Doc 0000151893

-~ ) ATTEMPTED BLOCKif'G OF THE LSD ~EACTICN WITH BAS @;-· Th~se exp~r'tm~nts wer~ carr led out b~caus~ ,·tt ts known that BAS Is a powerful ant 1-s~roton tn and the - i { possibility existed that the LSD psychosis was due to &n of the effects of serotonin within the ac~entuatton central nervous system {LSD In low concentratto~ potentiates rather than blocks the effects of serotonin tn smooth muscle preparations). The subjects used were 10 of the same IS Negro male~ former drug addicts who served· tn the experiments dea J ing wtth the acute effects of BAS. These patients rece tved the following drug combfnatlons in a randomized order (latin square): BAS placebo plus LSD placebo; BAS plus LSD placebo; BAS placebo plus LSD; and BAS plus LSD. Doses of BAS were ISO mg. every stx hours for four doses (total dose 600 mg.J. The last dose was given two hours before LSD. LSD was admtnlst~red orally in doses ranging between 0.5-1.5 mcgm./~g. (~verage of 1.1 mcgm./kg.). The smaller doses were gtven to the men who were tested ftrst stnce tfie posstbil tty exlsted that BAS and LSD might s yne rgl ze. , ., Methods. The methods used Included determination of' pupillary size~ threshold f'or knee jerk, resting ,. systolic blood pressure, .. response to a modtf'tcatton of f the Abramson-Jarvflc questionnaire, and evaluatlo~ of' the -- cltnJcal grade of the LSD reaction based on short psychiatric examinations. These methods and the means of stattstteal analysts employed have been previously described In other reports. The results are shown In the accompanying table. The onfy Important change noted was stgnJf'Icant blocking of' LSD Induced elevation in blood pressure by the BAS. All other aspects of' the reaction. Including mental response, were unaffected. A number of patients withdrew from all experiments after these tests were completed, primarily because of long persistence of the unpleasant BAS effects. Discussion. The results do not favor the hypothesis that LSD psychosis Is due to potenttatton of serotonin within the central nirvous system. They, however, eff~cts do not exclude this poss tbt·r tty since we do not know whether the symptoms caused by BAS are due fo per iphera r or to .. ·c~n~ral acttons. . . - • ...... .. ; , .. . ' • ,, ~ ::;... ,, 7 \!: ATTEMPTED BlOCK lf\G OF LSD RE.r\CTION WI TI-l BAS ·' '! The image displays a digitally rendered vault door on the left side with bright blue accents, set against a dark background with a gradient effect. To the right of the vault is white text on a black background. The text is a disclaimer originating from "The Black Vault," a database of declassified government documents, specifically mentioning a collection related to MKULTRA/Mind Control from the CIA. Below this text is a prominent yellow URL: http://mkultra.theblackvault.com. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, or redactions visible on this page. The page contains text detailing an experiment on blocking LSD reactions with a substance called BAS. There are handwritten annotations in the top right and bottom left and bottom right corners of the page. The top right contains a circled number "694" and the bottom right contains "4-349". In the bottom left corner is "Σεται 2" which is likely "Exhibit 2". There are no photographs, stamps, forms, diagrams, tables, or clear visual evidence of experimental procedures. The document appears to be a typed report with handwritten additions. we do not know whether the symptoms caused by BAS are due fo per iphera r or to .. ·c~n~ral acttons. . . - • ...... .. ; , .. . ' • ,, ~ ::;... ,, 7 \!: ATTEMPTED BlOCK lf\G OF LSD RE.r\CTION WI TI-l BAS ·' '! ~ j, r'· .)oo· .., \ ' -~ .. JRE DRUG - " i; ' · ·l ·a BAS PLACEBO + B.-\S + B/>.S .t. BAS Pl1\CE BO ' • ; . - .i. \ - LSD PlACEBO l SD PL .ACE BO L - S - D - .J. lS~ - :~ ,, .. "' ' I a,. ~ e r I eX . .f. 0.13 .f. 0.14 ... 