Doc 0000153389

-a DH.APt. 4. September 1953 W .. ..-.... "';. •· J.!emorandtun For the Record ·subject: 7isit to: the US·F:-tS Ky• . .. . 1.-- The write~ and_ Dr-. falik~ visited Dr. Isoell at Lexino-ton on the 2n1 e.nd .3rd · o-r September to observe· anc d:i.scuss froject '(bX'..3) A good deal. of the single dose_ work ha~ no.-; been done and several i."'lteresti.."'lg. developl!lents have occurred. ··:>t= ...••• 2. The experli:r:ent was started by establishing-the subjects (;) in the test ward and· allmd.r~ them to become used to the pe:-sonnel, env:i.ronnant, etc. • for a few weeks• l'he r:.orr..al Vllues for. these su.bjects for a large ~atter.r of tes-:.s were then deter::::lined. The tP.sts include physiological-,_ neurological, J=S~holcgical, and such things as cl.inica.J. abserm":.ion &"'ld 2§,. etc. Tile S'.lb~ects· were then 6iven daily doses of LSD a.11.d ··placebo and the testing conti."'lu.ed. The dos'Ss ,::iven were or. tte order or 100 E;a.!rma. All of the ;usual s:n:ptoz:s were reported on 7.he. first dose; :ho~~~r, ;,nE:m that sazne dose W!l,S repeated on the next day,.. no symptoms .. ··developed. In t!'le cour..s·e or further testi."'lg it becaz:e more evident that a tolera."'lce t-ras rapidl7 develot:ed by the ,$Ubjects. At the p~sent tb.e the data indicate that • e.!ter e. dose o! lCC ga.":l"'..a on a giYen day, at ~P-c?-St 4 days have to elaps~ before he wiD. again s!>o-..t symptoms of the drug. \{e observed one subj~ct \-:ho •.-~a.s shouing no sy:m;>ton:s on 135 gaJl'll:!a. after ha"ri..ng had SO gamma. t."le previous da7 a."1d then ~1fe saw him the next day after he had been eiven 180 ga.::ll".a. The only symptoms he ~-;as shm:ing at this level \-1-=re sli.~ht patellar hyperrefleY..ia and v-ery sl!ght J.t:_vJ.ZO:.asis. he on He indicated i:-1 all tl:ese trials thai;. felt~t..o drug action i·:~ile the orig inal 80 ga'!!!lB. C.ose he had reported _intens~·· reaction in a.ll departr:ents. It. ~-:culd seem a: at first glance that this property -vroulC. -i'1"'f'ose x::ost 3~ricus lirtd.tati:~=on :.~e ~ ~ 1 usefuJ..ness of this ·d~..lE:· C::_ . r- -~.-J~ . .3.~· Dr. Uikler ha-:; gotten very interesting results from photic ::;ti.'I:Ulation ....n ile ~11.6 t~e EEGs on react~~ ~~~2ects. His eeneral conclusion is that LSD poten tiates the ~:isual illusions bro~tilt. on by this type of stimulation. One suvject had clonus and. approached a.."'l epileptic seizure U."'lder this treat.nent. ne sa;.-: himself becorr:e first larger and then pro;;res::>ively s=aller until he The provided image is not a scanned CIA document but rather a digital artifact announcing the availability of declassified MKULTRA documents. Visually, it features a stylized graphic of a vault door on the left, rendered in shades of gray, silver, and blue, with intricate mechanical details suggesting security and storage. To the right, the title "THE BLACK VAULT" is displayed in a