Doc 0000153381

. . . -- ·- ., ._ _. ,~:~£:~~"-'"'~;~~~,~-~,/+?~>Jlf~~w~ ~(J) or The Anafeesfcs Ad~letton-lf4bi1Jty ~hleh Mtcht S~rv• !S Substitutes . For t:Qdc 1n c for Renewal on 113-149 lcqu~st N~ \ Scr. 31540 .. I. BACKGR:t.M> lNfCiMAT leN Since July''I9SI, • projcc~ dcst,ncd to determine tnc· - llabtllty of synthetic analGesics which might serve tddlctlo~ •• substitute• f6r codeine has been carried on within the Nattontl Institute of Mc~tal He41th Addiction Research Center, 1 . tt the Publlc He1lth Scrv~cc Hos~tlal, ~c~lngton, Kentucky. 0 v t t ng t h c p c r rod f r e;, J u I y 19 5 I -t o J u I y d 9 S2 t h c. pro I e c t was financed by a. grant of._ $30 000. whlch was transferred to the 1 ?ubllc Health Service by the Cfftcc of Naval 2cscarch. From july I, 1952 until january 1953, the project Wd$ rtnanc:ed by . - grant of $16,142.00 al$o from the office of Naval ~~additional R"esc•reh. from Januarv 1953 un~i l- Ju.n..~. 3-0,.. 1253.- th.-:. .;>fo.jeet ht!s ~~in .f ina nc:cd by. th-~ N., tie ~4 L l n.s flt u te. a f l..l#.n't .t I H~• It h. ;·h=; >-~~: ~ ·\:;~~~ ··~~-~t~-~{l~ ~;;\:-: ;~;;~~ i~ii;·t·i··::,.·· ~~lln·~·.-·,;_.:~-~d .,· th til no . \V loftGCr be 4blc to the su~oort ~rojcct. The reasons for c4rrylng on for resca~ch sv~th~ttc svbstltute$ for codctnc (whl~h was r~eemm~ndi!d by the Drus Add t c • loA Cor.w 1 t t cc,. NQ t I on~ I Rq:s caret\ Ccunc t I ) arc 4S fo ll Olfl: ... - Ft ... ~t)c!~ssifiei 101 j37475- c~t'3 --------- . r~ . 1:(. --· ·, po_s~Jblc tha.t the "l.tnttcd Statci ml;ht be cut cff from •II Its ----- usutl sources of opium. The single sourc:e of codeine h from opium or by svnthcala from mor~hlnc derived from oj)lum. At the tlmc the projects were begun, there was no aynthcttc compound · 7 •varlabl~ whlch was •~ s•fc for~scncr•l usc as was cod~fne and, .. -- •lthough synthetic an41gcslca were 1vallablc which would be entirely adequate·· for tbc rcj)lac~mcnt of morphlac. no synthetic ••• avalhtbl« which was •s Sifc •s codeine. Moreover, more than 60 per ccnt~of the Armed forccst rcqutrcmcftts for· n4rcotfcs were for code Inc ra thcr 'th•n for morph htc.. The tmportancc of • I the project ts thcrcfor~·obvtous, The image presents a graphic background from "The Black Vault," an online database of declassified government documents. The text states that this particular record is part of the MKULTRA/Mind Control Collection, housing over 20,000 declassified CIA pages. The background features a stylized image of a bank vault door with intricate locking mechanisms and glowing blue accents, symbolizing the secure and hidden nature of the archived information. A web address, "http://mkultra.theblackvault.com," is prominently displayed in yellow, indicating the source and accessibility of the document. There are no photographs of people, locations, equipment, handwritten annotations, signatures, official stamps, forms, diagrams, tables, or redactions visible on this page. This page is a typewritten document with several handwritten annotations. There are no photographs of people, locations, equipment, or subjects. In the top right corner, there is a circled number "4" and a symbol resembling a "7". Near the bottom right, the words "Declassified" and "date" are visible, with a long handwritten entry following "date". A handwritten annotation "A-23" is located in the bottom right quadrant of the page. There are also several small black dots and smudges scattered throughout, but no clear redactions or obscured content. would be entirely adequate·· for tbc rcj)lac~mcnt of morphlac. no synthetic ••• avalhtbl« which was •s Sifc •s codeine. Moreover, more than 60 per ccnt~of the Armed forccst rcqutrcmcftts for· n4rcotfcs were for code Inc ra thcr 'th•n for morph htc.. The tmportancc of • I the project ts thcrcfor~·obvtous, :but u~fortynatcly the faetltttes of the Addiction iesearcb Ccntc~~~crc not sufficient to carry out thc·wor1t unlcs( addlttonat f~nds c~;uld be obtained •nd• of ~oursc~ .... .,.., the work C4nnot be continued aft~r July 1 1953 ~ unless •ddtttonal 6 funds arc made available. -~·-.-.... l I. ·.. <;OR~ ACCCM?L ISHCD TO DATE ?art c f the work. accomp I 1-~hed l-o d~ tc- 'lrd'.-· cmb-o-dt:d t n . t ·r, -: . . . be · l~mi ~ann IJ4l. prosr~~ ~ .-_r-cl'e rt Sl?! id:: to Dr.-· _H. :.;.u-t:nby, Hr. ad of~ th~t ?hys-.Jd~~~Y .-i~~n-eh·,: :c;ff-1~:-· ~4~~ i ~~-~ ~4rc.h·,.' -~~ o.r, January 1953. It may be briefly summarlzed a-$· follows: .. ... ... -.. #.. . ' - DeclassifiidF'E,;s 191t187475- clate ... · . . ,·· .. ··-.-'·'···-<'·~··-~- ,.... . . 1., · The racemic ·l~~thy J. ether o·f N-mcthy lmorph 1n 4n ~ pcss•sscd too htsh addtctloft llablllty fer It to be rcgGrdcd 41 • tafc substitute for codeine~ '. -- -'·- 2. All of the add Jet ton I lab II tty of racemic 3-mcthyt or ether N-methylmorphlnctn was found to be due.;. to. the lcvorotcttory . laonacr. . . 3. The. dcxtrorotetcry 3-mcthyl ether of lmorph• N-m~t-hy __ ; Is devoid of addlcttoa lA!~ ltablllt~. . Strtcc thls compound fsad been reported to have powerful tntttusslvc effects ta antm•ls• extensive cltntcal testing tA ..... humans Js being carrJcd_cut cl~cwhere. ?rcltmfnary rciX'rts of results were madc·•t th• meeting o( the Orug Addtctton Committee, N4tlon1J Rcsearc:h Counc·J1 ln Janutry 1.953. Unfortunately, the 6 of of the drug were rc~orts the~cltnlcal·efflc4cy conFII~ttns tAd tb• matt~r ts not •• yet settled~ 4. 3~ethvlmethyfamtno-1-l-2'dlthicnyl-but-J-~~c • . . Thts drug wJs found t~ ~~~~~ss teo htsh ~ddletlon llabiltty to o¥cr, lt _ts rather lncffcctfvc when orally and .. . . . gJv~" . - . . prodvc~s . many ·u~des ir.!_bfc s i-.df!: •ff~.~t~."~.··\fu·rther- tnv~·;·"t_)·B~t i;,~<_of th ;:; cc~~ovnd ts not •arr3nt~d. S. !U., .2_, and !::.2-2-dt~hqnylimlno-cthyl valerates. ~'ork _with th\:se coml)ounda has almost bc8n c.omplet~d! ln dciciS 4--<1 •. .. - "J ... d b•J .,.;.._-187475- Dec\ass•l.dt• e . ~ 4. The page is a typed document with a handwritten annotation "A-22" in the lower right corner. There are significant black redactions obscuring a portion of the top of the page. Evidence of a declassification process is present in the lower right, with a "Declassified by" line and a date of "4 FEB 1977" filled in, followed by a numerical identifier. There are no photographs, diagrams, or forms with filled-in fields visible. . - . . prodvc~s . many ·u~des ir.!_bfc s i-.df!: •ff~.~t~."~.··\fu·rther- tnv~·;·"t_)·B~t i;,~<_of th ;:; cc~~ovnd ts not •arr3nt~d. S. !U., .2_, and !::.2-2-dt~hqnylimlno-cthyl valerates. ~'ork _with th\:se coml)ounda has almost bc8n c.omplet~d! ln dciciS 4--<1 •. .. - "J ... d b•J .,.;.._-187475- Dec\ass•l.dt• e . ~ 4. F 1 E . r 19 1 1 da.e . •... -l: .;:· ' ... '-· .' ...