Doc 0000153392

• ... / Nt~H Addlctlon e~s~arch \,,A !n,I.· er • ;; HS Ho s ~ l t a I .D eclassified .b,:, --157475- cate 4 H. 6 1977 · . . .i, . .... •• -- ' lt .. • ~ . ' l . ' ' ... -· . .) ·~ ~: ' ' ' • . · A. During th~ t~;t of Ju~c ~nd th: ftrst ~art of Julv, 1953, was tr4n~r~rred from the hcspttal's ~d~lnlstr~ti~e dtviston to ,.,f ihe N4ti,~nal lrr~tttut;. l./.~ntal H-:alth. Tht~ acl:r.inlstrrlri•Je . ~ ·. chang~ has functioned very well and only mtnor dlfft~ulttes have been encountered. Unc~rtalntics wtth r~,p~ct to th~ budg~t fer th~ curr~nt ftseal ytlr hdve hd~pcred pureb~stng to 5cma /ixtent. The prcj~-ct being earricd on for thz Dc:-'art;ncn~ of ., 04f~nsc w•s r~aetivdted 6•r!ng t\e month of Juty. Th~ prcj~ct •J for codeine. . . . . . . . ~ith coDt~nuinQ sc~rch far codaine ~ubatitut~c, the addtction ltt3:btltly of ..-,i:.;hJr~$ of n::>r;Jhine ~ud Natltn~, addlcttt:Jn ·to meJ£riclin~, with the clt~I~Jt cndocr1no!a~y of eddl~f\oA~ ~~~ wtth wlth chronic lnlcxlcation ai th~ dt~thy!amida of lys~rJ~C ~cld Declassified by -1374tb-..:. ~ate---------- ·~ 4 FEB 1£77 .•.. . ... ·- addiction. l~sofar·~s can Dz det~r~tned by th~ mca$ure~ • cm~loyed, r~s~on$~S durin~ aJdlctlon drc In the hormal range. Th1s wt:~}g~:sts· th47 t!;e r~(!!-;:.n for czcr:.:u;~~ 17-l:etosttlrotd gxerettan durtng addlctlea ts d~a to 4 block at th~ ~·~~itary level. The Section ha' been with N~uro~hvsioloalcal concern~d . or ~rellmtr.a~y ~~p~rtment~ en the ~ev~lo~ment 4 t•st for .. - ~~Y.slc_,J d:z;'}en1{ln~c· li~bttlty tn dooss with ~t;:p~rtdtr.~ ~ddictfoll In docs, 4nd with the lnt~rr~latl~nsh1ps of ~cr~hln¢ and Na lll n~. / & • a l i! e:hibitcJ to tv~Ive audtcnc~s. Declassified b Y -:---Hh-+1~ !:fate---._;__ ____ 4 FEB 1977' .. . ... ,,.'' ' ' ' • .. !l.S to 60 rng. to J7 nont~lerant 4d~tct3. • Dcftn 1 te cvidl!nce of to m~r;1hin~-iJl;e -tv~horl~ b~gan app!Zar i' t rh¢ 30-mg. levet. Eu})hort~l ',i1.S ~ dfetlnc~, r;nd pronounced at, th~ CO~mg. level .. Euphorla "'a& ~lso obs.:zrvcd '>VhCA 60 to 75 mg. were ~td~lnUtered oral1y. No untoward t~xlc r¢actton$ wer¢ observ~d. Sl~ty to 75 mg. of th~ lcvo lsc~¢r ~v~ry f~ur for morphln~ tn 2 strongly 4dd!ct~d r.-fltt~nts. r-.;. .. , s:vtclence of .•r ;· fli. u b s t t t u t i :l o f ~ r ..i no r ph t n The image depicts a graphic with a stylized title, "THE BLACK VAULT," presented against a dark background. To the left is an illustration of a large, metallic vault door with intricate mechanisms and a glowing blue light emanating from it. To the right of the vault illustration, white text explains that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the "MKULTRA/Mind Control Collection." The text further states that the CIA declassified over 20,000 pages and provides a URL for downloading the collection. There are no photographs of people or locations, no handwritten annotations, no official stamps, no forms, no diagrams, no tables, and no visible evidence of experimental procedures. The content is purely textual and illustrative, intended to introduce the source and nature of the document. The page appears to be a declassified report from the MKUltra collection. It contains handwritten annotations, including a circled number "19" and a notation "A-67". There are also official stamps and markings, such as "Declassified by" and a date entry "4 FEB 1977". Some content is obscured by scribbles and smudges, particularly in the upper left and lower left portions of the page. The header indicates it is a "QUARTERLY REPORT" for the period of "July 1 - September 30, 1953." Additionally, there is a line reading "date" followed by an input field that appears to be partially filled. The visual elements suggest the document has undergone a declassification process, with markings indicating its administrative history. untoward t~xlc r¢actton$ wer¢ observ~d. Sl~ty to 75 mg. of th~ lcvo lsc~¢r ~v~ry f~ur for morphln~ tn 2 strongly 4dd!ct~d r.