Doc 0000151892

~-~.-...::,. ··.~::-...~ :.. . .. . :; •.·.~,·:..:~...:.. .• ·r~.1.ii,~. . :~;· __ ;;:_~!;.:-.... :a.i~ . :.:._..-.;:...:z.::.·~: -~· ~..:-.:;:.-:=~ :.:~;,.··:.~~--~~ --~·:_:.· -~.;..-z. .... ~.:.:. ~-.;i::::·...o. ,:.i1.-::.:. :.~-=- .. Y . .. :i'};::, :~-=~·=:;-··::::_ ;::._ ...:rt.o.~~~ :.:.:-7-.-:--•: .M~-:.-·*"--··.> •. ;--: ·--~··:,-.. .- . -"..' ..· ~-'\ ! ~ EFFECTS OF ACUTE ADMINIS.TRAT ION OF BAS ·IN WAN ! Ij . _.· l BAS li-Benzyl-2-methyl-5-m¢thoxy was tryptamin~·) synthesized by 0. W. Wooley of the· Rocl::efellel".·tnstttute. I . He found that It was an effective anti-serotonin when tested against carotid artery rtngsl!l vitro. He: also found that BAS blocked the blood pressure elevation rcsu•ttng from Intravenous administration of LSD In dogs. Wt lldns, fn Boston, studied the effects· of BAS as an antihypertensive: agent. He found that It dtd cause reduction in blood· pressure of hypertensives, slg~tftcant and that, when administered chronically ln doses ranging between 40-160 mg. daily (total dose}, tt Induced effects. resembling those caused by reserpine ("intolerable" sedatton, snuffy gastrointestinal symptoms, etc.). no~e, Our experiments were carried out in order to study the effects of an acute or subacute administration of BAS tn human subjects, and were to experiments pfelimi~ary In which the substance woutd. be used in an effort to block the LSD reaction (see other report). Subjects used were all former· morphine addlcts who had been withdrawn from optates and had been abstinent from that drug for a pertod of at least three months. Al1 -were Negroes ranging in age from 21-40 years. All were in an excellent of physical health, and none had any stat~ evidence of a major psychosis. A-Js-2.__ - ·' - • I • ..... _, BAS was administered orally. Stngle doses, ranging between 5-400 mg. which were Increased gradually In ~· step-wtse fashion between experiments, caused no significant effects during the flrst 8 h~urs after administration. However, after the htgher doses patients began to report the development of effects occurring 12-16 hours after _ taking the drug. These effects Included dizziness, feelings \. o{ fatigue, nausea, and diarrhea. The observation schedule was accordtn~ly changed and patients were studied from the 12th to the 20th hour after oral admfntstratton of 400 mg • • of the drug. Nb slgntficant effects on temperature, pulse, respiratory rate, resting blood pressure, pupillary ~tze, or kneejerks were observed, although many of the pat)ents did report fatigue, mental depression, and nausea. Effects of repeated admtnrstratfon of doses of 150- The image presents a digital representation of a document's header from "THE BLACK VAULT". On the left, a stylized illustration of a bank vault door is visible, featuring intricate mechanical details and a blue glow. To the right, white text explains that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically from the MKULTRA/Mind Control Collection. This collection, housing over 20,000 declassified CIA pages, is available for download at a provided URL which is prominently displayed in yellow. The overall impression conveyed is one of secrecy, accessibility of information, and a direct link to highly classified historical records. 20th hour after oral admfntstratton of 400 mg • • of the drug. Nb slgntficant effects on temperature, pulse, respiratory rate, resting blood pressure, pupillary ~tze, or kneejerks were observed, although many of the pat)ents did report fatigue, mental depression, and nausea. Effects of repeated admtnrstratfon of doses of 150- 200 mg. were then studied. Drugs were given at eight-hour Intervals. No objective effects and no subjectTve reports occurred after the first two aoses. After the third dose, however, pJtients began to rtport weakness, fatigu~, dizziness, me~tal dullness, nausea,·and diarrhea. These effects persIsted fer two to· thr.ee days after the drug was dlsccntlnued. No obj~cttve changes were observed on puptl lary stze, reflexes, resting blood pressur~, temperature, . pulse, or rate. r~spJratory .. A-JF! r '· -. ·-· . - ·- ) Discuss Ton. In farge BAS tndu·ces marked doses-~ subjective effects without any obJective change. gr~at f lt ls not clear how these effects are produc~d; they could etther be central or perlpheral. It should be noted~ however, that although BAS Is a powerful antt-serotontn (as ts LSD) no symptoms resembling those seen after LSD were. observed. - J '.-- ... - i .... . . This page contains typewritten text, likely a research paper or report, with some handwritten annotations and markings. A circled "95" appears in the upper right corner, and an additional annotation "A-352" is written in the lower right. There's also a faint, abstract stamp-like mark in the upper left corner. The document appears to be a technical or scientific report due to the subject matter and the nature of the annotations. The image is a scanned page of a typewritten document. The text describes the administration and effects of a drug, likely within a medical or scientific study. There are no photographs, diagrams, forms, stamps, or redactions visible on this page. The only visual element aside from the text is a handwritten annotation in the lower right corner that reads "A-351". The page appears to be a typewritten document, with "Page 3" clearly visible at the top. The majority of the page contains text discussing the effects of BAS, with phrases like "subjective effects" and "anti-serotonin" being legible. There is a handwritten annotation on the right side of the page that reads "A-350." Some faint horizontal lines are present near the top and middle of the page, possibly from the original paper or printing process. The bottom right corner includes a fragment of a black vertical bar, likely indicating edge of the page or a binder.