--.. '..; 4 . -- ~>-;;,;;~e·.:_::{~' - ·-· el 75 ms;., In former .. . . .. . ~ aorphlnc: •ddlc:ts-•. They •rc •lso rcf&t"lvcly tncff'cct he In aupprc~ sIng ~bs t Inc nee from morph 1f tc. The low potency and low.addtctton 1Jabll1ttcs of these compounds sugscst that ?rc llml~•ry clintc•l trl•la of •ntltusslve effect 1nd side rca~tlons ere wtrrantcd. 6. d·t-2•2-d Jphcny 1-4-d Jmc tfly lam I no-butyrate. Tb Ia compound hts pro';)crt 1cs s lmllar to those- of the vttlcre tcs .. •nd• therefore, deserves a prc11mtnary clinical trtal. & It • NiEO FOR CCNT INUAT ICN 01 THE PROJECT AI though ;·ihc work to date bas uncovered r·rve drugs 'l' / which m4y have posstbfllttcs as synthetic substitutes for I . codeine, we believe the -~roject shovld:bc continued. The most .4 • ... pr_omtstng o! the drugs studt~d Is the d-3-mcthyl ether of N-mcthvl mori)hlnan. _Tf(Js drug Is complctcJv devoid of addict foil 1 iabtl tty •nd haa low toxicity. Unfortunately the reports con~~r~tng Its clinical efficacy are confllctlng and, at the moment, 1t. 13 not certain that lt wtll acrv¢ as an odequotc substitute for cod~in~. the o thcr four druss have not been- t.~te~ e l. tn 1 c.•ll-~.. . l t 1-s.- : ;: -· . , :} __t >c II c ·~:e:,tr 4, ~:o}•~: ~o:;y,~ ~~ ~'~-_/ ~ ~ l c C _ t h ~"~"" ~ ~ I ~ «- ud . llu t u n toward . sldc.ria~tlons m~y b~ pro~uced~ for t~ts r~aso", we cannot b~ ·ccrtatn that an .tdcquate synthetic substttute for codeine rs y.ct OR hdr.d. . . A-.zo •. I : r .- I Oeclasnified by -187475- date · :! FE'9 1g'17 ·~. . We druga for •· · pcrlod of oae- yc4~. The drugs to bc.:::•-.tcstcd Include: ll.Nor JDOr~htn•nJ 2)"! •nd !!, J-hydrcxy-2-n-dtmcthy.ltneri)hlnan; J) ! •nd - d 3-~ro~yf cthcrJ a( 3-hydrcxy~or~hlnan; ~J other agents •• ••v be su,gcstcd after consultation with the Drug AddtctJon \. CommIt tee The page contains typed text detailing scientific research, appearing to be numbered points relating to drug compounds and their addiction liabilities. There are two small black ink smudges near the top center, possibly obscured content. In the bottom right corner, there's a stamp that reads "Declassified by _____ 187475 date _____ 4 FEB 1977". There is also handwritten text in blue ink to the right of the stamp, appearing to be "A-21". The page has a slightly creased and aged appearance, typical of older documents. :! FE'9 1g'17 ·~. . We druga for •· · pcrlod of oae- yc4~. The drugs to bc.:::•-.tcstcd Include: ll.Nor JDOr~htn•nJ 2)"! •nd !!, J-hydrcxy-2-n-dtmcthy.ltneri)hlnan; J) ! •nd - d 3-~ro~yf cthcrJ a( 3-hydrcxy~or~hlnan; ~J other agents •• ••v be su,gcstcd after consultation with the Drug AddtctJon \. CommIt tee o ( the N.t t tonal Rcsca rb.h ~unc 11 • . V. M£1lCOS TO BE USED .. ·. ·These methods arc the ••m• •• those described In pr~¥tous -project dcsertptlons and hl" the scmt-annual report to the Cfftcc of Naval Research~ They lncludct 1. Octerm1nat1on of Hu~an Pharmaeolo~y and Toxtctty. ; Tbts Involves ad~lnistr4tlon of progressl~ely Increasing doses of the dryg under study to hum4n volunteers, ehtcfly fortr'er •or~hlnc •ddlcts. Cbscrvat·rons on resP'Iratory ~lnutc volume, I' pup11lary sfz~~ blood pressure, pulse rate, etc •• are m•de following administration of ths drug. 2. Ad~tnlstrattnn of STnrt~ Dos~s for th~ D~f~c:tton s.tm~ wc!y as those. on. human pharmacolosv., .. exc:c~t:dcta iled < · ·. . ~-·. . . ·:._ .._.. .. ·. . ·. ·:._:~. _-;.: _; ·:· ,: :·· ·.:;._:_:-_ :-,) :.:: _::_: _,,-:'-> -~: ~-,.: :. ~-:~; :':-;-·_,:_ __ ~:. . ,__~·- :: ... ~---. ·: '- - ..... .. <-: ¢b_ : ; . .