-fltt~nts. r-.;. .. , s:vtclence of .•r ;· fli. u b s t t t u t i :l o f ~ r ..i no r ph t n ~ •. whtch that of ~fil e~ceecl cod~tn~. . ~ -. l2l . c..;.~~thyl-.Ll-·5-desoxyrnorphin<a' H.~K-57}. .)~ r. • 1 :€ n t'"s ,t t Declassified by -187475-_ ~ate----.....:..----....;_ -' -· /\, • dtrectly readdlct&d to ~~-57 for a pzrtad of 17 dayJ. Tha d~se hours. £ven ~ft~r thts v~ry short p~rlod of addicticn clcfinlt~ 1 ibitln=ncc on wos 4pp~arcd ~brupt wtthdraw~l. Ab&ttnenc~ ~vident lA four hours. S~verc by ~Jcht~ and had Substded aft~r f~riy- hours. The confirm our thts drug ~ight r~sults ~~~r~sston th~t h4·S.-.h lgh ~dd ict to-n I iabi i I ty. eu. .: .:horia •.~t·a ~bs~Fv'ld in onl·1 ~ of thc:s'il .}at icnts. N_, u~ta\'!<!td - / toxic re::tions the dose Js tttil b~ve b~~n encount¢r~d a~d , ' ·--~­ t t ·~ ~ ·J ~ ~; ~ .. . ;, , . ! I • ···~. Declassified by -1.87475- oate·---------- ... • morohtnc-llk~ ~u~ • studies are tn ~r~grcss. b~ Addlctton l.tablflt-t~ZS of r.HH·::.hln~-Nalllnc Mlxtur~:. Two of tha oai'1enh vho wer.: addtcted to tt~~ t-to-5 of have readdietcd to mlxtur~ ccr~htne~~~llinq b~~n ~orphtn~ of both-dross th4t Wi:rC pre! zo t In fh<: Rth.tvre. fo llowtns wl tbdr~ua l of morph l n~, ftb$tln¢oe<: ~as far mvre In tens~ than f'r..d wl thdr"awa J of t!t<J mixture. following wlthdr4~1.-1l o( lc~Jr..; ~- Nitil tnt; no clear-cut cvldenc~ cf ab$ r lr.l'En~,g w-5s- obs¢rv~d. c. ~ep~ridin~ {Demerol) Addlcttoa. '/ . ~ project iiilth th~ ci inic~l $t~ff of t!i~'.ho-spiiat. Th:: ~tudy Followina cf ... recei~t ~ - - ..... ~ . ~ ~ - ... - , - .. · .. . • ., • .. • tl • ! 4 ' : ! - l, _ . ' . t L • ~ ~· l .. p .... 1 - >'"• - 4 ~ ' ~ • - .. - • r • 4 • ~ ft" ~ 'Wo • .,. '- ~ .l. . ~ .... - .... t ... A w - .. ~ ~· · c.~rr.\e, "'· : ! . cut• • i ;-::~< • : ! • :1~ . a 1- ' c The document is a typewritten report with some handwritten marginalia. At the top of the page, there is a handwritten annotation that reads "QUARTERLY REPORT." In the lower right corner, there is a section labeled "Declassified by" with a pre-printed date field and a handwritten entry "4 FEB 1977." There is also a handwritten annotation "A-66" and a heavily redacted, dark, striped area in the middle of the page. No photographs, diagrams, or structured data are present. - .. - • r • 4 • ~ ft" ~ 'Wo • .,. '- ~ .l. . ~ .... - .... t ... A w - .. ~ ~· · c.~rr.\e, "'· : ! . cut• • i ;-::~< • : ! • :1~ . a 1- ' c tY• ---••- ._ " ,. - .1 ~ "'· -•. _ ~ r , " --.-.- - ;-. ··"'. -.-.. .t.i ·-. • '~ •' t. l • ·f. r· .-.-. I , .. . . , ~- . L .,_ ' <. · .' n r' :-,. •'! p!rr • o. ~ t'" : ' . ~ h ,~s · p • t . d l i• t 1 a s· u. .. v~ " v of t~•\! r~corcis cf all p.::t ict<ts giving histortes c; mapcrid1ne.ijddlcttcn. Th~ tnfor~dtion 8747 Oeclassified by -1. 5- ·date 4 FEB 1977 . -;; . -:-, • oth~r c!r-us;; ut?.d, etc. in t!icldJtlonte ~vrveyln9 th;: rccord~t • psychlatrJc of tbc will undartat= t~~ st~fr ho~oJtal tnt~n~tv~ th« ~res~nc~ of physical de~endcnce tn ~ortm~ry" addicts dnd to ~tv.:fy ii1¢,Jcridin<! Jddictl-~n tn des;$. The methcd for provtng thet tn addtcts utlltzes ab1ttnenc~ occ~rs ~primary» m~perldlne ;~. of addlct ion to· ~-:p~rtdtnc but of-~ddJ.:tlcn to r"'-1. other drug for study. stabtttzed en ~rc s~lect~d Th~sa patl~nts ar~ ;.-:t ot,cridln~ for~ p~riod of 7 t9 10 day~, then the m2p~ridlnc .-:/ do~~s of mcp£rldinc ~re ts be ad~ini$t4rcd aAd the rettef of / wtthdr~wa! ~sym;.;to~s vbserv.:d. "t!Hrr~ ;:>o:::s lcl~, il-th:.'t1-JL!d addtct!cn to =e~crtdine ~nly is ~~ccssary Cor inclu:_icn in Declassified by -1.87475- date·-----~=---- 4 FEB 1977 - ~ahtbltcd lnvolunt~ry jerkino ~nd t~ltchlng of mu!elc ;rou~!