Doc 0000151904

. / ~. )· . {oY BLOCKING Of LSD REACTION BY ATT~~PTED ... . PRETREATI.4I.:NT WITH SOL I ' Puroose: To determine lf three days pr~trcafm4nf with BOL would attenuate the LSD reaction. Background: Glnzcl and ~~ycr-Grosa have reported that two ~ays prctrcatnent with 3 mg. of BO~plus an addlttonal I mg. on the day of the test, attenuated or CQI'Jlplctelv bloeked the reaction lndueqd by small dO$CI (40 to SO mcgm.) of LSD. We attempted to r~produec their cxpcrtments, using ~oscs of 1-I.S megrn. of LSD~ but could sh~w no slgnlflcant bfocktng. four of the 8 pat_tcnh used, however, had very mtnof' _r~acttons to LSD. The cxperlrnent, therefore, was repeated us1ng larger dos~s of LSD ln order to Insure a fairly marked degree of reaction. METHDS or §ub/ects: . Ten Negro male postaddlcts .. all whcx:t bad been ., . . . absttne~i f;om opiates for at least six months~ volunteered as . :ubJ:et: fort~~ ~~~~rtm~nt, ~~~ ~~t~ jn good mentai tnd phystcJt · ' eonditlon, end· all had LSD-effeets prevtousfy. expertene~d Dru~~: Druss w~r~ alt given ln solution. Gn~ mg. cf 30L . was 4dmin1stcred at 8 a.m. and 6 p.m. for three days prior to the LSD. On the morntng of the test I mg. of SOL wa$ gtven at • ., .... ......- -----,------:--..· ··---~-· ~:....:;.,_:··.:;.; ·.·.0:::-.:L. .• -..~ ·;..,..,; ;,.; .• -~;.,;.. ~ ... ·.-.:-·~.:··. ......... -~·. .. -, •." ::.-:..: .•· :._.;:;-_· .;., ---- ~---..... ~ .. -~·-"'--····- .••.. •' ~--.., ----~.· . ---·--···-··-e··--··-· --· •... - 6 o'clock, ~nd LSD Wit given at a o1elock. The dose or LSD I l· Wll 1.5 to. J mcsm./kg. LSD dos¢1 w~rt ehosen sr/ as to tnduce •t least a "Grad~ l~ rcaetton-thatluetnat1ons 1n all subJcet$J, ; '.; A randomized doublc-bllnd dcslgn was used. Each D~stgns p•ttent rqcc1v¢d the follow1ng treatn¢ntst ll) BOL p1ac~bo plus LSD, c1nd t2) SOL plus LSD. Th" eombtnaftons of sot.· plactbo plus -LSD plac:~bo, and SOl plu$ LSD plac<rbo wer~ not $tudled, p•rtty because of shortage and partly of~atertat b~e•us~ preYtout expcrt~cnts have shown that onfy 1neonsequcntial effects wou I'd. be expected. Obs~rvattons: Kneejerks w~r¢ as$CS$~d by d~termtnlng the angle through which 4 eal1brated harntner nus+ f'alt ln ord~r to cllett percepttbl¢ Systolic blood bar~ly kn~e]crk$. pressur~ was mea~ur~d by auscultatory method. Pupillary dlam~t~r wa~ , .mca$urcd tn a dark room under eon$tant condtttons of lt3ht and accommodations. Tbes~ observation$ w~rc The image displays a stylized graphic with the title "THE BLACK VAULT" in large, white, stylized lettering at the top. To the left, a detailed illustration of a large, round bank vault door is visible, rendered in shades of gray and blue, with intricate mechanical details. The right side of the image contains a block of white text on a black background, which explains that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically referencing the MKULTRA/Mind Control Collection. The text also provides a URL to download the collection. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures present in this image. expected. Obs~rvattons: Kneejerks w~r¢ as$CS$~d by d~termtnlng the angle through which 4 eal1brated harntner nus+ f'alt ln ord~r to cllett percepttbl¢ Systolic blood bar~ly kn~e]crk$. pressur~ was mea~ur~d by auscultatory method. Pupillary dlam~t~r wa~ , .mca$urcd tn a dark room under eon$tant condtttons of lt3ht and accommodations. Tbes~ observation$ w~rc obfaln•d twte~ bef~re and at Intervals of 1 2~t/2,- 4~ S-t/2,. and 7 hours after LSD. 1 A nodlfteat1on of th~ ~bramson~Jarvlk quesflonnatr~ WdS admlntster~d by the aide twice before ~nd at 1/2, 1-l/2, 3~ 4-t/2, 6,. and n hours after -LSD. · "Citnlcc1! ·grad~s" were assTgned ~n the basts ~f short m~ntar ttatus exanlnetlo~ p~rfa~,eJ et after LSD. tnt~rvals - ~-- --··--· ---·-·-··----·-- ·--~~---·----------- ---------------·-- .. ~------------·--·- .