bold, white, graffiti-like font against a dark background with a blue glow. Below the title, plain white text explains the origin of the document, identifying it as part of the MKULTRA/Mind Control Collection from The Black Vault, an online database of declassified government documents, and provides a web address. There are no photographs of people, locations, equipment, or subjects, nor are there any handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. The document is a typed memorandum with several handwritten annotations and stamps. A handwritten "DRAFT" and date appear at the top right. There are some dark smudges and ink marks scattered across the page, particularly in the margins, and a circular stamp with a handwritten number on the right side of the page. Several sections of text are redacted with solid black bars, obscuring content throughout. Near the bottom right, there is a "Declassified" stamp with a date of "4 FEB 1977" and a handwritten number "187475." There is also a handwritten notation "4-40" in the bottom right corner. ....n ile ~11.6 t~e EEGs on react~~ ~~~2ects. His eeneral conclusion is that LSD poten tiates the ~:isual illusions bro~tilt. on by this type of stimulation. One suvject had clonus and. approached a.."'l epileptic seizure U."'lder this treat.nent. ne sa;.-: himself becorr:e first larger and then pro;;res::>ively s=aller until he had to con- c~ude that he was observi."lg himself in the er::bryonic state. At this poi..'"lt a i!:a.."'l w'i.th a shoteu-"1 entered the pl.cture i."'l a tl:roeaten;r:g l'iay and the patient ;.ras so close to ccrrr..Usion that t.te e..~eri:nent h;.d to be· tero.inated. The subject i."lt.et" ~reted the e-t'isode as an atte.w:pt en his n:ct!'ler' s pa.....-t to abort •\nile sh~ 'i-'""~ carrying h : • t ;m. •n• e a..,: .so . If ~ ' . e J..t . t'n at ..D r .• ••: J•:•: .~. ·.".,U ..er \•iaS sn' .oc• t- ..;. • .. ""_.g b . l • .m . m~ • . J~...n . t• .' ce e l ecr . . roc . . es . anc . . t" • ' • a- . . . :J oe .. (Dr. ~:L1der) . couJ..d...·rec.d hi~ subqonS.~ic:us: ~4~;-~--,.r\no,th~~- $~jec.t'·:.·~9, :7ct. a ;Strong . ·· _ .. i·-~ ·tea~-t:.on-.-~--r -i·t. . f:r<.r::a.;~:t:?.-c~Eb.t::r-::~5-: E.i~s:::~~-~:~~~~~rriJiti---f1~~ ·i-.o~:~~~~rd- i~---t~~~ ~a~· .:-·-c·e;., '"e. ... ~a· ~; ,..,..:t'n·ri · ;;l.•.::. · r. ·e· ~:-e-s· . . ,~·a: · · :· a~~e's· ~-~~-- ... -o-·\.. ;"11-=-a~-·: ,;'"'!~ ~ e ,. -·~·..;.-· · · -· ,. · -.· · - •l...., ·- ;:J..-.>.J..,""" J.io ~ :--- .""'..... _.._......, V ••~ ..... .,.._~..,. .,..a..,o4J.e .4. The suppl;r sftuation with regard to LSD is critical. Dr. Isbell is in contsct v.rith l·~r. Zr::ckson at Sandoz and has been prci:'.ised ':rhateYer i:a::.erial beco:r.e7'a-..·a-l1able but th~ outlook is not geed. ·A sup~l7 of LAE -!:as also been orC.ered. a..':.d 'tihile t...'-:ere is ver:; !i':.tle i..."'