~ Abstlnenc~ ~ould not be ~rect~itJt~d wltb Nalllne in any of th¢se natlents. Studt~~ on m«oerldln¢ 4ddl~tion 4re describe~ in the d. Chrcn1: lntoxtc~tlon wlth the Dtcthvlamtde onlv 20 to ~0 mlc• ro~r~~•J s. Th: cff~cts of Glnslc cl0scs of the -~ Oeclassifled by _:_,..187475- date . 4. FE 8 1911 ·- • cardlo;rerns, blood chemistry, and ilvcr electrocnce~halosrJms, funr.flon t«sts. control an Fotlo~lng th~ p~~tod, otie~pt ~~s made fQ d.:+~rmln~ the thr~sh~ld d,se (dose which voutd Just lndu~¢ ~lid subj~ctiv« err~ets} t¢t e~ch pattcnt. in th!s doses af 20 to 40 were admln1st:rad dose rnicrcgr~ms ~ad th~ t,t • ~• h. .t'-~ i . . . - .. '" .. " .. ' , • .. • . \.. !I not bc•n d,se (dose which voutd Just lndu~¢ ~lid subj~ctiv« err~ets} t¢t e~ch pattcnt. in th!s doses af 20 to 40 were admln1st:rad dose rnicrcgr~ms ~ad th~ t,t • ~• h. .t'-~ i . . . - .. '" .. " .. ' , • .. • . \.. !I not bc•n rec~tving th~ drug daily tnduc~d ~c•crf~i su~Jccttvz ~ ~ \'$~ ~ ~ ~ f f t t 1 :: r \f fort! , f I t t h a t :::-J t i en h m i n \ 1 t h ·l v c 7 Oeclassifiecf by -187.475- date 4 FES 1977 ..;. . ~·. .. ·: - -. ··.·:-.:. -_ • 90 to -30-0 mlcroc..r am5. The of LSD-25 of ob]~ctlve effect~ tnclucl~ el~wdtlon (measur:d in ltshtJ, tendon a"d control!~d lncr~ascd r~f!exes, dccreas~d 4bdo:nln{Sl :kin r~flex¢s. Gooseflesh, ft;n: int~nti·o•l ··~ Th~ mcnt~f ~ffects of LS~-25 were very strlklng ~nd varlcd . .,. '.- fror.l .)erson to ~~rson. :t-~ obvloo1 cr,rretat ion wtth H~r-sondiity :J tfo~mlc~tlo~~ fc~1tnss of electric shticks on tb~ sktn; ttngl1ns noisss to b: loud bnd dlfflcult to cll:tlnguish; w~rc re~ortcd . . ~hanr•!S i :1 rhc. P·.lt ~~n t js t:~dy of vlston, cc!oratlon of lhands abn~rmal fa~tllar o~j~cts ~urni~3 Declassified ~ ~187475~ · date 4 FtB bt I · ... .... . .· •• dots of llghtt ond ctrcf:s of color. shadows~ d1n~l~g s~lnntng • ·Frequently, lnanimatc In obj~cts w~r~ d!atert~d ~nd ch~n;~d sl%e. Cc~aatonaltv, p6tlents reported se~tng vistons c~~st~t- had difflcutty in thcsG Dis·n~y ~~vl~s." ?~ttcnts d~scrtblng whi!e under th: of LSD-25 tblacklngil 1nd ;cns~ttcns t~flc~n;~ wer~ much more likely tq glve oood delcri?t1ons the day fo!towlng t!1~ ~xperlment •. Th~v com~latned of dlfficulty 1n '" Th~ eff~cts usualli b~gJn~JO mtnut¢S to one hour dft~r \ l"r4 ~ ~ .... :: •.. --.. .:..; J bur fh;;; . ph~tl~. ' stl~tJ)lttan ,y,!~ ~;nh~t!c~d. ~h~tte st!~~'Jl.~ti.r:>n ~~~ .. , Oeclassified by ~187475-. date 4 FEB 1977 - - !I \~'C can r.o t CertaJn tsoiatcd that Jn • ~hrenta. svm~toms ~rc obl~rv¢d such &chtzoJhre~1~, ~s dc~cr$cnalizatlon, d~r~ollzott~n ~nd haltuctna~lon~ 4re observed under LSD. Ho~sver, insfch~ is -. ah~dys Qalntaincd and aff~ct h usually a;::.)roprlah: .. "fh~ t.,t.al / I ptcturc of LSD-lntoxlcatton a dtstlnct constitute~ ~nd rcco~nlz-~. able clfnlcal cnttty, which could confused only w~ fc~l b~ intoxtc6tton with fact, lSD-intoxfcatton ~lth m~scaltn~. I~ The en chrontc ba3 eompletcd ~xperlment lntoxlc~tto~ bee~ tn 3 This heavily redacted page contains typed text detailing research on addiction and the effects of certain substances. There are no photographs, diagrams, or tables. Several redactions obscure portions of the text, particularly in the lower right quadrant. A handwritten annotation "A-65" appears in the lower right corner. Additionally, there is a declassification stamp with a handwritten date "4 FEB 1977", indicating the document has been officially released. The overall impression is of a scientific or research report, with markings suggesting it has undergone official review and release processes. insfch~ is -. ah~dys Qalntaincd and aff~ct h usually a;::.)roprlah: .. "fh~ t.,t.al / I ptcturc of LSD-lntoxlcatton a dtstlnct constitute~ ~nd rcco~nlz-~. able clfnlcal cnttty, which could confused only w~ fc~l b~ intoxtc6tton with fact, lSD-intoxfcatton ~lth m~scaltn~. I~ The en chrontc ba3 eompletcd ~xperlment lntoxlc~tto~ bee~ tn 3 pattenh. ., clec.lt:'!e - i:t the eff~~et . f_·d. "'- _ · _ ~~ . .