-~ ~ r l::a . · f . 1 ,.~ _ eP s--... . q . _r - .-:· . . f ~ h -~ . ::i_f:'y ~ ~S: . i -~.f ~t: i. . ear· - ~_f. f ~~ ~ t ·_-·o r,. - tn t-··:dru S a r: not -~~-de·, becdusc the ·t4kins of ::>hystolegic.a-1 obse-rvations tcnc!.s to neg.ate the pleasurable ·c.!'f'fcc:ts of the drugs.. New methods 4rc us~d In ~augtng the "«uphor1a" pr~~.t!-~ed bv the drug. A-ft .... ' . f ~- ... clinical ob .-:r s~r ·.-it v tt tocs·,f'or the lppcar- -.•n ee of OY"Crt bch•vtor rifscmbllng that accA tftcr tdmlnJstr.tloa of aorphlnc. 'lad 2) administration of projective an.d other psy~holo;lctl test~. or Ia both the 1bovc types of tcstlng, drugs arc given 1• • randomized balance order· an.d by code·. The order or - -·. ) ·, •dmlniatr4t ion IJ unknown· to both the subJects •nd the observers. Both positive 41\d ncGttlvc coAtrol druss Cmorphlnc,<cod~ln•• lad pltcebo) arc used. l. Admtnlstratton of Slnrlc Dos•s of th« Drug to P1ttcnts Showlna,~lcns of.Abstlnencc from Mor~htn~. Thts tv~c oJ CJC?crlmcnt ts urrlcd out by obtaining f:)4tlcnts who have b11 ~ n The page contains a typed report, likely from a scientific or research context, discussing drug efficacy and addiction liabilities. There are no photographs, diagrams, or clear visual evidence of experimental procedures. However, there are several instances of obscured content, represented by heavy black scribbles, primarily near the top left and center of the page, indicating redactions for security or privacy. Handwritten annotations are also present, including "A-20" in the bottom right corner, and a "Declassified by 187475- date 4 FEB 1977" form at the bottom. The overall appearance is that of a declassified government document. ion IJ unknown· to both the subJects •nd the observers. Both positive 41\d ncGttlvc coAtrol druss Cmorphlnc,<cod~ln•• lad pltcebo) arc used. l. Admtnlstratton of Slnrlc Dos•s of th« Drug to P1ttcnts Showlna,~lcns of.Abstlnencc from Mor~htn~. Thts tv~c oJ CJC?crlmcnt ts urrlcd out by obtaining f:)4tlcnts who have b11 ~ n t • k I n s I a r s c · a r,o;o u n t $ o f o p 14 t c s · d • 'p y • A f' tc r s t a b I I l z a t ton / on the I ~as t. .1moun t of mo-ri'h I ne wh t ch \I!OU I d Just ~rcvcnt t h c / · &p;lcar•ncc of s fgns of abst lncncc. morph1nc ls abruptly wtth- r dra•n fer a period of 30 hours. At fhts ttmc~ a stnslc large dose cf the dru~ under study Is admtntster~d 4nd observatr~ns --· .,....,.. ., . . ... ! .~ . . s. f hc admintstr~floR of_mcr?hOine and o( ecce-inc .to ·the sa~~ ~C: -~: •' ....• ·. ;iat:l.,nf~?.#~r\-~!{'~:t }r~f ::ii~.._ \ _ ~-~~-:.' ~:{fii~/~~~ k~~~~ -.-~:~;~~~~~:::· ~e -a x- -;.z I ec . .. ~ , - ~. ·-. lns druos which or no on abstinence f~r h~vc lit~l• ~ffccts from morphtn&. A-!r -. ., ... - - Declassified by ...:_1a'i-4t"-== ~at9·----r".! 4:" t F " E " B ' " \ " '! ' ! t 1 ~ ll---=- .... r ·./"\ .~· ·; . ··;._...( 4• · Sueorcsslo'-,. "c);( i~Lbs t'uune&.