Doc 0000151901

•. • -· _ ~~-::·:-... --·--·~ .. .:...~-- -·. -·-·. --~ ~ ........ ........... -.. ....;..'~··~ ·--~~··-:---···· ..... • . ..... . ~. - /~\. . . . . . Depo .. m . oF HEALTH, EDUCATION, AND ,, ELF ARE • Public H~a!th Servke NATIONAL INSTITUTES OF HEALTH IN R~'flNO ADIIUSS T~l: NATIOIIAL INSTITVTI O' MINTAL HIALT!I 25 June 1957 Alllllc:TtOII RIUARI:lf Cl!ITIR U.S. lfVDUC HI'AI.T!I SIII'IICI HOSPITAt. ,· ,._ 0. IOlt zooo LUIIIGTO• - f ' ·----- --- --.- - - ---- - ·-~ ------- ----==------ .. -~-----~- ----- ------ - - - - -~ . --- " I am enclostng copies of rhe fol lowtng reports whTch I t h t n k w U I I n r e r e s t yc u : I. Compa r t son o.f A lD-52 and LSD-25, 2. Compartson of MLD-41 and LSD-25, 3. Attempted Blocking of LSD-Reac~ ion ~Y P r e t r e a t men t w tr h BO L • As you wffl note, 1-.·tLD fs a psychotomimetic agent whYch, however, ls considerably less potent than LSD, whereas ALD ts at least- as potent as LSD. 'J!e were agdin unsuccessful Tn obtalnfr.g any sfgniffcanf' degree of b I o c k t n 9 o f t he l S D-r e a c t ro n b y p r e :- r e a t me n t w i t h BO l • I am, therefore, dropping this lfne of' inves~igation unless you feel ~hat I should study some o~her dosage schedule. Attempted blocking of the LSD-react ion wlrh dibenzyfine, the adrenolytfc drug, Is nGw_tn tile preltmJnary stage. Aff f can say at the moment Is tha~ we have had no untoward effects when O.~ mcg~./kg. o~ LSD was given two hour! Jfte~ I mg./kg. of dibenzyltne. I too am sorry that I wt f I not be go f_ng to Europe, bur is my work schedule so heavy tha~ I cannot ·spare the time. Very s Tncere ly, . ( 'i .r.t:.' I .. I • / -'j/ 1 ! .. // _,,. ... -·~ ,.,·-~-U- l't• / ..... 7 " . H'a r r i s I s b e I I , M. D • '\ D t r e c t o r __ . __ .. "'·· Hf:rn·· \ \ .·.\· ·· The image displays a digital graphic featuring the title "THE BLACK VAULT" in a stylized font. To the left, there is a depiction of a large, round vault door with intricate mechanical details, illuminated by a blue glow. The right side of the image contains text that explains the origin of the document from "The Black Vault," an online database of declassified government documents, specifically mentioning the "MKULTRA/Mind Control Collection" and providing a URL for download. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, or redactions visible in this graphic. / -'j/ 1 ! .. // _,,. ... -·~ ,.,·-~-U- l't• / ..... 7 " . H'a r r i s I s b e I I , M. D • '\ D t r e c t o r __ . __ .. "'·· Hf:rn·· \ \ .·.\· ·· Enclosures ... ~ •.• 1 The document is a typed letter with handwritten annotations. A United States government seal is at the top left. The letter is dated June 25, 1957, and includes a handwritten annotation of "(b)(3)" near the top center of the page, and "105" within a circle to the right of the date. Further down, there is a handwritten signature "Harris Isbell, M. D. Director" below the typed text. A handwritten number "A371" is present in the bottom right corner. There are no photographs, diagrams, tables, or explicit visual evidence of experimental procedures. Redactions are not apparent on the page.