~ . .,,..-. ,_.,-_ -..•.- J - !. - . · -~ - , . ~ .. - ,.. - ,., - .. s . - t . ~ - . ! - · . ~ $ "'' 1 • .I", ,, t .._ - - ... , .. ~ . . , . . .: ~ .t .r\ -.r~•o.•~ '.w· l\.._, - n .a . ... .~. . # l I t ~ · ~CQ ·- ta tol~r~nce to thts dc~e v~s ~viJ~nt by the 5~-eond ~J~ cf ~cl~I"• . -------~ .. --·. lst:-~i-~<~n ~n:J <1~~-~1r:!;:rac t~ tZ. -c·:;~·:-:i-~~-;: aft~r f.~-ur d ..: ~-~- .c:J ... i;;;~;- #. - ------ -- -- - -----------·-~ ·-.. Oeclassif~'CffiB 1ST1-18j475- date ---------- - • ~ncluded net only a ~eel ~rf~cfs but ~!so • ---- ,_ of LSD-25 after J4 dDys ~d~tnistratlon. C~velo~ment of toter• ~nc~ to LSJ-25 occurs more rd'>ld!y and aa~~ars to be mor~ comJiutc than wtth any drug w~ hav~ ever studi~d. The ra~ldity of thz r~~urn of th~ atf~cts remain~ to b: dct~rminqd. 2. Sioch~~tc~l Stu1ies , a •. CllnleJI E.ncoerlnolocy of· Addtctlon. .... ln the last quarterly report was ~om~lct~d durln9 thl• quart~r. :/- ~ lnfusiont ci lnter_r:dttoq-..,l uidts of A::TH dortng mat:"ltalntd H~w-tvttr th'-i. ln.:r-:~ze in t~rms of ,p<:rccntar,e of th:& IJHii) l di.l i ty €XCr¢tlon wss /g r~atcr durlng Eaintdtn~d addictlon. !n adrltt!on, Declassified by _:..t87475-· · date -,;,_-....,...4,-"~F""'':E~B~I9r-r7 - rl-.-- - ecun t durIng t tmed ACTH t n fus·! on~ was scmiwha t- slow~ r during matnt4Jn.\"!d addiction. but ab:ays felt to· zero (cr. n~ar-tv s-or • in cl'ght hours. lncrea~~ In excratton of f7-kctost~roldt aft~r th~ Injection of 1000 tntern~t1onal untts of chorionic ~onadotroptn for five consecutive day$ was as great tn t~rms of mllltgr~ms ~nd ln terms of p!!rcent.age chance fre,., fi1¢ usua I exer~t ion durtng oddletion as durtng th! ~ontrol p~rlod. t. ~ . --- The data d~finitely show that the test~s 4nd the adrenal of responding to the spccJflc gl~nds ar~ c:apabl~ pitult~rv The document is a declassified page from a report, with a handwritten notation "A-64" in the upper right corner. At the top of the page, there is a heavily redacted image of what appears to be a chemical apparatus or laboratory equipment. Below the redaction, the text details research on a drug's effects on addicts. Near the bottom, there is a "Declassified by" section with a handwritten date "4 FEB 1977" and a numerical identifier "187475". The page is also marked with what appears to be a handwritten "12" preceding a chemical name. day$ was as great tn t~rms of mllltgr~ms ~nd ln terms of p!!rcent.age chance fre,., fi1¢ usua I exer~t ion durtng oddletion as durtng th! ~ontrol p~rlod. t. ~ . --- The data d~finitely show that the test~s 4nd the adrenal of responding to the spccJflc gl~nds ar~ c:apabl~ pitult~rv hormones· addtc:tton to morJhine. excretion du~lng Neverth<:f¢~s, of 17-kztosten:>fds h mark~dly reduc~d· during <.1ddTctton and '/ ~tnh"nced during wlthdrllwdl. D;. Dorfmann, of th~ \~'o-recste!r 'J. foundation for Btolctv, kindly few Ex~~rlmeo}al analy~ed ~ sam~les of urine for ~a on ~ati~~ts who w~r¢ ~ddict¢d to mor~hlnc, a n d d u r 1n g a..c tit e w it h d r a w ~ I o f mo r ph t n e • T h e c x c r e t t o n o f cortlcotds is much lower during m~lntained cddiction. Th~ most reatonablc hypothesis explaining the known to dDt€ is f4ct~ the pitu:rary level durfnc morphfnc ecld!cl lon. ~ ~~ock ~t future work wllf lnc!ud~ dct~rrnln~tlon of tct~J adrGn~l- d frecfionGtton of urinary corttcoids by Dr. Dorfm~nn; a·nd ehortonic gonadatropln daterninatt~ns tto bR done by the Na t i on .;a I Ca n c ~ r I n s t I t u t c , pro v t de d e e r t 4 i n t ~ e h n i ~ ~ t d i f f t c ~.d t l :c :; /I -1"--; /.:r-!