! tl":is country a.t thP. pr~sent tir.e, the cutlcck for n:.ore is VI!Jry good. Dr. Isbell plaBe to go to high doses of LSD to test reversaJ.. of the tclE~rance, so. t=.:e expe::-i!::ent is usi."'lg :rruch rr.cre :na.teriaJ.. than 1-:as orig-i..."'!a.ll:t i."'!dicated. Z·.:en il SanC.cz can supply all o! ":.he.- L3D ":.hat ha.3 been crd~red, it probably Nill r.ot ~e rossible to ccr.:pl~te the present exper:L:-.ent as originall:r pla.r;::ed. The LAZ ~·:as ordered as a first attempt to fill this gap. 5. · To s~~ up th~ results so far, it has been found This page consists of typed text on aged, slightly yellowed paper with numerous ink splotches and dust. There are no photographs, diagrams, or official stamps visible. The top of the page has some faded handwritten notations, including "CRAFT 2" and "4 953" which appear to be document identifiers. Near the bottom, there is a "Declassified by" form with the fields "187475-" and "4 FEB 1977" filled in. A handwritten annotation "A-39" is present in the bottom right corner. The text itself discusses materials, their potential promise, and dangerous side effects. SanC.cz can supply all o! ":.he.- L3D ":.hat ha.3 been crd~red, it probably Nill r.ot ~e rossible to ccr.:pl~te the present exper:L:-.ent as originall:r pla.r;::ed. The LAZ ~·:as ordered as a first attempt to fill this gap. 5. · To s~~ up th~ results so far, it has been found t~at toler~11.ce develop~s on t~e first dosP. cf L3D and four or fiYe days are req.uired to overccrr.e it ~ven '.·:ith a 5G;; increase in dose, LSD pl~s photic stL~lation carri~s ths subjec~ b~ck i."'! tL~e a~d ..:C), :.::e -t~c~~~ ~~s ;~!l ~u";: a~:, "t ·.~~ f ~a !.i~. :--:~i:~ ·~:. ~: ~ ~:-~-,-~ s c b~ F :""'.-·!"" .~ ~~-:: ::-. ~ :·...:.:: ~ ~-: ~:: :-·. ~-~ ... .:: b~en those i.>:~:ol·ri"'lg the size .".nd co:t.or of h::.nds .;:.d. feet, ar.d L3J pot.;nt:.a":.es t-'1~ e f.~4 ec: . . .s c~L ' ::-• no t - ' ~ c s:': J.' 7U_1e ..:., :•. .c-n. _T n a.a . c • : • ~ " ' t • J .on, r:o t OXI . . C ~.E..r . t &:-L.~,.w. :. _~· .~J~~ 0"·"• =-: a.::-:. ~- ·a.·' O . 4 .i ..~i, . = . · . - .; •c . • : p liver, t::-ine, cr blood chc.n3es ha."le be~n fc1.:11C.. Tr~ere :.s nc grc.3s chan::~ in the ~ ~ :. ~ ..z . . . , ! .. . ~~A" :11... ' ; ..: . . ;.;~;. " .. ' ..s SJ ., . ..~~P a.! 1 .. , ... z-: . _ z: . : :. ~ ~ o t • . : 1 . .. ~ .e r ..• ~~~ ' -:: . . .I.f.' :: ~ - ~ ~ ·. " ., ., • : ·:~~ a. c•.c .. S @.' ' c - • . · . + ~ S" ·J ~ i · .. e t; ~ "" s ~ - ,,..,,.._..· ._.._.._ . ~ , ~ - - . - . · ;- i ,v.J..c. -,. d . . • r- ;....~.'" - "lz .. ; . , . v" · '.. - ;~! - . .;.. . ~_ ... e -... e .... ,._........ r:·: -.. · . T .l. · ;' • . . . . .. . . . . , . . ..- :; ~ ;.~ . .. d .-. - .,. · ; n v" · '.. - ;~! - . .;.. . ~_ ... e -... e .... ,._........ r:·: -.. · . T .l. · ;' • . . . . .. . . . . , . . ..- :; ~ ;.~ . .. d .-. - .,. · ; n .. t +- .J = ._a - .. - _ -:=u-. ~•.. . .. _., (..".. ....... '. . .-. ,,.... · . . , ~ ~ ·- o · - +...'.