Doc 0000151905

. ·. - . -· .,_ f!P Dep-·~oFHEALTH, EDUCATION, AND --..~LFAitJ• p._·· ! Health s~rvic:c NATIONAL INSTITUTES OF HEALTH uc 2 t ob ~ r I 9 57 tM 1111"'-TfNO AOOans TMC IIAnOIIA\. IIIStiTUTI OJ' MINTA!. KUI.TN A001cn011 RISIAaCK CIIITIIt U.S. Pu•uc HUI.TN SIPYICI HOSPtfAI. 1'. 0. lOll ZQOO ---- ---- ·---------. of 4 -.--ar.,---e-n.c lOSing t h re~ cop i ~s a- r~-~or_f_l! stud i ~s on t h~ Diet hy I am T c e of Lysergic Acid. Ill.- Effects of Pher.oxybenzamin~ on LSD-React icn i n ~-Ia n • " You w-t I I n v t e t h a t t h e p r ..: t r e a t men t w i t h ph e n ox 'I be n z a r. i n e did not alter si:;nificcfn·f!y the mental effects of I rncgm./kg. uf LSJ. 'w'e_ thought you would be interested in this information, and ycu may, of course, pass it on to any other ~ers:•ns who are working in the psychosomi:netic field. · Recently I have been att~mpttng to do the opposite. Rath~r than atfempting to attenuate the LSD-reaction, I have attempted to accentuat~ it by administering epinephrine. So far, w~ have tried a co~bination of I mcgm./kg. of LSD plus 0.4 mg./70 kg. of epinephrine subcutan~ously. There has been no evidence of any accentuation or blocking of the LSD-reaction as yet. The wori.: is continuing ar.d the dose of epinephrine will gradually be raised. We a r e a t s o i n i t l a t I n g p r e l i mi n a r y s t ud i e s on d - I y s e r g t c a c i d morpholide, d-lysergic acid pyrrol idid, d-dimefhylamide of lysergic acid, and 4-dihydro-lysergyla~tdo-d-oxazolidone. AI I of thes~ materials have been. furnished to u~ by the Sandoz Company. The obJect of the experi~ent~ wt IJ be to obtain information on the relation of cheli1tcal changes in the LSD molecule to changes in psychcsorr.irnetic activity. Th~ first experiments will be desi2n~d to get a rough ;;ppr':lxi:-nat!cr. cf H:~ ~ff~::7iv~ dvse rang~ irt uldn, after which critical experiments compari'ng these two dose levels : of each d rug w i t h two do s e I eve t s c f LSD i n the s am The image displays a promotional graphic for "The Black Vault," an online database of declassified government documents. On the left, a stylized, metallic vault door with intricate gears and a circular locking mechanism is depicted, illuminated with a blue glow. To the right of the vault, white text on a black background describes the nature of The Black Vault's collection, specifically highlighting the MKULTRA/Mind Control Collection and providing a website address. There are no photographs of people, locations, equipment, experimental procedures, or facilities, nor any handwritten annotations, signatures, stamps, forms, diagrams, tables, or redactions. experiments will be desi2n~d to get a rough ;;ppr':lxi:-nat!cr. cf H:~ ~ff~::7iv~ dvse rang~ irt uldn, after which critical experiments compari'ng these two dose levels : of each d rug w i t h two do s e I eve t s c f LSD i n the s am e s u b j e c t· s w i I l be carried out~ .. ·· _ loitth kindest personal regards, ·), ---Hl : tk h -- .... -.; The document is a typewritten letter dated October 2, 1957, from the National Institutes of Health. It features official letterhead with the seal of the Department of Health, Education, and Welfare. Handwritten annotations include circled numbers "(6)(3)" and "109" at the top, likely reference or control marks, and a numbered "4-392" in the bottom right quadrant. A signature, "Harri" followed by "Harris Isbell, M.D. Director," is present, as is a handwritten postscript. There is no visual evidence of experimental procedures, equipment, or facilities, nor are there photographs, diagrams, tables, or forms.