1.17 ... 0.17 .f. 2.04 .f. 0.29 + 2.0? .J. 0.43 ( . . . ·;~~ ............... "... 'J p f I I a r y S I ze - o. II .t. 0. 22 + 1.37 .f. 0.55 . .f. 3.79 -... 0.35 .J. 4.54 .J. o.2e - - ~ · . . vstollc 131ood Pressure .f. 0.59 - + o. I 0 .f. 0.12 .f. 0.31 + o. 70 .f. 0.36 ... 2.&0 .J. 0.46 I I - ·-- i- !l . '2 ~- •Jr.~ber of Quest fons 0.7 .! 0.9 5 -.f. 0.3 I 43 -.J. tJ 2 - -1. 13 ··.- ·• . - -- .:.A. \ .. ; : / I I n I c a I Grade 0 -.... 0· 0.3 -.f. 0.3 I • I - .f. 0.1 . I .J .J. o. I ~. - 'I - - ·i I ~ ; i ~ ( : Dose of LSD= O.S- 1.5 mcg.;/kg. (-t~Ye.0.95 mcg./kg.) · :·i ·\· :; ... . ,. )I '•..,., .. ,.·i Dosage of BAS= 600 mg. In 24 h~urs given In 4 doses of 150 mg. :{ ;! it Figures are,means ot observatIons on 10 subjects! sfand~rd errors. ', I! • ~ I r ji . • !I 1: •. • • : .. • ~ \ ) / @ ACUTE EFFECTS OF LARGE DOSES OF BOL IN ~N D-2-Brom-lysergTc aeld diethylamide (BOLl differs fro~ LSD only tn the presence of a bromine atom at carbon No • 2 • T h 1s ma t e r t a I · t s a po t e n t a n t t - s e r o The page is a typewritten document with handwritten annotations at the top and bottom. There are no photographs, diagrams, forms, or official stamps visible. The handwritten content includes a title at the top, "Page 2", and a numerical designation, "A-348", at the bottom right. The text appears to be a scientific or research report, discussing methods and results of a study involving LSD. There are no redactions or visual evidence of experimental procedures or equipment. ~N D-2-Brom-lysergTc aeld diethylamide (BOLl differs fro~ LSD only tn the presence of a bromine atom at carbon No • 2 • T h 1s ma t e r t a I · t s a po t e n t a n t t - s e r o to n t n J.!!. v T t r o • -- Roth I In et al have reported that the doses of SOL 20 times greater than those of LSD do not Induce a psychosis tn man. Since~ ltke. LSD, BOL reverses prolongation of hexobarbtta1 sleeptng-ttme by serotonin tt must be presumed that the drug do~s reach the central nervous system. These expert- ments have been· interpreted as not favor lng the hypothes ts wh lch attributes the LSD psychos ts to tnh iblt ton of bra tn serctontn. by LSD. It occurred to us that, because of the chemical stm11arlty of the two compounds SOL might possibly block the LSD reaction. It was first necessary to re-evaluate the acute effects of this substance tn man. Subjects used were IS Negro male addicts who had been abstinent from opiates for at least three months. All cf these subjects had bad considerable experience wtth the subjective effects induced by LSD. SOL was given orally. tntttal doses were 5 mcgm./kg. of bodywetght, whtch was Increased tn step-wise fashion, as the experiments proceeded to almost 9o mcgm./kg. The htghest total dose given was 8 mg. • - f i ... , .... -· Obs~rvat tons. Th~ following obs~rvattons w~r~ mad~ two hours b~for~ and for on~ hour aft~r th~ admlntstratTon of BOL: rectal t~mp~rature, r~sttng puis~ rat~, ,.respiratory i ' rate, resting systolic and dfastoftc blood pressures, threshold for ~licitation of kneejerk, pupillary stz~, modification of the Abramson-Jarvtk questionna.tre, and a short psychiatric examination. Results. Doses .of BOL up to 4 mg./70 kg. caused n~tth~r subJective nor objective eff~cts. Doses of 4 mg. or more p~r 70 kg. of bodyweight Induced mild effects, whfch are presented tn the tabfe. These Included small fncreas~s In systolic blood pressure, diameter of the pupil, and tn the threshold for kneejerks. The "mental" symptoms Included nervousness, nausea, chilly sensations, blurred vtston and, tn some patients, colored lights and hallucinations. '· React tons are described as resembling those ~fa very sma II dose of LSD and were milder than the effects of 0.5-1.5 mcgm. of LSD In This document contains a table that presents data on the attempted blocking of LSD reactions with BAS (Brom-DMA). The