-·frem W.orbh hae. ThIs. technic represents. the :21orc· sensU lvc:.rcf1acmc&at of the o11c . . du 1gncd above •. PatIents with .stro.ng dc~cndcftcc oA mor~htne · -----~ •r• aclectcd. After a tultablc stab11lz4tton 'pcrlcd,_Jhc ---· morphine 11 ebrv~tly dtsconttnucd and the 1amlnlstratton of th~ test drug ls begun before signs of abstinence a~pcar. tf absttaence Js,sup;lrcstcd com$)1et.~ly or p•rttally, ad."ftln.tstra tloa of the new drug Is-continued for a period of 10 to .14 davs, . •- ' f fcr which lt 11, 1bruptly withdrawn and obscrvattoni for stgas .. of •bstrncncc arc made. . . S. Direct Addtctton. Ttats. tc.c.hn.tc. lnvolvu th.c • dm t n 1 s t r a t 1o n of s u f' f 1 c I en t l y ~;1 a r s c • moun t s of t h c cf r u The document is a typed page from a declassified MKUltra file. It includes handwritten text in the top right corner, possibly a document identifier "A-19," and a stamp indicating "Declassified by" with a date of "4 FEB 1977." There are also several black ink smudges or blotches across the page, particularly in the upper left and middle sections, obscuring some of the text. The page discusses proposed drug testing methods for a year-long study involving human volunteers, specifically former morphine addicts, and details observations of physiological effects and the detection of euphoria. made. . . S. Direct Addtctton. Ttats. tc.c.hn.tc. lnvolvu th.c • dm t n 1 s t r a t 1o n of s u f' f 1 c I en t l y ~;1 a r s c • moun t s of t h c cf r u 9 ., . under test to former motphtnc add.let 'fOiuntccrs who nave bceft abst tnent for a period ,-oi at Jca .. t thr«.C IPOfttht before the :# experiment· Is ~cgun-. Sut table obscrvat lons for the dete-ct toft ·of tol~r•ncc •rc ctrrtcd out during th~ pcrlod of administra tion; After 30 days, er more of cbronle lntoxlc:etlon, the tes.t drugs arc abruptly wJ1hdr4wn. Vl •. · EVALUATl:N Cf DATA . ···The drug .wc-·.,·,-c~s~-ck.ing shoutd·_hav~ t·hc ·ro.ll.owtng"' . .··. .. -~-~ ~:...·.·- ~-- ~-·/.:<·~~-~~-.,-: -~<:---,;.-~---~·.:·· . >~:··;.- ·.~·,.·.<: .. _:- ·. . •• ... #;·_· - charactcrht ics: f) _lt s·ho.utd :;'#r·cc4b{y.bc ·a ·w~Z4~- analg~s i·ct •~ Jud~ed by anhnal 4!xpcrtmenfatton; 2J th¢ ra.tto of to.xtctty to therapeutic eFfects should be· favorable In antrnals and tn m4nJ· JJ it Should h4VC antlfu·5-$-tY·f!-· effects f.n. animal .-,ha-rm.acoJ ogJc41 cx~«rlm~nts; 4) It should be a sood antitussive agent ·.A-!7 ... -. - . -;; ___:_1 Oeclassifieo ~Y S74r~ date 4 FEB 1977 . ... . . . ' - . ~' . "- .· -. ,[ ·,. ta:·~m•nr 5 J t t ahoutd ·ret I eve or lupprcss abs t lftcActt from asorphlnc only p•rtl~llv~- ead prefera-bly not •t •II; 6J Jt should Jn~uc.~ ooly • ~nlld {;t4dc of physical dependence u~d•r· -· - --· --:- conditions of hls;h dosage;. laf'orm•tton submitted by ph4rmaccuttcal firma •nd unlvcrsftlca concerning dru~s •hlch should be tested wffl be lens ;/ sufflclc~tt· ~o evaluate t~e .tct of the drug In anlmal.s. .. ·, ~.. . S -- t . u .. d ies on Its tddlctJott liabllttv wilt ytcld Information oft the pbarmacolosv,- toxicology and euphoric potency of the drug end on Its ability to produc• and support physical dc~cndcncc on mor~hlnc. fr~m these d4t4 ~ satisfactory cv41uatron o( the addleflon llablllty~or the ~-- c ~ om~ound can be m•de. The dctcrctlnat ton of antltui.stve cfft:et muS=t be done chc•hcre •. Vt I. lCO.T I•.:N Cf TH£ ?