Doc 0000151896

' j. 25 Apr i 1 1 Y57 . 1M IIC""-'1'1N4 AODIIISS TlfC L ltA110liA~ IIIS11TUft 0' M IIIJAL HIALl'H AOOICTIOif ltUCAIIell CWIOTt• l • U.S. I"Vauc HULfll SCII'IICC HOSPITAt l 1'. 0. lOll ZOOO i l.lztii.TOII. XIJtfUCII1' i (h)]) ------ . ----- ..... ·-·-·· . ---· --------·- .. . .1 am enclosing copy of proposed budget for fiscal year 1958 which has already been sent to Mr. Robert E. Motley, ~-dministrative ~ss istant fo_r Bas !c Research, National .tnstltute or Mental Health. He will submit it shortly to the Office of Naval Xesearch. Also enclosed is letter to Mr .• Motley asking him · t o increase .ltem 3, under- travel,. by·~•nar. The material have been using is designated as 1-methyl .1. lysergic acid d!ethyla~ide. .1.t bears the Saneoz ~ode number ~~D-41, Lot No. 060001 273001. An!n:al pharzr.acology indicates toxicity is_ about equal to that of LSD in m!ce. The ~~ter!al is 3.7 times as active as LSD in inhibiting serotonin. .Lt !s pyrogenic in the rabbit, but less so than LSD! J.n mice it_is said to produce only minimal excitation and no mydriasis •. · .1.n the cat~ · ef'fects are a 1! tt 1 e different tha."'l those produced by LSD, ~ut studies are not complete. · . Ev~h1a.t! on he~e~ ::11 t~ough !ncomo!et_e, in . d . ica. tes that the-· material produces effects in man some·what 1 ilte LSE>, but . that MLD is· less potent. .tt induces ·mydriasis, e'!evat!on in blood pressure, facilitation of deep tendoh rerlexes and the usual constellation of LSD-l!ke subjective sy~ptoms. · The dose required to ~ncuce a Grade 3 reaction is prc~ably . .o n the order of 4-6 mcg./Kg. as compared with 2 mcg./kg. of LSD •. -- Other materials l have arc t-acetyl-lyserg!c acid dieth~-:tamt.:r~ bitartrate (;J.D-52) and Pyr~olidid of d-lysergic acid (LPD-82l~). Sincerely yours, ! .• / • .. () ~ .,._ . .'" I ,:;:A'/,'::·"" ~ -~ '•~-\._/ / '/.._ H~r I ri . S · ' .:., . 1 .. ·. S . • .. h -:; ?!l, : ..M.... -...D-·-. - Director- HL:rn. ~ /' /-... ., / Enclosures '- ,_ . -= ... -· to the Abramson-Jarvlk qucstlonnatr~, and assessment of •' the degre~ of the reaction by the clfnfeal sradt~g syst~m prcvtously·deserlbed. handling these data have M~thods.of been prcvtouslv. reported. The results are shown tn the aeeompanytng R~sults. -· table and The image is a screenshot from a website. On the left, there is a large, stylized illustration of a bank vault door with intricate mechanical details and a blue glow. On the right, text serves as a disclaimer, stating the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection and providing a website URL for access. No photographs, handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures are present. The visual elements are limited to the vault illustration and the textual disclaimer. ~ /' /-... ., / Enclosures '- ,_ . -= ... -· to the Abramson-Jarvlk qucstlonnatr~, and assessment of •' the degre~ of the reaction by the clfnfeal sradt~g syst~m prcvtously·deserlbed. handling these data have M~thods.of been prcvtouslv. reported. The results are shown tn the aeeompanytng R~sults. -· table and are suggestive of a reduction tn the Intensity of the. . LSD react ton. They show a reduct ton tn every aspect of the LSD reaction measured. The differences between the response seen after BOt plus LSD and those seen after BOL-plaeebo plus LSD reached stat:tstleal stgnlficanec in • the ease of effects on the kneeJerks and on blood pressure, but were not stgnlfleant on of pupillary size, mcasur~ments number of questions, and eltnteal grade. The experiment aetua lly was unsatisfactory for several reasons: (IJ The number of subjects was small because of BOL; (2) Six of the subjects were new, o~ th~ shortag~ a nd 4 of t h c s e pro ve d to b~ non -r e s po nd e r s ( h ad no men t a J symptoms with the dose of LSD used) wtth r~sultlng skewness tn the st~tisttcs; t3) the res~Hs of GJnzel and. Mav~r-Gross ....... ·. . suggest that cross-tolerance to LSD Js .develop_lng whtch . .. I tkely ·would n~t b~ c()mplete in· 2. oa.ys. In the· only 2 experienced subjects available., the L S0 r e a c t i o n wa s a I mo s t t o t a I I y b f o .c l:: e d by p r e t r e at me n t wtth BOt. --· ---- ------ -------- --·- --·"": - ---- --- .. ----- -~ ~~ -~---- .. . • .r •. The document is a declassified letter on official letterhead from the U.S. Public Health Service, National Institutes of Health, dated April 25, 1957. It displays a circular seal with the text "DEPT. OF HEALTH, EDUCATION, AND WELFARE" and "NATIONAL INSTITUTES OF HEALTH". There are two handwritten annotations: "(b)(3)" in the upper left quadrant and "98" circled in the upper right quadrant. The text of the letter discusses lysergic acid diethylamide (LSD) and related compounds. There are no photographs, diagrams, or tables present. No redactions are visible. This document page contains typed text reporting on the results of an experiment involving LSD and BOL. Handwritten annotations are present, including a "Page" label at the top and a "4-340" notation at the bottom right. There are no photographs, stamps, forms, diagrams, tables, or redations visible on this page. The text describes effects on human subjects, which could imply experimental procedures, but no visual evidence of these is present.