table has columns for different drug conditions (BAS PLACEBO + LSD PLACEBO, BAS + LSD PLACEBO, BAS + LSD, BAS PLACEBO + LSD) and rows for observed effects like pupillary reflex, pupillary size, systolic blood pressure, number of questions, and clinical grade. Handwritten annotations are present, including "A-347" in the top right corner. The page also includes typed text below the table providing details on the dosage of LSD and BAS used in the experiment, and indicating that the figures represent means of observations on 10 subjects with standard errors. tn the threshold for kneejerks. The "mental" symptoms Included nervousness, nausea, chilly sensations, blurred vtston and, tn some patients, colored lights and hallucinations. '· React tons are described as resembling those ~fa very sma II dose of LSD and were milder than the effects of 0.5-1.5 mcgm. of LSD In the same subjects (s.ee table). Jt Is estimated that the effects are no greater in degree than tnose !nduc~d by O.QS-0.5 mcgm./kg. of LSD. BOL rs, 'therefore, at least 100-200 t.imes less potent tha.n LSD. It ls, In fact, far f ~ s s po tent · than I y s erg t c a c i d mo no e thy I am t de CL A E ) • Dlscussfon. ·These result~ confi~m those of Rothft~ and do not favor the hypothesis which attributes the LSD psychbsls to a "deficlencyn of serotonin • . --~ -·--· - ~-~ ________ _____ ------------.-·- _. ., .... .. e "-"-" . ..... ....... .... "' .... -:_.. .... ~-,~~-~~ -~-:.:.;,. ,,._._.;,.~~ -=-··-·~ ~"':' ~ ;;~-:,~~,-:---~-~- ;,..~~;·~··"-::~ ·=-·"'"·' .. -, •.•.• x-::.: ~; -~''-"'-·' •".":: :;-c~-r ""'""• -/"'"~, -~- ·:...-., ! l. 1 l. D-2-B~\.M-LYSERGIC j EFFECTS OF 5-S WG./70 KG. OF ACID DIETHYLAMIDE j ,. i ~SURE DRUG - I 2 PLACEBO BOl LSD tetlar Reflex 3 + o. r s - + 0.12 + 0.68 -+ 0.2 2.29 - + 0.32 . ~ t I I a r v S i ze · - o. 16 - + o. re + 1.54 -+ 0.33 4.93 - + 0.36 stollc B-1 ood Pressure + 0.68 - + 0.2 + 0.95 - + 0.3 2.69 - + 0.3 ' nbe r of Que-stions ·2 - + I .2: 13 -+ 4.7 61 -+ I I in i ca I Grade 0 - + 0 0.6 -+ 0.15 ·2.0 - + l .. i .. . " _ :! Average dose of BOL = 6.0 mg./70 kg.= 86 mcg./kg. = 2 0.5 to 1.5 meg. of LSD/"s. (_Average I .I meg ./kg.). 3 Figures are means on IS subjects! standard errors. •. ,· .... ; -· The page contains typed text detailing research on the effects of BOL. Handwritten annotations include circled numbers "95" in the top right and bottom right corners, and a handwritten alphanumeric code "A-346" on the right side of the page. There are no photographs, stamps, forms, diagrams, tables, or obvious visual evidence of experimental procedures. The content appears to be from a scientific or research document, with the primary visual elements being the typed text and handwritten notes. The page consists of scanned text from a document. There are no photographs, diagrams, forms, or stamps visible. The only handwritten annotation is a number "A-345" in the lower right corner. The document appears to be a report discussing observations and results of an experiment involving BOL and LSD, with a discussion section. There are no visual cues related to experimental procedures or equipment. The document displays a table comparing the effects of different drugs (BOL and LSD) against a placebo, measuring various physiological and psychological responses. The table includes columns for "PLACEBO," "BOL," and "LSD," with rows detailing "Stellar Reflex," "Pupillary Size," "Stolic Blood Pressure," "Number of Questions," and "Clinical Grade." Handwritten annotations, including a number "1-344" in the lower right corner and superscripts marking footnotes at the top of some table entries, are visible. Additionally, a title at the top states "EFFECTS OF 5-8 MG./70 KG. OF D-2-BRUM-LYSERGIC ACID DIETHYLAMIDE." Three numbered footnotes below the table provide further context on the doses and measurement standards used in the experiment.