~JECT · -:. The experiments described 4bovc wflt b~ c~rrtcd out Itt the N.ttonal lnststut• of:M~ntal Hc4Hh, Addiction -~ese~rch Ccrat~r. ?u!:dtc: Hc•lth Scrvic:c Hospltat, lexington~ J(entuc:~y. This hos~ltal Is om~ound can be m•de. The dctcrctlnat ton of antltui.stve cfft:et muS=t be done chc•hcre •. Vt I. lCO.T I•.:N Cf TH£ ?~JECT · -:. The experiments described 4bovc wflt b~ c~rrtcd out Itt the N.ttonal lnststut• of:M~ntal Hc4Hh, Addiction -~ese~rch Ccrat~r. ?u!:dtc: Hc•lth Scrvic:c Hospltat, lexington~ J(entuc:~y. This hos~ltal Is d~vofcd cft•irciv t~ th~ tr~•t~e~t !~d :t~J~ or drug 4ddlc:tlon and, 4t the c:urrcilf· f[m~.- h the cn.ly ol.5e« . ·. t1er ~. -1 n- fh e · I d· 'l'th.e r··~' t·h:~~ ~--. j t t:~! e·~-- c~· ~ =·:b~- ~-.,· ~--fs -f:l:Ctnr·t ·;-_;_. e :l r :-\ ert - . . · . · . out. The·instttuticn provides th~ two rr~c:~ss4ry f4cil iti~s for this type of work: I} 4 pool of p.i·ftentJ ttho will voluntel-!r for ~xpcrlments of the type J~scr1b~d above; 2) strtet env l renmcn t a I con t r~ l, wh r c: ~r'·;5r.rv~Hrrs:· flhr l'h.frcf~~e t ton· of A-/t •. . . -~ Declassified by -1B'i"4'7o.--- oate 4 FED 1977 .. -'::."-' ..' . ~~ .· . :-"-· ~. ·"; ·.£ .• of dru;s otkcr tba~ thos~ ucdcr atudv Into the cx~crlmcntaf - • Jtu4t ron. . . . '· . VII I • EX?ER IM5NTAL ·?E~SCM£l Work will be c•rrfccf out under the dlrcctloft of H•rrts Isbell• M~c •• Drr~c:tcr of. .t he Addict len Research ,Center. ThJ1 lnvcltfg4tor has ha~ nine yc•r• of cxpcrfcnec In research Ja.Rarcotlc drug addiction and ha1 ~ubJtshcd macy ~•pers In .. ,:!k th Ia ifc I d. · He will be ass Is ted· by two other cxpcr lcnc:cd physicians. Dr.~· f. fraser •nd Dr. Abrab4m Jfkfcr. ·beth of ~>t;:>er lc~ee whcl':l have had ex:'cnslve In rescarc:b In odd let lon, •nd h4vc m4ny publtc:atro~s tn thts field~ In addltlo~ to the medical personnel, th~ p·.art-~ fmc_ ~~rvfcc·s o( • bloc:h~r:tlst •nd~~ prof~J$lcn~l psyc:bol"o" gls• wtll be m~dc •vatlable. A / lpcctal word for ccnduc:tlng thcs~ studies h.aa alre4dy bc~n ·act u~ and Is In op~r4tloA at the tim~ thrs proJect d~scrJ~­ t I on t s beIng wr Itt ~n l_A,r J I 30., 11-SJ J. ~- . , •. A-1) J • . . ' ......, ... "f' d bY. E"'B1971rS 14'To-, ~ecl_assl 1e 4 fo oats e:.--: ._ ... ·- . ;·:.~ •. . _. __ ... .. -~ . ·-,;·· . . ... --- . \ . . . ..... -~- The page displays typed text and a handwritten annotation. The text describes experimental procedures for administering drugs to patients and observing withdrawal symptoms. A handwritten annotation labeled "A-18" appears in the upper right corner. At the bottom right, a form indicates the document has been "Declassified by" in "1974/0" and the date is "4 FEB 1977". There are no photographs, diagrams, tables, or obscurities present. The document is a declassified page from a report, likely related to drug experimentation. It features several numbered sections discussing "Suppression of Abstinence from Morphine" and "Direct Addiction," followed by "EVALUATION OF DATA." There are no photographs, diagrams, or tables. The page contains handwritten annotations including a number "4-17" in the upper right corner. In the lower right corner, there is a "Declassified" stamp with a handwritten date of "4 FEB 1977" and a handwritten numerical entry "187475." There is some dark, horizontal scribbling across the middle of the page, obscuring some of the text. 11-SJ J. ~- . , •. A-1) J • . . ' ......, ... "f' d bY. E"'B1971rS 14'To-, ~ecl_assl 1e 4 fo oats e:.