=; / Declassi f ie d b Y -rrg'1 .~ .& II 7 475- 4 date ___ ....:!__:_..--;...._-~- .r, b. S~rum El¢ctro~hor~tlc Patt~rns. Thcs« studies have b€cn and extcnd~d mor~ ~~ttcrn~ h4vc been on 4ddtcts· and on At! coll~etcd form~r non~ddlct;. determinations are baing don~ In barbital buff~r, r~th~r thin ~hoi~h~tc buffer, as heretofore. The dlff~rencc in the ra~lo of blobulln Jo globulin b~ta gamm~ pr~vtously r~port~~ fr~tio 0.01. ' . N ~ u r e -d: y s 1·~ 1~ ~, i !': ~ t 5 t ~d ~ -: s ....,.._...........,_,...__ •w f: ......, • • _ _.. of "· tieclassified by __....,_187475- date 4 FEB ,97'7 .. .. . J /. • that 4 l4rgs dos~ of NJillnz Antagonize~ the depr~asont affects of morphine ~·r<~ i·hen ciotzs 4 sm~ll d.ose. Conver.s~ly, a il:ro~ or morphlne the of a ftxcd of dos~ 4nt~s~ntzcs ~rfect$ del~ b. Acdlc~tvn cf Chronic Sp1n~f Doss to The page contains text from a typed document, with some areas of heavy black redaction. There are also some handwritten annotations. At the top right, "page 4" is visible. In the bottom right, a handwritten annotation "4-63" is present. Just above this, a partially obscured section of text appears "Declassified by 187475" followed by "date. 4 FEB 1977". There are no photographs, diagrams, tables, or forms with filled-in fields. The content of this single page is primarily text describing an MK-57 drug and its effects. __....,_187475- date 4 FEB ,97'7 .. .. . J /. • that 4 l4rgs dos~ of NJillnz Antagonize~ the depr~asont affects of morphine ~·r<~ i·hen ciotzs 4 sm~ll d.ose. Conver.s~ly, a il:ro~ or morphlne the of a ftxcd of dos~ 4nt~s~ntzcs ~rfect$ del~ b. Acdlc~tvn cf Chronic Sp1n~f Doss to !!lorphin.c- Two c~ronlc sptn~l do~~ w~re Aftsr addtctton to thts no thr~e week~ mt~ture, ther~ ~as of toizrance to of mlxtur= ~vfcl~~ce th~ d~~ressant ~ffects t~c 'I i.t. .. .,_,.. ,..., L-.-...... ;.-~ ...... - .... • ~ ....... .., ~ ....... 4 ~ • •..: • 't-.11 .. "- eJch of thz l~jcctlon mlxtur~}~ ,-1 - DeclassHJ'ed by 1874""15 1 · · · (fa.te • Pt,. .. c::c .'~~''? . • ... c:. • ustn; two first tha m~nts ~cthoda. Th~ rn~thad lnvolv~i lnj~ctio~ of amounts ot the dally for three l4r~~ d~ug ~ndcr st~dy one~ io f1ve dtiVS ~ftcr whtch i5 !'ng./kg. of N.tltlne ~re ddt=tlnistured. Afti:r l:ij~ctlon of 50 m9./~s. of morphin~ for three to five and would som~timc$ vomit~~~ dev~lop~d tr~mors, conslst~~tiv .>! d l g a h o ! t; .s t + h ..: f c u n d <l t i o n o f' t h ;; b u 1 i d l n g :5 n d t i c l n. 1 r • ., . dbserved after cr w:r~ n~t gtth~r mor~hlne / . ; of sinale of methadone for three to ln tbe .... d~zcs flv~ d~ys. - $f~·:ldH'! l;;crz.a~!r;:? es ~o.-_.shincr dd,3lctio.1 .::-:-c:ce•3.:izd. ';:.he" "· afh:r Declassified by -1.S7475- ~ate---------- .. . a - .. - to In Chronic Add~~tion ~~p~rtdtn, S~tnai ;·tx bouts, to tcl~r~ncc ms./kg. th~ d~pressant eff~cts w~s evJdzot. At this tlm~ 15 contrl1ry~ the fle:tor r~fl~x 1MaS d~:;H¢3$CC end the dog G,:)pesr-\:d " to-be sedated \1fter N4l t ln~. When the numb~r of do5es of / . day' of abru)t withdr4wal wJs C4rrlcd A!t~r stxtz~n addJctl~n. ..:. of Declassified by 187475- ~ate ~ 1Sl? - .