- · --. -·-- -- . ·A-7ttJ .. • . . ... - .,; ... /"--- ( \ An~1vsts of Data: Areas of the flm•-aetlon .. curve w~rc calcvl4ted In the usual wa~ and meana tnd st~ndard errors extracted frQB the raw daf•• Questions wer~ counted, ; ' eliminating any answers that wer~ also reported pos1tlv~ prior to administration of LSD. R~sultst Results arc shown In the tabl~. There fppe~r' to be· a s 11gb t trend toward the reduct ton of a II aspects cf the LSD-reaef I on. Th c d t fiercnccs _, however arc s I I gh t and 1 not stgnlf1cant~ all being well w1thln th~ error of meaturement. Conetuston: It was eoncluced that admtnlstratton of 2 mg. of BOL daily for three days prior to cJdminhtratton of th~ LSD wtll net block the respon3e to 1.5 to 3 mcgm./ko. of LSD. , .. . .._. . - ---~\~: \ j .. • •. ATTtl.VTED CLCCKH-G OF TI~l£ LSD ~Er\CT,CN BY TH~St DAYS . ~ P P. ET~ 8\ Ttl£NT til iH t l. ..: G. Gf Bul . N 1C C DA I LY . MEASURE & lS) e~t PLI~E30 . Patellar R~fl~x 4.34 - .:0 C.3 'Puplllary Sl%e 9.47 -+ 0.53 1 , .61 1 1 .. 06 !. ·~ • Systolte Blood Pressure .I 5 .. 3? !0.79 ,. 4. 38 .j9 Number of PosttJY¢ Answers 76 - II ~ Grade ===========-=·= ==-===========±:=:., ____ .. ------ arc 10 errors • Flgur~s m~ans-on $Vbj~cts ~standard . . •. ,· .... ...; ; ' 1 ., -. -- ::· ~· .... The document page contains typed text detailing an experiment on the blocking of LSD reaction by pretreatment with BOL. Handwritten annotations include a circled number "108" near the top right, and a number "56.c" above it. Further down on the right side, a handwritten alphanumeric code "A-361" is visible. There is a faint "stamp" or mark that appears to be a small box with some markings inside at the bottom right corner. No photographs, diagrams, forms, tables, or organizational charts are present. The text formatting suggests it's a research report or notes. The image is a declassified document page with typed text and a handwritten annotation. The text details experimental procedures, including drug administration (LSD and BOL), dosage, and measurement of physiological responses such as kneejerks, blood pressure, and pupillary diameter. It also mentions a questionnaire and methods of assessing "clinical grades." There is a handwritten annotation in the bottom right corner that reads "A-360." The page appears to be a part of a research report or study protocol, with no visual evidence of experimental procedures, equipment, or facilities beyond the description in the text. of PosttJY¢ Answers 76 - II ~ Grade ===========-=·= ==-===========±:=:., ____ .. ------ arc 10 errors • Flgur~s m~ans-on $Vbj~cts ~standard . . •. ,· .... ...; ; ' 1 ., -. -- ::· ~· .... The document is a typewritten page with a handwritten annotation in the top right corner that reads "A-359". The text describes an analysis of data related to the administration of LSD and BOL, noting a slight trend towards reduction in LSD reaction, but concludes it wasn't significant. There are no photographs, stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. The page appears to be a standard report, with no unusual visual elements beyond the handwritten notation. The document contains a table summarizing data from an experiment presumably related to the effects of LSD. The table presents measurements for "Patellar Reflex", "Pupillary Size", "Systolic Blood Pressure", "Number of Positive Answers", and "Grade", under two conditions: "BOL PLACEBO & LSD" and "BCL + LSD". Handwritten marginalia includes "A-358" in the lower right corner. The table itself implies experimental procedures and data collection, while the title suggests the context of drug interaction studies. There are no images of people, locations, or equipment.