--: ._ ... ·- . ;·:.~ •. . _. __ ... .. -~ . ·-,;·· . . ... --- . \ . . . ..... -~- JX ... · £ST t:.~r~o. C~T .. . --- ... - ' . i. Personnel: ----·--- ____... __ ) 5 Psycbtatrlc Atdas GS-5 I Phy~1cal Sctcnc2 Aid~ GS~4 , I I Security C?e-5 Ald~ .. ·J CS-5 ~Sychologlst - ., diolog1ca I A1de 9S-4 ·: .. . . . Reserve f'or N.tght Olficrcnt-tal, -::--~ .. ~ .. -~---: __ -- . - ! i • Cvcrttmc_p~v-, ~-tilthin-Gr~dc raises, etc: : __ ~ r ,. . .. f. . ..: ....· · .. Mtaccllancous ,. --- ,. Exp~ns~s'~ · ,, · Tot a 1.::..;__ ____ .·.-·. --:····.·- ·- ,; Item 3~ "Ul$ecllancous.Expcns«s~ Includes money for ~.: . . ·. .· -._ ·. the of purc:has~ d~uss. c:h~mlc:a1s, giAS$war~, eiec:tro~nc2p~a1- .. _ " ......... . :. -. -. ~ ' -·-. . . . . -. ···';' ·--· ..: -.-. . .·· .. . . _. -">~- ~- · ffa.rr; ; s, M.b. . .. - _ ~ 3 t:~-t - or_ . .. -. -- ~ . - . ~ - .. . . . . . . . : . : - . - - - - . - ·- . - _ - - _ _ - - 4 . : : · : :. . . . . .. . ·: · "~­ . - . · . . . - . - . - .-.: - ~ ~ . . - . · · ' · : : ' . . · · . · . . :.. . -:. . ~ . . D Jrec tor . . . . . .· : ~ .:. : ~ ... s .. : ~ --- ' ~ a ·. r .. . c . h •.· · . . . ~ . .. , _ ~ .. . . .. _ ": . _ . . ..- .. -. ...• . . ~ 4• . :•: ·. . ~- •.. . -- ·.· . ...-~. - .. - _ ----- 4-/9 .· : ' i . - ... ~ - i • -- ·• • oe- ~.: i This document is a declassified CIA report containing handwritten marginalia and a stamp indicating it was declassified by "187475" on "4 FEB 1977". The top right corner features a handwritten annotation "A-16". Several areas of the text are obscured by black redactions, particularly towards the top of the page and a horizontal band across the middle. No photographs of people, locations, or equipment are present, nor are there any diagrams, schematics, or organizational charts. The visual content primarily consists of typed text and the aforementioned handwritten annotations and redactions. . .. _ ": . _ . . ..- .. -. ...• . . ~ 4• . :•: ·. . ~- •.. . -- ·.· . ...-~. - .. - _ ----- 4-/9 .· : ' i . - ... ~ - i • -- ·• • oe- ~.: i . ' Decl:1ssified by -187475 date 4 FEB 1977 . . . ..: .. . .. · . .. ~-- ·~· . . . -,_ .... · __ ··~·---:~"':.:.· \ ,, .· . . The document page is primarily text, but it contains several visual elements from its time. There's a handwritten annotation on the right side of the page, "A-15", in a fluid script. Near the bottom-left, a structured form with fields for "Declassified by" and "date" is filled in. The "Declassified by" field contains a handwritten number "187475-" and the date field is filled with "4 FEB 1977". A large black redacted area is visible in the top-center of the page, obscuring text. The page also has a watermark of sorts, possibly indicating it's a copy or has undergone some processing, and appears to be page 9 of a larger document. The document displays a typed list of estimated costs for personnel and miscellaneous expenses, likely related to a project. There are handwritten annotations at the top right ("A-14") and bottom right ("187475" and "4 FEB 1977") indicating a declassification date and an identifier. The majority of the page is blank, with some smudged or obscured areas, particularly in the top right and near the list of expenses, obscuring specific monetary values. No images of people, locations, equipment, or experimental procedures are visible.