· c:hange In the • but tn:t st~t.Utle~l sign1ftcancc: of th!! chanG~:; observed to be phottc stimulation defrn;tely r~malns ~v~iuated. H~w~ver, of optlc41 ~nhanced ~erce~tton pseudo-hallucla~tions. a. E.fi~c:ts o£ u.. ~ r;)hlnc on CondUlvn.ad lnhlbHton '/ m~thod used ~as ~s f~ll~wz: Agult rats ~ere fed 70 p~r cen~ "I rats hGd and had a constant of b3r b~cn train~d att~ined rot~ t:rrninJt~d by ~n cl~ctrlc sh~c~. After conditlon~ng The page is a scanned document with text and some handwritten additions. There are no photographs, diagrams, or tables. Several sections of text are obscured by black redactions, placed in the upper right and lower left portions of the page. There are also handwritten annotations: a number "A-62" is written in the upper right margin, and a "Declassified by" and "date" section is filled in with "187475" and "4 FEB 1977" respectively. The document is a declassified page with typed text, appearing to be research notes on meperidine addiction. Handwritten annotations are present in the top right corner, including "A-61" and some other faint marks. At the bottom, there's a "Declassified by" form with a handwritten date "4 FEB 1977" and a numerical identifier. There are also dark, pixelated redactions at the top and in the bottom center of the page, obscuring content. No photographs, diagrams, or structured data are visible. r~malns ~v~iuated. H~w~ver, of optlc41 ~nhanced ~erce~tton pseudo-hallucla~tions. a. E.fi~c:ts o£ u.. ~ r;)hlnc on CondUlvn.ad lnhlbHton '/ m~thod used ~as ~s f~ll~wz: Agult rats ~ere fed 70 p~r cen~ "I rats hGd and had a constant of b3r b~cn train~d att~ined rot~ t:rrninJt~d by ~n cl~ctrlc sh~c~. After conditlon~ng cccurr~d1 • Declassified by -187475--- 'J:.a :date l 1977 , .. . ~- Slv~n c:JV:try 7 to 10 ·':ltder: 3,._ 10 6,. 7 11, 4,. S, 14, 12 ttnd lf mg_.f;;c. It -w~$·.f.,tJncl thdt the -a~!::-1tn-· lstrAtlon of ih: of ;nhlbttton mor~hine ~Arkcdly aff~ct~d dcgrs~ rate of during the soundlng of tendzd b~r ~rC!$lng th~ buzz~r to the rate. An almost ·~~roach c~ntrol lin~~r dos¢-~rr~ct obttinad are with the consist~nt hy~othesls ~revlousrv dev~loo~d nent ln our o.:>,:;~r!!hu, w.z lnt~nd· to study t!-tt:;; .zf"f~cfs ·of ot~~r . ~:r "' crug!' ), s:..;c., to study • b • .. and ~tt.:::nt!on -i-c-~--£-r- a-f .. ·- t-~ - r -- .. L:2-25. 4 Declassified by r;;;.187 75- date . F'ta JG ;.., "'I • .. • alld an inc:rt?.4~e In ir.dlc:ators· of dnxietv. In the t~~·.Vl t-:sts,_ elevation of all cltntcal scales the ~~s ob!erv~d1 0r~at~st tncrea'~~ b:lr:g ln th~ ttechlzo.?hrento" end ":,dranota" sc.1!<:s. C. BIO?HYSlCAt STUDIES photic:_sttmul4tton in the ~leetr'.l-eneephofocraphic room. At -·-- . ftrst, photlc artifucts bot this ~t~muldtlon fr.duc~d w~s el tminatt:d by c.l~v4t lng the t rshr. \\'c. ~re ~t 1 f f ~-~r:..lng on . ., m :; T h € ~ p ;:: ~~ r a t u i f c r ~ ~ ~ r i :: g t h ~ c on c ~ n i r .il l b n c 1 . a 1c ,; h~ t . . / . . ln. the bt,..::ath w~s r;!t:-<a ived frc;:-:t- tht: ~'1~n·ufth~hrn:r aft,zr ov:.:r- s)1ll found to be poorly. After h~vl ~n~ w~a ~~~forml~g with fhg manufacturer, entire corres~ondcne~ th~ Jn~trv~:nt entire unit w~re rc~dered. Declassified by -187475----._ elate 4 F .E8 1977. ...- • o. Htp. H.£., ond B.zil'!vill~t, R. E.! f:.ffccts ot iotoxtcetton on and Chront~ aarbiturat~ ~~tivatlon ~~scut~r Coordination. Arch. Neurol. & fsv~hl~t~~ 70; l80-l8S (Aug.) 1953" . Wiklar, A., H. and H.! N-AIIvt- ~ra,er~ f.~ l~belf, nor:nor.:lhln.-:: Effects cf =;tncle: :.>c~cs. 4nd f'r~ci:.llt.ltion of Acut~ tti\bstin~nc~ Syndrc::"'~i:t Du:-tr:g Addletio~ ro Worr->h1ne, !.i~thacl~ne or h;:roln ln !;.:Hl l!'ost-~d.Jk.ts }. J. r· ha rmaco L. & f. ~;Jltr. The rt3;J • ., & fsv~hl~t~~ 70; l80-l8S (Aug.) 1953" . Wiklar, A., H. and H.! N-AIIvt- ~ra,er~ f.~ l~belf, nor:nor.:lhln.-:: Effects cf =;tncle: :.>c~cs. 4nd f'r~ci:.llt.ltion of Acut~ tti\bstin~nc~ Syndrc::"'~i:t Du:-tr:g Addletio~ ro Worr->h1ne, !.i~thacl~ne or h;:roln ln !;.:Hl l!'ost-~d.Jk.ts }. J. r· ha rmaco L. & f. ~;Jltr. The rt3;J • ., I C'): tl ) s ... ~o {S ~;.:d-.) 1953. - - _,- A.: •.;;.'1kl~r, An>ilcclltl • ._ . ila:':!e'r;o; ~r l~-::7-ur.~ . ~ ?re:o~nt~d = '. -~. ' I• • edlcal Dlr~ct-;r H~n·is· tabzJ ~~ r "N-A I l v I n ::-r m~ r ::J h i A ~ t; n d 0 t h ~ r An t 3 c :} n ! s t .s t o ny 1'-<~rcot ic: Dru<:~:.n Uni•Hrs of l dtnnls ::oJt~r:-c ~ w of M..acllcirn~. _~:htc~so, lt! .. , Jr.;Jy 29,. 