-.. C .1 I - . . ~ . ~ ;~ . .. _ ;t ~ -; t . . . . ~ .. ~ .. . _ , . . . .. . . , . . .. . . . .. ; . : . . . ·"-!!'c-: J · . 1" \ " .. " : " . ~ ., , . • . • . . · c · ;J : . 1 .. ' , " _ ! _ ... .,.. ( " '" ... " ,. ' .. . .. . ... . .. ; . C-3.J~. . "1; - ) . - . . . .5 .. ._ .. - . :: . : . . . .. . , ;_ : .. ~ -= ..... , .. > . .. . .- . '. : .. l) • S d·-•-r-t:•Je,..,,.J.. ....... l~. . r f"' ~ \~ · ..... ' v T - "" • C . : . ;, . . . . . . , .~ - 1 - ,.....,. l..... , d , . . _ r . .- ~ " v ' s , ... . .. . .. ~ ; . .. . . . ~ .. - ... . .. ; .. : . t-.,-: l. .- · ..t ~ .-.. - , ro ... " ·r - ..; c: c . - >e - ~ - - ~on.. ,L.....:,-:=,~.:-J~ ·o - n ~e - . n obs~:_-,.~:;C.. l:.~ t:l.c.od t:r~:3L1re ·is !'~=<"!..ia~l:.r ~J.~~t£tori.. f~C!1 .::-.rot:.nrJ 11; t .. o n~,;~ JJ,.-:: ~.~ ... ,about ~00 gerr..,...aj ~nd the pulse rate increase a alon~ ~·Tith the resJ:iratory rate. 'I'he pupils- are u.'1.i.for"~..l;r di~ated by about Jrr:m. Hyperrefie:d.a seer.ts ab1ays tJ occur. L --r~ ~ .. ~~~~.=.n..;,... :- ~.,... Ts~i'!)ll ,....;: 1 f-??._1 ~is ,.~?...i~ to ~-:.i.--:::~~ d~-=~s i:1 ~~ e.. t:,cr-~;t. :.,, ':> .... ~- ~00 gerr..,...aj ~nd the pulse rate increase a alon~ ~·Tith the resJ:iratory rate. 'I'he pupils- are u.'1.i.for"~..l;r di~ated by about Jrr:m. Hyperrefie:d.a seer.ts ab1ays tJ occur. L --r~ ~ .. ~~~~.=.n..;,... :- ~.,... Ts~i'!)ll ,....;: 1 f-??._1 ~is ,.~?...i~ to ~-:.i.--:::~~ d~-=~s i:1 ~~ e.. t:,cr-~;t. :.,, ':> .... ~- .. -·-.J.* .---·..:_., -··--. ·--- - brec...l-< C.o-.::1 ::.:-:e tcler~.n~~. s~ also ;>lans to c.s.rry 01:lt. tb=- chronic testin;: ::-or~ 0!' le2s as Gri~5~;1j}··1_y :~·:*lr:=--.8d,. t~:, .::, -..rill r,o (:~,.!~)~ :.·o a':. ~:!;:cl: 1~i:>:.~~r l..::-rFlS 0~ ~:r-~.;_. CJe ~·ri11 .bo:-:~.:.:1 ~-;c:-:( ".·:i~.rl. l~ ~\·11-sn !~e !1:J.s :;. et:.fpl;r· a."":d.·\·i1t:.:1 the· LD c..:-:Fcri::.e::t ;.:i.:: it. 1_lo~·r · ~"- .! . ' - ' -. --- ~-~. .· ,; . · ! t .· . ·· •· ' ·! 7-. Dr. Is"::ell ha.s talked to. Charle7 ~vint~rs of !·!erks about the new l!alline .derivat:ives that were disc~s.sed at the last J:.eetins. Ke found ·that· aD. of the good r..at-eria.ls h!!d already been turned over to him. Ee felt that there · "!ccld be lit!:.le p:-ofit to us to try ar.y r.:ore cf the'ie materials, sir..ce none of thea shew any·r~al promise. Unifor~y, they ~ave such serious side and a.!'tP-r effects that t.hej a.re q,uite da:·•..gerous to use. He pointec out that ..~. . .. .-re•,. w-hile testin6 one of the acetyl.I:.St"t:adols in a patient, a.l.most lost . .... the. i:"'..a!l a..•d had to make a wild telephone call to Le:dilgton to fL""ld out what to do to b~_ng the man out or it. •· s. The writer r:akes hUli'.ble apolos:,y !or the interminable length or this r~port. ... .• ~;~ .· .·. . "/ .. ,. ' : .. . ~- ·. ..·.-.. /. . :. .. ·. ·. ~ .. '. ·.. ~-·· •·· . . ··- . - ·-- .. • . ! . . Declassified by -18747u.5-- . date -----r-- 4 , F . E , B : : 19 : 7 ~ 7 - --- -· ... .. ... . . -··· .-· , . .. '·. ..