Doc 0000153388

.FEDERAL SECURITY AGENCY PUBLIC HEALTH SERVICE LEXINGTON. KENTUCKY ' ~ - .. · 3 August 1953 ·- . NlM-f'AddJetion Rcs~arch Cuhrc -\' J " ::~J~-~~C~~~~~ ;;.o .~-,;~;~-, ~ . . - .. , # . ·" . - -·-. - - ---~-----·------- ------- -·--.- ----·----·- ·' -.-.- -~-- . -----;....__--=---- .: - - --- . -_.--------· --- ------- ----- ---------- ~-.. ...__ -----.,.__._ .. . --:-·--- --------~------- · . - --...:.... .. . . ---------=---.. -:-.- -:-_ __ _;_·----~---------~ t feel sure you will be Interested to learn that w~ were a-b-re to begln-'our experiments. with- LSD-25 during the month of July. We obtained 5 subjiets who agreed to take the drug chronically. All of these were negro male patients and all of them phystcally were In very excellent shape. The time s o fa r h a s b ~·c n s p e n t ex e J u.s i v e I y I n o b t a I n i n g eo n t r o I d a t a wh I e h r n c [ u d c s ph v s t ; a ·r a n d ,;p s y c h i a t r f c c x am i n d t ions , Ro r s c h a c h a n d Go I d s t e i n -S c h e r e .f t c s t s , Mi n n c so t a Mu I t i ph a s I c P c r s o n a I it v .lnveBtorics, efcctrocnccphalogs:"ams,_ steadiness tes.t, blood chemistries and hamat-·ofogy. w~ shou'ld be in posit ion to begin exploratory ~t~dtcs destgned·t~ d~termtne the minimal ~ff~etivc dose for each m~n ~irly In Ausust. · Arrangemc!lt1 have been made wUh the Sandoz Company to obta fn a supply of the drug. --· The behavtor of the patients tn our ward has been dtsappolnt rngly quief. All five of the men have been extFemely quie-t, · agreeabf~ and polite with each other, the psychiatric atde! ·and the doctors. They; definitely:- arc ""ore--reserved than- we ~~p~cted and we have a dlsttnct feeling that they arc som~what afraid~ most especially of tbc physicians· Involved. We_have made a strenuous effort to bre-ak throush this barrJcr_bur· .. h ..tv.~ · s t1 The image displays a graphic representation of a vault door, set against a dark background with blue lighting effects. Text overlays the graphic, identifying the source of the document as "The Black Vault," an online database of declassified government documents. The text specifically mentions the MKULTRA/Mind Control Collection, housing over 20,000 declassified CIA pages, and provides a URL for downloading the collection. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures present in this image. polite with each other, the psychiatric atde! ·and the doctors. They; definitely:- arc ""ore--reserved than- we ~~p~cted and we have a dlsttnct feeling that they arc som~what afraid~ most especially of tbc physicians· Involved. We_have made a strenuous effort to bre-ak throush this barrJcr_bur· .. h ..tv.~ · s t1 c c ~ c de d .. on l y . p tt r t i a I t y -.· · The r e I a t ions h i p w i t h t h ~ , psychiatr-ic aidcs,.who ac'tucilty will be the key observers, fs becoming somewhat mor~ free and easy, but the· degree of r~pport attatn~d so .far Is not nearly so sreat as we expect wtth whrte subjects. Rcscrv~ 4Qd lack of rapport with the physicians are as great as Initially. In all probability, this type of behavior is to b~ expected with patients of this type. Perhaps the dr~g will br~ak down some of th~ barriers. ---·---·-------------.-· - ~-~ -··- -- ,. ..-. . I ( ... Dedassified by -127475- cab ----,4~F~E81"l'11"19r'"l"77..--- r hav~.al~o h~~rd that the AI come ter" has been rep a 1r ed If -and Is being shipped. If no particular dtfflculttcs arc expcrle~eed In th~ LSD experiment, thJs·wtll ~nablc us to. begin preliminary work with alcohol some time during the fa II • Experiments wtth 1-N-allylnor Dromoran and the 3-mcthyl ether of N-allylnor Dromoran arc not encouraging. Both compounds produce deflni tc ·subject tve effects when given orally. The margin appears be quite small. howcvc~ t~ Total doses of 7.5 orally seldom cause any perceptible mg~ ·effects. Doses of 10 orally almost lnv4rtably do, mg~ b~t disturbing toxic effects, chiefly of vasovagal c~nc~mttantl~ types (markcd,persplration, dizziness on standing, weakness - and drop In blood pressure) are observed, and these toxic e f fcc t s de f i n i t e I y In t e r f e r e wi t h t h e e I i c It a t Ion of ~ct,epressed" material from the patients. yours, Vc~y sln~erely " _· /' - . ·-~ H J :.rn ... .. · __ .. . - . . .. : -~·. ':_:.. ~ _..._ -: . -:~ !· .. ·-·..: ~. ·.: .. ·. ... ··-. . ~ ·;.• . . .. -.... ·- ... . - ;; :· •: :. ' ; :, This page from a declassified CIA document contains a typed letter dated August 3, 1953, from the Federal Security Agency, Public Health Service, Lexington, Kentucky, to the NIMH Addiction Research Center. The letter discusses experiments with LSD-25 involving negro male patients and their behavior. Visually, the document includes several handwritten annotations and markings. There is a circled notation "(b)(3)" and another circled "15" near the top right. In the bottom right corner, a handwritten "4-38" appears. A "Declassified by" stamp with a numerical identifier and date "4 FEB 1977" is present at the bottom. Additionally, there are some abstract black marks towards the center of the page that obscure unknown content. No photographs, diagrams, or forms with filled-in fields are visible. . ·-~ H J :.rn ... .. · __ .. . - . . .. : -~·. ':_:.. ~ _..._ -: . -:~ !· .. ·-·..: ~. ·.: .. ·. ... ··-. . ~ ·;.• . . .. -.... ·- ... . - ;; :· •: :. ' ; :, ; )· : ~'- i';o/}>:~~i :¢~}'~ j~ i~f·{j~{:~4~;~J{f'~ ~o:ii b~·:: ;~: ~;;.': -~-';> .: •' .' ·. :• : .· < ... .. . . -----·· ----··----··--- . . -. ·- ;; - ... Dodas~!fi~d by -187475_ • ddc 4 C'EE 1977 This page contains typed text and handwritten elements. The header indicates "Page 2" and a date stamp "1-3-53". There are several handwritten annotations; a signature above "Harris Isbell, M.D. Director of Research", a handwritten word "HI:rn", and a number "A-37". Additionally, a boxed area at the bottom left contains the fields "Doclassified by" and "date" with entries "187475" and "4 FEB 1977" respectively. Scanned document noise and some dark smudges are visible throughout the page, particularly a large black scribble in the upper right quadrant.