1';t33 .. ___ _ ___ 1'. ;"-.-'. ·? !~ t i ~ .... ~ .....,. . . ~ \ t t ~~or:!~~-! Daclassjfied by _4-Fr~ SJ9~!.;- date ____ _._ _ __:;;-J.W~-- -- . ~ . ~: -.- -~~ '-,;-. -·.- .;":.· - t~. . 1. Bioch~r;,ht 1\nnd- ~U.:n!'"':31l "Hv.n~~d me~~tn:~ ~f f n t ~ r ;-t o1 t t ~' n <1 l ;, !w s 1o I a r i c .i I CQ :1 s r :·~ s s • t<-, r. r r ·i! ~ J , • CJn.4..:ili~ At'svst 3:::-3~cd·. 4, 1:;53, u.ld th~ ln:·~rL~l for ~=etins, Socl~tv ~har~Gcolo~y ~nd ~xp~r~~~ntal Th~ra?::vtlc!·, t-,;<.:w t~~vcn, C~nn., S<!;;~. c; ... :;, !-.153. a. "Cllnle~J Munlfest~tlon~ of Drvg Addtei·ton1~ t!ntv~r~lty o-r Nd;:raska Collcfi~ of :.~~dlclr.:?, ~inco1o, N~b. · ' Cgr.unisstoner ef N;;trcottcs, ·~·ashln:;t~l'\ 1 ~:.. b. !'C!H~r.! c:. curb l h:-ra tc I cdc:r. ic~t IcoH ef School, De~t~ ~herm~colosv, Hsrv~rd ~~d~~~~ "~s ton;- 1.\1S!. t ,. . .. ~ .. T . ! .i \;! 2 r. .$ ~ t ': . .' ...~. f ! .. t • t • ~ • . ~ . . . . . - , f • 4 - , ; . ... · . . ,. - _ . f • • t - - ~ " - " " ') " - , " .. ' I • ~ • .· . _ ., . , , - ~ . . . . . S .. ~ t . - ... t : ~ ,. . ~ ~ The page contains printed text forming a research excerpt on meperidine addiction and chronic intoxication with LSD-251. Several dark, horizontal smudges appear at the top of the page, indicating redactions or obscured content. In the lower right corner, a handwritten annotation, "A-60," is visible. Below the main text, a form labeled "Declassified by" has a handwritten entry of "187475-" with the date "4 FEB 1977" filled in. The overall page is document-like, with minimal visual elements beyond the text, redactions, and official declassification stamp. The page contains typed text describing a drug experiment involving six patients. There are two redacted areas at the top of the page, obscuring some of the text. In the lower right corner, there is a handwritten annotation "4-59" positioned above a small, dark symbol. Below the main text, there is a form-like section indicating "Declassified by" with a number and a date filled in: "187475" and "4 FEB 1977." The document itself appears to be a typewritten report, with no photographs, diagrams, or other visual elements beyond the typed content and the handwritten markings. f • • t - - ~ " - " " ') " - , " .. ' I • ~ • .· . _ ., . , , - ~ . . . . . S .. ~ t . - ... t : ~ ,. . ~ ~ .... ~ ·-~" J \. ~ "'.:; -..1 ,. 1 r • .. d. Durin; a Cycle "t~~~r lt~b ~cf!cx C~anccs ot A·!t·:i~tir.::1 ln '15~~!i?•:'dl.:. . ;~;~.': P. · Declassified date l :. \;;ikler, A.: E. t c c t e d ~ u n ~ 1 1o r c i ~ e r. hr e ~ v i' : y c h l 4 t r l c: A;socl~tio~. S:~t~mber, 1953 • .. ·• ---- Hl :rn •J • - . 18747'5- Decl~ssified by ' 4 1 ·. " £. s date-· l9J:> This page is a typed document with some handwritten annotations. There are two dark, scribbled redactions near the top and center of the page. A handwritten annotation "A-58" is located in the upper right corner. A stamp indicates the document was "Declassified by" and is dated "4 FEB 1977" with a number "187475" next to it. The text discusses the effects of LSD-25, including objective and mental effects observed in patients. There are no images of people, locations, equipment, or experimental procedures visible. The document is a typewritten page with some handwritten annotations on the right side, including a signature-like mark and possibly a number. There is a redacted or obscured area at the top, appearing as a dark, textured shadow, and another similar redacted area at the bottom. In the lower right corner, there is a form indicating "Declassified by" with a number "187475" and "date" followed by "4 FEB 1977". The text describes the subjective effects of LSD-25 on