t • No change. in his overt behavior was obaer:\!ed. At II o 1ciock, pupils had increased 4 mm. in diameter; knee Jerk had become rep~titive on a single I iofd tap. The: p:·ri-ent conrinu~c to repcrt nervous- .• LSD· was·.' .t.a ken, pu.pils w-zre ·3 rnm._._larger tha;'l prio.r to ingesrion ' of the drug. i~n~c j.arks were still r:10re active rhan be·(crc the drug, but, by this time, the patient was no longer rep.orting subje6tive tensations of any kin~ and he had begun to read again. --------~~~--f.?_!.!9wi_ng ___ iil~r_!'!i!:lg ___h e repor·ted that h_e __ experienced nc furt~·r ... . '1 .... . - ~ ~ . , .. lvc -, sub j e c..!/s e n sa t to n s a ; t e r 2 p. m • This Ts,. therefore, an I -r~lu~tration of a very mild reaction to a rather large dose of ~· ! LSD and despite the occurence o~ marked physiological changes. 1 . ! t¥Pdera·te reaction. This degree of LSD effect includes alt ·the symptoms listed above under the mild reaction, In addition, the subject experiences changes in visual perception. These consist largely of alteration ln the size, sflape and color of the subject's own body, or parts of his body, of other people, or of ·inanimate objects. t/ood in th ts grade of react ion is usually one of slight depression._ Ordinarily, a distinct change ln overt behavior occurs.· The patient stops re-adlng and does not spontaneously carry out any other activiry requiring intel- 1e c t u a I e f f o r t ; r a t h e r s-i t s q u i e t I y b y h i r:1 s ~ 1 f • Ho we v e. r , h e c a n converse rationally, answer· questions accurately, and carry out tasks involving some degree of m.zntaleffcrt, although:the time r e q u i red to c a r r y o u t t h e s e t a s k s i s i nc r e a s e d • Oc c a s l o n a I f y , patients are quite elated, laughing and giggling .. Subject is definitely apprehensive; he may perceive a few "eler:1entary" ha(lucinc:dions Cliahts, coiors possibiy forming diagrams and r r p a t f The page is a typed document with handwritten annotations. There is no photographic content, stamps, forms, diagrams, schematics, or organizational charts. The document is primarily text discussing LSD intoxication, its effects, and variations in individual responses. There are several handwritten annotations: one is a large, dark block obscuring part of the text near the bottom right, and another is the handwritten alphanumeric designation "A-323" in the bottom right corner. r e a s e d • Oc c a s l o n a I f y , patients are quite elated, laughing and giggling .. Subject is definitely apprehensive; he may perceive a few "eler:1entary" ha(lucinc:dions Cliahts, coiors possibiy forming diagrams and r r p a t f e r n s ..., h i c h a r e mo s t p r 0 m i n e. n t 0 n c 0 s n g f h-e e ye s .0 r g 0 i il g into th-z dark.}. True haflucinations do not: occur •. Subjec·~ is l!orientedn tkr.ovts who anc!"where !1e is and the day o-f th~ ii.onthl. insight is retained: the subject realizes that his subjective experiences ar~ due to the drugi H € does not reporf experiencing n .. a St!nsat ion that he.-is -!inother .person or· Hlat a part of is 4-320 ... - "A body does not; ue long . to him. Example of moderate reaction. A white rna re,. age 27, -· received. 75 meg. of LS!) at 9:45a.m. At 10:15, pu~ils were ! ! dilated f ~m., and knee jerks had increased~ At this time the patte~t reported sensations that some change was occurring and that he felt nervous and was trembling inside. At 10:~5_, these sensations were increasing, pupils were now 3 mm. la·rger than before taking the drug and the knee~jerk had become extremely hyperactive. The patient initially was el~t~d, talked very volubfy, but by 12:45, preferred to sit quietly, although he .... answered questions readily when inter•./ie•.·,eC:. At 12:45, he reported that his vfstcn was blurred; that his· hands appeared to change size and shape as he watched them. At timc$ other 1 p~oplc appeered to be quite small and, at other times, exrreme•y ' I large. On closing his eyes the patient saw shim~ering white '· lights. Despite the distortion oF his hands,~~ther persons and inanimate objects, he identified the hand~ as being his own and unerringly Identified other objects and other persons. At 4:45p.m., the patient no longer re;Jortet! ·:isual drstori ions, but stiff was exp~ricncing apprehension and nervous-IT~·=ss. symptorr.s gradual&·