Doc 0000151894

.. e. <) . GIVE§. ATTEMPTS TO BLOCK LSD REACTION WITn BOL SIMULTANEOUSlY ''Ill TH LSD ,. These experiments were carried out because the close chemical stmtlarlty of BOLand LSD that suggest~d BOL might block the LSD by competing. with LSD r~actlon for receptor sltes. Subjects used were IS nontolerant former morphine rn addicts, all Negro males who were good physical con dition who presented no evidence of major psychoses • • Mbst of these patients had had considerable experience wtth LSD. They received, in randomized order, the following drug combinartons: BOL placebo plus LSD placebo; BOL plus LSD; and BOL placebo plus LSD. The combtnatton of SOL plus LSD placebo was not studied because of the shortage of BOt, and also because the results should be wirn tdenttcal those described In the dealing repor~ wi~h the acute effects of BOL. The dosage of BOL was ~-4 mg./70 kc. of bodyweight and was given with the LSD. Ntne pattenti recetvid. the .. higher dose. The dose of.LSD was 0.5-1.5 mcgm./kg. Smaller doses were used.in rhe firs~ pa~i·znts tested, because of the ;:>osslbl1 Hy ~hat the drugs mtght synergtze • .. • , .. ... ... ·- 4" - -- - -~ . ·. · .... M~thods. Mea s urcmen ts Inc I uded t hresho I d Tor knee jerks • pupillary diameter, systolic blood pressure, th~Abramson­ qu~stlonnalrc, Jarvlk and grading of mental effects using scal~ Th~ the previously described. results are shown In table~ the a eopy of wh feh was sent wlth my letter of 8 March 1957. It Is obvious that there was no significant r~etJon blocking of the LSD and no aeeentuatton of it. CO:nelusfon. Admfnhtratron of BOL slmultaneous.ly with LSD does not bloek or aceentua te the LSD reaet ion. There h no reason to believe that gJvfng BOL after LSD results~ would•gtve any different slnee Ginzel and Mayer Gross have reported that Intravenous admf-nlstratlon of SOL does not reverse the LSD reaction. These results suggest that the attenuation of the LSD reaetJon observed after two days pre-treatment with LSD is due to the development of eross tolerance. ____ -------·· --- -----------·-. -·-- ___ ._... --·-····- .. -- .-. ,. ';; . ... i . ... The image is a screenshot featuring a digital representation of a vault door on the left side and text on the right. The vault door is detailed with a heavy, metallic appearance, complete with multiple locks, gears, and a large dial. The text is presented in white and yellow, with the heading "THE BLACK VAULT" in a stylized font. It describes that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection housed there, and provides a URL for downloading the collection. This visual presentation suggests the thematic content of the document and its origin from a source dedicated to publicizing declassified information, employing imagery often associated with secrecy and security. of eross tolerance. ____ -------·· --- -----------·-. -·-- ___ ._... --·-····- .. -- .-. ,. ';; . ... i . ... The document is a typed page of research notes, likely from an experiment. There are handwritten annotations in the upper right corner: a circle around the number "96" and a diagonal line through it. Below that, a diagonal handwritten notation appears to be "4-343". The page contains no photographs, stamps, forms, diagrams, tables, or visual evidence of experimental procedures, equipment, or facilities. The text is clear and legible, with no visible redactions. The page contains primarily typed text. There are no photographs, official stamps, forms, diagrams, or structured data visible. The text discusses experimental methods and conclusions related to LSD reactions and an abbreviation "BOL." There is a handwritten annotation in the lower right corner that reads "4-342." The page is titled "Page 2" at the top. No specific experimental procedures or equipment are visually depicted, only the written findings.