Doc 0000153390

A .. HEALTH. ~UCATION. AND VvELF/ ±FF9E--H"·C Seef..ffi+Ff:?c~,., . .. . -··- -- - PUBLIC HEALTH SERVICE LEXINGTON. KENTUCKY ·' .·_. 16 September 1953 -- (!). ..:.~'•~ ... ' l,._lf&..,.TIHG. AODlltCSS ~11t: .. · IIEOICXec~~!W.t~ :tf4~~~· ...,;~"'. ·~·'. . PUBLIC HU1.TK 5£JtYIC£ HOSPif'L a N I M-t Add t c:.t to n Res e' r c: h Ce ri t e .r .. ...~ : ·. __ .. ----··--- -- ----· --- - ___,_-------·· -·-·· ------~--- ------------- ---~- - .· .· n. Yc. ~--~~-_; b~. i ~t ere$ te-d .. t fh--~l~ ...p ro-gr~_s_s_ ~ f our-~-x per imen t s wit~ LSD to date. Original I~ we had' planned to determine the threth~l~ dose for each patl~nt ind1vtdually, and this wa• attempted e~rJy in August, u1ing a supply of LSD which .. was more years old. than~two Negative subjective reports were obtained with doses of 20 to 70 mlcrcgrams. Finally, patients were given lOO micro-· grams in divt.dec doses, with mC!rked subj~c:ttve effects (as weft as objtc:"'tivel ap~earing in all 5 patients. We then a t t ~mp ted to t it rate: t h ~ ~ f'(e c ts in e a c n pa t i >! n t , g i "i n g doses of 8 0 to. 9 0 m tc r-oc": rams • V" r y I i t tl e e f f e c t wa s o b s e r v ·~ d • These dos!S wer~ adm1n1itered en th~ ddy following the 100 micro gram dose. These doses were raised'.progressively until 120·tc · 130 micrograms were being giv~n to 4 o~ the subjects and 90 micrograms to the oth~r, ~ithcut any significant effects of any kin~. It was found that the time of day Qtd not alter the lack.~of eifects and, al~c, that a fresh supply of LSD produced no c:hange fn the effects, or ldck of them. Since the ldc:k of effec:ts might be due to tolerance, adm.inis tr ation of the drug wes dtscentinued and after flv~ days was da.~tn admirdst~red7 wrth "'.;r\~Pd suhl~etive· and nbi~ct'tve ic c~anges a~~eari~3 with doses of 90 [20 mtc:rogr~ms. Mean while~ tests-of the dru~ in individuaJs ~ho had not been .· receicinc tt hnd s.ftown 1trc·na oo:sftive results .. The findinas -- ·._.:. ~·- ~-~er:! ye ry s (t V'€ a:r ~ rj rd de ve I n ~ f The provided image is not a declassified CIA document page but rather a digital informational graphic. It features a stylized image of a bank vault door on the left. The right side contains text in white and yellow fonts against a black background. The white text states that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection and that it contains over 20,000 pages declassified by the CIA. A yellow URL, "http://mkultra.theblackvault.com," is provided for accessing the collection. There are no photographs, handwritten annotations, stamps, forms, diagrams, tables, redactions, or evidence of experimental procedures visible on this graphic. ic c~anges a~~eari~3 with doses of 90 [20 mtc:rogr~ms. Mean while~ tests-of the dru~ in individuaJs ~ho had not been .· receicinc tt hnd s.ftown 1trc·na oo:sftive results .. The findinas -- ·._.:. ~·- ~-~er:! ye ry s (t V'€ a:r ~ rj rd de ve I n ~ f h:>l era n ce.. - UGCC!_S_ :"jo O;)me 0 . - . J!'.· -- . . . It ~as, therefore, necessary tc obtain m~asur~"'en~s af~er single do~es at wrdcly scattered intervals. As long as the interval was as much as S days, thzr~ was no noticeable . ... ... ··-----·. . - -~--------- •. Dec!a~sified by 4-k187475- -... date t:.B ~JJ .. . ... -- . . . ·.---·--e .. f ' I ... dccrel!'se tn effect,. but there may be some decrease ·in effeet if the ·dru·g ts: admTnister~d every· third day •. n ' '-Wh e n g i v e a t prop e r t n t e r v a l s , LSD t n d u c e s .. v e r y.- de f i n 1 t ~ . blood pr~ssore rise, p~oillary dtlatatio~, tncreas~ tn deep t~ndon reflexes, and diminution in superficial skin reflexes. The pupil [ary effects and blood pressure effects appear to be suitable for measurements of tolerance. ,. ·• ' LSD appears to' fac.tlttcste ·synchrom·izatton of th~ electro- encephaloaram by photle sttmv\atton. Photlc stlmulatton also to seems ;nhance, the p. erception of elementary halluctnations. . Appa ' rently the supply· of LSD ts qut . te ltmited. and we may be uRable to obtain sufftctent amounts of the drug to carry out the study as Qrt·gtnalty planned. However, we believe we .... have sufftclent material to accom~ttsh the following: l J Effects of larger doses in non-tolerant patients-; 21 Oetermtnatton of whether tolerance occurs after one single dose of LSO; . 31 Controlled-studies .of tot,~rance develooment in 5 patients; 41 Compdriscn of LSD~with LAE • , . Sincerely ycurs, -· lkv~. ~(~.: :72o:t-~(-.~ Harris lsbet t, M.D. Director of Resedrch 4-.'1 I ____ -·-·----------- . -·-- .. --- ..- -··-·- --·--· ._ . < ... - • .. .--·~ ., ... -- Declassified by~18747.5- date .faw #/ The document is a typewritten letter with several handwritten annotations and an official stamp. A circular seal with an emblem is present at the top left. Handwritten marginalia appears in the top right, including a circled "17" and the symbol "A-42" on the right side. A stamp indicating "Declassified by [signature or identifier] 187475- 4 FEB 1977" is located at the bottom left. A black redacted area is visible towards the top right. While the document discusses experimental procedures, there are no visual representations of people, locations, equipment, or experimental setups. .. --- ..- -··-·- --·--· ._ . < ... - • .. .--·~ ., ... -- Declassified by~18747.5- date .faw #/ On the page, there are several lines of typewritten text discussing the effects of LSD and research plans. A handwritten signature is present, accompanied by typed text identifying the signatory as Harris Isbell, M.D., Director of Research. In the bottom right corner, there is a form with fields for "Declassified by" and "date," showing a handwritten date of "FEB 1377" and a number "187475". There is also a handwritten annotation "A-41" in the upper right corner. The document appears to be declassified, as indicated by the form at the bottom.