patients, including visual distortions, hallucinations, and altered perceptions, as well as physiological monitoring with EEG. The page contains text that appears to be a typewritten report. There are several black ink smudges obscuring parts of the text, primarily in the top right and bottom left corners. In the bottom right, "Declassified" is stamped with a date of "1977-187475". There is also a handwritten annotation that appears to be a signature or identifier to the right of the stamp, and a short line of handwriting near the top right corner. Overall, the page is dominated by dense blocks of text with minimal visual elements beyond these annotations and smudges. The document page contains typewritten text, with a handwritten annotation at the bottom right reading "A-55". There is also a "Declassified by" form with a handwritten date "4 FEB 1977" and a numerical field "187475". Portions of the upper right corner and a section running diagonally across the middle are obscured by black redactions, with a faint horizontal line visible beneath the upper redaction. No photographs, diagrams, or specific experimental equipment are depicted. This document page is primarily text-based with minimal visual elements. There are no photographs, diagrams, schematics, or organizational charts. The page does contain a handwritten annotation of "A-54" in the lower right quadrant, and there are black scribbled redactions obscuring portions of the top and middle of the page. A stamped form in the lower right corner indicates "Declassified by" with a handwritten date of "4 FEB 1977". This page contains typewritten text, with several instances of handwritten annotations and official markings. There are two redacted blocks of text at the top and middle of the page, obscuring sensitive information. In the lower right corner, there is a "Declassified by" stamp with a number and date ("187475" and "4 FEB 1977"). There is also a handwritten annotation that appears to be "A.5". The document discusses serum electrophoretic patterns and neurophysiological studies related to drug addiction and their effects. The document is a scanned page of typescript with some handwritten annotations and stamps. There are several large, dark, irregular redactions at the top of the page, obscuring some text. Another redaction appears near the bottom right. A handwritten annotation, "A-52", is visible in the upper right corner. In the lower right section, there is a stamp that reads "Declassified by," followed by a handwritten number "187475-" and a handwritten date "4 FEB 1977". There are no photographs, diagrams, or structured data present. This page contains typescript text describing experiments with dogs related to addiction liability. There are handwritten annotations, including the numbers "A-51" in the upper right corner and a declassification block with the date "4 FEB 1977" and an identifier "187475". A black ink smudge or redaction is present near the bottom of the page, obscuring some text. The document appears to be a research report or record related to drug experimentation. The page is a typed document with handwritten annotations and an official stamp. There is a declassification stamp at the bottom right that reads "Declassified by 4 FEB 1977" with a handwritten number "187475" above it. There are also some handwritten marginalia at the top right corner, including "A-56". A large block of text in the middle of the page is obscured by black redaction marks. The page contains typed text detailing an experiment on rats involving conditioned inhibition and the effects of morphine. There are no photographs, diagrams, or organizational charts present. However, there are several handwritten annotations an