Doc 0000151889

~~ .... Oep·~'·· of HEALTH, EDUCATION, AND\. _c..rAR- Pul Health Service. 1 NATIONAL INSTITUTES OF HEALTH . 8 March 1957 IN ltiPLY1NCI ADORISI TM& NAtiOIIAI. IIISTfTVTI 0,.· ~IIITAL HIAt.Tif AODICTIOII R..:SIARCH CIIITU ,· U.S. ftVIIUC HIAI.TII SIIIYICI HOSPITAL P. 0. 801 zooo LllUII.lQII. KIIITVCII:T l I have tested the new Jot of mater ta I on 3 men us tn;'\ , doses of I to 1.5 ~./kg. of body weight. Typical ) ~ :r" reactions appeared which were of the same Intensity I r~_.. t."" o b s e r ve d i n t he s a me pa t i en t s d u r t ng . a pre e e d t ng (.._ " )f"""f' week, using a lot of older materia I. t, therefore, / ~~ fezl that the new matertal is blologlcally active as ' , . t h e o I d , a n d t h a ~ a n y f u r t h e r t e s t i n g of it I s \ • o ;L...-- >· j //-· _./< - u nne c e s s a r y • l f you w t s h mo r e ext e n s Tv e · t e s t i n g I . please let me know. ~ I am enclosing a table showtng resuUs obtained when 2-4 mg./70 kg. of SOL-148 wer~ administered simultaneo~ ly r. with .S-1.5 mcg./kg. of LSD. There is, obviously, no stat 1st lea I dtfference tn any of the measurements. I have cbt~lned a copy of Nature contalnlng the paper by Ginzel and Mayer-Gross_ in which blocking of lSD-25 by SOl was reported. Thts apparently occurred only when BOL was given for ~t feast tv..o days prtor to LSD. I wtll prcc~cd ~o inv~stigate tf1ts. It sounds more like tolerance than tt does like competitive blocking. 0 the r s a Is o report that 1 n t r a ve no us in j e c t .1 on of Bu l at ·the h-eight of··the reaction, dt.d n·ot a lte.r the LSD- .. . react ion. ·Very stncer~ly yours, f-\ .. > (' t . ~: -~y \ ., ~: ~:: ~- / - ;,~ .. - . -~.. .~ -. Ha r r i s I s be I The page presents a black background with a stylized blue-hued graphic of a bank vault door on the left. The title "THE BLACK VAULT" is prominently displayed in white, distressed lettering across the top center. Below the title, white text details the document's origin from "The Black Vault," an online database of declassified government documents, specifically mentioning the "MKULTRA/Mind Control Collection," compiled by the CIA, and providing a URL. A yellow, clickable hyperlink, "http://mkultra.theblackvault.com," is located at the bottom. There are no photographs, handwritten annotations, signatures, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. l at ·the h-eight of··the reaction, dt.d n·ot a lte.r the LSD- .. . react ion. ·Very stncer~ly yours, f-\ .. > (' t . ~: -~y \ ., ~: ~:: ~- / - ;,~ .. - . -~.. .~ -. Ha r r i s I s be I I , M. D. Director HI: I w Enclosur~ j -{- . . ·------. --· -·-p··--·· -- •. . ... ~ - The document is a typed letter dated March 8, 1957, from the National Institutes of Health. It features multiple handwritten annotations, including circled numbers, a note in the margin, and a signature. A circled "90" appears in the upper right quadrant, and a section of text is circled with smaller numbers "(2)(3)" next to it. There is a handwritten note in the margin that reads "humans and (?) sample ok". The signature at the bottom appears to be that of Harris Isbell, M. D., Director, along with the label "Director." A small marginal note "-6" is present on the left side of the page.